{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:55:53Z","timestamp":1771682153226,"version":"3.50.1"},"reference-count":73,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2014\/15\/B\/NZ2\/01073"],"award-info":[{"award-number":["2014\/15\/B\/NZ2\/01073"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Coumarins belong to a group of secondary metabolites well known for their high biological activities including antibacterial and antifungal properties. Recently, an important role of coumarins in plant resistance to pathogens and their release into the rhizosphere upon pathogen infection was discovered. It is also well documented that coumarins play a crucial role in the Arabidopsis thaliana growth under Fe-limited conditions. However, the mechanisms underlying interplay between plant resistance, accumulation of coumarins and Fe status, remain largely unknown. In this work, we investigated the effect of both mentioned factors on the disease severity using the model system of Arabidopsis\/Dickeya spp. molecular interactions. We evaluated the disease symptoms in Arabidopsis plants, wild-type Col-0 and its mutants defective in coumarin accumulation, grown in hydroponic cultures with contrasting Fe regimes and in soil mixes. Under all tested conditions, Arabidopsis plants inoculated with Dickeya solani IFB0099 strain developed more severe disease symptoms compared to lines inoculated with Dickeya dadantii 3937. We also showed that the expression of genes encoding plant stress markers were strongly affected by D. solani IFB0099 infection. Interestingly, the response of plants to D. dadantii 3937 infection was genotype-dependent in Fe-deficient hydroponic solution.<\/jats:p>","DOI":"10.3390\/ijms22126449","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:27:07Z","timestamp":1623839227000},"page":"6449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Interplay between Coumarin Accumulation, Iron Deficiency and Plant Resistance to Dickeya spp."],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-9217","authenticated-orcid":false,"given":"Izabela","family":"Perkowska","sequence":"first","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-1109","authenticated-orcid":false,"given":"Marta","family":"Potrykus","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland"},{"name":"Department of Environmental Toxicology, Faculty of Health Sciences with Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Debowa 23 A, 80-204 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Siwinska","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Siudem","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-2307","authenticated-orcid":false,"given":"Ewa","family":"Lojkowska","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ihnatowicz","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1114197","DOI":"10.1080\/15592324.2015.1114197","article-title":"The Essential Role of Coumarin Secretion for Fe Acquisition from Alkaline Soil","volume":"11","author":"Clemens","year":"2016","journal-title":"Plant Signal. Behav."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/nph.12471","article-title":"Involvement of the ABCG37 Transporter in Secretion of Scopoletin and Derivatives by Arabidopsis Roots in Response to Iron Deficiency","volume":"201","author":"Fourcroy","year":"2014","journal-title":"New Phytol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41589-018-0019-2","article-title":"Biosynthesis of Redox-Active Metabolites in Response to Iron Deficiency in Plants","volume":"14","author":"Rajniak","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1104\/pp.113.220426","article-title":"Mutually Exclusive Alterations in Secondary Metabolism Are Critical for the Uptake of Insoluble Iron Compounds by Arabidopsis and Medicago Truncatula","volume":"162","author":"Lin","year":"2013","journal-title":"Plant Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1104\/pp.113.228544","article-title":"Feruloyl-CoA 6\u2032-Hydroxylase1-Dependent Coumarins Mediate Iron Acquisition from Alkaline Substrates in Arabidopsis","volume":"164","author":"Schmid","year":"2014","journal-title":"Plant Physiol."},{"key":"ref_6","first-page":"1711","article-title":"Accumulation and Secretion of Coumarinolignans and Other Coumarins in Arabidopsis Thaliana Roots in Response to Iron Deficiency at High PH","volume":"7","author":"Fourcroy","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/jxb\/ery005","article-title":"Scopoletin 8-Hydroxylase: A Novel Enzyme Involved in Coumarin Biosynthesis and Iron-Deficiency Responses in Arabidopsis","volume":"69","author":"Siwinska","year":"2018","journal-title":"J. Exp. Bot."