{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:30:57Z","timestamp":1792650657191,"version":"4.5.0"},"reference-count":234,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, and has low bioavailability, which hinders its clinical use. To circumvent these drawbacks, drug delivery systems (DDSs) have been used. In this review, we summarize the DDSs used to carry CUR and their antimicrobial effect against viruses, bacteria, and fungi, including drug-resistant strains and emergent pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used alone or as a PS in aPDT. They also show low cytotoxicity, in vivo biocompatibility, and improved wound healing. Although there are several in vitro and some in vivo investigations describing the nanotechnological aspects and the potential antimicrobial application of CUR-loaded DDSs, clinical trials are not reported and further studies should translate this evidence to the clinical scenarios of infections.<\/jats:p>","DOI":"10.3390\/ijms22137130","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T12:03:27Z","timestamp":1625141007000},"page":"7130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-2429","authenticated-orcid":false,"given":"Jeffersson Krishan","family":"Trigo-Gutierrez","sequence":"first","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, School of Dentistry, S\u00e3o Paulo State University (Unesp), Araraquara 14800-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliana","family":"Vega-Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, School of Dentistry, S\u00e3o Paulo State University (Unesp), Araraquara 14800-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Brand\u00e3o","family":"Soares","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, School of Dentistry, S\u00e3o Paulo State University (Unesp), Araraquara 14800-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-7625","authenticated-orcid":false,"given":"Ewerton Garcia de Oliveira","family":"Mima","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Dental Materials and Prosthodontics, School of Dentistry, S\u00e3o Paulo State University (Unesp), Araraquara 14800-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1056\/NEJMc1305749","article-title":"Globalization, climate change, and human health","volume":"369","author":"Davis","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_2","unstructured":"Saker, L., Lee, K., Cannito, B., Gilmore, A., and Campbell-Lendrum, D. (2004). Globalization and Infectious Diseases: A Review of the Linkages, WHO. WHO Special Programme on Tropical Diseases Research."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1007\/s11356-020-12167-z","article-title":"COVID-19 pandemic: The possible influence of the long-term ignorance about climate change","volume":"28","author":"Gorji","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/541340","article-title":"Multidrug resistance: An emerging crisis","volume":"2014","author":"Tanwar","year":"2014","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41564-019-0357-1","article-title":"Drug repurposing for antimicrobial discovery","volume":"4","author":"Farha","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1039\/C7NP90026K","article-title":"Editorial: Are natural products the solution to antimicrobial resistance?","volume":"34","author":"Moore","year":"2017","journal-title":"Nat. Prod. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nunes, T.S.B.S., Rosa, L.M., Vega-Chac\u00f3n, Y., and Mima, E.G.D.O. (2020). Fungistatic action of N-Acetylcysteine on Candida albicans biofilms and its interaction with antifungal agents. Microorganisms, 8.","DOI":"10.3390\/microorganisms8070980"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hewlings, S.J., and Kalman, D.S. (2017). Curcumin: A review of its effects on human health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: Lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2012","journal-title":"Aaps J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tomeh, M.A., Hadianamrei, R., and Zhao, X. (2019). A review of curcumin and its derivatives as anticancer agents. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051033"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Praditya, D., Kirchhoff, L., Br\u00fcning, J., Rachmawati, H., Steinmann, J., and Steinmann, E. (2019). Anti-infective properties of the golden spice curcumin. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00912"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cas, M.D., and Ghidoni, R. (2019). Dietary Curcumin: Correlation between bioavailability and health potential. Nutrients, 11.","DOI":"10.3390\/nu11092147"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The Chemistry of curcumin: From extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"ref_14","first-page":"66","article-title":"Curcumin-hybrid nanoparticles in drug delivery system (review)","volume":"2","author":"Deljoo","year":"2019","journal-title":"Asian J. Nanosci. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jscs.2012.12.009","article-title":"Advanced drug delivery systems: Aanotechnology of health design a review","volume":"18","author":"Safari","year":"2014","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Moghadamtousi, S.Z., Kadir, H.A., Hassandarvish, P., Tajik, H., Abubakar, S., and Zandi, K. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Res. Int., 2014.","DOI":"10.1155\/2014\/186864"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tifs.2017.12.004","article-title":"Impact of curcumin nanoformulation on its antimicrobial activity","volume":"72","author":"Santos","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/ptr.6658","article-title":"Anti-microbial activity of curcumin nanoformulations: New trends and future perspectives","volume":"34","author":"Sharifi","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gao, Y., Tai, W., Wang, N., Li, X., Jiang, S., Debnath, A.K., Du, L., and Chen, S. (2019). Identification of novel natural products as effective and broad-spectrum anti-zika virus inhibitors. Viruses, 11.","DOI":"10.3390\/v11111019"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Patwardhan, M., Morgan, M.T., Dia, V., and D\u2019Souza, D.H. (2020). Heat sensitization of hepatitis A virus and Tulane virus using grape seed extract, gingerol and curcumin. Food Microbiol., 