{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:06:06Z","timestamp":1792109166747,"version":"4.4.0"},"reference-count":195,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Human umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. UCB provides practical advantages, including a lower risk of graft-versus-host-disease and permissive human leukocyte antigen mismatching. These advantageous properties have so far been applied for stem cell, mesenchymal stromal cell, and chimeric antigen receptor T cell therapies. However, UCB-derived professional antigen-presenting cells are increasingly being utilized in the context of immune tolerance and regenerative therapy. Here, we review the cell-specific characteristics as well as recent advancements in UCB-based cell therapies focusing on dendritic cells, monocytes, B lymphocytes, innate lymphoid cells, and macrophages.<\/jats:p>","DOI":"10.3390\/ijms22115923","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T21:42:06Z","timestamp":1622497326000},"page":"5923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-1211","authenticated-orcid":false,"given":"Sarah","family":"Cunningham","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Schwabachanlage 12, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hackstein","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Schwabachanlage 12, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/tan.12792","article-title":"Impact of HLA in cord blood transplantation outcomes","volume":"87","author":"Ruggeri","year":"2016","journal-title":"HLA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1056\/NEJM198910263211707","article-title":"Hematopoietic Reconstitution in a Patient with Fanconi\u2019s Anemia by Means of Umbilical-Cord Blood from an HLA-Identical Sibling","volume":"321","author":"Gluckman","year":"1989","journal-title":"N. 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