{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:35:12Z","timestamp":1775914512787,"version":"3.50.1"},"reference-count":173,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myocardial infarction is one of the major causes of mortality worldwide and is a main cause of heart failure. This disease appears as a final point of atherosclerotic plaque progression, destabilization, and rupture. As a consequence of cardiomyocytes death during the infarction, the heart undergoes unfavorable cardiac remodeling, which results in its failure. Therefore, therapies aimed to limit the processes of atherosclerotic plaque progression, cardiac damage during the infarction, and subsequent remodeling are urgently warranted. A hopeful therapeutic option for the future medicine is targeting and regulating non-coding RNA (ncRNA), like microRNA, circular RNA (circRNA), or long non-coding RNA (lncRNA). In this review, the approaches targeted at ncRNAs participating in the aforementioned pathophysiological processes involved in myocardial infarction and their outcomes in preclinical studies have been concisely presented.<\/jats:p>","DOI":"10.3390\/ijms22115718","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:07:02Z","timestamp":1622113622000},"page":"5718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Therapies Targeted at Non-Coding RNAs in Prevention and Limitation of Myocardial Infarction and Subsequent Cardiac Remodeling\u2014Current Experience and Perspectives"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-4192","authenticated-orcid":false,"given":"Michal","family":"Kowara","sequence":"first","affiliation":[{"name":"Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Borodzicz-Jazdzyk","sequence":"additional","affiliation":[{"name":"Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Rybak","sequence":"additional","affiliation":[{"name":"Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Kubik","sequence":"additional","affiliation":[{"name":"Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Cudnoch-Jedrzejewska","sequence":"additional","affiliation":[{"name":"Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.18388\/abp.2001_3893","article-title":"The human genome structure and organization","volume":"48","year":"2001","journal-title":"Acta Biochim. Pol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-med-051010-162644","article-title":"Human Genome Sequencing in Health and Disease","volume":"63","author":"Lupski","year":"2012","journal-title":"Annu. Rev. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1440-1681.2008.04880.x","article-title":"Searching for Functional Genetic Variants in Non-Coding DNA","volume":"35","author":"Cobb","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/gb-2004-5-4-105","article-title":"The mammalian transcriptome and the function of non-coding DNA sequences","volume":"5","author":"Shabalina","year":"2004","journal-title":"Genome Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nature01266","article-title":"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs","volume":"420","author":"Okazaki","year":"2002","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: Classification, Biology and Functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1101\/gr.247239.118","article-title":"Decrypting noncoding RNA interactions, structures, and functional networks","volume":"29","author":"Fabbri","year":"2019","journal-title":"Genome Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-981-10-5203-3_2","article-title":"Long Noncoding RNA: Genome Organization and Mechanism of Action","volume":"1008","author":"Akhade","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Alessio, E., Bonadio, R.S., Buson, L., Chemello, F., and Cagnin, S. (2020). A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010302"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-genet-120417-031441","article-title":"piRNA-Guided Genome Defense: From Biogenesis to Silencing","volume":"52","author":"Czech","year":"2018","journal-title":"Annu. Rev. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molcel.2018.06.034","article-title":"The Biogenesis, Functions, and Challenges of Circular RNAs","volume":"71","author":"Li","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1093\/eurheartj\/ehx165","article-title":"Non-coding RNAs in cardiovascular diseases: Diagnostic and therapeutic perspectives","volume":"39","author":"Poller","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/gt.2011.50","article-title":"MicroRNA therapeutics","volume":"18","author":"Broderick","year":"2011","journal-title":"Gene Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/gt.2011.100","article-title":"Chemical modification and design of anti-miRNA oligonucleotides","volume":"18","author":"Lennox","year":"2011","journal-title":"Gene Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrd.2016.117","article-title":"Non-coding RNAs as drug targets","volume":"16","author":"Matsui","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bajan, S., and Hutvagner, G. (2020). RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs. Cells, 9.","DOI":"10.3390\/cells9010137"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/CIRCRESAHA.117.311311","article-title":"RNA Therapeutics in Cardiovascular Disease","volume":"123","author":"Lucas","year":"2018","journal-title":"Circ. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nmeth.2598","article-title":"CRISPR RNA\u2013guided activation of endogenous human genes","volume":"10","author":"Maeder","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1038\/ncomms4596","article-title":"CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation","volume":"5","author":"Wang","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fgene.2018.00471","article-title":"Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors","volume":"9","author":"Dong","year":"2018","journal-title":"Front. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ejhf.495","article-title":"MicroRNAs in heart failure: From biomarker to target for therapy","volume":"18","author":"Vegter","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2741\/s546","article-title":"Epigenetic regulation as a promising tool for treatment of atherosclerosis","volume":"12","author":"Skuratovskaia","year":"2020","journal-title":"Front. Biosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11883-020-00839-7","article-title":"Acute Coronary Syndrome with Non-ruptured Plaques (NONRUPLA): Novel Ideas and Perspectives","volume":"22","author":"Leopoulou","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of Plaque Formation and Rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/CIRCRESAHA.114.302355","article-title":"Atherosclerotic plaque destabilization: Mechanisms, models, and therapeutic strategies","volume":"114","author":"Weber","year":"2014","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"16","author":"Basatemur","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MOL.0000000000000394","article-title":"The walking dead: Macrophage inflammation and death in atherosclerosis","volume":"28","author":"Kavurma","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/joim.12406","article-title":"Inflammation and plaque vulnerability","volume":"278","author":"Hansson","year":"2015","journal-title":"J. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1161\/ATVBAHA.114.303424","article-title":"Mechanoresponsive Networks Controlling Vascular Inflammation","volume":"34","author":"Bryan","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.yjmcc.2012.05.011","article-title":"Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells","volume":"53","author":"Pfenniger","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.115.306300","article-title":"MicroRNA Regulation of Atherosclerosis","volume":"118","author":"Feinberg","year":"2016","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1161\/ATVBAHA.118.310227","article-title":"Impact of miRNA in Atherosclerosis","volume":"38","author":"Lu","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/cvr\/cvz203","article-title":"Non-coding RNAs in cardiovascular cell biology and atherosclerosis","volume":"115","author":"Fasolo","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1161\/ATVBAHA.120.314222","article-title":"Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy","volume":"40","author":"Pierce","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nm.3200","article-title":"MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion","volume":"19","author":"Soh","year":"2013","journal-title":"Nat. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.atherosclerosis.2018.02.010","article-title":"Induction of microRNA-10a using retinoic acid receptor-\u03b1 and retinoid x receptor-\u03b1 agonists inhibits atherosclerotic lesion formation","volume":"271","author":"Lee","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/CIRCRESAHA.114.302213","article-title":"Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice","volume":"114","author":"Loyer","year":"2014","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00380-018-1169-6","article-title":"Downregulation of miR-34a promotes endothelial cell growth and suppresses apoptosis in atherosclerosis by regulating Bcl-2","volume":"33","author":"Su","year":"2018","journal-title":"Heart Vessel."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Alves-Fernandes, D.K., and Jasiulionis, M.G. (2019). The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133153"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/ATVBAHA.118.311298","article-title":"miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)","volume":"38","author":"Badi","year":"2018","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.3487","article-title":"MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1","volume":"20","author":"Schober","year":"2014","journal-title":"Nat. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.atherosclerosis.2014.07.005","article-title":"MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1","volume":"236","author":"Lv","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/CIRCRESAHA.115.304164","article-title":"miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice","volume":"115","author":"Distel","year":"2014","journal-title":"Circ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1172\/JCI81676","article-title":"MicroRNA-33\u2013dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis","volume":"125","author":"Ouimet","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.redox.2018.03.003","article-title":"MicroRNA-98 regulates foam cell formation and lipid accumulation through repression of LOX-1","volume":"16","author":"Dai","year":"2018","journal-title":"Redox Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/ATVBAHA.113.302701","article-title":"MicroRNA-155 Deficiency Results in Decreased Macrophage Inflammation and Attenuated Atherogenesis in Apolipoprotein E\u2013Deficient Mice","volume":"34","author":"Du","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1172\/JCI61716","article-title":"MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages","volume":"122","author":"Wei","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1073\/pnas.0902636106","article-title":"Inositol phosphatase SHIP1 is a primary target of miR-155","volume":"106","author":"Chaudhuri","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1253\/circj.CJ-16-1165","article-title":"MicroRNA-182 Promotes Lipoprotein Lipase Expression and Atherogenesisby Targeting Histone Deacetylase 9 in Apolipoprotein E-Knockout Mice","volume":"82","author":"Cheng","year":"2018","journal-title":"Circ. J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"He, P.-P., Ouyang, X.-P., Li, Y., Lv, Y.-C., Wang, Z.-B., Yao, F., Xie, W., Tan, Y.