90.","DOI":"10.1016\/j.fm.2020.103461"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.antiviral.2019.04.011","article-title":"Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis","volume":"167","author":"Li","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Roshdy, W.H., Rashed, H.A., Kandeil, A., Mostafa, A., Moatasim, Y., Kutkat, O., Shama, N.M.A., Gomaa, M.R., El-Sayed, I.H., and El Guindy, N.M. (2020). EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241739"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/jm070295s","article-title":"Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus","volume":"50","author":"Wen","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.bmcl.2010.01.152","article-title":"SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii","volume":"20","author":"Ryu","year":"2010","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1248\/bpb.b12-00623","article-title":"Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus","volume":"35","author":"Park","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Adeyemi, O.S., Obeme-Imom, J.I., Akpor, B.O., Rotimi, D., Batiha, G.E.-S., and Owolabi, A. (2020). Altered redox status, DNA damage and modulation of L-tryptophan metabolism contribute to antimicrobial action of curcumin. Heliyon, 6.","DOI":"10.1016\/j.heliyon.2020.e03495"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"G\u00fcran, M., \u015eanl\u0131t\u00fcrk, G., Kerk\u00fckl\u00fc, N.R., Altundag, E.M., and Yal\u00e7\u0131n, A.S. (2019). Combined effects of quercetin and curcumin on anti-inflammatory and antimicrobial parameters in vitro. Eur. J. Pharm., 859.","DOI":"10.1016\/j.ejphar.2019.172486"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2217\/fmb-2019-0042","article-title":"Bacterial viability after antimicrobial photodynamic therapy with curcumin on multiresistant Staphylococcus aureus","volume":"14","author":"Freitas","year":"2019","journal-title":"Futur. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Teixeira, C.G.D.S., Sanit\u00e1, P.V., Ribeiro, A.P.D., Dias, L.M., Jorge, J.H., and Pavarina, A.C. (2020). Antimicrobial photodynamic therapy effectiveness against susceptible and methicillin-resistant Staphylococcus aureus biofilms. Photodiagn. Photodyn., 30.","DOI":"10.1016\/j.pdpdt.2020.101760"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejpb.2021.01.012","article-title":"Antimicrobial and antibiofilm photodynamic therapy against vancomycin resistant Staphylococcus aureus (VRSA) induced infection in vitro and in vivo","volume":"160","author":"Akhtar","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Paolillo, F.R., Rodrigues, P.G.S., Bagnato, V.S., Alves, F., Pires, L., and Corazza, A.V. (2020). The effect of combined curcumin-mediated photodynamic therapy and artificial skin on Staphylococcus aureus-infected wounds in rats. Lasers Med. Sci., 1\u20138.","DOI":"10.1007\/s10103-020-03160-6"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/1751-7915.13734","article-title":"Synergistic effect of hypocrellin B and curcumin on photodynamic inactivation of Staphylococcus aureus","volume":"14","author":"Li","year":"2021","journal-title":"Microb. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Corr\u00eaa, T.Q., Blanco, K.C., Garcia, \u00c9.B., Perez, S.M.L., Chianfrone, D.J., Morais, V.S., and Bagnato, V.S. (2020). Effects of ultraviolet light and curcumin-mediated photodynamic inactivation on microbiological food safety: A study in meat and fruit. Photodiagn. Photodyn., 30.","DOI":"10.1016\/j.pdpdt.2020.101678"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Le, T.D., Phasupan, P., and Nguyen, L.T. (2020). Antimicrobial photodynamic efficacy of selected natural photosensitizers against food pathogens: Impacts and interrelationship of process parameters. Photodiagn. Photodyn., 32.","DOI":"10.1016\/j.pdpdt.2020.102024"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1021\/acsami.9b18693","article-title":"Highly virulent bactericidal effects of curcumin-based \u03bc-cages fabricated by two-photon polymerization","volume":"12","author":"Versace","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Alves, F., Guimar\u00e3es, G.G., Inada, N.M., Pratavieira, S., Bagnato, V.S., and Kurachi, C. (2021). Strategies to improve the antimicrobial efficacy of photodynamic, sonodynamic, and sonophotodynamic therapies. Lasers Surg. Med.","DOI":"10.1002\/lsm.23383"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Azucena, R.-C.I., Roberto, C.-L.J., Martin, Z.-R., Rafael, C.-Z., Leonardo, H.-H., Gabriela, T.-P., and Araceli, C.-R. (2019). Drug susceptibility testing and synergistic antibacterial activity of curcumin with antibiotics against Enterotoxigenic Escherichia coli. Antibiotics, 8.","DOI":"10.3390\/antibiotics8020043"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sanchez-Villamil, J.I., Navarro-Garcia, F., Castillo-Romero, A., Guti\u00e9rrez-Guti\u00e9rrez, F., Tapia, D., and Tapia-Pastrana, G. (2019). Curcumin blocks cytotoxicity of Enteroaggregative and Enteropathogenic Escherichia coli by blocking Pet and EspC Proteolytic release from bacterial outer membrane. Front. Cell. Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00334"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s12029-019-00301-1","article-title":"Effects of Curcumin and Silymarin on the Shigella dysenteriae and Campylobacter jejuni in vitro","volume":"51","author":"Kareem","year":"2019","journal-title":"J. Gastrointest. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pdpdt.2019.04.002","article-title":"Curcumin-mediated photodynamic inactivation (PDI) against DH5\u03b1 contaminated in oysters and cellular toxicological evaluation of PDI-treated oysters","volume":"26","author":"Gao","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1099\/jmm.0.001168","article-title":"Blue light emitting diodes enhance the antivirulence effects of curcumin against Helicobacter pylori","volume":"69","author":"Darmani","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Abdulrahman, H., Misba, L., Ahmad, S., and Khan, A.U. (2020). Curcumin induced photodynamic therapy mediated suppression of quorum sensing pathway of Pseudomonas aeruginosa: An approach to inhibit biofilm in vitro. Photodiagn. Photodyn., 30.","DOI":"10.1016\/j.pdpdt.2019.101645"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Chang, K., Cheng, Y., Lai, M., and Hu, A. (2019). Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem-resistant Acinetobacter baumannii. Rapid Commun. Mass Spectrom., 34.","DOI":"10.1002\/rcm.8548"},{"key":"ref_44","first-page":"3","article-title":"In vitro antibacterial activity of curcumin-meropenem combination against extensively drug-resistant (XDR) bacteria isolated from burn wound infections","volume":"10","author":"Sharahi","year":"2020","journal-title":"Avicenna J. Phytomed."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Lakes, J.E., Richards, C.I., and Flythe, M.D. (2020). Inhibition of bacteroidetes and firmicutes by select phytochemicals. Anaerobe, 61.","DOI":"10.1016\/j.anaerobe.2019.102145"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.freeradbiomed.2019.08.003","article-title":"Antibacterial activity of new structural class of semisynthetic molecule, triphenyl-phosphonium conjugated diarylheptanoid","volume":"143","author":"Kumari","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kumar, P., Kandi, S.K., Mukhopadhyay, K., and Rawat, D.S. (2020). Gagandeep Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies. Eur. J. Med. Chem., 195.","DOI":"10.1016\/j.ejmech.2020.112276"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Polaquini, C.R., Mor\u00e3o, L.G., Nazar\u00e9, A.C., Torrezan, G.S., Dilarri, G., Cavalca, L.B., Campos, D.L., Silva, I.C., Pereira, J.A., and Scheffers, D.-J. (2019). Antibacterial activity of 3,3\u2032-dihydroxycurcumin (DHC) is associated with membrane perturbation. Bioorg. Chem., 90.","DOI":"10.1016\/j.bioorg.2019.103031"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Cerveira, M.M., Vianna, H.S., Ferrer, E.M.K., da Rosa, B.N., de Pereira, C.M.P., Baldissera, M.D., Lopes, L.Q.S., Rech, V.C., Giongo, J.L., and Vaucher, R.D.A. (2021). Bioprospection of novel synthetic monocurcuminoids: Antioxidant, antimicrobial, and in vitro cytotoxic activities. Biomed. Pharm., 133.","DOI":"10.1016\/j.biopha.2020.111052"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Duracka, M., Lukac, N., Kacaniova, M., Kantor, A., Hleba, L., Ondruska, L., and Tvrda, E. (2019). Antibiotics versus natural biomolecules: The case of in vitro induced bacteriospermia by Enterococcus faecalis in rabbit semen. Molecules, 24.","DOI":"10.3390\/molecules24234329"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Rocha, M.P., Santos, M.S., Rodrigues, P.L.F., Ara\u00fajo, T.S.D., de Oliveira, J.M., Rosa, L.P., Bagnato, V.S., and da Silva, F.C. (2021). Photodynamic therapry with curcumin in the reduction of Enterococcus faecalis biofilm in bone cavity: Microbiological and spectral fluorescense analysis. Photodiagn. Photodyn., 33.","DOI":"10.1016\/j.pdpdt.2020.102084"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rafeeq, S., Shiroodi, S., Schwarz, M.H., Nitin, N., and Ovissipour, R. (2020). Inactivation of Aeromonas hydrophila and Vibrio parahaemolyticus by curcumin-mediated photosensitization and nanobubble-ultrasonication approaches. Foods, 9.","DOI":"10.3390\/foods9091306"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S423","DOI":"10.4103\/jpbs.JPBS_127_20","article-title":"Can herbal extracts serve as antibacterial root canal irrigating solutions? antimicrobial efficacy of Tylophora indica, Curcumin longa, Phyllanthus amarus, and sodium hypochlorite on Enterococcus faecalis biofilms formed on tooth substrate: In vitro study","volume":"12","author":"Ganapathy","year":"2020","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pdpdt.2019.06.002","article-title":"Comparison of the effect of photodynamic therapy with curcumin and methylene Blue on Streptococcus mutans bacterial colonies","volume":"27","author":"Azizi","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Soares, J.M., Silva, K.O.O., Inada, N.M., Bagnato, V.S., and Blanco, K.C. (2020). Optimization for microbial incorporation and efficiency of photodynamic therapy using variation on curcumin formulation. Photodiagn. Photodyn., 29.","DOI":"10.1016\/j.pdpdt.2020.101652"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.pdpdt.2019.07.011","article-title":"The effectiveness of curcumin-mediated antimicrobial photodynamic therapy depends on pre-irradiation and biofilm growth times","volume":"27","author":"Gutierres","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, X., Yin, L., Ramage, G., Li, B., Tao, Y., Zhi, Q., Lin, H., and Zhou, Y. (2019). Assessing the impact of curcumin on dual-species biofilms formed by Streptococcus mutans and Candida albicans. Microbiology, 8.","DOI":"10.1002\/mbo3.937"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.pdpdt.2019.04.021","article-title":"Changes of microbial cell survival, metabolic activity, efflux capacity, and quorum sensing ability of Aggregatibacter actinomycetemcomitans due to antimicrobial photodynamic therapy-induced bystander effects","volume":"26","author":"Pourhajibagher","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Pan, H., Wang, D., and Zhang, F. (2020). In vitro antimicrobial effect of curcumin-based photodynamic therapy on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Photodiagn. Photodyn., 32.","DOI":"10.1016\/j.pdpdt.2020.102055"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.pdpdt.2019.06.009","article-title":"Comparison of different laser-based photochemical systems for periodontal treatment","volume":"27","author":"Wenzler","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zago, L.H.D.P., De Annunzio, S.R., De Oliveira, K.T., Barbugli, P.A., Valdes, B.R., Feres, M., and Fontana, C.R. (2020). Antimicrobial photodynamic therapy against metronidazole-resistant dental plaque bact\u00e9ria. J. Photochem. Photobiol. B Biol., 209.","DOI":"10.1016\/j.jphotobiol.2020.111903"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sha, A.M., Garib, B.T., and Sha, A. (2019). Antibacterial effect of curcumin against clinically isolated Porphyromonas gingivalis and connective tissue reactions to curcumin gel in the subcutaneous tissue of rats. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/6810936"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pdpdt.2019.07.005","article-title":"Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: A randomized and controlled split-mouth clinical trial","volume":"27","author":"Ivanaga","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/14787210.2020.1756774","article-title":"Total mouth photodynamic therapy mediated by blue led and curcumin in individuals with AIDS","volume":"18","author":"Rosa","year":"2020","journal-title":"Expert Rev. Anti-Infect."