{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:06:02Z","timestamp":1793325962930,"version":"4.5.0"},"reference-count":144,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center of Postgraduate Medical Education","award":["501-1-022-26-21"],"award-info":[{"award-number":["501-1-022-26-21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Placental abruption is the separation of the placenta from the lining of the uterus before childbirth. It is an infrequent perinatal complication with serious after-effects and a marked risk of maternal and fetal mortality. Despite the fact that numerous placental abruption risk factors are known, the pathophysiology of this issue is multifactorial and not entirely clear. The aim of this review was to examine the current state of knowledge concerning the molecular changes on the maternal\u2013fetal interface occurring in placental abruption. Only original research articles describing studies published in English until the 15 March 2021 were considered eligible. Reviews, book chapters, case studies, conference papers and opinions were excluded. The systematic literature search of PubMed\/MEDLINE and Scopus databases identified 708 articles, 22 of which were analyzed. The available evidence indicates that the disruption of the immunological processes on the maternal\u2013fetal interface plays a crucial role in the pathophysiology of placental abruption. The features of chronic non-infectious inflammation and augmented immunological cytotoxic response were found to be present in placental abruption samples in the reviewed studies. Various molecules participate in this process, with only a few being examined. More advanced research is needed to fully explain this complicated process.<\/jats:p>","DOI":"10.3390\/ijms22126612","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T04:21:21Z","timestamp":1624249281000},"page":"6612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular Changes on Maternal\u2013Fetal Interface in Placental Abruption\u2014A Systematic Review"],"prefix":"10.3390","volume":"22","author":[{"given":"Monika","family":"B\u0105czkowska","sequence":"first","affiliation":[{"name":"Center of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Zgliczy\u0144ska","sequence":"additional","affiliation":[{"name":"Center of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Faryna","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biela\u0144ski Hospital, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Przytu\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biela\u0144ski Hospital, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u0142a\u017cej","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"The Greater Poland Cancer Center, Department of Surgical, Oncological, and Endoscopic Gynecology, 61-866 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-5983","authenticated-orcid":false,"given":"Micha\u0142","family":"Ciebiera","sequence":"additional","affiliation":[{"name":"Center of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0412.2010.01030.x","article-title":"Placental abruption: Epidemiology, risk factors and consequences","volume":"90","author":"Tikkanen","year":"2011","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_2","unstructured":"Schmidt, P., Skelly, C.L., and Raines, D.A. (2020). Placental Abruption, Statpearls."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ananth, C.V., Keyes, K.M., Hamilton, A., Gissler, M., Wu, C., Liu, S., Luque-Fernandez, M.A., Skj\u00e6rven, R., Williams, M.A., and Tikkanen, M. (2015). An International Contrast of Rates of Placental Abruption: An Age-Period-Cohort Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125246"},{"key":"ref_4","first-page":"443","article-title":"Abruptio placenta and adverse pregnancy outcome","volume":"60","author":"Hossain","year":"2010","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_5","first-page":"422","article-title":"Risk factors of placental abruption","volume":"18","author":"Ghaheh","year":"2013","journal-title":"J. Res. Med. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/jmf.13.1.45.49","article-title":"Placental abruption in term pregnancies: Clinical significance and obstetric risk factors","volume":"13","author":"Sheiner","year":"2003","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1055\/s-0037-1599149","article-title":"Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review","volume":"34","author":"Downes","year":"2017","journal-title":"Am. J. Perinatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/AOG.0b013e3181a66f2d","article-title":"Recurring Complications in Second Pregnancy","volume":"113","author":"Lykke","year":"2009","journal-title":"Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/ppe.12089","article-title":"Placental Abruption as a Significant Risk Factor for Long-term Cardiovascular Mortality in a Follow-up Period of More Than a Decade","volume":"28","author":"Pariente","year":"2014","journal-title":"Paediatr. P\u00e9rinat. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tjog.2019.01.010","article-title":"Analysis of 62 placental abruption cases: Risk factors and clinical outcomes","volume":"58","author":"Li","year":"2019","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kawanishi, Y., Yoshioka, E., Saijo, Y., Itoh, T., Miyamoto, T., Sengoku, K., Ito, Y., Ito, S., Miyashita, C., and Araki, A. (2019). The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children\u2019s Study (JECS). PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219379"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1093\/aje\/kwy138","article-title":"Physical Exertion Immediately Prior to Placental Abruption: A Case-Crossover Study","volume":"187","author":"Chahal","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2018.04.008","article-title":"Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies","volume":"66","author":"Workalemahu","year":"2018","journal-title":"Placenta"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/j.semperi.2014.03.001","article-title":"Ischemic placental disease: A unifying concept for preeclampsia, intrauterine growth restriction, and placental abruption","volume":"38","author":"Ananth","year":"2014","journal-title":"Semin. Perinatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3109\/14767050903334885","article-title":"Ischemic placental disease: Maternal versus fetal clinical presentations by gestational age","volume":"23","author":"Ananth","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3389\/fimmu.2018.01659","article-title":"Disruption in the Regulation of Immune Responses in the Placental Subtype of Preeclampsia","volume":"9","author":"Geldenhuys","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.2741\/2740","article-title":"The role of the endometrium in the regulation of immune cell activity","volume":"13","author":"Wicherek","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Norman, J.E., Bollapragada, S., Yuan, M., and Nelson, S.M. (2007). Inflammatory pathways in the mechanism of parturition. BMC Pregnancy Childbirth, 7.","DOI":"10.1186\/1471-2393-7-S1-S7"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cmi.2014.46","article-title":"Immune cells in term and preterm labor","volume":"11","author":"Stlouis","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejogrb.2005.05.019","article-title":"The molecular changes during placental detachment","volume":"125","author":"Wicherek","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/aji.12517","article-title":"Thrombin Augments LPS-Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation","volume":"76","author":"Mhatre","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic Function and Composition Changes of Immune Cells during Normal and Pathological Pregnancy at the Maternal-Fetal Interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2010.05932.x","article-title":"Placental Hofbauer cells and complications of pregnancy","volume":"1221","author":"Tang","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"531543","DOI":"10.3389\/fimmu.2020.531543","article-title":"Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease","volume":"11","author":"Goldstein","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1067\/mob.2003.55","article-title":"Soluble HLA-DR levels in the maternal circulation of normal and pathologic pregnancy","volume":"188","author":"Steinborn","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0301-2115(02)00350-0","article-title":"Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia","volume":"109","author":"Banasik","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0002-9440(10)61230-8","article-title":"Mechanisms of Abruption-Induced Premature Rupture of the Fetal Membranes: Thrombin-Enhanced Interleukin-8 Expression in Term Decidua","volume":"167","author":"Lockwood","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejogrb.2006.01.016","article-title":"Evidence of placental abruption as a chronic process: Associations with vaginal bleeding early in pregnancy and placental lesions","volume":"128","author":"Ananth","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0897.2007.00490.x","article-title":"RCAS1 Decidual Immunoreactivity during Placental Abruption: Immune Cell Presence and Activity","volume":"58","author":"Wicherek","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1017\/S1462399410001675","article-title":"Novel insights into molecular mechanisms of abruption-induced preterm birth","volume":"12","author":"Buhimschi","year":"2010","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at the maternal-fetal interface: Perspectives and challenges","volume":"16","author":"PrabhuDas","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41421-020-0167-x","article-title":"Inflammasome activation and regulation: Toward a better understanding of complex mechanisms","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell Discov."