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1104\/pp.18.00178","article-title":"Scopoletin 8-Hydroxylase-Mediated Fraxetin Production Is Crucial for Iron Mobilization","volume":"177","author":"Tsai","year":"2018","journal-title":"Plant Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s41477-019-0510-0","article-title":"COSY Catalyses Trans-Cis Isomerization and Lactonization in the Biosynthesis of Coumarins","volume":"5","author":"Vanholme","year":"2019","journal-title":"Nat. Plants"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-313X.2008.03568.x","article-title":"Scopoletin Is Biosynthesized via Ortho-Hydroxylation of Feruloyl CoA by a 2-Oxoglutarate-Dependent Dioxygenase in Arabidopsis Thaliana","volume":"55","author":"Kai","year":"2008","journal-title":"Plant J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.arplant.54.031902.135018","article-title":"Iron Transport and Signaling in Plants","volume":"54","author":"Curie","year":"2003","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-phyto-080516-035537","article-title":"Iron and Immunity","volume":"55","author":"Verbon","year":"2017","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nph.16005","article-title":"Iron Acquisition Strategies in Land Plants: Not so Different after All","volume":"224","author":"Grillet","year":"2019","journal-title":"New Phytol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Siwinska, J., Kadzinski, L., Banasiuk, R., Gwizdek-Wisniewska, A., Olry, A., Banecki, B., Lojkowska, E., and Ihnatowicz, A. (2014). Identification of QTLs Affecting Scopolin and Scopoletin Biosynthesis in Arabidopsis Thaliana. BMC Plant Biol., 14.","DOI":"10.1186\/s12870-014-0280-9"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yang, L., Ding, W., Xu, Y., Wu, D., Li, S., Chen, J., and Guo, B. (2016). New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia Solanacearum. Molecules, 21.","DOI":"10.3390\/molecules21040468"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1093\/jxb\/eru203","article-title":"Scopoletin Is a Phytoalexin against Alternaria Alternata in Wild Tobacco Dependent on Jasmonate Signalling","volume":"65","author":"Sun","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1462-2920.2009.02063.x","article-title":"The Nature of Tobacco Resistance against Botrytis Cinerea Depends on the Infection Structures of the Pathogen","volume":"12","author":"Trapani","year":"2010","journal-title":"Environ. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1515\/znc-2005-1-216","article-title":"Morning Glory Systemically Accumulates Scopoletin and Scopolin after Interaction with Fusarium Oxysporum","volume":"60","author":"Shimizu","year":"2005","journal-title":"Z. Naturforsch. C J. Biosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10681-005-9045-8","article-title":"Fungitoxic Effect of Scopolin and Related Coumarins on Sclerotinia Sclerotiorum. A Way to Overcome Sunflower Head Rot","volume":"147","author":"Prats","year":"2006","journal-title":"Euphytica"},{"key":"ref_20","first-page":"e14387","article-title":"LC-MS Quantification of Scopoletin in Cassava(Manihot Esculenta Crantz) Varieties, Local Derived Foods, and Activity on Some Food Spoilage Fungi","volume":"44","author":"Ndam","year":"2020","journal-title":"J. Food Process. Preserv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF01874474","article-title":"Accumulation of Phytoalexins in Leaves of Plane Tree(Platanus Spp.) Expressing Susceptibility or Resistance ToCeratocystis Fimbriata f. Sp.Platani","volume":"101","author":"Modafar","year":"1995","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/07352689.2011.616039","article-title":"Review Scopoletin\u2014A Coumarin Phytoalexin with Medicinal Properties","volume":"31","author":"Gnonlonfin","year":"2012","journal-title":"Crit. Rev. Plant Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7324\/JAPS.2018.8901","article-title":"Scopoletin from Lasianthus Lucidus Blume(Rubiaceae): A Potential Antimicrobial against Multidrug-Resistant Pseudomonas Aeruginosa","volume":"8","author":"Napiroon","year":"2018","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_24","first-page":"47","article-title":"Scopoletin reduces intracellular survival of Salmonella typhi within U937 human macrophage cell line in vitro","volume":"1","author":"Acharya","year":"2013","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mogana, R., Adhikari, A., Tzar, M.N., Ramliza, R., and Wiart, C. (2020). Antibacterial Activities of the Extracts, Fractions and Isolated Compounds from Canarium Patentinervium Miq. against Bacterial Clinical Isolates. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-2837-5"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"E5213","DOI":"10.1073\/pnas.1722335115","article-title":"MYB72-Dependent Coumarin Exudation Shapes Root Microbiome Assembly to Promote Plant Health","volume":"115","author":"Stringlis","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","first-page":"721","article-title":"Current Natural Products with Antihypertensive Activity","volume":"13","author":"Bai","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12558","DOI":"10.1073\/pnas.1820691116","article-title":"Plant-Derived Coumarins Shape the Composition of an Arabidopsis Synthetic Root Microbiome","volume":"116","author":"Voges","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.chom.2020.09.006","article-title":"Root-Secreted Coumarins and the Microbiota Interact to Improve Iron Nutrition in Arabidopsis","volume":"28","author":"Harbort","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tplants.2020.09.008","article-title":"Coumarin Communication along the Microbiome-Root-Shoot Axis","volume":"26","author":"Stassen","year":"2021","journal-title":"Trends Plant Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/pcp\/pcz076","article-title":"The Age of Coumarins in Plant-Microbe Interactions","volume":"60","author":"Stringlis","year":"2019","journal-title":"Plant Cell Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.phyto.37.1.307","article-title":"WITHHOLDING AND EXCHANGING IRON: Interactions between Erwinia Spp. and Their Plant Hosts","volume":"37","author":"Expert","year":"1999","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.nbt.2017.08.010","article-title":"Molecular Methods as Tools to Control Plant Diseases Caused by Dickeya and Pectobacterium Spp: A Minireview","volume":"39 Pt B","author":"Motyka","year":"2017","journal-title":"New Biotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1094\/PDIS-04-15-0439-RE","article-title":"Biodiversity of Dickeya Spp. Isolated from Potato Plants and Water Sources in Temperate Climate","volume":"100","author":"Potrykus","year":"2016","journal-title":"Plant Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-3059.2011.02427.x","article-title":"Dickeya Species: An Emerging Problem for Potato Production in Europe","volume":"60","author":"Toth","year":"2011","journal-title":"Plant Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-313X.2005.02451.x","article-title":"Siderophore-Mediated Upregulation of Arabidopsis Ferritin Expression in Response to Erwinia Chrysanthemi Infection","volume":"43","author":"Dellagi","year":"2005","journal-title":"Plant J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1364-3703.2012.00790.x","article-title":"Iron Deficiency Affects Plant Defence Responses and Confers Resistance to Dickeya Dadantii and Botrytis Cinerea","volume":"13","author":"Kieu","year":"2012","journal-title":"Mol. Plant Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-313X.2008.03775.x","article-title":"NRAMP Genes Function in Arabidopsis Thaliana Resistance to Erwinia Chrysanthemi Infection","volume":"58","author":"Segond","year":"2009","journal-title":"Plant J."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Golanowska, M., Potrykus, M., Motyka-Pomagruk, A., Kabza, M., Bacci, G., Galardini, M., Bazzicalupo, M., Makalowska, I., Smalla, K., and Mengoni, A. (2018). Comparison of Highly and Weakly Virulent Dickeya Solani Strains, With a View on the Pangenome and Panregulon of This Species. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01940"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1094\/MPMI-09-13-0270-R","article-title":"Regulators Involved in Dickeya Solani Virulence, Genetic Conservation, and Functional Variability","volume":"27","author":"Potrykus","year":"2014","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1365-3059.2009.02028.x","article-title":"First Report of Bacterial Soft Rot on Potato Caused by Dickeya Sp. (Syn. Erwinia Chrysanthemi) in Poland","volume":"58","author":"Wolf","year":"2009","journal-title":"Plant Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/nph.12737","article-title":"Conserved Histidine of Metal Transporter AtNRAMP1 Is Crucial