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/ijdr.IJDR_521_17","article-title":"Variable antifungal activity of curcumin against planktonic and biofilm phase of different candida species","volume":"31","author":"Narayanan","year":"2020","journal-title":"Indian J. Dent. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.colsurfb.2018.10.079","article-title":"Antibiofilm efficacy of curcumin in combination with 2-aminobenzimidazole against single- and mixed-species biofilms of Candida albicans and Staphylococcus aureus","volume":"174","author":"Tan","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pdpdt.2019.05.002","article-title":"Fluorescence spectroscopy of Candida albicans biofilms in bone cavities treated with photodynamic therapy using blue LED (450 nm) and curcumin","volume":"26","author":"Rodrigues","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pdpdt.2019.06.015","article-title":"Antifungal effect of photodynamic therapy mediated by curcumin on Candida albicans biofilms in vitro","volume":"27","author":"Ma","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Jord\u00e3o, C.C., de Sousa, T.V., Klein, M.I., Dias, L.M., Pavarina, A.C., and Carmello, J.C. (2020). Antimicrobial photodynamic therapy reduces gene expression of Candida albicans in biofilms. Photodiagn. Photodyn., 31.","DOI":"10.1016\/j.pdpdt.2020.101825"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"180","DOI":"10.5978\/islsm.28_19-OR-14","article-title":"Antimicrobial effect on Candida albicans biofilm by application of different wavelengths and dyes and the synthetic killer decapeptide KP","volume":"28","author":"Merigo","year":"2019","journal-title":"Laser Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/21505594.2020.1868814","article-title":"Verapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella","volume":"12","author":"Pavarina","year":"2021","journal-title":"Virulence"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Nagargoje, A.A., Akolkar, S.V., Siddiqui, M.M., Subhedar, D.D., Sangshetti, J.N., Khedkar, V.M., and Shingate, B.B. (2019). Quinoline based monocarbonyl curcumin analogs as potential antifungal and antioxidant agents: Synthesis, bioevaluation and molecular docking study. Chem. Biodivers., 17.","DOI":"10.1002\/cbdv.201900624"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Jennings, M., and Parks, R. (2020). Curcumin as an antiviral agent. Viruses, 12.","DOI":"10.3390\/v12111242"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jff.2017.12.017","article-title":"Antiviral potential of curcumin","volume":"40","author":"Mathew","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Teli, D.M., Shah, M.B., and Chhabria, M.T. (2021). In silico screening of natural compounds as potential inhibitors of SARS-CoV-2 main protease and spike RBD: Targets for COVID-19. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.599079"},{"key":"ref_76","first-page":"1","article-title":"Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: Insights from computational studies","volume":"11","author":"Jena","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s00203-020-02163-9","article-title":"Addressing the potential role of curcumin in the prevention of COVID-19 by targeting the Nsp9 replicase protein through molecular docking","volume":"203","author":"Kumar","year":"2021","journal-title":"Arch. Microbiol."},{"key":"ref_78","first-page":"1","article-title":"Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV","volume":"5","author":"Patel","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Allam, L., Ghrifi, F., Mohammed, H., El Hafidi, N., El Jaoudi, R., El Harti, J., Lmimouni, B., Belyamani, L., and Ibrahimi, A. (2020). Targeting the GRP78-dependant SARS-CoV-2 cell entry by peptides and small molecules. Bioinform. Biol. Insights, 14.","DOI":"10.1177\/1177932220965505"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ibrahim, M.A., Abdelrahman, A.H., Hussien, T.A., Badr, E.A., Mohamed, T.A., El-Seedi, H.R., Pare, P.W., Efferth, T., and Hegazy, M.-E.F. (2020). In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors. Comput. Biol. Med., 126.","DOI":"10.1016\/j.compbiomed.2020.104046"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kumar, S., Kashyap, P., Chowdhury, S., Kumar, S., Panwar, A., and Kumar, A. (2021). Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication. Phytomedicine, 85.","DOI":"10.1016\/j.phymed.2020.153317"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13337-020-00598-8","article-title":"Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor","volume":"31","author":"Maurya","year":"2020","journal-title":"Virusdisease"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, X., Omarini, A.B., and Li, B. (2020). Virtual screening for functional foods against the main protease of SARS-CoV-2. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13481"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Barh, D., Tiwari, S., Weener, M.E., Azevedo, V., G\u00f3es-Neto, A., Gromiha, M.M., and Ghosh, P. (2020). Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19. Comput. Biol. Med., 126.","DOI":"10.1016\/j.compbiomed.2020.104051"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Zheng, D., Huang, C., Huang, H., Zhao, Y., Khan, M.R.U., Zhao, H., and Huang, L. (2020). Antibacterial mechanism of curcumin: A review. Chem. Biodivers., 17.","DOI":"10.1002\/cbdv.202000171"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2853045","article-title":"Antibacterial action of curcumin against Staphylococcus aureus: A brief review","volume":"2016","author":"Teow","year":"2016","journal-title":"J. Trop. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.pdpdt.2018.01.016","article-title":"Curcumin-mediated photodynamic therapy for the treatment of oral infections\u2014a review","volume":"21","author":"Santezi","year":"2018","journal-title":"Photodiagn. Photodyn."