-L., Li, L., and Zhang, M. (2015). MicroRNA-590 Inhibits Lipoprotein Lipase Expression and Prevents Atherosclerosis in apoE Knockout Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138788"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2018.08.034","article-title":"MicroRNA-124-3p inhibits collagen synthesis in atherosclerotic plaques by targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) in vascular smooth muscle cells","volume":"277","author":"Chen","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.15252\/emmm.201607492","article-title":"Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis","volume":"9","author":"Rotllan","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_53","first-page":"2216","article-title":"Effects of MiR-21 on the proliferation and migration of vascular smooth muscle cells in rats with atherosclerosis via the Akt\/ERK signaling pathway","volume":"23","author":"Sun","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1161\/ATVBAHA.114.304088","article-title":"MicroRNA-24 regulates macrophage behavior and retards atherosclerosis","volume":"34","author":"Jenkins","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2018.01.045","article-title":"MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I","volume":"270","author":"Ren","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1016\/j.jacc.2015.03.570","article-title":"An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells: Role of MicroRNA-223 in Smooth Muscle Function and Atherogenesis","volume":"65","author":"Shan","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, C., Fang, Z., Jiang, T., Zhang, Q., Liu, C., Zhang, C., and Xiang, Y. (2013). Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. BMC Med. Genom., 6.","DOI":"10.1186\/1755-8794-6-16"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e001223","DOI":"10.1136\/openhrt-2019-001223","article-title":"MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability","volume":"7","author":"Singh","year":"2020","journal-title":"Open Heart"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1161\/CIRCULATIONAHA.111.084186","article-title":"MicroRNA-145 Targeted Therapy Reduces Atherosclerosis","volume":"126","author":"Lovren","year":"2012","journal-title":"Circulation"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1160\/TH13-11-0905","article-title":"MiR-143\/145 deficiency attenuates the progression of atherosclerosis in Ldlr-\/-mice","volume":"112","author":"Sala","year":"2014","journal-title":"Thromb. Haemost."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCRESAHA.116.309321","article-title":"MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin","volume":"120","author":"Anuar","year":"2017","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1007\/s12035-016-0163-1","article-title":"MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1","volume":"54","author":"Xia","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1038\/ncomms12429","article-title":"Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans","volume":"7","author":"Holdt","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"eaaw1868","DOI":"10.1126\/scitranslmed.aaw1868","article-title":"Long noncoding RNA SNHG12 integrates a DNA-PK\u2013mediated DNA damage response and vascular senescence","volume":"12","author":"Haemmig","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes","volume":"329","author":"Tsai","year":"2010","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20170351","article-title":"Thymic stromal lymphopoietin-induced HOTAIR activation promotes endothelial cell proliferation and migration in atherosclerosis","volume":"37","author":"Peng","year":"2017","journal-title":"Biosci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1073\/pnas.1810729116","article-title":"SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4","volume":"116","author":"Lyu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1172\/JCI98230","article-title":"Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN","volume":"129","author":"Hu","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-1409-4","article-title":"LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation","volume":"10","author":"Ye","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nm.4479","article-title":"Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA","volume":"24","author":"Sallam","year":"2018","journal-title":"Nat. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"E8660","DOI":"10.1073\/pnas.1803725115","article-title":"Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells","volume":"115","author":"Ahmed","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.18632\/oncotarget.23230","article-title":"LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagy","volume":"9","author":"Song","year":"2017","journal-title":"Oncotarget"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/CIRCULATIONAHA.117.029015","article-title":"Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation","volume":"139","author":"Cremer","year":"2019","journal-title":"Circulation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1074\/jbc.RA118.005050","article-title":"Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes","volume":"294","author":"Cho","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/ATVBAHA.109.196832","article-title":"ANRIL expression is associated with atherosclerosis risk at chromosome 9p21","volume":"30","author":"Holdt","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e003376","DOI":"10.1161\/JAHA.112.003376","article-title":"MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-\/- mice","volume":"1","author":"Horie","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/ATVBAHA.116.308916","article-title":"microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis","volume":"37","author":"Ouimet","year":"2017","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3892\/etm.2017.4171","article-title":"MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1","volume":"13","author":"Chen","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1517\/14728222.2013.745512","article-title":"Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients","volume":"17","author":"Santovito","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/ATVBAHA.114.304029","article-title":"Cholesterol loading reprograms the microRNA-143\/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype","volume":"35","author":"Vengrenyuk","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"50","DOI":"10.12688\/f1000research.1-50.v1","article-title":"The distribution of circulating microRNA and their relation to coronary disease","volume":"1","author":"Freedman","year":"2012","journal-title":"F1000Res"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1172\/JCI57275","article-title":"Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis","volume":"121","author":"Rayner","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/ATVBAHA.112.300639","article-title":"Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"33","author":"Marquart","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1161\/ATVBAHA.113.301732","article-title":"Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-\/- mice--brief report","volume":"33","author":"Rotllan","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/jmcb\/mjz015","article-title":"miR-145 improves metabolic inflammatory disease through multiple pathways","volume":"12","author":"He","year":"2020","journal-title":"J. Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/SLA.0000000000001466","article-title":"Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability","volume":"262","author":"Wezel","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.omtn.2019.09.021","article-title":"Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization","volume":"18","author":"Foks","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.atherosclerosis.2017.04.011","article-title":"Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis","volume":"261","author":"Welten","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1161\/01.CIR.0000054781.50889.0C","article-title":"Eliminating Atherogenesis in Mice by Switching Off Hepatic Lipoprotein Secretion","volume":"107","author":"Lieu","year":"2003","journal-title":"Circulation"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2337\/db10-0778","article-title":"Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice","volume":"60","author":"Parathath","year":"2011","journal-title":"Diabetes"},{"key":"ref_91","first-page":"275","article-title":"Advances in Antisense Oligonucleotide Development for Target Identification, Validation, and as Novel Therapeutics","volume":"2","author":"Mansoor","year":"2008","journal-title":"Gene Regul. Syst. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.1102281108","article-title":"miR-33a\/b contribute to the regulation of fatty acid metabolism and insulin signaling","volume":"108","author":"Davalos","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1111\/jcmm.13269","article-title":"microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105873","DOI":"10.1016\/j.biocel.2020.105873","article-title":"MicroRNA-520c-3p targeting of RelA\/p65 suppresses atherosclerotic plaque formation","volume":"131","author":"Wang","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e23608","DOI":"10.1002\/jcla.23608","article-title":"Overexpressed miR-335-5p reduces atherosclerotic vulnerable plaque formation in acute coronary syndrome","volume":"35","author":"Sun","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/ijmm.2017.2995","article-title":"MicroRNA let-7g alleviates atherosclerosis via the targeting of LOX-1 in vitro and in vivo","volume":"40","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.yjmcc.2018.09.004","article-title":"MicroRNA-23a-5p promotes atherosclerotic plaque progression and vulnerability by repressing ATP-binding cassette transporter A1\/G1 in macrophages","volume":"123","author":"Yang","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/iub.2155","article-title":"Downregulation of microRNA-135b promotes atherosclerotic plaque stabilization in atherosclerotic mice by upregulating erythropoietin receptor","volume":"72","author":"Wu","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCRESAHA.116.309318","article-title":"MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions","volume":"120","author":"Eken","year":"2017","journal-title":"Circ. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"643","DOI":"10.15252\/emmm.201506031","article-title":"Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice","volume":"8","author":"Ulrich","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.114.011675","article-title":"LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity","volume":"130","author":"Wu","year":"2014","journal-title":"Circulation"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1161\/ATVBAHA.119.313749","article-title":"Macrophage-Enriched lncRNA RAPIA: A Novel Therapeutic Target for Atherosclerosis","volume":"40","author":"Sun","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-020-00825-9","article-title":"Targeting myocardial ischaemic injury in the absence of reperfusion","volume":"115","author":"Basalay","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"ref_104","first-page":"62","article-title":"Cardiac Remodeling: Concepts, Clinical Impact, Pathophysiological Mechanisms and Pharmacologic Treatment","volume":"106","author":"Polegato","year":"2016","journal-title":"Arq. Braz. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jcmg.2010.10.008","article-title":"Left Ventricular Remodeling in Heart Failure: Current Concepts in Clinical Significance and Assessment","volume":"4","author":"Konstam","year":"2011","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fcvm.2018.00073","article-title":"Deciphering Non-coding RNAs in Cardiovascular Health and Disease","volume":"5","author":"Das","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00018-017-2640-8","article-title":"Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases","volume":"75","author":"Dong","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: A review of the major forms of apoptosis, necrosis and autophagy","volume":"43","year":"2019","journal-title":"Cell Biol. Int."