{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:58:31Z","timestamp":1790632711393,"version":"4.1.0"},"reference-count":146,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n (COLCIENCIAS)","doi-asserted-by":"publisher","award":["125380763038, 125380763188 and SGR code BPIN 2020000100144."],"award-info":[{"award-number":["125380763038, 125380763188 and SGR code BPIN 2020000100144."]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006461","name":"Agencia de Innovaci\u00f3n y Desarrollo de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PI-0030-2017"],"award-info":[{"award-number":["PI-0030-2017"]}],"id":[{"id":"10.13039\/501100006461","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-translational modifications (PTMs) have been extensively studied in malignancies due to its relevance in tumor pathogenesis and therapy. This review is focused on the dysregulation of glycosyltransferase expression in CRC and its impact in cell function and in several biological pathways associated with CRC pathogenesis, prognosis and therapeutic approaches. Glycan structures act as interface molecules between cells and their environment and in several cases facilitate molecule function. CRC tissue shows alterations in glycan structures decorating molecules, such as annexin-1, mucins, heat shock protein 90 (Hsp90), \u03b21 integrin, carcinoembryonic antigen (CEA), epidermal growth factor receptor (EGFR), insulin-like growth factor-binding protein 3 (IGFBP3), transforming growth factor beta (TGF-\u03b2) receptors, Fas (CD95), PD-L1, decorin, sorbin and SH3 domain-containing protein 1 (SORBS1), CD147 and glycosphingolipids. All of these are described as key molecules in oncogenesis and metastasis. Therefore, glycosylation in CRC can affect cell migration, cell\u2013cell adhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemness regulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization and gut microbiota composition; all such functions are associated with the prognosis and evolution of the disease. According to these findings, multiple strategies have been evaluated to alter oligosaccharide processing and to modify glycoconjugate structures in order to control CRC progression and prevent metastasis. Additionally, immunotherapy approaches have contemplated the use of neo-antigens, generated by altered glycosylation, as targets for tumor-specific T cells or engineered CAR (Chimeric antigen receptors) T cells.<\/jats:p>","DOI":"10.3390\/ijms22115822","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:22:15Z","timestamp":1622420535000},"page":"5822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["The Role of Glycosyltransferases in Colorectal Cancer"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-1703","authenticated-orcid":false,"given":"Cecilia","family":"Fern\u00e1ndez-Ponce","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Biotechnology and Public Health, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain"},{"name":"Institute of Biomedical Research Cadiz (INIBICA), Cadiz 11009, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-9050","authenticated-orcid":false,"given":"Noelia","family":"Geribaldi-Dold\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research Cadiz (INIBICA), Cadiz 11009, Spain"},{"name":"Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"S\u00e1nchez-Gomar","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Biotechnology and Public Health, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain"},{"name":"Institute of Biomedical Research Cadiz (INIBICA), Cadiz 11009, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Navarro Quiroz","sequence":"additional","affiliation":[{"name":"Center of Mathematics, Computing and Cognition (CMCC) Laboratory of Computational Biology and Bioinformatics\u2014LBCB, Federal University of ABC, Sao Paulo 09210-580, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-2910","authenticated-orcid":false,"given":"Linda","family":"Atencio Ibarra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sim\u00f3n Bol\u00edvar University, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Gomez Escorcia","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de la Costa, Barranquilla 080001, Colombia"},{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n en Biomol\u00e9culas, Care4you S.A.S., Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5307-8539","authenticated-orcid":false,"given":"Ricardo","family":"Fern\u00e1ndez-Cisnal","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research Cadiz (INIBICA), Cadiz 11009, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-3257","authenticated-orcid":false,"given":"Gustavo","family":"Aroca Martinez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sim\u00f3n Bol\u00edvar University, Barranquilla 080001, Colombia"},{"name":"Cl\u00ednica de la Costa, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garc\u00eda-C\u00f3zar","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Biotechnology and Public Health, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain"},{"name":"Institute of Biomedical Research Cadiz (INIBICA), Cadiz 11009, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-6409","authenticated-orcid":false,"given":"Elkin","family":"Navarro Quiroz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n en Biomol\u00e9culas, Care4you S.A.S., Barranquilla 080001, Colombia"},{"name":"Faculty of Basic and Biomedical Sciences, Sim\u00f3n Bol\u00edvar University, Barranquilla 080001, Colombia"},{"name":"School of Medicine, Fundaci\u00f3n Universitaria San Martin, Puerto Colombia 080002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1002\/ijc.32055","article-title":"Global trends in colorectal cancer mortality: Projections to the year 2035","volume":"144","author":"Araghi","year":"2019","journal-title":"Int. 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