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/08927014.2018.1439935","article-title":"Antimicrobial sonodynamic and photodynamic therapies against Candida albicans","volume":"34","author":"Alves","year":"2018","journal-title":"Biofouling"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.2174\/1381612826666200513112607","article-title":"Curcumin for the management of periodontal diseases: A review","volume":"26","author":"Forouzanfar","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2174\/1570163817666200518074629","article-title":"Anti-Candida activity of curcumin: A systematic review","volume":"18","author":"Cheraghipour","year":"2021","journal-title":"Curr. Drug Discov. Technol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0169-409X(00)00124-1","article-title":"Block copolymer micelles for drug delivery: Design, characterization and biological significance","volume":"47","author":"Kataoka","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1208\/s12249-018-1098-9","article-title":"Pluronic-based mixed polymeric micelles enhance the therapeutic potential of curcumin","volume":"19","author":"Akbar","year":"2018","journal-title":"Aaps Pharmscitech"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"16880","DOI":"10.1021\/acsami.7b03347","article-title":"Silver-decorated polymeric micelles combined with curcumin for enhanced antibacterial activity","volume":"9","author":"Huang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1007\/s11033-019-04700-2","article-title":"Antibacterial effects of curcumin encapsulated in nanoparticles on clinical isolates of Pseudomonas aeruginosa through downregulation of efflux pumps","volume":"46","author":"Takrami","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopha.2017.01.033","article-title":"Enhanced effect in combination of curcumin- and ketoconazole-loaded methoxy poly (ethylene glycol)-poly (\u03b5-caprolactone) micelles","volume":"88","author":"Teng","year":"2017","journal-title":"Biomed. Pharm."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Pourhajibaghera, M., Esboeibc, B., Hodjata, M., and Bahadord, A. (2020). Sonodynamic excitation of nanomicelle curcumin for eradication of Streptococcus mutans under sonodynamic antimicrobial chemotherapy: Enhanced anti-caries activity of nanomicelle curcumin. Photodiagn. Photodyn., 30.","DOI":"10.1016\/j.pdpdt.2020.101780"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Rupel, K., Zupin, L., Brich, S., Mardirossian, M., Ottaviani, G., Gobbo, M., Di Lenarda, R., Pricl, S., Crovella, S., and Zacchigna, S. (2021). Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light. J. Biophotonics, 14.","DOI":"10.1002\/jbio.202000350"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Dias, V.H.C., Malacrida, A.M., dos Santos, A.R., Batista, A.F.P., Campanerut-S\u00e1, P.A.Z., Braga, G., Bona, E., Caetano, W., and Mikcha, J.M.G. (2021). pH interferes in photoinhibitory activity of curcumin nanoencapsulated with pluronic\u00ae P123 against Staphylococcus aureus. Photodiagn. Photodyn., 33.","DOI":"10.1016\/j.pdpdt.2020.102085"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1039\/C9BM01386E","article-title":"A shear-thinning electrostatic hydrogel with antibacterial activity by nanoengineering of polyelectrolytes","volume":"8","author":"Zhu","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-00851-2","article-title":"Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity","volume":"19","author":"Barros","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Valizadeh, H., Abdolmohammadi-Vahid, S., Danshina, S., Gencer, M.Z., Ammari, A., Sadeghi, A., Roshangar, L., Aslani, S., Esmaeilzadeh, A., and Ghaebi, M. (2020). Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients. Int. Immunopharmacol., 89.","DOI":"10.1016\/j.intimp.2020.107088"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.exppara.2012.04.010","article-title":"Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice","volume":"131","author":"Aditya","year":"2012","journal-title":"Exp. Parasitol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/jphp.12611","article-title":"Curcumin as potential therapeutic natural product: A nanobiotechnological perspective","volume":"68","author":"Shome","year":"2016","journal-title":"J. Pharm. Pharm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.2147\/IJN.S210320","article-title":"Nano encapsulated curcumin: And its potential for biomedical applications","volume":"15","author":"Chen","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_105","first-page":"1","article-title":"Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis","volume":"7","author":"Ding","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s12088-019-00811-3","article-title":"Curcumin encapsulated PEGylated nanoliposomes: A potential anti-infective therapeutic agent","volume":"59","author":"Mittal","year":"2019","journal-title":"Indian J. Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Battista, S., Maggi, M.A., Bellio, P., Galantini, L., D\u2019Archivio, A.A., Celenza, G., Colaiezzi, R., and Giansanti, L. (2020). Curcuminoids-loaded liposomes: Influence of lipid composition on their physicochemical properties and efficacy as delivery systems. Colloids Surf. A Phys. Eng. Asp., 597.","DOI":"10.1016\/j.colsurfa.2020.124759"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1039\/C9FO00901A","article-title":"Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules","volume":"11","author":"Gao","year":"2020","journal-title":"Food Funct."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1039\/D0TB02036B","article-title":"Combinatorial liposomes of berberine and curcumin inhibit biofilm formation and intracellular methicillin resistant Staphylococcus aureus infections and associated inflammation","volume":"9","author":"Bhatia","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1002\/jps.24590","article-title":"Gelucire-based nanoparticles for curcumin targeting to oral mucosa: Preparation, characterization, and antimicrobial activity Assessment","volume":"104","author":"Hazzah","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ejpb.2011.11.015","article-title":"Artemisinin and artemisinin plus curcumin liposomal formulations: Enhanced antimalarial efficacy against Plasmodium berghei-infected mice","volume":"80","author":"Isacchi","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Coma-Cros, E.M., Biosca, A., Lantero, E., Manca, M.L., Caddeo, C., Guti\u00e9rrez, L., Ram\u00edrez, M., Borgheti-Cardoso, L.N., Manconi, M., and Fern\u00e0ndez-Busquets, X. (2018). Antimalarial activity of orally administered curcumin incorporated in Eudragit\u00ae-containing liposomes. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051361"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2217\/nnm.12.80","article-title":"Advances in nanotechnology-based delivery systems for curcumin","volume":"7","author":"Sun","year":"2012","journal-title":"Nanomedicine"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1039\/C5SM02958A","article-title":"Nanoemulsions: Formation, properties and applications","volume":"12","author":"Gupta","year":"2016","journal-title":"Soft Matter"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2013007236","article-title":"Nanocurcumin: A promising therapeutic advancement over native curcumin","volume":"30","author":"Flora","year":"2013","journal-title":"Crit. Rev. Drug Carr. Syst."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s13346-019-00633-2","article-title":"Tetrahydrocurcumin-loaded vaginal nanomicrobicide for prophylaxis of HIV\/AIDS: In silico study, formulation development, and in vitro evaluation","volume":"9","author":"Mirani","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/21691401.2020.1725023","article-title":"Antiviral activity of curcumin-nanoemulsion associated with photodynamic therapy in vulvar cell lines transducing different variants of HPV-16","volume":"48","author":"Bonfim","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/2211738507666191210163408","article-title":"Antiviral action of curcumin encapsulated in nanoemulsion against four serotypes of dengue virus","volume":"8","author":"Nabila","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1208\/s12249-016-0652-6","article-title":"Intravaginal delivery of polyphenon 60 and curcumin nanoemulsion gel","volume":"18","author":"Kaur","year":"2017","journal-title":"Aaps Pharmscitech"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.carbpol.2018.08.079","article-title":"Pickering emulsions stabilized nanocellulosic-based nanoparticles for coumarin and curcumin nanoencapsulations: In vitro release, anticancer and antimicrobial activities","volume":"201","author":"Ngwabebhoh","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1007\/s00253-019-09990-x","article-title":"Curcumin-loaded self-emulsifying drug delivery system (cu-SEDDS): A promising approach for the control of primary pathogen and secondary bacterial infections in cutaneous leishmaniasis","volume":"103","author":"Khan","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ijbiomac.2019.08.085","article-title":"Antioxidant and antibacterial activities of omega-3 rich oils\/curcumin nanoemulsions loaded in chitosan and alginate-based microbeads","volume":"140","author":"Hashim","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1039\/C9FO00320G","article-title":"Neutral fabrication of UV-blocking and antioxidation lignin-stabilized high internal phase emulsion encapsulates for high efficient antibacterium of natural curcumin","volume":"10","author":"Chen","year":"2019","journal-title":"Food Funct."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Lewi\u0144ska, A., Jaromin, A., and Jezierska, J. (2020). Role of architecture of N-oxide surfactants in the design of nanoemulsions for Candida skin infection. Colloids Surf. B Biointerfaces, 187.","DOI":"10.1016\/j.colsurfb.2019.110639"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2217\/nnm.14.41","article-title":"A vision for cyclodextrin nanoparticles in drug delivery systems and pharmaceutical applications","volume":"9","author":"Lakkakula","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.2174\/15680266113136660194","article-title":"Recent advances in the use of cyclodextrins in antifungal formulations","volume":"13","author":"Macaev","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_127","first-page":"2807","article-title":"Novel curcumin oral delivery systems","volume":"33","author":"Kurita","year":"2013","journal-title":"Anticancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0032-9592(03)00258-9","article-title":"Cyclodextrins and their uses: A review","volume":"39","year":"2004","journal-title":"Process. Biochem."},{"key":"ref_129","unstructured":"Atwood, J.L. (1996). Comprehensive Supramolecular Chemistry, Pergamon."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Saokham, P., Muankaew, C., Jansook, P., and Loftsson, T. (2018). Solubility of cyclodextrins and drug\/cyclodextrin complexes. Molecules, 23.","DOI":"10.3390\/molecules23051161"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","article-title":"Cyclodextrin-based pharmaceutics: Past, present and future","volume":"3","author":"Davis","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4236\/jct.2015.63029","article-title":"Multiple actions of curcumin including anticancer, anti-inflammatory, antimicrobial and enhancement via cyclodextrin","volume":"06","author":"Smith","year":"2015","journal-title":"J. Cancer Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/jps.23046","article-title":"Impact of curcumin supersaturation in antibacterial photodynamic therapy\u2014effect of cyclodextrin type and amount: Studies on curcumin and curcuminoides XLV","volume":"101","author":"Hegge","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2012.09.011","article-title":"Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT)","volume":"83","author":"Hegge","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3109\/03639045.2014.919315","article-title":"Formulation and characterization of lyophilized curcumin solid dispersions for antimicrobial photodynamic therapy (aPDT): Studies on curcumin and curcuminoids LII","volume":"41","author":"Wikene","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.colsurfb.2018.02.008","article-title":"Antimicrobial coatings on polyethylene terephthalate based on curcumin\/cyclodextrin complex embedded in a multilayer polyelectrolyte architecture","volume":"164","author":"Shlar","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.eurpolymj.2019.06.018","article-title":"Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings","volume":"118","author":"Gupta","year":"2019","journal-title":"Eur. Polym. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"988","DOI":"10.2174\/1389200220666191001104834","article-title":"Curcumin-C3 complexed with \u03b1-, \u03b2-cyclodextrin exhibits antibacterial and antioxidant properties suitable for cancer treatments","volume":"20","author":"Reddy","year":"2020","journal-title":"Curr. Drug Metab."