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fimmu.2013.00242","article-title":"NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges","volume":"4","author":"Slim","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"The Society of Gynecologic Oncology, American College of Obstetricians and Gynecologists and the Society for Maternal\u2013Fetal Medicine, Cahill, A.G., Beigi, R., Heine, R.P., Silver, R.M., and Wax, J.R. (2018). Placenta Accreta Spectrum. Am. J. Obstet. Gynecol., 219, B2\u2013B16.","DOI":"10.1016\/j.ajog.2018.09.042"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/GRF.0000000000000392","article-title":"Pathophysiology of Placenta Accreta Spectrum Disorders: A Review of Current Findings","volume":"61","author":"Jauniaux","year":"2018","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_36","unstructured":"Rathbun, K.M., and Hildebrand, J.P. (2021). Placenta Abnormalities, Statpearls."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2147\/IJWH.S218933","article-title":"Retained placenta after vaginal delivery: Risk factors and management","volume":"11","author":"Perlman","year":"2019","journal-title":"Int. J. Womens Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3109\/15513818309025879","article-title":"Preliminary Report: Immunoperoxidase-Linked Human Placental Lactogen as a Histopathologic Index of Perinatal Morbidity and Mortality","volume":"1","author":"Altshuler","year":"1983","journal-title":"Pediatr. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0892-0362(87)90019-5","article-title":"Prenatal cocaine use associated with down regulation of receptors in human placenta","volume":"9","author":"Wang","year":"1987","journal-title":"Neurotoxicology Teratol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/humrep\/14.4.1101","article-title":"Generation of peroxynitrite and apoptosis in placenta of patients with chorioamnionitis: Possible implications in placental abruption","volume":"14","author":"Nakatsuka","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0301-2115(02)00113-6","article-title":"Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the placenta and myometrium","volume":"105","author":"Zekanowska","year":"2002","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/jmf.11.1.11.17","article-title":"Thrombin-enhanced matrix metalloproteinase-1 expression: A mechanism linking placental abruption with premature rupture of the membranes","volume":"11","author":"Rosen","year":"2002","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1095\/biolreprod.103.015800","article-title":"Homocysteine Induces Trophoblast Cell Death with Apoptotic Features","volume":"69","author":"Maggiano","year":"2003","journal-title":"Biol. Reprod."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejogrb.2003.12.006","article-title":"Urokinase plasminogen activator (uPA) and its receptor (uPAR) in gestational tissues; measurements and clinical implications","volume":"114","author":"Perlik","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"382.e1","DOI":"10.1016\/j.ajog.2007.02.035","article-title":"Progestin inhibits and thrombin stimulates the plasminogen activator\/inhibitor system in term decidual stromal cells: Implications for parturition","volume":"196","author":"Norwitz","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-0897.2008.00615.x","article-title":"The Increase in Metallothionein and Ectopic Decidual Immunoreactivity with Respect to the Progression of Labor at Term and the Lack of Analogical Changes in Placental Abruption","volume":"60","author":"Galazka","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/1933719109336623","article-title":"Intra-Amniotic Infection Upregulates Decidual Cell Vascular Endothelial Growth Factor (VEGF) and Neuropilin-1 and -2 Expression: Implications for Infection-Related Preterm Birth","volume":"16","author":"Snegovskikh","year":"2009","journal-title":"Reprod. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/jcp.2010.088765","article-title":"An imbalance of COX level is not related to placental abruption","volume":"64","author":"Avagliano","year":"2011","journal-title":"J. Clin. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.placenta.2011.01.006","article-title":"The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro","volume":"32","author":"Kumar","year":"2011","journal-title":"Placenta"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.ajpath.2012.08.036","article-title":"Abruption-Induced Preterm Delivery Is Associated with Thrombin-Mediated Functional Progesterone Withdrawal in Decidual Cells","volume":"181","author":"Lockwood","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.placenta.2013.07.064","article-title":"Thrombin weakens the amnion extracellular matrix (ECM) directly rather than through protease activated receptors","volume":"34","author":"Puthiyachirakkal","year":"2013","journal-title":"Placenta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.placenta.2014.10.001","article-title":"Decidual GM-CSF is a critical common intermediate necessary for thrombin and TNF induced in-vitro fetal membrane weakening","volume":"35","author":"Kumar","year":"2014","journal-title":"Placenta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/biolre\/ioz144","article-title":"Distinct preterm labor phenotypes have unique inflammatory signatures and contraction associated protein profiles","volume":"101","author":"Singh","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Nishimura, F., Mogami, H., Moriuchi, K., Chigusa, Y., Mandai, M., and Kondoh, E. (2020). Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0231944"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ajpath.2019.10.020","article-title":"Thrombin-Induced Decidual Colony-Stimulating Factor-2 Promotes Abruption-Related Preterm Birth by Weakening Fetal Membranes","volume":"190","author":"Sinkey","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_56","first-page":"94","article-title":"Clinical significance of subchorionic and retroplacental hematomas detected in the first trimester of pregnancy","volume":"102","author":"Nagy","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/AOG.0b013e3181e90170","article-title":"Ultrasound-Detected Subchorionic Hemorrhage and the Obstetric Implications","volume":"116","author":"Norman","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/AOG.0b013e31821568de","article-title":"Perinatal Outcomes in Women With Subchorionic Hematoma: A systematic review and meta-analysis","volume":"117","author":"Tuuli","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"ref_59","first-page":"14","article-title":"Adverse infant outcomes associated with first-trimester vaginal bleeding","volume":"78","author":"Williams","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0002-9378(11)90686-3","article-title":"Risk factors for preterm premature rupture of fetal membranes: A multicenter case-control study","volume":"163","author":"Harger","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0002-9378(95)91327-0","article-title":"Histologic evidence of old intrauterine bleeding is more frequent in prematurity","volume":"173","author":"Salafia","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/35025229","article-title":"Thrombin signalling and protease-activated receptors","volume":"407","author":"Coughlin","year":"2000","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/bj3130353","article-title":"Cellular consequences of thrombin-receptor activation","volume":"313","author":"Grand","year":"1996","journal-title":"Biochem. J."},{"key":"ref_64","first-page":"107","article-title":"Effects of thrombin on steroid-modulated cultured endometrial stromal cell fibrinolytic potential","volume":"81","author":"Lockwood","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"13295","DOI":"10.1074\/jbc.M114.550541","article-title":"Effect of Thrombin on Human Amnion Mesenchymal Cells, Mouse Fetal Membranes, and Preterm Birth","volume":"289","author":"Mogami","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1095\/biolreprod.107.062182","article-title":"Expression of Prothrombin and Protease Activated Receptors in Human Myometrium during Pregnancy and Labor1","volume":"78","author":"Morrison","year":"2008","journal-title":"Biol. Reprod."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1067\/mob.2001.117638","article-title":"The role of thrombin in preterm parturition","volume":"185","author":"Elovitz","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/jmf.10.5.297.300","article-title":"Plasma levels of thrombin-antithrombin complexes predict preterm premature rupture of the fetal membranes","volume":"10","author":"Rosen","year":"2001","journal-title":"J. Matern. Fetal Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/jmf.11.6.368.373","article-title":"Activation of coagulation system in preterm labor and preterm premature rupture of membranes","volume":"11","author":"Chaiworapongsa","year":"2002","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1071-5576(01)00121-6","article-title":"Thrombin-stimulated uterine contractions in the pregnant and nonpregnant rat","volume":"8","author":"Phillippe","year":"2001","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1210\/jc.2003-030141","article-title":"Effects of Thrombin, Hypoxia, and Steroids on Interleukin-8 Expression in Decidualized Human Endometrial Stromal Cells: Implications for Long-Term Progestin-Only Contraceptive-Induced Bleeding","volume":"89","author":"Lockwood","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.ajog.2004.08.003","article-title":"Mechanisms of abruption-induced premature rupture of the fetal membranes: Thrombin enhanced decidual matrix metalloproteinase-3 (stromelysin-1) expression","volume":"191","author":"MacKenzie","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.4049\/jimmunol.161.6.3071","article-title":"Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms","volume":"161","author":"Zhang","year":"1998","journal-title":"J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3835(00)00446-8","article-title":"Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells","volume":"156","author":"Tomita","year":"2000","journal-title":"Cancer Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cam4.20","article-title":"GM-CSF enhances tumor invasion by elevated MMP -2, -9, and -26 expression","volume":"2","author":"Gutschalk","year":"2013","journal-title":"Cancer Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0955-0674(93)90040-W","article-title":"Structural biochemistry and activation of matrix metalloproteases","volume":"5","author":"Kleiner","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_77","first-page":"231","article-title":"Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization","volume":"76","author":"Lockwood","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1161\/01.ATV.17.10.1931","article-title":"Thrombin Receptor-Mediated Increase of Two Matrix Metalloproteinases, MMP-1 and MMP-3, in Human Endothelial Cells","volume":"17","author":"Orvain","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/14767050500123632","article-title":"Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes","volume":"18","author":"Stephenson","year":"2005","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1055\/s-0037-1616230","article-title":"Plasmin and Matrix Metalloproteinases in Vascular Remodeling","volume":"86","author":"Lijnen","year":"2001","journal-title":"Thromb. Haemost."