{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:39:14Z","timestamp":1792096754989,"version":"4.4.0"},"reference-count":115,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Curcumin, an active component of the rhizome turmeric, has gained much attention as a plant-based compound with pleiotropic pharmacological properties. It possesses anti-inflammatory, antioxidant, hypoglycemic, antimicrobial, neuroprotective, and immunomodulatory activities. However, the health-promoting utility of curcumin is constrained due to its hydrophobic nature, water insolubility, poor bioavailability, rapid metabolism, and systemic elimination. Therefore, an innovative stride was taken, and complexes of metals with curcumin have been synthesized. Curcumin usually reacts with metals through the \u03b2-diketone moiety to generate metal\u2013curcumin complexes. It is well established that curcumin strongly chelates several metal ions, including boron, cobalt, copper, gallium, gadolinium, gold, lanthanum, manganese, nickel, iron, palladium, platinum, ruthenium, silver, vanadium, and zinc. In this review, the pharmacological, chemopreventive, and therapeutic activities of metal\u2013curcumin complexes are discussed. Metal\u2013curcumin complexes increase the solubility, cellular uptake, and bioavailability and improve the antioxidant, anti-inflammatory, antimicrobial, and antiviral effects of curcumin. Metal\u2013curcumin complexes have also demonstrated efficacy against various chronic diseases, including cancer, arthritis, osteoporosis, and neurological disorders such as Alzheimer\u2019s disease. These biological activities of metal\u2013curcumin complexes were associated with the modulation of inflammatory mediators, transcription factors, protein kinases, antiapoptotic proteins, lipid peroxidation, and antioxidant enzymes. In addition, metal\u2013curcumin complexes have shown usefulness in biological imaging and radioimaging. The future use of metal\u2013curcumin complexes may represent a new approach in the prevention and treatment of chronic diseases.<\/jats:p>","DOI":"10.3390\/ijms22137094","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T02:44:39Z","timestamp":1625107479000},"page":"7094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":220,"title":["Metal\u2013Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin"],"prefix":"10.3390","volume":"22","author":[{"given":"Sahdeo","family":"Prasad","sequence":"first","affiliation":[{"name":"Research and Development Laboratory, Noble Pharma LLC, Menomonie, WI 54751, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"DuBourdieu","sequence":"additional","affiliation":[{"name":"Research and Development Laboratory, Vets-Plus Inc., Menomonie, WI 54751, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Research and Development Laboratory, Vets-Plus Inc., Menomonie, WI 54751, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla","family":"Kumar","sequence":"additional","affiliation":[{"name":"Research and Development Laboratory, Vets-Plus Inc., Menomonie, WI 54751, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Lall","sequence":"additional","affiliation":[{"name":"Research and Development Laboratory, Vets-Plus Inc., Menomonie, WI 54751, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/mnfr.201100741","article-title":"Multitargeting by turmeric, the golden spice: From kitchen to clinic","volume":"57","author":"Gupta","year":"2013","journal-title":"Mol. 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