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ijbiomac.2020.01.206","article-title":"Antioxidant, antibacterial and anti-cancer activities of \u03b2-and \u03b3-CDs\/curcumin loaded in chitosan nanoparticles","volume":"147","author":"Alizadeh","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/myc.13051","article-title":"Clinical isolates of Trichophyton rubrum are completely inhibited by photochemical treatment with a \u03b3-cyclodextrin formulation of curcuminoids","volume":"63","author":"Brasch","year":"2020","journal-title":"Mycoses"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1080\/14756366.2020.1801670","article-title":"Hydroxypropyl-\u03b2-cyclodextrin as an effective carrier of curcumin-piperine nutraceutical system with improved enzyme inhibition properties","volume":"35","author":"Tykarska","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"42559","DOI":"10.1039\/C7RA07303H","article-title":"The mode of antimicrobial action of curcumin depends on the delivery system: Monolithic nanoparticles vs. supramolecular inclusion complex","volume":"7","author":"Shlar","year":"2017","journal-title":"Rsc Adv."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1351\/pac200476101825","article-title":"Past, present and futute of cyclodextrin research","volume":"76","author":"Szejtli","year":"2004","journal-title":"Pure Appl. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1002\/jcp.28024","article-title":"Chitosan-based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects","volume":"234","author":"Saheb","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.carbpol.2018.05.033","article-title":"Chitosan-based hydrogels: From preparation to biomedical applications","volume":"196","author":"Guilherme","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.progpolymsci.2006.06.001","article-title":"Chitin and chitosan: Properties and applications","volume":"31","author":"Rinaudo","year":"2006","journal-title":"Prog. Polym. Sci."},{"key":"ref_147","first-page":"932","article-title":"Relationship between antibacterial activity of chitosan and surface characteristics of cell wall","volume":"25","author":"Chung","year":"2004","journal-title":"Acta Pharm. Sin."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nano.2014.09.004","article-title":"Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent","volume":"11","author":"Krausz","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ijbiomac.2017.12.044","article-title":"Synthesis, characterisation and biomedical applications of curcumin conjugated chitosan microspheres","volume":"110","author":"Saranya","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.msec.2017.03.032","article-title":"Curcumin-loaded polysaccharide nanoparticles: Optimization and anticariogenic activity against Streptococcus mutans","volume":"75","author":"Maghsoudi","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ijbiomac.2017.07.101","article-title":"Curcumin-loaded chitosan\/carboxymethyl starch\/montmorillonite bio-nanocomposite for reduction of dental bacterial biofilm formation","volume":"105","author":"Jahanizadeh","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_152","first-page":"1304","article-title":"Efficacy of thermosensitive chitosan\/\u03b2-glycerophosphate hydrogel loaded with \u03b2-cyclodextrin-curcumin for the treatment of cutaneous wound infection in rats","volume":"15","author":"Zhao","year":"2017","journal-title":"Exp. Med."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Niranjan, R., Kaushik, M., Prakash, J., Venkataprasanna, K.S., Arpana, C., Balashanmugam, P., and Venkatasubbu, G.D. (2019). Enhanced wound healing by PVA\/chitosan\/curcumin patches: In vitro and in vivo study. Colloids Surf. B Biointerfaces, 182.","DOI":"10.1016\/j.colsurfb.2019.06.068"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ijbiomac.2019.08.153","article-title":"Wound healing potential of curcumin cross-linked chitosan\/polyvinyl alcohol","volume":"140","author":"Abbas","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Ma, S., Moser, D., Han, F., Leonhard, M., Schneider-Stickler, B., and Tan, Y. (2020). Preparation and antibiofilm studies of curcumin loaded chitosan nanoparticles against polymicrobial biofilms of Candida albicans and Staphylococcus aureus. Carbohydr. Polym., 241.","DOI":"10.1016\/j.carbpol.2020.116254"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.2147\/IJN.S241702","article-title":"Antiviral activity of chitosan nanoparticles encapsulating curcumin against Hepatitis C virus genotype 4a in human hepatoma cell lines","volume":"15","author":"Loutfy","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3923\/pjbs.2019.614.622","article-title":"Antiviral activity of curcumin loaded milk proteins nanoparticles on Potato virus Y","volume":"22","author":"Taha","year":"2019","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jps.22263","article-title":"Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: Studies on curcumin and curcuminoides XLII","volume":"100","author":"Hegge","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1021\/jf104402t","article-title":"Curcumin nanoparticles: Preparation, characterization, and antimicrobial study","volume":"59","author":"Buttar","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/21691401.2015.1129628","article-title":"Enhanced anti-cancer and antimicrobial activities of curcumin nanoparticles","volume":"45","author":"Adahoun","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s40820-014-0020-6","article-title":"High-throughput screening of nanoparticle-stabilizing ligands: Application to preparing antimicrobial curcumin nanoparticles by antisolvent precipitation","volume":"7","author":"Shlar","year":"2015","journal-title":"Nano-Micro Lett."