{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:27:10Z","timestamp":1791466030334,"version":"4.3.4"},"reference-count":98,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-15-00254"],"award-info":[{"award-number":["18-15-00254"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes mellitus and related disorders significantly contribute to morbidity and mortality worldwide. Despite the advances in the current therapeutic methods, further development of anti-diabetic therapies is necessary. Mitochondrial dysfunction is known to be implicated in diabetes development. Moreover, specific types of mitochondrial diabetes have been discovered, such as MIDD (maternally inherited diabetes and deafness) and DAD (diabetes and Deafness). Hereditary mitochondrial disorders are caused by certain mutations in the mitochondrial DNA (mtDNA), which encodes for a substantial part of mitochondrial proteins and mitochondrial tRNA necessary for mitochondrial protein synthesis. Study of mtDNA mutations is challenging because the pathogenic phenotype associated with such mutations depends on the level of its heteroplasmy (proportion of mtDNA copies carrying the mutation) and can be tissue-specific. Nevertheless, modern sequencing methods have allowed describing and characterizing a number of mtDNA mutations associated with human disorders, and the list is constantly growing. In this review, we provide a list of mtDNA mutations associated with diabetes and related disorders and discuss the mechanisms of their involvement in the pathology development.<\/jats:p>","DOI":"10.3390\/ijms22136733","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:28:41Z","timestamp":1624447721000},"page":"6733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The Role of Mitochondrial Mutations and Chronic Inflammation in Diabetes"],"prefix":"10.3390","volume":"22","author":[{"given":"Siarhei A.","family":"Dabravolski","sequence":"first","affiliation":[{"name":"Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine, 210026 Vitebsk, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara A.","family":"Orekhova","sequence":"additional","affiliation":[{"name":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza S.","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol 456552, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-8338","authenticated-orcid":false,"given":"Evgeny E.","family":"Bezsonov","sequence":"additional","affiliation":[{"name":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"},{"name":"Institute of Human Morphology, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-9233","authenticated-orcid":false,"given":"Antonina V.","family":"Starodubova","sequence":"additional","affiliation":[{"name":"Federal Research Centre for Nutrition, Biotechnology and Food Safety, 109240 Moscow, Russia"},{"name":"Therapy Faculty, Pirogov Russian National Research Medical University, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana V.","family":"Popkova","sequence":"additional","affiliation":[{"name":"V.A. Nasonova Institute of Rheumatology, 115522 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-4681","authenticated-orcid":false,"given":"Alexander N.","family":"Orekhov","sequence":"additional","affiliation":[{"name":"Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"},{"name":"Institute of Human Morphology, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.14336\/AD.2018.0326","article-title":"Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?","volume":"10","author":"Flynn","year":"2019","journal-title":"Aging Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. 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