for Optimal Plant Growth under Manganese Deficiency at Chilling Temperatures","volume":"202","author":"Ihnatowicz","year":"2014","journal-title":"New Phytol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Chaparro, J.M., Badri, D.V., Bakker, M.G., Sugiyama, A., Manter, D.K., and Vivanco, J.M. (2013). Root Exudation of Phytochemicals in Arabidopsis Follows Specific Patterns That Are Developmentally Programmed and Correlate with Soil Microbial Functions. PLoS ONE, 8.","DOI":"10.1371\/annotation\/51142aed-2d94-4195-8a8a-9cb24b3c733b"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1104\/pp.105.063743","article-title":"Genome-Wide Identification and Testing of Superior Reference Genes for Transcript Normalization in Arabidopsis","volume":"139","author":"Czechowski","year":"2005","journal-title":"Plant Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e00044","DOI":"10.1002\/pld3.44","article-title":"Soil Mixture Composition Alters Arabidopsis Susceptibility to Pseudomonas Syringae Infection","volume":"2","author":"Hassan","year":"2018","journal-title":"Plant Direct"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Carvalhais, L.C., Dennis, P.G., Fan, B., Fedoseyenko, D., Kierul, K., Becker, A., von Wiren, N., and Borriss, R. (2013). Linking Plant Nutritional Status to Plant-Microbe Interactions. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068555"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0065-2296(09)51012-9","article-title":"Chapter 12 Role of Iron in Plant\u2013Microbe Interactions","volume":"Volume 51","author":"Lemanceau","year":"2009","journal-title":"Advances in Botanical Research"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-540-68027-7_6","article-title":"Plant-Microbe Interactions in the Rhizosphere and Nutrient Cycling","volume":"Volume 10","author":"Marschner","year":"2007","journal-title":"Nutrient Cycling in Terrestrial Ecosystems. Soil Biology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1365-313X.1995.07010121.x","article-title":"Signalling Potential of Iron in Plant\u2014Microbe Interactions: The Pathogenic Switch of Iron Transport in Erwinia Chrysanthemi","volume":"7","author":"Masclaux","year":"1995","journal-title":"Plant J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1094\/MPMI-08-20-0229-CR","article-title":"What Are the Top 10 Unanswered Questions in Molecular Plant-Microbe Interactions?","volume":"33","author":"Harris","year":"2020","journal-title":"MPMI"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10658-020-02163-x","article-title":"The Occurrence of Bacteria from Different Species of Pectobacteriaceae on Seed Potato Plantations in Poland","volume":"159","author":"Zoledowska","year":"2021","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1099\/ijs.0.052944-0","article-title":"Dickeya Solani Sp. Nov., a Pectinolytic Plant-Pathogenic Bacterium Isolated from Potato(Solanum Tuberosum)","volume":"64","author":"Nijhuis","year":"2014","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/aab.12020","article-title":"A New Clade of Dickeya Spp. Plays a Major Role in Potato Blackleg Outbreaks in North Finland","volume":"162","author":"Degefu","year":"2013","journal-title":"Ann. Appl. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.5114\/bta.2016.60781","article-title":"A Review on Dickeya Solani, a New Pathogenic Bacterium Causing Loss in Potato Yield in Europe","volume":"97","author":"Golanowska","year":"2016","journal-title":"BioTechnologia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1364-3703.2010.00675.x","article-title":"Expression of Arabidopsis Pathogenesis-Related Genes during Nematode Infection","volume":"12","author":"Hamamouch","year":"2011","journal-title":"Mol. Plant Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.phyto.36.1.453","article-title":"Systemic Resistance Induced by Rhizosphere Bacteria","volume":"36","author":"Bakker","year":"1998","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1104\/pp.118.2.637","article-title":"Superoxide Dismutase in Arabidopsis: An Eclectic Enzyme Family with Disparate Regulation and Protein Localization","volume":"118","author":"Kliebenstein","year":"1998","journal-title":"Plant Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/cr.2010.36","article-title":"The Arabidopsis P450 Protein CYP82C2 Modulates Jasmonate-Induced Root Growth Inhibition, Defense Gene Expression and Indole Glucosinolate Biosynthesis","volume":"20","author":"Liu","year":"2010","journal-title":"Cell Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-arplant-042811-105522","article-title":"Iron Uptake, Translocation, and Regulation in Higher Plants","volume":"63","author":"Kobayashi","year":"2012","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Schmidt, H., G\u00fcnther, C., Weber, M., Sp\u00f6rlein, C., Loscher, S., B\u00f6ttcher, C., Schobert, R., and Clemens, S. (2014). Metabolome Analysis of Arabidopsis Thaliana Roots Identifies a Key Metabolic Pathway for Iron Acquisition. