{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:00Z","timestamp":1790959320867,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This article describes the synthesis and characterization of \u03b2-cyclodextrin-based nano-sponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles (AuNPs) onto both systems, for the potential release of the drugs by means of laser irradiation. The NS-MPH and NS-CYT inclusion compounds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), UV\u2013Vis, and proton nuclear magnetic resonance (1H-NMR). Thus, the inclusion of MPH and CYT inside the cavities of NSs was confirmed. The association of AuNPs with the ICs was confirmed by SEM, EDS, TEM, and UV\u2013Vis. Drug release studies using NSs synthesized with different molar ratios of \u03b2-cyclodextrin and diphenylcarbonate (1:4 and 1:8) demonstrated that the ability of NSs to entrap and release the drug molecules depends on the crosslinking between the cyclodextrin monomers. Finally, irradiation assays using a continuous laser of 532 nm showed that photothermal drug release of both MPH and CYT from the cavities of NSs via plasmonic heating of AuNPs is possible.<\/jats:p>","DOI":"10.3390\/ijms22126446","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:27:07Z","timestamp":1623839227000},"page":"6446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-4432","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Salazar","sequence":"first","affiliation":[{"name":"Departmento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, Santiago 7800003, Chile"},{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile"},{"name":"Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Yutronic","sequence":"additional","affiliation":[{"name":"Departmento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, Santiago 7800003, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0608-5087","authenticated-orcid":false,"given":"Marcelo J.","family":"Kogan","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Farmacol\u00f3gica y Toxicol\u00f3gica, Universidad de Chile, Sergio Livingstone 1007, Santiago 8380492, Chile"},{"name":"Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jara","sequence":"additional","affiliation":[{"name":"Departmento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, \u00d1u\u00f1oa, Santiago 7800003, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Osmani, R.A.M., Kulkarni, P.K., Gowda, V., Hani, U., Gupta, V.K., Prerana, M., and Saha, C. 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