{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:43:46Z","timestamp":1790534626370,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fond de recherche Qu\u00e9bec \u2013 Sant\u00e9","award":["Post-doctoral fellowship"],"award-info":[{"award-number":["Post-doctoral fellowship"]}]},{"name":"Canadian Institute for Health Research","award":["CIHR MOP142724"],"award-info":[{"award-number":["CIHR MOP142724"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>During tubo-ovarian high-grade serous carcinoma (HGSC) progression, tumoral cells undergo phenotypic changes in their epithelial marker profiles, which are essential for dissemination processes. Here, we set out to determine whether standard epithelial markers can predict HGSC patient prognosis. Levels of E-CADH, KRT7, KRT18, KRT19 were quantified in 18 HGSC cell lines by Western blot and in a Discovery cohort tissue microarray (TMA) (n = 101 patients) using immunofluorescence. E-CADH and KRT7 levels were subsequently analyzed in the TMA of the Canadian Ovarian Experimental Unified Resource cohort (COEUR, n = 1158 patients) and in public datasets. Epithelial marker expression was highly variable in HGSC cell lines and tissues. In the Discovery cohort, high levels of KRT7 and KRT19 were associated with an unfavorable prognosis, whereas high E-CADH expression indicated a better outcome. Expression of KRT7 and E-CADH gave a robust combination to predict overall survival (OS, p = 0.004) and progression free survival (PFS, p = 5.5 \u00d7 10\u22124) by Kaplan\u2013Meier analysis. In the COEUR cohort, the E-CADH-KRT7 signature was a strong independent prognostic biomarker (OS, HR = 1.6, p = 2.9 \u00d7 10\u22124; PFS, HR = 1.3, p = 0.008) and predicted a poor patient response to chemotherapy (p = 1.3 \u00d7 10\u22124). Our results identify a combination of two epithelial markers as highly significant indicators of HGSC patient prognosis and treatment response.<\/jats:p>","DOI":"10.3390\/ijms22105325","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T23:34:46Z","timestamp":1621380886000},"page":"5325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-944X","authenticated-orcid":false,"given":"Laudine","family":"Communal","sequence":"first","affiliation":[{"name":"Institut du Cancer de Montr\u00e9al, Montreal, QC H2X 0A9, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal, QC H2X 0A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Roy","sequence":"additional","affiliation":[{"name":"Institut du Cancer de Montr\u00e9al, Montreal, QC H2X 0A9, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal, QC H2X 0A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5395-8090","authenticated-orcid":false,"given":"Maxime","family":"Cahuzac","sequence":"additional","affiliation":[{"name":"Institut du Cancer de Montr\u00e9al, Montreal, QC H2X 0A9, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal, QC H2X 0A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurosh","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Institut du Cancer de Montr\u00e9al, Montreal, QC H2X 0A9, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal, QC H2X 0A9, Canada"},{"name":"Department of Pathology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"K\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Provencher","sequence":"additional","affiliation":[{"name":"Institut du Cancer de Montr\u00e9al, Montreal, QC H2X 0A9, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal, QC H2X 0A9, Canada"},{"name":"Division of Gynecologic Oncology, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-266X","authenticated-orcid":false,"given":"Anne-Marie","family":"Mes-Masson","sequence":"additional","affiliation":[{"name":"Institut du Cancer de Montr\u00e9al, Montreal, QC H2X 0A9, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal, QC H2X 0A9, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ygyno.2019.08.029","article-title":"Defining the molecular evolution of extrauterine high grade serous carcinoma","volume":"155","author":"Beirne","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Papp","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3322\/caac.21559","article-title":"Epithelial ovarian cancer: Evolution of management in the era of precision medicine","volume":"69","author":"Lheureux","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1158\/1078-0432.CCR-20-0103","article-title":"Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE)","volume":"26","author":"Talhouk","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1158\/1078-0432.CCR-08-0196","article-title":"Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome","volume":"14","author":"Tothill","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network (2011). Integrated genomic analyses of ovarian carcinoma. Nature, 474, 609\u2013615.","DOI":"10.1038\/nature10166"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/emmm.201201823","article-title":"Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer","volume":"5","author":"Tan","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1158\/1078-0432.CCR-18-0784","article-title":"Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma","volume":"24","author":"Chen","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/1878-0261.12096","article-title":"Revisiting epithelial-mesenchymal transition in cancer metastasis: The connection between epithelial plasticity and stemness","volume":"11","author":"Liao","year":"2017","journal-title":"Mol. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sharma, P., Alsharif, S., Fallatah, A., and Chung, B.M. (2019). Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin. Cells, 8.","DOI":"10.3390\/cells8050497"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rosso, M., Majem, B., Devis, L., Lapyckyj, L., Besso, M.J., Llaurado, M., Abascal, M.F., Matos, M.L., Lanau, L., and Castellvi, J. (2017). E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184439"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"81176","DOI":"10.18632\/oncotarget.20885","article-title":"An updated meta-analysis of the prognostic value of decreased E-cadherin expression in ovarian cancer","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/jcp.2005.029876","article-title":"Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer","volume":"59","author":"Voutilainen","year":"2006","journal-title":"J. Clin. Pathol."},{"key":"ref_14","first-page":"11","article-title":"Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness","volume":"1198","author":"Birchmeier","year":"1994","journal-title":"Biochim. Biophys Acta"},{"key":"ref_15","first-page":"166","article-title":"Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer","volume":"30","author":"Ramalingam","year":"2016","journal-title":"Oncology (Williston Park)"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1432-0436.1993.tb00648.x","article-title":"The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas","volume":"53","author":"Moll","year":"1993","journal-title":"Differentiation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/onc.2010.456","article-title":"Keratins in health and cancer: More than mere epithelial cell markers","volume":"30","author":"Karantza","year":"2011","journal-title":"Oncogene"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1158\/1078-0432.CCR-03-0114","article-title":"Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer","volume":"10","author":"Woelfle","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cen, D., Chen, J., Li, Z., Zhao, J., and Cai, X. (2017). Prognostic significance of cytokeratin 19 expression in pancreatic neuroendocrine tumor: A meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187588"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1245\/s10434-011-2175-4","article-title":"Cytokeratin 7 is a predictive marker for survival in patients with esophageal squamous cell carcinoma","volume":"19","author":"Oue","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12032-020-01362-0","article-title":"Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer","volume":"37","author":"Yang","year":"2020","journal-title":"Med. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.5114\/pjp.2016.63774","article-title":"Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma","volume":"67","author":"Czapiewski","year":"2016","journal-title":"Pol. J. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3892\/or.2020.7886","article-title":"KRT7 promotes epithelialmesenchymal transition in ovarian cancer via the TGFbeta\/Smad2\/3 signaling pathway","volume":"45","author":"An","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"144947","DOI":"10.1016\/j.gene.2020.144947","article-title":"FoxM1 promotes the migration of ovarian cancer cell through KRT5 and KRT7","volume":"757","author":"Zhang","year":"2020","journal-title":"Gene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17819","DOI":"10.18632\/oncotarget.14867","article-title":"Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance","volume":"8","author":"Ricciardelli","year":"2017","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1038\/sj.onc.1208214","article-title":"Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling","volume":"24","author":"Ouellet","year":"2005","journal-title":"Oncogene"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1038\/s41379-020-0586-0","article-title":"Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa","volume":"33","author":"Communal","year":"2020","journal-title":"Mod. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Labouba, I., Le Page, C., Communal, L., Kristessen, T., You, X., Peant, B., Barres, V., Gannon, P.O., Mes-Masson, A.M., and Saad, F. (2015). Potential Cross-Talk between Alternative and Classical NF-kappaB Pathways in Prostate Cancer Tissues as Measured by a Multi-Staining Immunofluorescence Co-Localization Assay. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131024"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43843","DOI":"10.18632\/oncotarget.5983","article-title":"CSIOVDB: A microarray gene expression database of epithelial ovarian cancer subtype","volume":"6","author":"Tan","year":"2015","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2012.20","article-title":"Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer","volume":"307","author":"Bolton","year":"2012","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1470-2045(13)70253-5","article-title":"Hormone-receptor expression and ovarian cancer survival: An Ovarian Tumor Tissue Analysis consortium study","volume":"14","author":"Sieh","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_32","unstructured":"Ovarian Tumor Tissue Analysis (OTTA) Consortium, Goode, E.L., Block, M.S., Kalli, K.R., Vierkant, R.A., Chen, W., Fogarty, Z.C., Gentry-Maharaj, A., Toloczko, A., and Hein, A. (2017). Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer. JAMA Oncol., 3, e173290."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.annonc.2020.05.019","article-title":"Prognostic gene expression signature for high-grade serous ovarian cancer","volume":"31","author":"Millstein","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1757-2215-7-76","article-title":"The EMT (epithelial-mesenchymal-transition)-related protein expression indicates the metastatic status and prognosis in patients with ovarian cancer","volume":"7","author":"Takai","year":"2014","journal-title":"J. Ovarian Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2014.10.004","article-title":"The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions","volume":"46","author":"Davidson","year":"2015","journal-title":"Hum. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1038\/ncomms6165","article-title":"Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition","volume":"5","author":"Gormally","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41419-017-0156-7","article-title":"Honokiol is a FOXM1 antagonist","volume":"9","author":"Halasi","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_39","first-page":"321","article-title":"Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis","volume":"36","author":"Sano","year":"2010","journal-title":"Int. J. Oncol."},{"key":"ref_40","first-page":"1041","article-title":"FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells","volume":"33","author":"Liu","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chen, S., Su, T., Zhang, Y., Lee, A., He, J., Ge, Q., Wang, L., Si, J., Zhuo, W., and Wang, L. (2020). Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS\/KRT7. Gut Microbes, 1\u201315.","DOI":"10.2139\/ssrn.3405559"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1038\/onc.2016.25","article-title":"Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression","volume":"35","author":"Huang","year":"2016","journal-title":"Oncogene"},{"key":"ref_43","first-page":"2016","article-title":"Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia","volume":"55","author":"Badea","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.humpath.2018.08.006","article-title":"High proliferation rate and TNM stage but not histomorphological subtype are independent prognostic markers for overall survival in papillary renal cell carcinoma","volume":"83","author":"Polifka","year":"2019","journal-title":"Hum. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ijc.23565","article-title":"Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer","volume":"123","author":"Mertz","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Werner, S., Keller, L., and Pantel, K. (2019). Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies. Mol. Aspects Med.","DOI":"10.1016\/j.mam.2019.09.001"},{"key":"ref_47","first-page":"2294","article-title":"Cytokeratin 7 and thyroid transcription factor\u20141 levels in patients with lung cancer complicated with superior vena cava syndrome and their correlation with clinicopathological characteristics","volume":"24","author":"Tong","year":"2019","journal-title":"J. BUON"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13048-019-0587-0","article-title":"Evaluation of the value of preoperative CYFRA21-1 in the diagnosis and prognosis of epithelial ovarian cancer in conjunction with CA125","volume":"12","author":"Jin","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/sj.bjc.6601851","article-title":"CYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: Results of a meta-analysis in 2063 patients","volume":"90","author":"Pujol","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/REP-14-0234","article-title":"Epithelial ovarian cancer stem cells: Underlying complexity of a simple paradigm","volume":"149","author":"Garson","year":"2015","journal-title":"Reproduction"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1038\/s41388-017-0106-y","article-title":"Aggressive serous epithelial ovarian cancer is potentially propagated by EpCAM(+)CD45(+) phenotype","volume":"37","author":"Akhter","year":"2018","journal-title":"Oncogene"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44312","DOI":"10.18632\/oncotarget.17871","article-title":"The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer","volume":"8","author":"Tayama","year":"2017","journal-title":"Oncotarget"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.celrep.2017.02.028","article-title":"Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer","volume":"18","author":"Medrano","year":"2017","journal-title":"Cell Rep."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Le Page, C., Rahimi, K., Kobel, M., Tonin, P.N., Meunier, L., Portelance, L., Bernard, M., Nelson, B.H., Bernardini, M.Q., and Bartlett, J.M.S. (2018). Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4242-8"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/PGP.0000000000000274","article-title":"An Immunohistochemical Algorithm for Ovarian Carcinoma Typing","volume":"35","author":"Kobel","year":"2016","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/ERC-11-0329","article-title":"Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients","volume":"19","author":"Gyorffy","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ouellet, V., Zietarska, M., Portelance, L., Lafontaine, J., Madore, J., Puiffe, M.L., Arcand, S.L., Shen, Z., Hebert, J., and Tonin, P.N. (2008). Characterization of three new serous epithelial ovarian cancer cell lines. BMC Cancer, 8.","DOI":"10.1186\/1471-2407-8-152"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Letourneau, I.J., Quinn, M.C., Wang, L.L., Portelance, L., Caceres, K.Y., Cyr, L., Delvoye, N., Meunier, L., de Ladurantaye, M., and Shen, Z. (2012). Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer. BMC Cancer, 12.","DOI":"10.1186\/1471-2407-12-379"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.18632\/genesandcancer.76","article-title":"Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease","volume":"6","author":"Fleury","year":"2015","journal-title":"Genes Cancer"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/10\/5325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:03:41Z","timestamp":1760162621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/10\/5325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["ijms22105325"],"URL":"https:\/\/doi.org\/10.3390\/ijms22105325","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]}}}