{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:37:19Z","timestamp":1781710639788,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["DEC-2013\/09\/B\/NZ5\/00758"],"award-info":[{"award-number":["DEC-2013\/09\/B\/NZ5\/00758"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Increased airway wall thickness and remodeling of bronchial mucosa are characteristic of asthma and may arise from altered integrin signaling on airway cells. Here, we analyzed the expression of \u03b21-subfamily integrins on blood and airway cells (flow cytometry), inflammatory biomarkers in serum and bronchoalveolar lavage, reticular basement membrane (RBM) thickness and collagen deposits in the mucosa (histology), and airway geometry (CT-imaging) in 92 asthma patients (persistent airflow limitation subtype: n = 47) and 36 controls. Persistent airflow limitation was associated with type-2 inflammation, elevated soluble \u03b12 integrin chain, and changes in the bronchial wall geometry. Both subtypes of asthma showed thicker RBM than control, but collagen deposition and epithelial \u03b11 and \u03b12 integrins staining were similar. Type-I collagen accumulation and RBM thickness were inversely related to the epithelial expression of the \u03b12 integrin chain. Expression of \u03b12\u03b21 integrin on T-cells and eosinophils was not altered in asthma. Collagen I deposits were, however, more abundant in patients with lower \u03b12\u03b21 integrin on blood and airway CD8+ T-cells. Thicker airway walls in CT were associated with lower \u03b12 integrin chain on blood CD4+ T-cells and airway eosinophils. Our data suggest that \u03b12\u03b21 integrin on inflammatory and epithelial cells may protect against airway remodeling advancement in asthma.<\/jats:p>","DOI":"10.3390\/ijms22126315","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T10:30:25Z","timestamp":1623666625000},"page":"6315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interactions via \u03b12\u03b21 Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9634-0963","authenticated-orcid":false,"given":"Stanislawa","family":"Bazan-Socha","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-981X","authenticated-orcid":false,"given":"Bogdan","family":"Jakiela","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Zuk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Zarychta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"},{"name":"Pulmonary Hospital, 34-500 Zakopane, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Soja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-5007","authenticated-orcid":false,"given":"Krzysztof","family":"Okon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Dziedzina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Institute of Computer Science, College of Natural Sciences, University of Rzesz\u00f3w, 35-310 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Dropinski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-2499","authenticated-orcid":false,"given":"Krzysztof","family":"Wojcik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Padjas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Marcinkiewicz","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, College of Engineering, Temple University, Philadelphia, PA 19122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Bazan","sequence":"additional","affiliation":[{"name":"Institute of Computer Science, College of Natural Sciences, University of Rzesz\u00f3w, 35-310 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","article-title":"Asthma","volume":"344","author":"Busse","year":"2001","journal-title":"N. 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