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102444"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/nph.14477","article-title":"One Way. Or Another? Iron Uptake in Plants","volume":"214","author":"Tsai","year":"2017","journal-title":"New Phytol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/nph.12980","article-title":"\u03b2-Glucosidase BGLU42 Is a MYB72-Dependent Key Regulator of Rhizobacteria-Induced Systemic Resistance and Modulates Iron Deficiency Responses in Arabidopsis Roots","volume":"204","author":"Zamioudis","year":"2014","journal-title":"New Phytol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/jxb\/erp053","article-title":"Influence of Arabidopsis Thaliana Accessions on Rhizobacterial Communities and Natural Variation in Root Exudates","volume":"60","author":"Micallef","year":"2009","journal-title":"J. Exp. Bot."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tplants.2012.04.001","article-title":"The Rhizosphere Microbiome and Plant Health","volume":"17","author":"Berendsen","year":"2012","journal-title":"Trends Plant Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Perkowska, I., Siwinska, J., Olry, A., Grosjean, J., Hehn, A., Bourgaud, F., Lojkowska, E., and Ihnatowicz, A. (2021). Identification and Quantification of Coumarins by UHPLC-MS in Arabidopsis Thaliana Natural Populations. Molecules, 26.","DOI":"10.3390\/molecules26061804"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3389\/fpls.2017.00394","article-title":"Quantitative Methods to Assess Differential Susceptibility of Arabidopsis Thaliana Natural Accessions to Dickeya Dadantii","volume":"8","author":"Rigault","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1094\/Phyto-78-1216","article-title":"Fertile Interspecific Somatic Hybrids of Solanum: A Novel Source of Resistance to Erwinia Soft Rot","volume":"78","author":"Austin","year":"1988","journal-title":"Phytopathology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1094\/MPMI-18-1107","article-title":"Potato Homologs of Arabidopsis Thaliana Genes Functional in Defense Signaling--Identification, Genetic Mapping, and Molecular Cloning","volume":"18","author":"Pajerowska","year":"2005","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2135\/cropsci2000.4041156x","article-title":"QTL Analysis of New Sources of Resistance to Erwinia Carotovora Ssp. Atroseptica in Potato Done by AFLP, RFLP, and Resistance-Gene-Like Markers","volume":"40","author":"Marczewski","year":"2000","journal-title":"Crop Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0006-3002(54)90003-7","article-title":"On the Mechanism of Photoreactivation of Ultraviolet-Inactivated Bacteriophage","volume":"15","author":"Lennox","year":"1954","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1105\/tpc.107.056747","article-title":"Analysis of the Arabidopsis O-Acetylserine(Thiol)Lyase Gene Family Demonstrates Compartment-Specific Differences in the Regulation of Cysteine Synthesis","volume":"20","author":"Heeg","year":"2008","journal-title":"Plant Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1746-4811-9-4","article-title":"Protocol: Optimising Hydroponic Growth Systems for Nutritional and Physiological Analysis of Arabidopsis Thaliana and Other Plants","volume":"9","author":"Conn","year":"2013","journal-title":"Plant Methods"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0003-2697(87)90612-9","article-title":"Universal Chemical Assay for the Detection and Determination of Siderophores","volume":"160","author":"Schwyn","year":"1987","journal-title":"Anal. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/12\/6449\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:16:54Z","timestamp":1760163414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/12\/6449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":73,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["ijms22126449"],"URL":"https:\/\/doi.org\/10.3390\/ijms22126449","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]}}}