{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:43:46Z","timestamp":1780429426724,"version":"3.54.1"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI16\/00498"],"award-info":[{"award-number":["PI16\/00498"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathogenic mechanisms underlying nonalcoholic fatty liver disease (NAFLD) are beginning to be understood. RUNX1 is involved in angiogenesis, which is crucial in inflammation, but its role in nonalcoholic steatohepatitis (NASH) remains unclear. The aim of this study was to analyze RUNX1 mRNA hepatic and jejunal abundance in women with morbid obesity (MO) and NAFLD. RUNX1, lipid metabolism-related genes, and TLRs in women with MO and normal liver (NL, n = 28), NAFLD (n = 41) (simple steatosis (SS, n = 24), or NASH (n = 17)) were analyzed by RT-qPCR. The RUNX1 hepatic expression was higher in SS than in NL or NASH, as likewise confirmed by immunohistochemistry. An increased expression of hepatic FAS was found in NAFLD. Hepatic RUNX1 correlated positively with FAS. There were no significant differences in the jejunum RUNX1 expressions in the different groups. Jejunal FXR expression was lower in NASH than in NL, while the TLR9 expression increased as NAFLD progressed. Jejunal RUNX1 correlated positively with jejunal PPAR\u03b3, TLR4, and TLR5. In summary, the hepatic expression of RUNX1 seems to be involved in the first steps of the NAFLD process; however, in NASH, it seems to be downregulated. Our findings provide important insights into the role of RUNX1 in the context of NAFLD\/NASH, suggesting a protective role.<\/jats:p>","DOI":"10.3390\/ijms22105239","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T23:17:16Z","timestamp":1621207036000},"page":"5239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-1368","authenticated-orcid":false,"given":"Laia","family":"Bertran","sequence":"first","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)\u2014Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-1762","authenticated-orcid":false,"given":"Angela","family":"Pastor","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)\u2014Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-9801","authenticated-orcid":false,"given":"Marta","family":"Portillo-Carrasquer","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)\u2014Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Binetti","sequence":"additional","affiliation":[{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)\u2014Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Servei Anatomia Patol\u00f2gica, Hospital Universitari Joan XXIII Tarragona, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Vives","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, URV, IISPV, Avinguda Doctor Josep Laporte, 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e0tima","family":"Sabench","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, URV, IISPV, Avinguda Doctor Josep Laporte, 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Porras","sequence":"additional","affiliation":[{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Riesco","sequence":"additional","affiliation":[{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Del Castillo","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, URV, IISPV, Avinguda Doctor Josep Laporte, 2, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3bal","family":"Richart","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)\u2014Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain"},{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-6428","authenticated-orcid":false,"given":"Teresa","family":"Auguet","sequence":"additional","affiliation":[{"name":"Grup de Recerca GEMMAIR (AGAUR)\u2014Medicina Aplicada (URV), Departament de Medicina i Cirurgia, Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain"},{"name":"Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafr\u00e9 Guasch, 4, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1053\/j.gastro.2020.01.052","article-title":"Nonalcoholic Fatty Liver Disease 2020: The State of the 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