{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:58:17Z","timestamp":1793116697427,"version":"4.5.0"},"reference-count":100,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["VEGA1\/0536\/19"],"award-info":[{"award-number":["VEGA1\/0536\/19"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Erythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2\/STAT5, PI3K\/AKT, and MAPK. The canonical EPOR\/JAK2\/STAT5 pathway is a known regulator of differentiation, proliferation, and cell survival of erythroid progenitors. In addition, its role in the protection of other cells, including cancer cells, is under intense investigation. The involvement of EPOR\/JAK2\/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. The transcriptomics, proteomics, and epigenetic studies reviewed in this article provide a detailed understanding of EPO signalization. Advances in this area of research may be useful for improving the efficacy of EPO therapy in hematologic disorders, as well as in cancer treatment.<\/jats:p>","DOI":"10.3390\/ijms22137109","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:00:10Z","timestamp":1625115610000},"page":"7109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["STAT5 as a Key Protein of Erythropoietin Signalization"],"prefix":"10.3390","volume":"22","author":[{"given":"Zuzana","family":"T\u00f3thov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Medical Biology, Faculty of Medicine, P.J. \u0160af\u00e1rik University in Ko\u0161ice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Tomc","sequence":"additional","affiliation":[{"name":"Medical Centre for Molecular Biology, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-292X","authenticated-orcid":false,"given":"Nata\u0161a","family":"Debeljak","sequence":"additional","affiliation":[{"name":"Medical Centre for Molecular Biology, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-2979","authenticated-orcid":false,"given":"Peter","family":"Sol\u00e1r","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Faculty of Medicine, P.J. \u0160af\u00e1rik University in Ko\u0161ice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2174\/138161208799316393","article-title":"Erythropoietin: New approaches to improved molecular designs and therapeutic alternatives","volume":"14","author":"Debeljak","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.cell.2017.02.026","article-title":"Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation","volume":"168","author":"Kim","year":"2017","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.cell.2015.02.011","article-title":"Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands","volume":"160","author":"Moraga","year":"2015","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"McGraw, K.L., Fuhler, G.M., Johnson, J.O., Clark, J.A., Caceres, G.C., Sokol, L., and List, A.F. (2012). Erythropoietin receptor signaling is membrane raft dependent. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034477"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Maurer, B., Kollmann, S., Pickem, J., Hoelbl-Kovacic, A., and Sexl, V. (2019). STAT5A and STAT5B-Twins with Different Personalities in Hematopoiesis and Leukemia. Cancers, 11.","DOI":"10.3390\/cancers11111726"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI25227","article-title":"Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis","volume":"116","author":"Menon","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.exphem.2003.08.009","article-title":"Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway","volume":"31","author":"Yoon","year":"2003","journal-title":"Exp. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/ml500165r","article-title":"Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein","volume":"5","author":"Cumaraswamy","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ernst, S., and Muller-Newen, G. (2019). Nucleocytoplasmic Shuttling of STATs. A Target for Intervention?. Cancers, 11.","DOI":"10.3390\/cancers11111815"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sathyanarayana, B.K., Li, P., Lin, J.X., Leonard, W.J., and Lee, B. (2016). Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160339"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1038\/sj.onc.1204807","article-title":"Src directly tyrosine-phosphorylates STAT5 on its activation site and is involved in erythropoietin-induced signaling pathway","volume":"20","author":"Okutani","year":"2001","journal-title":"Oncogene"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ajh.25295","article-title":"Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis","volume":"94","author":"Beneduce","year":"2019","journal-title":"Am. J. Hematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1182\/blood.V91.10.3734","article-title":"Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway","volume":"91","author":"Chin","year":"1998","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/bbrc.1998.9445","article-title":"Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin","volume":"252","author":"Ota","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.exphem.2020.03.003","article-title":"Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis","volume":"84","author":"Held","year":"2020","journal-title":"Exp. Hematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-065X.2008.00754.x","article-title":"Janus kinases in immune cell signaling","volume":"228","author":"Ghoreschi","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Able, A.A., Burrell, J.A., and Stephens, J.M. (2017). STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity. Biology, 6.","DOI":"10.3390\/biology6010020"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33282","DOI":"10.1074\/jbc.M102924200","article-title":"CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling","volume":"276","author":"Arai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_19","first-page":"e27080","article-title":"STATs get their move on","volume":"2","author":"Reich","year":"2013","journal-title":"JAKSTAT"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gillinder, K.R., Tuckey, H., Bell, C.C., Magor, G.W., Huang, S., Ilsley, M.D., and Perkins, A.C. (2017). Direct targets of pSTAT5 signalling in