{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:59:39Z","timestamp":1782730779664,"version":"3.54.5"},"reference-count":112,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002811","name":"Cathay General Hospital","doi-asserted-by":"publisher","award":["CGH-MR-A109017"],"award-info":[{"award-number":["CGH-MR-A109017"]}],"id":[{"id":"10.13039\/501100002811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Skin barrier functions, environmental insults, and genetic backgrounds are intricately linked and form the basis of common inflammatory skin disorders, such as atopic dermatitis, psoriasis, and seborrheic dermatitis, which may seriously affect one\u2019s quality of life. Topical therapy is usually the first line of management. It is believed that successful topical treatment requires pharmaceutical formulation from a sufficient dosage to exert therapeutic effects by penetrating the stratum corneum and then diffusing to the target area. However, many factors can affect this process including the physicochemical properties of the active compound, the composition of the formulation base, and the limitations and conditions of the skin barrier, especially in inflammatory skin. This article briefly reviews the available data on these issues and provides opinions on strategies to develop a suitable formulation for inflammatory skin disease treatment.<\/jats:p>","DOI":"10.3390\/ijms22116078","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T11:12:13Z","timestamp":1622805133000},"page":"6078","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Strategies to Develop a Suitable Formulation for Inflammatory Skin Disease Treatment"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6337-4817","authenticated-orcid":false,"given":"Jiun-Wen","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Medical Research, Cathay General Hospital, Taipei 10630, Taiwan"},{"name":"Program in Pharmaceutical Biotechnology, College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiou-Hwa","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cathay General Hospital, Taipei 10630, Taiwan"},{"name":"Department of Dermatology, College of Medicine, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/emm.1999.2","article-title":"Bricks and mortar of the epidermal barrier","volume":"31","author":"Nemes","year":"1999","journal-title":"Exp. Mol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clindermatol.2011.08.025","article-title":"Epidermal barrier function and systemic diseases","volume":"30","author":"Jacques","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/aja.1001800206","article-title":"Avian sebokeratocytes and marine mammal lipokeratinocytes: Structural, lipid biochemical, and functional considerations","volume":"180","author":"Elias","year":"1987","journal-title":"Am. J. Anat."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lee, A.Y. (2020). Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041194"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/jid.2008.88","article-title":"\u201cOutside-to-inside\u201d (and now back to \u201coutside\u201d) pathogenic mechanisms in atopic dermatitis","volume":"128","author":"Elias","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","first-page":"119","article-title":"Epidermal pathogenesis of inflammatory dermatoses","volume":"10","author":"Elias","year":"1999","journal-title":"Am. J. Contact Dermat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clindermatol.2011.08.019","article-title":"Abnormal epidermal barrier in the pathogenesis of contact dermatitis","volume":"30","author":"Proksch","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2174\/1381612825666190404121507","article-title":"Limitations and Opportunities in Topical Drug Delivery: Interaction Between Silica Nanoparticles and Skin Barrier","volume":"25","author":"Arriagada","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1600-0625.2000.009003165.x","article-title":"The 500 Dalton rule for the skin penetration of chemical compounds and drugs","volume":"9","author":"Bos","year":"2000","journal-title":"Exp. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jdermsci.2014.08.010","article-title":"Classification of inflammatory skin diseases: A proposal based on the disorders of the three-layered defense systems, barrier, innate immunity and acquired immunity","volume":"76","author":"Dainichi","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_11","unstructured":"Justiz Vaillant, A.A., Sabir, S., and Jan, A. (2021). Physiology, Immune Response. StatPearls, StatPearls Publishing."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41577-019-0162-3","article-title":"T cells and the skin: From protective immunity to inflammatory skin disorders","volume":"19","author":"Ho","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00281-019-00742-7","article-title":"T cell pathology in skin inflammation","volume":"41","author":"Sabat","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/pcmr.12949","article-title":"An update on Vitiligo pathogenesis","volume":"34","author":"Seneschal","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/bjd.18902","article-title":"Phenotype and function of circulating memory T cells in human vitiligo","volume":"183","author":"Martins","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jdermsci.2018.12.005","article-title":"Circulating CCL20: A potential biomarker for active vitiligo together with the number of Th1\/17 cells","volume":"93","author":"Zhang","year":"2019","journal-title":"J. Dermatol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000288166","article-title":"Epidermal permeability barrier recovery is delayed in vitiligo-involved sites","volume":"23","author":"Liu","year":"2010","journal-title":"Skin Pharm. