{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:33:29Z","timestamp":1790739209367,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center","award":["2013\/11\/B\/ST8\/03401"],"award-info":[{"award-number":["2013\/11\/B\/ST8\/03401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim was to examine the efficiency of a scaffold made of poly (L-lactic acid)-co-poly(\u03f5-caprolactone), collagen (COL), polyaniline (PANI), and enriched with adipose-derived stem cells (ASCs) as a nerve conduit in a rat model. P(LLA-CL)-COL-PANI scaffold was optimized and electrospun into a tubular-shaped structure. Adipose tissue from 10 Lewis rats was harvested for ASCs culture. A total of 28 inbred male Lewis rats underwent sciatic nerve transection and excision of a 10 mm nerve trunk fragment. In Group A, the nerve gap remained untouched; in Group B, an excised trunk was used as an autograft; in Group C, nerve stumps were secured with P(LLA-CL)-COL-PANI conduit; in Group D, P(LLA-CL)-COL-PANI conduit was enriched with ASCs. After 6 months of observation, rats were sacrificed. Gastrocnemius muscles and sciatic nerves were harvested for weight, histology analysis, and nerve fiber count analyses. Group A showed advanced atrophy of the muscle, and each intervention (B, C, D) prevented muscle mass decrease (p &lt; 0.0001); however, ASCs addition decreased efficiency vs. autograft (p &lt; 0.05). Nerve fiber count revealed a superior effect in the nerve fiber density observed in the groups with the use of conduit (D vs. B p &lt; 0.0001, C vs. B p &lt; 0.001). P(LLA-CL)-COL-PANI conduits with ASCs showed promising results in managing nerve gap by decreasing muscle atrophy.<\/jats:p>","DOI":"10.3390\/ijms22115588","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T13:14:21Z","timestamp":1621948461000},"page":"5588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Bioactive Nanofiber-Based Conduits in a Peripheral Nerve Gap Management\u2014An Animal Model Study"],"prefix":"10.3390","volume":"22","author":[{"given":"Tomasz","family":"D\u0119bski","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-2838","authenticated-orcid":false,"given":"Ewa","family":"Kije\u0144ska-Gawro\u0144ska","sequence":"additional","affiliation":[{"name":"Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, Poleczki 19, 02-822 Warsaw, Poland"},{"name":"Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Zo\u0142oci\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-939X","authenticated-orcid":false,"given":"Katarzyna","family":"Siennicka","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-0785","authenticated-orcid":false,"given":"Anna","family":"S\u0142ysz","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-5446","authenticated-orcid":false,"given":"Wiktor","family":"Paskal","sequence":"additional","affiliation":[{"name":"Centre for Preclinical Research, Department of Methodology, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-1791","authenticated-orcid":false,"given":"Pawe\u0142 K.","family":"W\u0142odarski","sequence":"additional","affiliation":[{"name":"Centre for Preclinical Research, Department of Methodology, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"\u015awi\u0119szkowski","sequence":"additional","affiliation":[{"name":"Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Woloska 141, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-4433","authenticated-orcid":false,"given":"Zygmunt","family":"Pojda","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"D\u0119bski, T., and Noszczyk, B.H. 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