erythropoiesis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180922"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/MOH.0000000000000415","article-title":"Integrative view on how erythropoietin signaling controls transcription patterns in erythroid cells","volume":"25","author":"Perreault","year":"2018","journal-title":"Curr. Opin. Hematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/107999002760274863","article-title":"Differential roles of SOCS family members in EpoR signal transduction","volume":"22","author":"Jegalian","year":"2002","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/msb.2011.50","article-title":"Division of labor by dual feedback regulators controls JAK2\/STAT5 signaling over broad ligand range","volume":"7","author":"Bachmann","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1182\/blood-2003-09-3126","article-title":"Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3","volume":"103","author":"Peltola","year":"2004","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Singh, S., Dev, A., Verma, R., Pradeep, A., Sathyanarayana, P., Green, J.M., Narayanan, A., and Wojchowski, D.M. (2012). Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038530"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1182\/blood-2004-10-4093","article-title":"Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways","volume":"105","author":"Tong","year":"2005","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1101\/gr.122879.111","article-title":"Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme","volume":"22","author":"Wang","year":"2012","journal-title":"Genome Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"14381","DOI":"10.1038\/s41598-017-14366-0","article-title":"Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells","volume":"7","author":"Sollinger","year":"2017","journal-title":"Sci Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1016\/j.celrep.2019.08.020","article-title":"A Unique Epigenomic Landscape Defines Human Erythropoiesis","volume":"28","author":"Schulz","year":"2019","journal-title":"Cell Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2017.01.003","article-title":"Chromatin priming of genes in development: Concepts, mechanisms and consequences","volume":"49","author":"Bonifer","year":"2017","journal-title":"Exp. Hematol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101583","DOI":"10.1016\/j.isci.2020.101583","article-title":"Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-established Chromatin Architecture","volume":"23","author":"Perreault","year":"2020","journal-title":"iScience"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni.1995","article-title":"Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5","volume":"12","author":"Yang","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg3682","article-title":"Transcriptional enhancers: From properties to genome-wide predictions","volume":"15","author":"Shlyueva","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2015.12.014","article-title":"Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis","volume":"36","author":"Huang","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2013.01.038","article-title":"Modification of enhancer chromatin: What, how, and why?","volume":"49","author":"Calo","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.exphem.2017.03.004","article-title":"Epo reprograms the epigenome of erythroid cells","volume":"51","author":"Perreault","year":"2017","journal-title":"Exp. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1074\/jbc.M116.749465","article-title":"Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis","volume":"292","author":"Ueda","year":"2017","journal-title":"J. Biol Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1158\/1541-7786.MCR-08-0243","article-title":"An erythropoietin autocrine\/paracrine axis modulates the growth and survival of human prostate cancer cells","volume":"7","author":"Jeong","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0898-6568(99)00063-7","article-title":"Activation of STAT5 during EPO-directed suppression of apoptosis","volume":"12","author":"Bittorf","year":"2000","journal-title":"Cell Signal."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.yexcr.2008.11.005","article-title":"TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells","volume":"315","author":"Pregi","year":"2009","journal-title":"Exp. Cell Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbrc.2014.01.165","article-title":"EPO-independent functional EPO receptor in breast cancer enhances estrogen receptor activity and promotes cell proliferation","volume":"445","author":"Reinbothe","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1158\/1541-7786.MCR-09-0264","article-title":"Erythropoietin-induced activation of the JAK2\/STAT5, PI3K\/Akt, and Ras\/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line","volume":"8","author":"Shi","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1158\/1078-0432.CCR-05-2287","article-title":"Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs","volume":"12","author":"Gewirtz","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"38251","DOI":"10.18632\/oncotarget.16368","article-title":"Erythropoietin drives breast cancer progression by activation of its receptor EPOR","volume":"8","author":"Chan","year":"2017","journal-title":"Oncotarget"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Merkle, R., Steiert, B., Salopiata, F., Depner, S., Raue, A., Iwamoto, N., Schelker, M., Hass, H., Wasch, M., and Bohm, M.E. (2016). Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells. PLoS Comput. Biol., 12.","DOI":"10.1371\/journal.pcbi.1005049"},{"key":"ref_46","first-page":"518","article-title":"No erythropoietin-induced growth is observed in non-small cell lung cancer cells","volume":"52","author":"Frille","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000092099","article-title":"Induction of signalling in non-erythroid cells by pharmacological levels of erythropoietin","volume":"3","author":"Dunlop","year":"2006","journal-title":"Neurodegener Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1038\/sj.onc.1208635","article-title":"Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma","volume":"24","author":"Lai","year":"2005","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/carcin\/23.11.1797","article-title":"Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs","volume":"23","author":"Yasuda","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3892\/or.2013.2566","article-title":"Human erythropoietin increases the pro-angiogenic potential of A2780 ovarian adenocarcinoma cells under hypoxic conditions","volume":"30","author":"Kriska","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/14728222.2018.1406924","article-title":"Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas","volume":"22","author":"Orlova","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"14510","DOI":"10.18632\/oncotarget.7587","article-title":"Role of erythropoietin in the angiogenic activity of bone marrow endothelial cells of MGUS and multiple myeloma patients","volume":"7","author":"Lamanuzzi","year":"2016","journal-title":"Oncotarget"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/0886022X.2011.559675","article-title":"Comparison of the therapeutic efficacy of epoetin beta and epoetin alfa in maintenance phase hemodialysis patients","volume":"33","author":"Loughnan","year":"2011","journal-title":"Ren Fail."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000493097","article-title":"Comparing Therapeutic Efficacy and Safety of Epoetin Beta and Epoetin Alfa in the Treatment of Anemia in End-Stage Renal Disease Hemodialysis Patients","volume":"48","author":"Azmandian","year":"2018","journal-title":"Am. J. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/bcr2921","article-title":"Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer","volume":"13","author":"Furth","year":"2011","journal-title":"Breast Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1089\/107999000750053726","article-title":"Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: Lack of specificity of stat signals during red blood cell development","volume":"20","author":"Watowich","year":"2000","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"28961","DOI":"10.18632\/oncotarget.5009","article-title":"Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Villarino, A., Laurence, A., Robinson, G.W., Bonelli, M., Dema, B., Afzali, B., Shih, H.Y., Sun, H.W., Brooks, S.R., and Hennighausen, L. (2016). Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T-cell effector and regulatory functions. Elife, 5.","DOI":"10.7554\/eLife.08384"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41467-017-02688-6","article-title":"Actionable perturbations of damage responses by TCL1\/ATM and epigenetic lesions form the basis of T-PLL","volume":"9","author":"Schrader","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/s41467-018-03987-2","article-title":"Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target","volume":"9","author":"Dufva","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e1435181","DOI":"10.1080\/23723556.2018.1435181","article-title":"A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia","volume":"5","author":"Pham","year":"2018","journal-title":"Mol. Cell. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41375-018-0342-3","article-title":"Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia","volume":"33","author":"Cross","year":"2018","journal-title":"Leukemia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/bjh.14456","article-title":"CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare chronic neutrophilic leukaemia manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep venous thrombosis","volume":"180","author":"Luo","year":"2018","journal-title":"Br. J. Haematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1172\/JCI94509","article-title":"STAT5BN642H is a driver mutation for T-cell neoplasia","volume":"128","author":"Pham","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1038\/s41467-019-10422-7","article-title":"Structural and functional consequences of the STAT5B(N642H) driver mutation","volume":"10","author":"Erdogan","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1038\/s41375-019-0471-3","article-title":"STAT5B(N642H) drives transformation of NKT cells: A novel mouse model for CD56(+) T-LGL leukemia","volume":"33","author":"Klein","year":"2019","journal-title":"Leukemia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.molimm.2008.10.004","article-title":"Non-erythroid activities of erythropoietin: Functional effects on murine dendritic cells","volume":"46","author":"Lifshitz","year":"2009","journal-title":"Mol. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.leukres.2017.04.005","article-title":"Iron overload promotes erythroid apoptosis through regulating HIF-1a\/ROS signaling pathway in patients with myelodysplastic syndrome","volume":"58","author":"Zheng","year":"2017","journal-title":"Leuk Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/16078454.2019.1700330","article-title":"Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients","volume":"25","author":"Zhang","year":"2020","journal-title":"Hematology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0006-291X(03)01303-2","article-title":"Expression of erythropoietin receptor splice variants in human cancer","volume":"307","author":"Arcasoy","year":"2003","journal-title":"Biochem Biophys Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1084\/jem.20122760","article-title":"Erythropoietin: Multiple targets, actions, and modifying influences for biological and clinical consideration","volume":"210","author":"Broxmeyer","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ccell.2015.09.008","article-title":"Erythropoietin Stimulates Tumor Growth via EphB4","volume":"28","author":"Pradeep","year":"2015","journal-title":"Cancer Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1084\/jem.20100665","article-title":"Erythropoietin protects against diabetes through direct effects on pancreatic beta cells","volume":"207","author":"Choi","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.micinf.2011.10.005","article-title":"The pleiotropic effects of erythropoietin in infection and inflammation","volume":"14","author":"Nairz","year":"2011","journal-title":"Microbes Infect."