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"520.e1","DOI":"10.1016\/j.ajog.2015.06.014","article-title":"Progesterone inhibits in vitro fetal membrane weakening","volume":"213","author":"Kumar","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101.e1","DOI":"10.1016\/j.ajog.2018.04.014","article-title":"Infection-induced thrombin production: A potential novel mechanism for preterm premature rupture of membranes (PPROM)","volume":"219","author":"Feng","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"319.e1","DOI":"10.1016\/j.ajog.2007.06.012","article-title":"Histologic evidence of inflammation and risk of placental abruption","volume":"197","author":"Nath","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.0001-6349.2005.00694.x","article-title":"Histologic placental lesions in women with recurrent preterm delivery","volume":"84","author":"Ghidini","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"451906","DOI":"10.1155\/2014\/451906","article-title":"The Multiple Roles of EG-VEGF\/PROK1 in Normal and Pathological Placental Angiogenesis","volume":"2014","author":"Alfaidy","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1111\/j.1582-4934.2008.00554.x","article-title":"Role of EG-VEGF in human placentation: Physiological and pathological implications","volume":"13","author":"Hoffmann","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1210\/en.2007-1695","article-title":"Prokineticin-1: A Novel Mediator of the Inflammatory Response in Third-Trimester Human Placenta","volume":"149","author":"Denison","year":"2008","journal-title":"Endocrinology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/molehr\/5.10.961","article-title":"Expression of cyclo-oxygenase in human endometrium during the implantation period","volume":"5","author":"Marions","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2741\/2316","article-title":"Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors","volume":"12","author":"Diao","year":"2007","journal-title":"Front. Biosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijgo.2006.06.016","article-title":"Placental tissue cyclo-oxygenase 1 and 2 in pre-eclamptic and normal pregnancy","volume":"95","author":"Aksoy","year":"2006","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1248\/bpb.32.2053","article-title":"Examination of the Expression of Cyclooxygenase-2 in Placenta Villi from Sufferers of Pregnancy Induced Hypertension","volume":"32","author":"Okawara","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/01.pgp.0000236950.56785.a8","article-title":"A Fetal Cyclooxygenase-2 Gene Polymorphism Is Associated With Placental Malperfusion","volume":"26","author":"Polydorides","year":"2007","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0002-9378(94)90047-7","article-title":"Nitric oxide metabolites and preterm pregnancy complications","volume":"171","author":"Jaekle","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/humupd\/dmw004","article-title":"The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding","volume":"22","author":"Schatz","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/11383","article-title":"Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1","volume":"5","author":"Nakashima","year":"1999","journal-title":"Nat. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/gyno.2000.5981","article-title":"The Clinical Significance of Tumor-Associated Antigen RCAS1 Expression in the Normal, Hyperplastic, and Malignant Uterine Endometrium","volume":"79","author":"Sonoda","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1182\/blood.V98.2.313.h8000313_313_321","article-title":"Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells","volume":"98","author":"Matsushima","year":"2001","journal-title":"Blood"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2249.2001.01461.x","article-title":"Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: The possible role in immune privilege","volume":"123","author":"Ohshima","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/bbrc.2001.4892","article-title":"Molecular Cloning and Characterization of Mouse EBAG9, Homolog of a Human Cancer Associated Surface Antigen: Expression and Regulation by Estrogen","volume":"284","author":"Tsuchiya","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ijc.1300","article-title":"Expression of human tumor-associated antigen RCAS1 in Reed-Sternberg cells in association with Epstein-Barr virus infection: A potential mechanism of immune evasion","volume":"93","author":"Ohshima","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.18388\/abp.2003_3642","article-title":"Comparative analysis of RCAS1 level in neoplasms and placenta","volume":"50","author":"Wicherek","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1203\/00006450-200003000-00004","article-title":"Labor-Associated Changes in Fas Ligand Expression and Function in Human Placenta","volume":"47","author":"Balkundi","year":"2000","journal-title":"Pediatr. Res."