{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:53:45Z","timestamp":1773089625474,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["2018R1A5A2025272"],"award-info":[{"award-number":["2018R1A5A2025272"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["2019R1A2C1002555"],"award-info":[{"award-number":["2019R1A2C1002555"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["2020R1C1C1006534"],"award-info":[{"award-number":["2020R1C1C1006534"]}]},{"name":"Korean Medical Device Development Fund grant by the Korean government (the Ministy of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health &amp; Welfare, the Ministry of Food and Drug Safety)","award":["9991006790, KMDF_PR_20200901_0117"],"award-info":[{"award-number":["9991006790, KMDF_PR_20200901_0117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acupuncture modulates the mesolimbic dopamine (DA) system; an area implicated in drug abuse. However, the mechanism by which peripheral sensory afferents, during acupuncture stimulation, modulate this system needs further investigation. The lateral hypothalamus (LH) has been implicated in reward processing and addictive behaviors. To investigate the role of the LH in mediating acupuncture effects, we evaluated the role of LH and spinohypothalamic neurons on cocaine-induced psychomotor activity and NAc DA release. Systemic injection of cocaine increased locomotor activity and 50 kHz ultrasonic vocalizations (USVs), which were attenuated by mechanical stimulation of needles inserted into HT7 but neither ST36 nor LI5. The acupuncture effects were blocked by chemical lesions of the LH or mimicked by activation of LH neurons. Single-unit extracellular recordings showed excitation of LH and spinohypothalamic neurons following acupuncture. Our results suggest that acupuncture recruits the LH to suppress the mesolimbic DA system and psychomotor responses following cocaine injection.<\/jats:p>","DOI":"10.3390\/ijms22115994","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T15:58:44Z","timestamp":1622563124000},"page":"5994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of Lateral Hypothalamus in Acupuncture Inhibition of Cocaine Psychomotor Activity"],"prefix":"10.3390","volume":"22","author":[{"given":"DanBi","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Byeol","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeonhee","family":"Ryu","sequence":"additional","affiliation":[{"name":"Korean Medicine Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Hyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Center, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle B.","family":"Bills","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-8861","authenticated-orcid":false,"given":"Scott C.","family":"Steffensen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience, Brigham Young University, Provo, UT 84602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13020-016-0088-7","article-title":"Acupuncture therapy for drug addiction","volume":"11","author":"Motlagh","year":"2016","journal-title":"Chin. 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