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2019.11.007","article-title":"Kidney-secreted erythropoietin lowers lipidemia via activating JAK2-STAT5 signaling in adipose tissue","volume":"50","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"F1689","DOI":"10.1152\/ajprenal.90333.2008","article-title":"JAK2\/Y343\/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells","volume":"295","author":"Breggia","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"F1354","DOI":"10.1152\/ajprenal.00131.2008","article-title":"Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury","volume":"294","author":"Salahudeen","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ebiom.2018.07.014","article-title":"Using microRNAs as Novel Predictors of Urologic Cancer Survival: An Integrated Analysis","volume":"34","author":"Chen","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"10655","DOI":"10.1073\/pnas.1611596113","article-title":"Circulating microRNA signature for the diagnosis of very high-risk prostate cancer","volume":"113","author":"Alhasan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1111\/febs.15302","article-title":"Erythropoietin induces miRNA-210 by JAK2\/STAT5 signaling in PBMCs of End-stage Renal Disease patients","volume":"287","author":"Felaco","year":"2020","journal-title":"FEBS J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00125-016-4152-8","article-title":"Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice","volume":"60","author":"Kaltenecker","year":"2017","journal-title":"Diabetologia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101026","DOI":"10.1016\/j.molmet.2020.101026","article-title":"STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue","volume":"40","author":"Kaltenecker","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbrc.2018.12.131","article-title":"Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR\/STAT pathway","volume":"509","author":"Tsuma","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exphem.2020.09.190","article-title":"Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain, and bone","volume":"92","author":"Noguchi","year":"2020","journal-title":"Exp. Hematol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3389\/fphys.2019.01534","article-title":"The Many Facets of Erythropoietin Physiologic and Metabolic Response","volume":"10","author":"Suresh","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Suresh, S., Alvarez, J.C., Dey, S., and Noguchi, C.T. (2020). Erythropoietin-Induced Changes in Bone and Bone Marrow in Mouse Models of Diet-Induced Obesity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051657"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"584696","DOI":"10.3389\/fcell.2020.584696","article-title":"Effects of Erythropoietin in White Adipose Tissue and Bone Microenvironment","volume":"8","author":"Suresh","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"11685","DOI":"10.1096\/fj.202000888R","article-title":"Erythropoietin signaling in osteoblasts is required for normal bone formation and for bone loss during erythropoietin-stimulated erythropoiesis","volume":"34","author":"Suresh","year":"2020","journal-title":"FASEB J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8744","DOI":"10.7150\/thno.45845","article-title":"Erythropoietin receptor in B-cells plays a role in bone remodeling in mice","volume":"10","author":"Kolomansky","year":"2020","journal-title":"Theranostics"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/jnc.13757","article-title":"Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra","volume":"139","author":"Marcuzzi","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2017.11.014","article-title":"Effects of erythropoietin on astrocytes and brain endothelial cells in primary culture during anoxia depend on simultaneous signaling by other cytokines and on duration of anoxia","volume":"113","author":"Malatiali","year":"2018","journal-title":"Neurochem. Int."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1038\/sj.onc.1208140","article-title":"The erythropoietin-receptor pathway modulates survival of cancer cells","volume":"23","author":"Pajonk","year":"2004","journal-title":"Oncogene"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/cdd.2008.1","article-title":"Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin","volume":"15","author":"Byts","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1167\/iovs.07-0721","article-title":"Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes","volume":"49","author":"Zhang","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mce.2012.12.027","article-title":"Erythropoietin improves insulin resistance via the regulation of its receptor-mediated signaling pathways in 3T3L1 adipocytes","volume":"367","author":"Pan","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12950-016-0126-3","article-title":"AG490 suppresses EPO-mediated activation of JAK2-STAT but enhances blood flow recovery in rats with critical limb ischemia","volume":"13","author":"Chai","year":"2016","journal-title":"J. Inflamm."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.curtheres.2015.07.001","article-title":"Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis via the Janus-Activated Kinase 2\/Signal Transducer and Activator of Transcription 5 Pathway in Rats with Epilepsy","volume":"77","author":"Ma","year":"2015","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1182\/blood-2009-07-230870","article-title":"Erythropoietin accelerates smooth muscle cell-rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release","volume":"115","author":"Janmaat","year":"2010","journal-title":"Blood"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1111\/ajt.15369","article-title":"Erythropoietin, a multifaceted protein with innate and adaptive immune modulatory activity","volume":"19","author":"Cantarelli","year":"2019","journal-title":"Am. J. Transplant."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/13\/7109\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:35Z","timestamp":1760163875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/13\/7109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":100,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijms22137109"],"URL":"https:\/\/doi.org\/10.3390\/ijms22137109","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}