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bishnoi, A., and Parsad, D. (2018). Clinical and Molecular Aspects of Vitiligo Treatments. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051509"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/ced.14435","article-title":"Vitiligo: An update on systemic treatments","volume":"46","author":"Searle","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2500\/aap.2019.40.4202","article-title":"Pathophysiology of atopic dermatitis: Clinical implications","volume":"40","author":"Kim","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-319-64804-0_3","article-title":"Atopic Dermatitis: Pathophysiology","volume":"1027","author":"Tarbox","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_23","first-page":"590","article-title":"Atopic Dermatitis: Diagnosis and Treatment","volume":"101","author":"Frazier","year":"2020","journal-title":"Am. Fam. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kamiya, K., Kishimoto, M., Sugai, J., Komine, M., and Ohtsuki, M. (2019). Risk Factors for the Development of Psoriasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184347"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJMra041320","article-title":"Psoriasis","volume":"352","author":"Schon","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2133.2004.06009.x","article-title":"Psoriasis: Immunopathogenesis and evolving immunomodulators and systemic therapies; U.S. experiences","volume":"151","author":"Kormeili","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_28","first-page":"392","article-title":"The possibilities and principles of methotrexate treatment of psoriasis\u2014The updated knowledge","volume":"31","year":"2014","journal-title":"Postepy. Dermatol. Alergol."},{"key":"ref_29","unstructured":"Goldsmith, L.A., Katz, S.I., Gilchrest, B.A., Paller, A.S., Leffell, D.J., and Wolff, K. (2012). Psoriasis. Fitzpatrick\u2019s Dermatology in General Medicine, The McGraw-Hill Companies, Inc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cei.13449","article-title":"IL-17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa","volume":"201","author":"Fletcher","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(18)31559-9","article-title":"Melanoma","volume":"392","author":"Schadendorf","year":"2018","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/ced.13023","article-title":"Innate immunity in cutaneous melanoma","volume":"42","author":"Mignogna","year":"2017","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.semcancer.2019.08.002","article-title":"Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment","volume":"59","author":"Marzagalli","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"ref_34","first-page":"641","article-title":"Effect of Chrysanthemum indicum on absorption characteristics of Cd and its effect on quality of medicinal materials","volume":"44","author":"Zhang","year":"2019","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/1523-1747.ep12464142","article-title":"Quantitative alterations in cutaneous Langerhans cells during the evolution of malignant melanoma of the skin","volume":"91","author":"Stene","year":"1988","journal-title":"J. Investig. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrc.2016.37","article-title":"From melanocytes to melanomas","volume":"16","author":"Shain","year":"2016","journal-title":"Nat. Rev. Cancer."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Boyer, M., Cayrefourcq, L., Dereure, O., Meunier, L., Becquart, O., and Alix-Panabieres, C. (2020). Clinical Relevance of Liquid Biopsy in Melanoma and Merkel Cell Carcinoma. Cancers, 12.","DOI":"10.3390\/cancers12040960"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1158\/0008-5472.CAN-18-0365","article-title":"Oncogenic BRAF(V600E) Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis","volume":"78","author":"Shabaneh","year":"2018","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2016.04.037","article-title":"The barrier function of organotypic non-melanoma skin cancer models","volume":"233","author":"Zoschke","year":"2016","journal-title":"J. Control Release"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000232305","article-title":"Retinoids, methotrexate and cyclosporine","volume":"38","author":"Dubertret","year":"2009","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_41","first-page":"481","article-title":"A dermatologist perspective in the pharmacological treatment of patients with psoriasis and psoriatic arthritis","volume":"5","author":"Francesco","year":"2020","journal-title":"Expert Rev. Clin. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Schakel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1468-3083.2011.03991.x","article-title":"Methotrexate in psoriasis: A systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity","volume":"25","author":"Montaudie","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2165\/00002018-200225130-00003","article-title":"Comparative tolerability of systemic treatments for plaque-type psoriasis","volume":"25","author":"McClure","year":"2002","journal-title":"Drug. Saf."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Aickara, D., Bashyam, A.M., Pichardo, R.O., and Feldman, S.R. (2020). Topical methotrexate in dermatology: A review of the literature. J. Dermatolog. Treat., 1\u20136.","DOI":"10.1080\/09546634.2020.1770170"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jid.2019.09.018","article-title":"Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis","volume":"140","author":"Ozcan","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11882-020-00944-2","article-title":"Role of the Microbiome in Allergic Disease Development","volume":"20","author":"Aguilera","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.anai.2020.08.025","article-title":"On the surface: Skin microbial exposure contributes to allergic disease","volume":"125","author":"DeVore","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/jocd.13538","article-title":"Potential role of the skin microbiota in Inflammatory skin diseases","volume":"20","author":"Chen","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.18176\/jiaci.0293","article-title":"Skin Allergy Committee of Spanish Society of Allergy Committee of Spanish Society of Allergy and Clinical Immunology (SEAIC). Basic Skin Care and Topical Therapies for Atopic Dermatitis: Essential Approaches and Beyond","volume":"28","author":"Lazaro","year":"2018","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/1203475415605498","article-title":"The Skin Microbiome in Atopic Dermatitis and Its Relationship to Emollients","volume":"20","author":"Lynde","year":"2016","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Glatz, M., Jo, J.H., Kennedy, E.A., Polley, E.C., Segre, J.A., Simpson, E.L., and Kong, H.H. (2018). Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192443"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jaad.2016.04.066","article-title":"Cutaneous microbiome effects of fluticasone propionate cream and adjunctive bleach baths in childhood atopic dermatitis","volume":"75","author":"Gonzalez","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-2230.2003.01239.x","article-title":"Contact allergy: The role of skin chemistry and metabolism","volume":"28","author":"Basketter","year":"2003","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.0105-1873.2004.00290.x","article-title":"A chemical dataset for evaluation of alternative approaches to skin-sensitization testing","volume":"50","author":"Gerberick","year":"2004","journal-title":"Contact Dermatitis"},{"key":"ref_57","first-page":"128","article-title":"Adverse reactions of externally applied drugs and inert substances","volume":"36","author":"Zesch","year":"1988","journal-title":"Derm. Beruf Umwelt"},{"key":"ref_58","first-page":"74","article-title":"Skin irritation by topical drugs","volume":"31","author":"Zesch","year":"1983","journal-title":"Derm. Beruf Umwelt"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3109\/10717544.2013.879355","article-title":"Comprehensive review on additives of topical dosage forms for drug delivery","volume":"22","author":"Garg","year":"2015","journal-title":"Drug Deliv."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2174\/0929867324666171009120154","article-title":"Recent Advances and Perspectives in Liposomes for Cutaneous Drug Delivery","volume":"25","author":"Carita","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2016.04.030","article-title":"Chemical penetration enhancers in stratum corneum\u2014Relation between molecular effects and barrier function","volume":"232","author":"Pham","year":"2016","journal-title":"J. Control Release"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijpharm.2016.05.004","article-title":"Transdermal permeation of drugs with differing lipophilicity: Effect of penetration enhancer camphor","volume":"507","author":"Xie","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"169","DOI":"10.15171\/apb.2018.021","article-title":"Chemical Enhancer: A Simplistic Way to Modulate Barrier Function of the Stratum Corneum","volume":"8","author":"Haque","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2003.10.016","article-title":"Role of solvent in interactions between fatty acids-based formulations and lipids in porcine stratum corneum","volume":"94","author":"Wang","year":"2004","journal-title":"J. Control Release"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1021\/mp100068s","article-title":"Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function","volume":"7","author":"Hathout","year":"2010","journal-title":"Mol. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/17425247.2020.1713087","article-title":"Permeation enhancers in transdermal drug delivery: Benefits and limitations","volume":"17","author":"Kovacik","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_67","first-page":"9","article-title":"Direct or indirect skin lipid-ordering effect of pyrrolidone carboxylate sodium after topical treatment with penetration enhancers","volume":"5","author":"Lin","year":"1995","journal-title":"Biomed. Mater. Eng."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jdermsci.2015.01.010","article-title":"Human sebum extract induces barrier disruption and cytokine expression in murine epidermis","volume":"78","author":"Guo","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_69","first-page":"1542","article-title":"Non-invasive method to monitor molecular changes in human stratum corneum during acute barrier disruption using reflectance NIR spectroscopy","volume":"2018","author":"Shin","year":"2018","journal-title":"Annu. Int. Conf. IEEE. Eng. Med. Biol. Soc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000081111","article-title":"How do dermatological vehicles influence the horny layer?","volume":"17","author":"Gloor","year":"2004","journal-title":"Skin Pharm. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00105-003-0512-7","article-title":"Effects of emulsions on the stratum corneum barrier and hydration","volume":"54","author":"Gloor","year":"2003","journal-title":"Hautarzt"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.biotechadv.2015.01.010","article-title":"Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers","volume":"33","author":"Witting","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0378-6323.186500","article-title":"Topical peptides as cosmeceuticals","volume":"83","author":"Pai","year":"2017","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/09687688.2010.522203","article-title":"Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery","volume":"27","author":"Desai","year":"2010","journal-title":"Mol. Membr. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2016.12.022","article-title":"Topical and cutaneous delivery using nanosystems","volume":"247","author":"Roberts","year":"2017","journal-title":"J. Control Release"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1389450115666140113100338","article-title":"A review on skin targeted delivery of bioactives as ultradeformable vesicles: Overcoming the penetration problem","volume":"15","author":"Priyanka","year":"2014","journal-title":"Curr. Drug Targets"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/17425247.2020.1727883","article-title":"SLN and NLC for topical, dermal, and transdermal drug delivery","volume":"17","author":"Souto","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"American Academy of Allergy, Asthma and Immunology, and American College of Allergy, Asthma and Immunology (2006). Contact dermatitis: A practice parameter. Ann. Allergy Asthma Immunol., 97, S1\u2013S38.","DOI":"10.1016\/S1081-1206(10)60811-3"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"489627","DOI":"10.1155\/2010\/489627","article-title":"Occupational protein contact dermatitis: Two case reports","volume":"2010","author":"Rocha","year":"2010","journal-title":"Case Rep. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1034\/j.1600-0536.2002.460202.x","article-title":"Occupational protein contact dermatitis from spices in a butcher: A new presentation of the mugwort-spice syndrome","volume":"46","author":"Anliker","year":"2002","journal-title":"Contact Dermatitis"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1046\/j.1365-4362.1998.00337.x","article-title":"Occupational protein contact dermatitis caused by meat and fish","volume":"37","author":"Boehncke","year":"1998","journal-title":"Int. J. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jcis.2010.10.025","article-title":"Visualization, dermatopharmacokinetic analysis and monitoring the conformational effects of a microemulsion formulation in the skin stratum corneum","volume":"354","author":"Hathout","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.0022-202X.2004.23235.x","article-title":"Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation","volume":"123","author":"Man","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1038\/s41598-017-09578-3","article-title":"The activation of PPARgamma by 2,4,6-Octatrienoic acid protects human keratinocytes from UVR-induced damages","volume":"7","author":"Flori","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3892\/etm.2021.9876","article-title":"Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis-like dermatitis animal model via the downregulation of interleukin-23","volume":"21","author":"Guo","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000499477","article-title":"Formulation and Artificial Sebum Effects on the Percutaneous Absorption of Zinc Pyrithione through Excised Human Skin","volume":"32","author":"Rush","year":"2019","journal-title":"Skin Pharm. Physiol."},{"key":"ref_87","unstructured":"Vogel, H.G., Hock, F.J., Maas, J., and Mayer, D. (2006). Safety Assays in Skin Pharmacology. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Springer."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000512122","article-title":"Curcumin-Loaded Self-Microemulsifying Gel for Enhancing Wound Closure","volume":"33","author":"Guo","year":"2020","journal-title":"Skin Pharm. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Guo, J.W., Cheng, Y.P., Liu, C.Y., Thong, H.Y., Huang, C.J., Lo, Y., Wu, C.Y., and Jee, S.H. (2020). Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-Induced Psoriasis-Like Dermatitis in Mice. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050457"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejpb.2016.01.002","article-title":"Size dependent skin penetration of nanoparticles in murine and porcine dermatitis models","volume":"100","author":"Try","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/exd.13536","article-title":"Skin toxicology and 3Rs-Current challenges for public health protection","volume":"27","author":"Riebeling","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/15569527.2018.1540494","article-title":"United States regulatory requirements for skin and eye irritation testing","volume":"38","author":"Choksi","year":"2019","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2133.1990.tb01847.x","article-title":"Susceptibility to irritants: Role of barrier function, skin dryness and history of atopic dermatitis","volume":"123","author":"Tupker","year":"1990","journal-title":"Br. J. Dermatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"692","DOI":"10.23736\/S0392-0488.17.05697-8","article-title":"How to improve adherence to treatment in patients with mild-to-moderate psoriasis","volume":"153","author":"Piaserico","year":"2018","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1468-3083.2011.04061.x","article-title":"What is new in topical therapy for psoriasis?","volume":"25","author":"Reich","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/CCID.S157297","article-title":"Skin acceptability of a cosmetic moisturizer formulation in female subjects with sensitive skin","volume":"11","author":"Nisbet","year":"2018","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/jocd.12547","article-title":"Cutaneous acceptability of a moisturizing cream in subjects with sensitive skin","volume":"18","author":"Snatchfold","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/jocd.12486","article-title":"Assessment of the efficacy of a new complex antisensitive skin cream","volume":"17","author":"Wang","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/cod.12909","article-title":"Skin care products can aggravate epidermal function: Studies in a murine model suggest a pathogenic role in sensitive skin","volume":"78","author":"Li","year":"2018","journal-title":"Contact Dermatitis"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000493641","article-title":"Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis","volume":"32","author":"Elias","year":"2019","journal-title":"Skin Pharm. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.anai.2018.07.008","article-title":"Does moisturizing the skin equate with barrier repair therapy?","volume":"121","author":"Elias","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1582-4934.2002.tb00186.x","article-title":"Cytochromes P450 and experimental models of drug metabolism","volume":"6","author":"Zuber","year":"2002","journal-title":"J. Cell. Mol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/exd.13483","article-title":"Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents","volume":"27","author":"Smith","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1046\/j.1523-1747.2001.01298.x","article-title":"Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes","volume":"116","author":"Baron","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0006-291X(02)02134-4","article-title":"Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes","volume":"297","author":"Zhu","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000057751","article-title":"mRNA expression of multiple cytochrome p450 isozymes in four types of cultured skin cells","volume":"127","author":"Saeki","year":"2002","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/jpet.106.105858","article-title":"Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450","volume":"319","author":"Vyas","year":"2006","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1124\/jpet.106.111724","article-title":"Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands","volume":"319","author":"Du","year":"2006","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0006-2952(01)00718-3","article-title":"Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450","volume":"62","author":"Janmohamed","year":"2001","journal-title":"Biochem. Pharm."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/1523-1747.ep12384210","article-title":"Multiple cytochrome P450 isozymes in murine skin: Induction of P450 1A, 2B, 2E, and 3A by dexamethasone","volume":"102","author":"Jugert","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2165\/00128071-200304110-00005","article-title":"Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders","volume":"4","author":"Loden","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Guo, J.W., Chien, C.C., and Chen, J.H. (2020). CYP3A Excipient-Based Microemulsion Prolongs the Effect of Magnolol on Ischemia Stroke Rats. 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