{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:39:09Z","timestamp":1790829549829,"version":"4.1.0"},"reference-count":190,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP19H03442"],"award-info":[{"award-number":["JP19H03442"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["20ek0109476h0001"],"award-info":[{"award-number":["20ek0109476h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Tenascin-C (TNC) is a large extracellular matrix (ECM) glycoprotein and an original member of the matricellular protein family. TNC is transiently expressed in the heart during embryonic development, but is rarely detected in normal adults; however, its expression is strongly up-regulated with inflammation. Although neither TNC-knockout nor -overexpressing mice show a distinct phenotype, disease models using genetically engineered mice combined with in vitro experiments have revealed multiple significant roles for TNC in responses to injury and myocardial repair, particularly in the regulation of inflammation. In most cases, TNC appears to deteriorate adverse ventricular remodeling by aggravating inflammation\/fibrosis. Furthermore, accumulating clinical evidence has shown that high TNC levels predict adverse ventricular remodeling and a poor prognosis in patients with various heart diseases. Since the importance of inflammation has attracted attention in the pathophysiology of heart diseases, this review will focus on the roles of TNC in various types of inflammatory reactions, such as myocardial infarction, hypertensive fibrosis, myocarditis caused by viral infection or autoimmunity, and dilated cardiomyopathy. The utility of TNC as a biomarker for the stratification of myocardial disease conditions and the selection of appropriate therapies will also be discussed from a clinical viewpoint.<\/jats:p>","DOI":"10.3390\/ijms22115828","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:22:15Z","timestamp":1622420535000},"page":"5828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Tenascin-C in Heart Diseases\u2014The Role of Inflammation"],"prefix":"10.3390","volume":"22","author":[{"given":"Kyoko","family":"Imanaka-Yoshida","sequence":"first","affiliation":[{"name":"Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"},{"name":"Mie University Research Center for Matrix Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tucker, R.P., Drabikowski, K., Hess, J.F., Ferralli, J., Chiquet-Ehrismann, R., and Adams, J.C. (2006). Phylogenetic analysis of the tenascin gene family: Evidence of origin early in the chordate lineage. BMC Evol. Biol., 6.","DOI":"10.1186\/1471-2148-6-60"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/19336918.2015.1008333","article-title":"Transcriptional regulation of tenascin genes","volume":"9","author":"Chiovaro","year":"2015","journal-title":"Cell Adh. Migr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"612482","DOI":"10.3389\/fimmu.2020.612482","article-title":"Early Days of Tenascin-R Research: Two Approaches Discovered and Shed Light on Tenascin-R","volume":"11","author":"Rathjen","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"612497","DOI":"10.3389\/fimmu.2020.612497","article-title":"Tenascin-X-Discovery and Early Research","volume":"11","author":"Miller","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"623305","DOI":"10.3389\/fimmu.2020.623305","article-title":"Tenascin-W: Discovery, Evolution, and Future Prospects","volume":"11","author":"Degen","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(86)90374-0","article-title":"Tenascin: An extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis","volume":"47","author":"Mackie","year":"1986","journal-title":"Cell"},{"key":"ref_7","first-page":"a004960","article-title":"Tenascins and the importance of adhesion modulation","volume":"3","author":"Tucker","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"611789","DOI":"10.3389\/fimmu.2020.611789","article-title":"Tenascin-C: From Discovery to Structure-Function Relationships","volume":"11","author":"Chiquet","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"620182","DOI":"10.3389\/fimmu.2020.620182","article-title":"Serendipity; Close Encounter of Tenascin C","volume":"11","author":"Sakakura","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12079-009-0069-z","article-title":"Matricellular proteins: An overview","volume":"3","author":"Bornstein","year":"2009","journal-title":"J. Cell Commun. Signal."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0955-0674(02)00361-7","article-title":"Matricellular proteins: Extracellular modulators of cell function","volume":"14","author":"Bornstein","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1253\/circj.CJ-12-1033","article-title":"Tenascin-C in cardiovascular tissue remodeling: From development to inflammation and repair","volume":"76","year":"2012","journal-title":"Circ. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"C781","DOI":"10.1152\/ajpcell.00353.2020","article-title":"Tenascin-C in cardiac disease: A sophisticated controller of inflammation, repair, and fibrosis","volume":"319","author":"Tawara","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1158\/2326-6066.CIR-19-0276","article-title":"Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype","volume":"8","author":"Deligne","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1158\/2326-6066.CIR-20-0074","article-title":"Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma","volume":"8","author":"Spenle","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41584-020-00570-2","article-title":"Location, location, location: How the tissue microenvironment affects inflammation in RA","volume":"17","author":"Buckley","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"620773","DOI":"10.3389\/fonc.2021.620773","article-title":"Macrophages and Extracellular Matrix in Breast Cancer: Partners in Crime or Protective Allies?","volume":"11","author":"Deligne","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1432-0436.2003.7104506.x","article-title":"The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse","volume":"71","author":"Matsumoto","year":"2003","journal-title":"Differentiation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"620541","DOI":"10.3389\/fimmu.2021.620541","article-title":"Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C","volume":"12","author":"Yonebayashi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Monda, E., Palmiero, G., Rubino, M., Verrillo, F., Amodio, F., Di Fraia, F., Pacileo, R., Fimiani, F., Esposito, A., and Cirillo, A. (2020). Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186462"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","article-title":"Inflammation in Heart Failure: JACC State-of-the-Art Review","volume":"75","author":"Murphy","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM199007263230405","article-title":"Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure","volume":"323","author":"Levine","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/HJH.0000000000001628","article-title":"Tenascin-C promotes chronic pressure overload-induced cardiac dysfunction, hypertrophy and myocardial fibrosis","volume":"36","author":"Podesser","year":"2018","journal-title":"J. Hypertens"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1097\/HJH.0000000000002097","article-title":"Epigenetic modulation of tenascin C in the heart: Implications on myocardial ischemia, hypertrophy and metabolism","volume":"37","author":"Acar","year":"2019","journal-title":"J. Hypertens"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/labinvest.3780313","article-title":"Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction","volume":"81","author":"Hiroe","year":"2001","journal-title":"Lab. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.1131","article-title":"Tenascin-C is a useful marker for disease activity in myocarditis","volume":"197","author":"Hiroe","year":"2002","journal-title":"J. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/path.1730","article-title":"Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis","volume":"205","author":"Morimoto","year":"2005","journal-title":"J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/FJC.0b013e318033dfd4","article-title":"Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: Involvement of tenascin-C induced by aldosterone-mediated inflammation","volume":"49","author":"Nishioka","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00380-012-0311-0","article-title":"Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1\/endothelin receptor A cascade","volume":"28","author":"Fujita","year":"2013","journal-title":"Heart Vessel."},{"key":"ref_30","first-page":"517","article-title":"Interaction between cell and extracellular matrix in heart disease: Multiple roles of tenascin-C in tissue remodeling","volume":"19","author":"Hiroe","year":"2004","journal-title":"Histol. Histopathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4161\/19336918.2014.987587","article-title":"Tenascin-C: Form versus function","volume":"9","author":"Giblin","year":"2015","journal-title":"Cell Adh. Migr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1242\/jcs.190546","article-title":"Tenascin-C at a glance","volume":"129","author":"Midwood","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"607587","DOI":"10.3389\/fimmu.2020.607587","article-title":"The Role of Tenascin-C in Tissue Injury and Repair After Stroke","volume":"11","author":"Okada","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-407697-6.00007-6","article-title":"New insights into the developmental mechanisms of coronary vessels and epicardium","volume":"303","author":"Nakajima","year":"2013","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"a037143","DOI":"10.1101\/cshperspect.a037192","article-title":"Epicardium in Heart Development","volume":"12","author":"Cao","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0008-6363(97)00146-6","article-title":"Differences in development of coronary arteries and veins","volume":"36","author":"Mentink","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/(SICI)1097-0177(199703)208:3<338::AID-AJA5>3.0.CO;2-J","article-title":"The development of the coronary vessels and their differentiation into arteries and veins in the embryonic quail heart","volume":"208","author":"Mentink","year":"1997","journal-title":"Dev. Dyn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/dvdy.20022","article-title":"Formation and remodeling of the coronary vascular bed in the embryonic avian heart","volume":"230","author":"Kattan","year":"2004","journal-title":"Dev. Dyn."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.diff.2011.03.002","article-title":"Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development","volume":"81","author":"Ando","year":"2011","journal-title":"Differentiation"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1002\/jcp.22614","article-title":"Tenascin-C enhances crosstalk signaling of integrin alphavbeta3\/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells","volume":"226","author":"Ishigaki","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/ar.22985","article-title":"Tenascin-C in development and disease of blood vessels","volume":"297","author":"Yoshida","year":"2014","journal-title":"Anat. Rec."