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1522-4","article-title":"LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p\/Sirt1 axis","volume":"10","author":"Mao","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11010-014-2273-2","article-title":"miR-133a mediates the hypoxia-induced apoptosis by inhibiting TAGLN2 expression in cardiac myocytes","volume":"400","author":"Li","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"ref_111","first-page":"5934","article-title":"Investigating the expression of miRNA-133 in animal models of myocardial infarction and its effect on cardiac function","volume":"23","author":"Zhang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-09530-1","article-title":"Therapeutic role of miR-19a\/19b in cardiac regeneration and protection from myocardial infarction","volume":"10","author":"Gao","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.110.964684","article-title":"MicroRNA-494 Targeting Both Proapoptotic and Antiapoptotic Proteins Protects Against Ischemia\/Reperfusion-Induced Cardiac Injury","volume":"122","author":"Wang","year":"2010","journal-title":"Circulation"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yjmcc.2019.05.007","article-title":"MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24","volume":"132","author":"Han","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Zhang, D.Y., Wang, B.J., Ma, M., Yu, K., Zhang, Q., and Zhang, X.W. (2019). MicroRNA-325-3p protects the heart after myocardial infarction by inhibiting RIPK3 and programmed necrosis in mice. BMC Mol. Biol., 20.","DOI":"10.1186\/s12867-019-0133-z"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jcp.10174","article-title":"Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling","volume":"193","author":"Abbate","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","article-title":"Inhibition of miR-15 Protects Against Cardiac Ischemic Injury","volume":"110","author":"Hullinger","year":"2012","journal-title":"Circ. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e23099","DOI":"10.1002\/jcla.23099","article-title":"Expression profiling and bioinformatics analysis of circulating microRNAs in patients with acute myocardial infarction","volume":"34","author":"Zhong","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"17615","DOI":"10.1073\/pnas.1206432109","article-title":"Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function","volume":"109","author":"Bernardo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1084\/jem.20101547","article-title":"miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes","volume":"208","author":"Qian","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2019.03.016","article-title":"Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease","volume":"285","author":"Moghaddam","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-01952-2","article-title":"MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy","volume":"4","author":"Fukuoka","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.carpath.2014.03.009","article-title":"The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a\/b-3p in human atherosclerotic coronary artery","volume":"23","author":"Hao","year":"2014","journal-title":"Cardiovasc. Pathol."},{"key":"ref_124","first-page":"5335","article-title":"Downregulation of microRNA199a5p attenuates hypoxia\/reoxygenationinduced cytotoxicity in cardiomyocytes by targeting the HIF1alphaGSK3betamPTP axis","volume":"19","author":"Liu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e008024","DOI":"10.1161\/JAHA.117.008024","article-title":"Inflammation, Autophagy, and Apoptosis after Myocardial Infarction","volume":"7","author":"Wang","year":"2018","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/jcmm.12242","article-title":"Overexpression of microRNA-99a attenuates heart remodelling and improves cardiac performance after myocardial infarction","volume":"18","author":"Li","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jacc.2016.07.739","article-title":"Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction","volume":"68","author":"Gupta","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2019.03.007","article-title":"Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b","volume":"130","author":"Cai","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-11777-7","article-title":"Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS\/VEGF-A axis","volume":"10","author":"Garikipati","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10741-019-09882-2","article-title":"Long non-coding RNAs in cardiac hypertrophy","volume":"25","author":"Sun","year":"2020","journal-title":"Hear. Fail. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: Signaling pathways and novel therapeutic targets","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2014Concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_134","first-page":"59","article-title":"MicroRNAs in the development of left ventricular remodeling and postmyocardial infarction heart failure","volume":"130","author":"Sygitowicz","year":"2020","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_135","first-page":"980","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"456","author":"Thum","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1159\/000479995","article-title":"Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7","volume":"42","author":"Yuan","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/abbs\/gmp018","article-title":"Regulation of TGF-beta signaling by Smad7","volume":"41","author":"Yan","year":"2009","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-018-0805-5","article-title":"MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"664","DOI":"10.7150\/thno.15162","article-title":"miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury","volume":"7","author":"Shi","year":"2017","journal-title":"Theranostics"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/jcmm.14704","article-title":"MiR-590-3p regulates proliferation, migration and collagen synthesis of cardiac fibroblast by targeting ZEB1","volume":"24","author":"Yuan","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/cvr\/cvaa287","article-title":"Angiogenesis after acute myocardial infarction","volume":"117","author":"Wu","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_142","first-page":"107","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/CIRCRESAHA.113.301780","article-title":"MicroRNA-26a Regulates Pathological and Physiological Angiogenesis by Targeting BMP\/SMAD1 Signaling","volume":"113","author":"Icli","year":"2013","journal-title":"Circ. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/ATVBAHA.116.308695","article-title":"Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression","volume":"37","author":"Templin","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.7150\/thno.33920","article-title":"LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction","volume":"9","author":"Hao","year":"2019","journal-title":"Theranostics"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"108354","DOI":"10.1016\/j.abb.2020.108354","article-title":"Lnc-Ang362 is a pro-fibrotic long non-coding RNA promoting cardiac fibrosis after myocardial infarction by suppressing Smad7","volume":"685","author":"Chen","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.7150\/ijbs.28103","article-title":"Cardiac fibrosis: New insights into the pathogenesis","volume":"14","author":"Ma","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2018.03.007","article-title":"Connective tissue growth factor (CTGF) from basics to clinics","volume":"68\u201369","author":"Ramazani","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.12659\/MSM.910000","article-title":"Long Noncoding RNA (lncRNA) n379519 Promotes Cardiac Fibrosis in Post-Infarct Myocardium by Targeting miR-30","volume":"24","author":"Wang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"20190788","DOI":"10.1042\/BSR20190788","article-title":"The microRNA in ventricular remodeling: The miR-30 family","volume":"39","author":"Zhang","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1080\/15384101.2020.1750257","article-title":"LncRNA-GAS5 regulates PDCD4 expression and mediates myocardial infarction-induced cardiomyocytes apoptosis via targeting MiR-21","volume":"19","author":"Zhou","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.yjmcc.2008.08.015","article-title":"Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin","volume":"45","author":"Liu","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.stem.2018.09.009","article-title":"Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation","volume":"23","author":"Friedman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.yjmcc.2018.08.013","article-title":"Loss of long non-coding RNA CRRL promotes cardiomyocyte regeneration and improves cardiac repair by functioning as a competing endogenous RNA","volume":"122","author":"Chen","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/CIRCRESAHA.114.302476","article-title":"The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489","volume":"114","author":"Wang","year":"2014","journal-title":"Circ. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/CIRCRESAHA.114.303784","article-title":"Loss of MicroRNA-155 Protects the Heart From Pathological Cardiac Hypertrophy","volume":"114","author":"Seok","year":"2014","journal-title":"Circ. Res."},{"key":"ref_158","first-page":"1402","article-title":"Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses","volume":"38","author":"Du","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1093\/eurheartj\/ehv713","article-title":"A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223","volume":"37","author":"Wang","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.yexcr.2019.04.039","article-title":"Glucose impairs angiogenesis and promotes ventricular remodelling following myocardial infarction via upregulation of microRNA-17","volume":"381","author":"Yan","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1038\/mtna.2016.12","article-title":"Combination of microRNA-21 and microRNA-146a Attenuates Cardiac Dysfunction and Apoptosis During Acute Myocardial Infarction in Mice","volume":"5","author":"Huang","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-014-0423-z","article-title":"MicroRNA-144 is a circulating effector of remote ischemic preconditioning","volume":"109","author":"Li","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00395-018-0694-x","article-title":"Intravenous miR-144 reduces left ventricular remodeling after myocardial infarction","volume":"113","author":"Li","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1161\/CIRCULATIONAHA.109.928424","article-title":"MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease","volume":"122","author":"Hu","year":"2010","journal-title":"Circulation"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2017.08.013","article-title":"MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease","volume":"112","author":"Martinez","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.116.309589","article-title":"Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction","volume":"120","author":"Lesizza","year":"2017","journal-title":"Circ. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"8369","DOI":"10.1111\/jcmm.14714","article-title":"Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction","volume":"23","author":"Li","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV Infection by Targeting MicroRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/HCO.0000000000000162","article-title":"Therapeutic applications of noncoding RNAs","volume":"30","author":"Latronico","year":"2015","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2019.07.007","article-title":"Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression","volume":"308","author":"Jiang","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jconrel.2018.05.041","article-title":"Co-delivery of LOX-1 siRNA and statin to endothelial cells and macrophages in the atherosclerotic lesions by a dual-targeting core-shell nanoplatform: A dual cell therapy to regress plaques","volume":"283","author":"Zhao","year":"2018","journal-title":"J. Control. Release"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41569-019-0218-x","article-title":"RNA-based diagnostic and therapeutic strategies for cardiovascular disease","volume":"16","author":"Lu","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.149187","article-title":"SARS-CoV-2 vaccines: A triumph of science and collaboration","volume":"6","author":"Golob","year":"2021","journal-title":"JCI Insight"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/11\/5718\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:08:56Z","timestamp":1760162936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/11\/5718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":173,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["ijms22115718"],"URL":"https:\/\/doi.org\/10.3390\/ijms22115718","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]}}}