},{"key":"ref_103","first-page":"817","article-title":"Increasing amniotic fluid magnesium concentrations with stable maternal serum levels: A prospective clinical trial","volume":"50","author":"Mezad","year":"2005","journal-title":"J. Reprod. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000086824","article-title":"The Role of RCAS1 and Oxytocinase in Immune Tolerance during Pregnancy","volume":"20","author":"Wicherek","year":"2005","journal-title":"Fetal Diagn. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.pharmtox.39.1.267","article-title":"Metallothionein: An Intracellular Protein to Protect Against Cadmium Toxicity","volume":"39","author":"Klaassen","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mrfmmm.2003.07.013","article-title":"Metallothioneins in human tumors and potential roles in carcinogenesis","volume":"533","author":"Cherian","year":"2003","journal-title":"Mutat. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2559.2004.01922.x","article-title":"Metallothionein expression in human neoplasia","volume":"45","author":"Theocharis","year":"2004","journal-title":"Histopathology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1124\/mol.52.2.195","article-title":"Enhanced Apoptosis in Metallothionein Null Cells","volume":"52","author":"Kondo","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/mc.10017","article-title":"Ribozyme-mediated downregulation of human metallothionein II(a) induces apoptosis in human prostate and ovarian cancer cell lines","volume":"33","author":"Tekur","year":"2002","journal-title":"Mol. Carcinog."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/toxsci\/kfg095","article-title":"Metallothionein Is a Potential Negative Regulator of Apoptosis","volume":"73","author":"Shimoda","year":"2003","journal-title":"Toxicol. Sci."},{"key":"ref_111","first-page":"4029","article-title":"The possible biological role of metallothionein in apoptosis","volume":"13","author":"Sikora","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_112","first-page":"461","article-title":"Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes","volume":"298","author":"Wang","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ygyno.2005.07.003","article-title":"Metallothionein and RCAS1 expression in comparison to immunological cells activity in endometriosis, endometrial adenocarcinoma and endometrium according to menstrual cycle changes","volume":"99","author":"Wicherek","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1073\/pnas.87.8.3137","article-title":"Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures","volume":"87","author":"Schroeder","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","first-page":"159","article-title":"Tissue specific induction of metallothionein synthesis by tumor necrosis factor-alpha","volume":"75","author":"Sato","year":"1992","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0092-8674(84)90270-8","article-title":"Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells","volume":"38","author":"Friedman","year":"1984","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0014-5793(93)81483-G","article-title":"Induction of metallothionein in a human astrocytoma cell line by interleukin-1 and heavy metals","volume":"317","author":"Kikuchi","year":"1993","journal-title":"FEBS Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(95)03243-9","article-title":"Interactions of metallothionein with murine lymphocytes: Plasma membrane binding and proliferation","volume":"108","author":"Borghesi","year":"1996","journal-title":"Toxicology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000107649","article-title":"Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture","volume":"65","author":"Wicherek","year":"2008","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10654-015-0067-9","article-title":"Placental abruption and long-term maternal cardiovascular disease mortality: A population-based registry study in Norway and Sweden","volume":"31","author":"DeRoo","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine Infection and Preterm Delivery","volume":"342","author":"Goldenberg","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"644","DOI":"10.12968\/hosp.2003.64.11.2343","article-title":"The role of infection in preterm labour and birth","volume":"64","author":"Lamont","year":"2003","journal-title":"Hosp. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The Role of Inflammation and Infection in Preterm Birth","volume":"25","author":"Romero","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1749-6632.1994.tb21736.x","article-title":"The Role of Progestationally Regulated Stromal Cell Tissue Factor and Type-1 Plasminogen Activator Inhibitor (PAI-1) in Endometrial Hemostasis and Menstruation","volume":"734","author":"Lockwood","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1749-6632.2001.tb03793.x","article-title":"Decidual cell-expressed tissue factor maintains hemostasis in human endometrium","volume":"943","author":"Lockwood","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2005.12.006","article-title":"The Uterine Spiral Arteries in Human Pregnancy: Facts and Controversies","volume":"27","author":"Pijnenborg","year":"2006","journal-title":"Placenta"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1210\/jc.2009-0065","article-title":"Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells","volume":"94","author":"Lockwood","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0002-9378(12)90756-5","article-title":"Amniotic fluid contains tissue factor, a potent initiator of coagulation","volume":"165","author":"Lockwood","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0301-2115(00)00448-6","article-title":"Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in amniotic fluid and blood plasma: Implications for the mechanism of amniotic fluid embolism","volume":"95","author":"Uszynski","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1055\/s-0037-1614933","article-title":"Abnormal Expression of Type 1 Plasminogen Activator Inhibitor and Tissue Factor in Severe Preeclampsia","volume":"79","author":"Estelles","year":"1998","journal-title":"Thromb. Haemost."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1055\/s-0038-1654878","article-title":"Assay and Content of Tissue Thromboplastin in Different Organs","volume":"14","author":"Astrup","year":"1965","journal-title":"Thromb. Haemost."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00016346309158165","article-title":"The Mechanism of Hypofibrinogen\u00e6mia in Premature Separation of the Normally Implanted Placenta","volume":"42","author":"Nilsen","year":"1963","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_133","first-page":"491","article-title":"Erythrocyte hemolysis and fibrination-fibrinolysis during retained abruptio placentae with hypovolemia and transient anuria","volume":"31","author":"Schneider","year":"1968","journal-title":"Obstet. Gynecol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jsbmb.2005.08.011","article-title":"Progesterone receptors in the human uterus and their possible role in parturition","volume":"97","author":"Thijssen","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrendo.2013.96","article-title":"MicroRNAs\u2014mediators of myometrial contractility during pregnancy and labour","volume":"9","author":"Renthal","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1210\/jc.2009-2136","article-title":"Human Labor Is Associated with Reduced Decidual Cell Expression of Progesterone, But Not Glucocorticoid, Receptors","volume":"95","author":"Lockwood","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/path.4589","article-title":"Mechanisms of chorioamnionitis-associated preterm birth: Interleukin-1beta inhibits progesterone receptor expression in decidual cells","volume":"237","author":"Kayisli","year":"2015","journal-title":"J. Pathol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1933719115597787","article-title":"Agonist-Dependent Downregulation of Progesterone Receptors in Human Cervical Stromal Fibroblasts","volume":"23","author":"Ackerman","year":"2016","journal-title":"Reprod. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"11565","DOI":"10.1038\/ncomms11565","article-title":"Molecular evidence of functional progesterone withdrawal in human myometrium","volume":"7","author":"Nadeem","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/1933719117716775","article-title":"Control of Progesterone Receptor-A Transrepressive Activity in Myometrial Cells: Implications for the Control of Human Parturition","volume":"25","author":"Patel","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mce.2011.09.016","article-title":"Progesterone receptors, their isoforms and progesterone regulated transcription","volume":"357","author":"Jacobsen","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone Withdrawal and Estrogen Activation in Human Parturition Are Coordinated by Progesterone Receptor A Expression in the Myometrium","volume":"87","author":"Mesiano","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1210\/jc.2003-031037","article-title":"Prostaglandins Differentially Modulate Progesterone Receptor-A and -B Expression in Human Myometrial Cells: Evidence for Prostaglandin-Induced Functional Progesterone Withdrawal","volume":"89","author":"Madsen","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2007-0077","article-title":"Nuclear Progesterone Receptors in the Human Pregnancy Myometrium: Evidence that Parturition Involves Functional Progesterone Withdrawal Mediated by Increased Expression of Progesterone Receptor-A","volume":"92","author":"Merlino","year":"2007","journal-title":"J. Clin. Endocrinol. 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