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1073\/pnas.93.13.6594","article-title":"Skin wounds and severed nerves heal normally in mice lacking tenascin-C","volume":"93","author":"Forsberg","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1101\/gad.6.10.1821","article-title":"Mice develop normally without tenascin","volume":"6","author":"Saga","year":"1992","journal-title":"Genes Dev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ydbio.2008.09.029","article-title":"Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation","volume":"324","author":"Ishii","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1165\/rcmb.2002-0266OC","article-title":"Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture","volume":"30","author":"Hirsch","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/japplphysiol.00258.2019","article-title":"Tenascin-C deficiency impairs alveolarization and microvascular maturation during postnatal lung development","volume":"128","author":"Mund","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1460-9568.2006.04657.x","article-title":"Enhanced novelty-induced activity, reduced anxiety, delayed resynchronization to daylight reversal and weaker muscle strength in tenascin-C-deficient mice","volume":"23","author":"Morellini","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.mcn.2006.04.002","article-title":"Delayed onset of odor detection in neonatal mice lacking tenascin-C","volume":"32","author":"Lemasson","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/hipo.20585","article-title":"Genetic ablation of tenascin-C expression leads to abnormal hippocampal CA1 structure and electrical activity in vivo","volume":"19","author":"Gurevicius","year":"2009","journal-title":"Hippocampus"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1038\/s41598-020-61919-x","article-title":"Tenascin-C inactivation impacts lung structure and function beyond lung development","volume":"10","author":"Gremlich","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/ehf2.12794","article-title":"Tenascin-C aggravates ventricular dilatation and angiotensin-converting enzyme activity after myocardial infarction in mice","volume":"7","author":"Santer","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Perera-Gonzalez, M., Kiss, A., Kaiser, P., Holzweber, M., Nagel, F., Watzinger, S., Acar, E., Szabo, P.L., Gon\u00e7alves, I.F., and Weber, L. (2021). The Role of Tenascin C in Cardiac Reverse Remodeling Following Banding-Debanding of the Ascending Aorta. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042023"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.jacc.2017.07.789","article-title":"Bone Marrow-Derived Tenascin-C Attenuates Cardiac Hypertrophy by Controlling Inflammation","volume":"70","author":"Song","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"H1072","DOI":"10.1152\/ajpheart.00255.2009","article-title":"Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice","volume":"298","author":"Nishioka","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e001052","DOI":"10.1161\/JAHA.114.001052","article-title":"Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation","volume":"3","author":"Tajiri","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/HYPERTENSIONAHA.115.06004","article-title":"Tenascin-C May Accelerate Cardiac Fibrosis by Activating Macrophages via the Integrin alphaVbeta3\/Nuclear Factor-kappaB\/Interleukin-6 Axis","volume":"66","author":"Shimojo","year":"2015","journal-title":"Hypertension"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/cvr\/cvy244","article-title":"Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization","volume":"115","author":"Kimura","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.exger.2019.02.008","article-title":"The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice","volume":"119","author":"Nagel","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.jacc.2006.03.033","article-title":"Serum tenascin-C might be a novel predictor of left ventricular remodeling and prognosis after acute myocardial infarction","volume":"47","author":"Sato","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/(SICI)1096-9896(199607)179:3<321::AID-PATH555>3.0.CO;2-8","article-title":"Tenascin and fibronectin expression in healing human myocardial scars","volume":"179","author":"Willems","year":"1996","journal-title":"J. Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9440(10)62954-9","article-title":"Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury","volume":"167","author":"Tamaoki","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2014.07.005","article-title":"Revisiting the matricellular concept","volume":"37","author":"Sage","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1083\/jcb.118.6.1411","article-title":"Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes","volume":"118","author":"Danowski","year":"1992","journal-title":"J. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1097-0169(1996)33:4<263::AID-CM3>3.0.CO;2-A","article-title":"Living adult rat cardiomyocytes in culture: Evidence for dissociation of costameric distribution of vinculin from costameric distributions of attachments","volume":"33","author":"Danowski","year":"1996","journal-title":"Cell Motil. Cytoskelet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0169(1999)42:1<1::AID-CM1>3.0.CO;2-0","article-title":"Vinculin, Talin, Integrin alpha6beta1 and laminin can serve as components of attachment complex mediating contraction force transmission from cardiomyocytes to extracellular matrix","volume":"42","author":"Yoshida","year":"1999","journal-title":"Cell Motil. Cytoskelet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0008-6363(00)00089-4","article-title":"Structural basis of regional dysfunction in acutely ischemic myocardium","volume":"47","author":"Mazhari","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/30270","article-title":"The molecular elasticity of the extracellular matrix protein tenascin","volume":"393","author":"Oberhauser","year":"1998","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0021-9290(03)00172-6","article-title":"Folding-unfolding of FN-III domains in tenascin: An elastically coupled two-state system","volume":"36","author":"Huerta","year":"2003","journal-title":"J. Biomech."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/srep04051","article-title":"Tenascin C protects aorta from acute dissection in mice","volume":"4","author":"Kimura","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_70","first-page":"206039","article-title":"Danger signals in the initiation of the inflammatory response after myocardial infarction","volume":"2013","author":"Smeets","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.yjmcc.2015.11.002","article-title":"Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)","volume":"94","author":"Turner","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1369\/0022155418757443","article-title":"Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate Immunity","volume":"66","author":"Marzeda","year":"2018","journal-title":"J. Histochem. Cytochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2008.06.007","article-title":"The immune system and cardiac repair","volume":"58","author":"Frangogiannis","year":"2008","journal-title":"Pharmacol. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm.1987","article-title":"Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease","volume":"15","author":"Midwood","year":"2009","journal-title":"Nat. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s41467-017-01718-7","article-title":"Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers","volume":"8","author":"Marzeda","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4330\/wjc.v8.i5.340","article-title":"Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4","volume":"8","author":"Maqbool","year":"2016","journal-title":"World J. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"ra86","DOI":"10.1126\/scisignal.aaf3596","article-title":"Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages","volume":"9","author":"Piccinini","year":"2016","journal-title":"Sci. Signal."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ajpath.2015.09.015","article-title":"Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C\/Toll-Like Receptor 4 Signaling","volume":"186","author":"Benbow","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1002\/hep.24639","article-title":"Tenascin-C: A novel mediator of hepatic ischemia and reperfusion injury","volume":"54","author":"Kuriyama","year":"2011","journal-title":"Hepatology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.vph.2012.07.003","article-title":"The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction","volume":"58","author":"Turner","year":"2013","journal-title":"Vascul. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/CIRCRESAHA.117.311071","article-title":"Resident and Monocyte-Derived Macrophages in Cardiovascular Disease","volume":"122","author":"Honold","year":"2018","journal-title":"Circ. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jacbts.2018.03.001","article-title":"The Role of Macrophages in Nonischemic Heart Failure","volume":"3","author":"Chen","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1172\/JCI81321","article-title":"Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction","volume":"125","author":"Liu","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fcvm.2019.00101","article-title":"The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling","volume":"6","author":"Dunne","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The Extracellular Matrix in Ischemic and Nonischemic Heart Failure","volume":"125","author":"Frangogiannis","year":"2019","journal-title":"Circ. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2741\/2692","article-title":"Macrophage activation and polarization","volume":"13","author":"Martinez","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trsl.2017.10.001","article-title":"Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction","volume":"191","author":"Ma","year":"2018","journal-title":"Transl. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1253\/circj.CJ-18-0063","article-title":"Inflammatory Mechanisms of Cardiovascular Remodeling","volume":"82","author":"Anzai","year":"2018","journal-title":"Circ. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1038\/s41467-018-05274-6","article-title":"A positive feedback loop bi-stably activates fibroblasts","volume":"9","author":"Yeo","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1096\/fj.201601307R","article-title":"CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction","volume":"31","author":"Hesse","year":"2017","journal-title":"FASEB J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1089\/wound.2017.0732","article-title":"Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma","volume":"6","author":"Bhattacharyya","year":"2017","journal-title":"Adv. Wound Care"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1172\/JCI87491","article-title":"The extracellular matrix in myocardial injury, repair, and remodeling","volume":"127","author":"Frangogiannis","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1007\/s00018-011-0783-6","article-title":"Advances in tenascin-C biology","volume":"68","author":"Midwood","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.ajpath.2020.06.008","article-title":"Tenascin-C Induces Phenotypic Changes in Fibroblasts to Myofibroblasts with High Contractility through the Integrin \u03b1v\u03b21\/Transforming Growth Factor \u03b2\/SMAD Signaling Axis in Human Breast Cancer","volume":"190","author":"Katoh","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cardfail.2012.02.009","article-title":"Prognostic value of serum tenascin-C levels on long-term outcome after acute myocardial infarction","volume":"18","author":"Sato","year":"2012","journal-title":"J. Card. Fail."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/cphy.c150006","article-title":"Pathophysiology of Myocardial Infarction","volume":"5","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yjmcc.2015.12.018","article-title":"Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling","volume":"91","author":"Lindsey","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.matbio.2018.01.013","article-title":"Extracellular matrix remodeling and cardiac fibrosis","volume":"68\u201369","author":"Li","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1172\/JCI108843","article-title":"Evidence for cardiomyopathy in familial diabetes mellitus","volume":"60","author":"Regan","year":"1977","journal-title":"J. Clin. Investig."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4087632","DOI":"10.1155\/2016\/4087632","article-title":"Inflammatory Cardiomyopathy: A Current View on the Pathophysiology, Diagnosis, and Treatment","volume":"2016","author":"Krejci","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.jacc.2006.07.049","article-title":"Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy","volume":"48","author":"Assomull","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J. Cell Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1253\/circj.CJ-11-1184","article-title":"Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases","volume":"75","author":"Manabe","year":"2011","journal-title":"Circ. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1038\/npjamd.2016.18","article-title":"Macrophages in age-related chronic inflammatory diseases","volume":"2","author":"Oishi","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/ehf2.12341","article-title":"Telbivudine in chronic lymphocytic myocarditis and human parvovirus B19 transcriptional activity","volume":"5","author":"Elsanhoury","year":"2018","journal-title":"ESC Heart Fail."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.181.2.713","article-title":"T cell genetic background determines default T helper phenotype development in vitro","volume":"181","author":"Hsieh","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/cvr\/cvx221","article-title":"Local production of tenascin-C acts as a trigger formonocyte\/macrophage recruitment that provokes cardiac dysfunction","volume":"114","author":"Abbadi","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"(2011). JCS Joint Working Group and treatment of myocarditis (JCS 2009): Digest version. Circ. J., 75, 734\u2013743.","DOI":"10.1253\/circj.CJ-88-0008"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pin.12868","article-title":"Inflammation in myocardial disease: From myocarditis to dilated cardiomyopathy","volume":"70","year":"2020","journal-title":"Pathol. Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jjcc.2020.08.004","article-title":"Immune cell infiltration landscapes in pediatric acute myocarditis analyzed by CIBERSORT","volume":"77","author":"Kawada","year":"2021","journal-title":"J. Cardiol."},{"key":"ref_115","first-page":"30077","article-title":"Update on acute myocarditis","volume":"S1050-1738","author":"Ammirati","year":"2020","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.4103\/1673-5374.235022","article-title":"Matricellular proteins as possible biomarkers for early brain injury after aneurysmal subarachnoid hemorrhage","volume":"13","author":"Suzuki","year":"2018","journal-title":"Neural Regen Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jjco\/hyx154","article-title":"Immune checkpoint inhibitor-related myocarditis","volume":"48","author":"Tajiri","year":"2018","journal-title":"Jpn J. Clin. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/CIRCRESAHA.117.310221","article-title":"Inflammatory Cardiomyopathic Syndromes","volume":"121","author":"Trachtenberg","year":"2017","journal-title":"Circ. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and inflammatory cardiomyopathy: Current evidence and future directions","volume":"18","author":"Tschope","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1093\/eurheartj\/ehaa664","article-title":"Pathological features of COVID-19-associated myocardial injury: A multicentre cardiovascular pathology study","volume":"41","author":"Basso","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"107300","DOI":"10.1016\/j.carpath.2020.107300","article-title":"Myocarditis is rare in COVID-19 autopsies: Cardiovascular findings across 277 postmortem examinations","volume":"50","author":"Halushka","year":"2021","journal-title":"Cardiovasc. Pathol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/01.CIR.99.8.1091","article-title":"From myocarditis to cardiomyopathy: Mechanisms of inflammation and cell death: Learning from the past for the future","volume":"99","author":"Kawai","year":"1999","journal-title":"Circulation"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.4049\/jimmunol.113.6.1726","article-title":"Involvement of T lymphocytes in the pathogenesis of coxsackie virus B3 heart disease","volume":"113","author":"Woodruff","year":"1974","journal-title":"J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmv.2131","article-title":"An overview of the immune mechanisms of viral myocarditis","volume":"30","author":"Lasrado","year":"2020","journal-title":"Rev. Med. Virol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.clim.2012.07.003","article-title":"Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-alpha-reactive CD4 T cells in A\/J mice","volume":"144","author":"Gangaplara","year":"2012","journal-title":"Clin. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.molimm.2020.06.017","article-title":"Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection","volume":"124","author":"Basavalingappa","year":"2020","journal-title":"Mol. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1172\/JCI44583","article-title":"Impaired thymic tolerance to alpha-myosin directs autoimmunity to the heart in mice and humans","volume":"121","author":"Lv","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/nm960","article-title":"Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity","volume":"9","author":"Eriksson","year":"2003","journal-title":"Nat. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.4049\/jimmunol.1103610","article-title":"Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis","volume":"189","author":"Tajiri","year":"2012","journal-title":"J. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3389\/fimmu.2019.01987","article-title":"Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection","volume":"10","author":"Mills","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"18220","DOI":"10.1073\/pnas.1307336110","article-title":"Tenascin-C is an innate broad-spectrum, HIV-1\u2013neutralizing protein in breast milk","volume":"110","author":"Fouda","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Mansour, R.G., Stamper, L., Jaeger, F., McGuire, E., Fouda, G., Amos, J., Barbas, K., Ohashi, T., Alam, S.M., and Erickson, H. (2016). The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155261"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41385-019-0164-2","article-title":"Determinants of Tenascin-C and HIV-1 envelope binding and neutralization","volume":"12","author":"Mangan","year":"2019","journal-title":"Mucosal. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Sur, S., Khatun, M., Steele, R., Isbell, T.S., Ray, R., and Ray, R.B. (2021). Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-\u03b2 in Triggering Inflammatory Signals in Cells of Distant Organ. Int. J. Mol. Sci., 22.","DOI":"10.1101\/2021.02.08.430369"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"12126","DOI":"10.1038\/s41598-018-29714-x","article-title":"The Streptococcus pyogenes fibronectin\/tenascin-binding protein PrtF.2 contributes to virulence in an influenza superinfection","volume":"8","author":"Herrera","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/cvr\/cvn063","article-title":"Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis","volume":"79","author":"Leipner","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e010633","DOI":"10.1161\/CIRCIMAGING.120.010633","article-title":"Monitoring of the Evolution of Immune Checkpoint Inhibitor Myocarditis With Cardiovascular Magnetic Resonance","volume":"13","author":"Sato","year":"2020","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"624703","DOI":"10.3389\/fimmu.2021.624703","article-title":"Immunomodulatory Role of Tenascin-C in Myocarditis and Inflammatory Cardiomyopathy","volume":"12","author":"Tajiri","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0065-2776(08)00604-4","article-title":"Pathogenesis of Myocarditis and Dilated Cardiomyopathy","volume":"Volume 99","author":"Cihakova","year":"2008","journal-title":"Advances in Immunology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1002\/eji.200636484","article-title":"Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis","volume":"36","author":"Sonderegger","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.matbio.2014.01.007","article-title":"Tenascins in stem cell niches","volume":"37","author":"Orend","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1083\/jcb.137.3.755","article-title":"Tenascin supports lymphocyte rolling","volume":"137","author":"Clark","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1182\/blood-2011-11-393645","article-title":"Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration","volume":"119","author":"Okuno","year":"2012","journal-title":"Blood"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.exphem.2013.09.009","article-title":"The role of Tenascin C in the lymphoid progenitor cell niche","volume":"41","author":"Ellis","year":"2013","journal-title":"Exp. Hematol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1002\/eji.200636271","article-title":"Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse","volume":"36","author":"Nakahara","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.4049\/jimmunol.0900725","article-title":"Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis","volume":"182","author":"Kanayama","year":"2009","journal-title":"J. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.4049\/jimmunol.1101524","article-title":"alpha9beta1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation","volume":"187","author":"Kanayama","year":"2011","journal-title":"J. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/art.34401","article-title":"Endogenous activation of adaptive immunity: Tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease","volume":"64","author":"Ruhmann","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"609752","DOI":"10.3389\/fimmu.2020.609752","article-title":"The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases","volume":"11","author":"Matsumoto","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Tajiri, K., Imanaka-Yoshida, K., Tsujimura, Y., Matsuo, K., Hiroe, M., Aonuma, K., Ieda, M., and Yasutomi, Y. (2021). A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Gu\u00e8rin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-\u03b1. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020794"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1536\/ihj.16-225","article-title":"Fulminant Myocarditis With Prolonged Active Lymphocytic Infiltration After Hemodynamic Recovery","volume":"58","author":"Tanimura","year":"2017","journal-title":"Int. Heart J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(16)31713-5","article-title":"Dilated cardiomyopathy","volume":"390","author":"Weintraub","year":"2017","journal-title":"Lancet"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"Dilated Cardiomyopathy: Genetic Determinants and Mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1161\/CIRCULATIONAHA.108.769489","article-title":"Predictors of Outcome in Patients With Suspected Myocarditis","volume":"118","author":"Kindermann","year":"2008","journal-title":"Circulation"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ejhf.767","article-title":"Clinical impact of the presence of macrophages in endomyocardial biopsies of patients with dilated cardiomyopathy","volume":"19","author":"Nakayama","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ejhf.464","article-title":"Significance of myocardial tenascin-C expression in left ventricular remodelling and long-term outcome in patients with dilated cardiomyopathy","volume":"18","author":"Yokokawa","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.humpath.2008.12.017","article-title":"High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: Expression of tenascin C as a possible marker for inflammation","volume":"40","author":"Tsukada","year":"2009","journal-title":"Hum. Pathol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"9123","DOI":"10.1021\/ac202159p","article-title":"Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C","volume":"83","author":"Kobayashi","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"635166","DOI":"10.3389\/fimmu.2021.635166","article-title":"Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies","volume":"12","author":"Dhaouadi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/01.CIR.0000027823.07104.86","article-title":"Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C","volume":"106","author":"Sato","year":"2002","journal-title":"Circulation"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2967\/jnumed.109.071340","article-title":"Dynamic expression of tenascin-C after myocardial ischemia and reperfusion: Assessment by 125I-anti-tenascin-C antibody imaging","volume":"51","author":"Taki","year":"2010","journal-title":"J. Nucl. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13550-015-0100-8","article-title":"Effect of postconditioning on dynamic expression of tenascin-C and left ventricular remodeling after myocardial ischemia and reperfusion","volume":"5","author":"Taki","year":"2015","journal-title":"EJNMMI Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1536\/ihj.17-734","article-title":"Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C","volume":"60","author":"Ageyama","year":"2019","journal-title":"Int. Heart J."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1253\/circj.71.327","article-title":"Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy","volume":"71","author":"Terasaki","year":"2007","journal-title":"Circ. J."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cardfail.2009.06.443","article-title":"Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure","volume":"15","author":"Fujimoto","year":"2009","journal-title":"J. Card Fail."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"608563","DOI":"10.1155\/2013\/608563","article-title":"Can serum tenascin-C be used as a marker of inflammation in patients with dilated cardiomyopathy?","volume":"2013","author":"Kotby","year":"2013","journal-title":"Int. J. Pediatr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10735-014-9573-4","article-title":"De novo expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in human cardiac allografts: Potential impact for targeted therapy of rejection","volume":"45","author":"Franz","year":"2014","journal-title":"J. Mol. Histol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00125-020-05108-5","article-title":"Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: A French prospective cohort","volume":"63","author":"Gellen","year":"2020","journal-title":"Diabetologia"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/1354750X.2020.1810319","article-title":"Plasma Tenascin-C: A prognostic biomarker in heart failure with preserved ejection fraction","volume":"25","author":"Kanagala","year":"2020","journal-title":"Biomarkers"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Mishra, S., and Kass, D.A. (2020). Cellular and molecular pathobiology of heart failure with preserved ejection fraction. Nat. Rev. Cardiol., in print.","DOI":"10.1038\/s41569-020-00480-6"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jacep.2017.03.002","article-title":"Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation","volume":"3","author":"Nattel","year":"2017","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"E219","DOI":"10.25011\/cim.v40i6.29122","article-title":"Association among tenascin-C and NT-proBNP levels and arrhythmia prevalence in heart failure","volume":"40","author":"Ozmen","year":"2017","journal-title":"Clin. Investig. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10840-019-00670-4","article-title":"Serum tenascin-C levels in atrium predict atrial structural remodeling processes in patients with atrial fibrillation","volume":"59","author":"Shiomi","year":"2019","journal-title":"J. Interv. Card Electrophysiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cvr\/cvr183","article-title":"The role of tenascin C in cardiovascular disease","volume":"92","author":"Golledge","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/19336918.2014.1000075","article-title":"Tenascin-C in cardiovascular remodeling: Potential impact for diagnosis, prognosis estimation and targeted therapy","volume":"9","author":"Franz","year":"2015","journal-title":"Cell Adh. Migr."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/echo.12328","article-title":"Assessment of tenascin-C levels in ventricular noncompaction\/hypertrabeculation patients: A cross-sectional study","volume":"31","author":"Erer","year":"2014","journal-title":"Echocardiography"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jjcc.2011.11.008","article-title":"Serum tenascin-C levels as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy","volume":"59","author":"Kitaoka","year":"2012","journal-title":"J. Cardiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.carpath.2018.10.005","article-title":"Expression of tenascin C in cardiovascular lesions of Kawasaki disease","volume":"38","author":"Yokouchi","year":"2018","journal-title":"Cardiovasc. Pathol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/tropej\/fmt058","article-title":"Serum tenascin-C: A novel biomarker for diagnosis and predicting prognosis of rheumatic carditis?","volume":"59","author":"Karatas","year":"2013","journal-title":"J. Trop Pediatr."},{"key":"ref_180","first-page":"350","article-title":"The role of tenascin-C and oxidative stress in rheumatic and congenital heart valve diseases: An observational study","volume":"13","author":"Karatas","year":"2013","journal-title":"Anadolu Kardiyol. Derg."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2310\/JIM.0b013e3182880c11","article-title":"Tenascin-C as predictor of left ventricular remodeling and mortality in patients with dilated cardiomyopathy","volume":"61","author":"Sarli","year":"2013","journal-title":"J. Investig. Med."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Yoshikane, Y., Okuma, Y., Miyamoto, T., Hashimoto, J., Fukazawa, R., Kato, T., Takeda, A., Suda, K., Hiroe, M., and Imanaka-Yoshida, K. (2020). Serum tenascin-C predicts resistance to steroid combination therapy in high-risk Kawasaki disease: A multicenter prospective cohort study. Pediatric Rhematol., in press.","DOI":"10.21203\/rs.3.rs-64333\/v1"},{"key":"ref_183","first-page":"2927","article-title":"Biomarkers and heart disease","volume":"18","author":"Sun","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-981-13-6657-4_18","article-title":"Practical Application of Periostin as a Biomarker for Pathological Conditions","volume":"1132","author":"Kii","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Abdelaziz Mohamed, I., Gadeau, A.P., Hasan, A., Abdulrahman, N., and Mraiche, F. (2019). Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis. Cells, 8.","DOI":"10.3390\/cells8121558"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clinbiochem.2018.07.003","article-title":"The multiple functions and mechanisms of osteopontin","volume":"59","author":"Icer","year":"2018","journal-title":"Clin. Biochem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"e1054","DOI":"10.1161\/CIR.0000000000000490","article-title":"Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association","volume":"135","author":"Chow","year":"2017","journal-title":"Circulation"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1074\/jbc.M109.051961","article-title":"Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture","volume":"285","author":"Kii","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1046\/j.1471-4159.1995.64062465.x","article-title":"Galectin-3, a beta-galactoside-binding animal lectin, binds to neural recognition molecules","volume":"64","author":"Probstmeier","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-319-18497-5_27","article-title":"The Role of Matricellular Proteins in Brain Edema after Subarachnoid Hemorrhage","volume":"121","author":"Suzuki","year":"2016","journal-title":"Acta Neurochir. Suppl."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/11\/5828\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:10:28Z","timestamp":1760163028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/11\/5828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":190,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["ijms22115828"],"URL":"https:\/\/doi.org\/10.3390\/ijms22115828","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]}}}