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"No, D.S., AlGburi, A., Huynh, P., Moret, A., Ringard, M., Comito, N., Drider, D., Takhistov, P., and Chikindas, M.L. (2017). Antimicrobial efficacy of curcumin nanoparticles against Listeria monocytogenes is mediated by surface charge. J. Food Saf., 37.","DOI":"10.1111\/jfs.12353"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Gutierrez, J.K.T., Zanatta, G.C., Ortega, A.L.M., Balastegui, M.I.C., Sanit\u00e1, P.V., Pavarina, A.C., Barbugli, P., and Mima, E.G.D.O. (2017). Encapsulation of curcumin in polymeric nanoparticles for antimicrobial photodynamic therapy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187418"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Sakima, V.T., Barbugli, P.A., Cerri, P.S., Chorilli, M., Carmello, J.C., Pavarina, A.C., and Mima, E.G.D.O. (2018). Antimicrobial photodynamic therapy mediated by curcumin-loaded polymeric nanoparticles in a murine model of oral candidiasis. Molecules, 23.","DOI":"10.3390\/molecules23082075"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.2147\/IDR.S213200","article-title":"Evaluation of nano-curcumin effects on expression levels of virulence genes and biofilm production of multidrug-resistant Pseudomonas aeruginosa isolated from burn wound infection in Tehran, Iran","volume":"12","author":"Shariati","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ejpb.2019.07.023","article-title":"Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy","volume":"142","author":"Preis","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Jaguezeski, A.M., Souza, C.F., Perin, G., Reis, J.H., Gomes, T.M., Baldissera, M.D., Vaucher, R.A., de Andrade, C.M., Stefani, L.M., and Gundel, S.S. (2019). Effect of free and nano-encapsulated curcumin on treatment and energetic metabolism of gerbils infected by Listeria monocytogenes. Microb. Pathog., 134.","DOI":"10.1016\/j.micpath.2019.103564"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Pourhajibagher, M., Omrani, L.R., Noroozian, M., Ghorbanzadeh, Z., and Bahador, A. (2021). In vitro antibacterial activity and durability of a nano-curcumin-containing pulp capping agent combined with antimicrobial photodynamic therapy. Photodiagn. Photodyn., 33.","DOI":"10.1016\/j.pdpdt.2020.102150"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Pourhajibagher, M., Plotino, G., Chiniforush, N., and Bahador, A. (2020). Dual wavelength irradiation antimicrobial photodynamic therapy using indocyanine green and metformin doped with nano-curcumin as an efficient adjunctive endodontic treatment modality. Photodiagn. Photodyn., 29.","DOI":"10.1016\/j.pdpdt.2019.101628"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"31044","DOI":"10.1021\/acsomega.0c04065","article-title":"Photoinduced antimicrobial activity of curcumin-containing coatings: Molecular interaction, stability and potential application in food decontamination","volume":"5","author":"Chen","year":"2020","journal-title":"ACS Omega"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Ahmadi, H., Haddadi-Asl, V., Ghafari, H.-A., Ghorbanzadeh, R., Mazlum, Y., and Bahador, A. (2020). Shear bond strength, adhesive remnant index, and anti-biofilm effects of a photoexcited modified orthodontic adhesive containing curcumin doped poly lactic-co-glycolic acid nanoparticles: An ex-vivo biofilm model of S. mutans on the enamel slab bonded brackets. Photodiagn. Photodyn., 30.","DOI":"10.1016\/j.pdpdt.2020.101674"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1016\/j.ijbiomac.2020.08.190","article-title":"The potential use of curcumin-\u03b2-cyclodextrin inclusion complex\/chitosan-loaded cellulose sponges for the treatment of chronic wound","volume":"164","author":"Kiti","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/biof.1504","article-title":"Biological properties of metal complexes of curcumin","volume":"45","author":"Shakeri","year":"2019","journal-title":"BioFactors"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.ijbiomac.2017.06.096","article-title":"Nano cellulose dispersed chitosan film with Ag NPs\/Curcumin: An in vivo study on albino rats for wound dressing","volume":"104","author":"Bajpai","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"De Freitas, C.F., Kimura, E., Rubira, A.F., and Muniz, E.C. (2020). Curcumin and silver nanoparticles carried out from polysaccharide-based hydrogels improved the photodynamic properties of curcumin through metal-enhanced singlet oxygen effect. Mater. Sci. Eng. C, 112.","DOI":"10.1016\/j.msec.2020.110853"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.nano.2015.11.016","article-title":"Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity","volume":"12","author":"Seabra","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00430-017-0525-y","article-title":"Antimicrobial and antibiofilm activity of curcumin-silver nanoparticles with improved stability and selective toxicity to bacteria over mammalian cells","volume":"207","author":"Jaiswal","year":"2017","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.colsurfb.2015.01.050","article-title":"Green synthesis of curcumin conjugated nanosilver for the applications in nucleic acid sensing and anti-bacterial activity","volume":"127","author":"Abiad","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1021\/acs.jafc.5b04559","article-title":"Combination of silver nanoparticles and curcumin nanoparticles for enhanced anti-biofilm activities","volume":"64","author":"Loo","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.4155\/fmc-2018-0152","article-title":"Green synthesis and biological activity of silver-curcumin nanoconjugates","volume":"10","author":"Abdellah","year":"2018","journal-title":"Futur. Med. Chem."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.msec.2018.12.053","article-title":"Synergistic antibacterial effects of curcumin modified silver nanoparticles through ROS-mediated pathways","volume":"99","author":"Song","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"11822","DOI":"10.1039\/C9DT01650C","article-title":"Rationally designed curcumin based ruthenium(ii) antimicrobials effective against drug-resistant Staphylococcus aureus","volume":"48","author":"Srivastava","year":"2019","journal-title":"Dalton Trans."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s10856-011-4369-5","article-title":"Fabrication of silver nanocomposite films impregnated with curcumin for superior antibacterial applications","volume":"22","author":"Varaprasad","year":"2011","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijbiomac.2015.01.050","article-title":"Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications","volume":"75","author":"Srivatsan","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.msec.2016.03.069","article-title":"Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin","volume":"64","author":"Anjum","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Soumya, K.R., Snigdha, S., Sugathan, S., Mathew, J., and Radhakrishnan, E.K. (2017). Zinc oxide\u2013curcumin nanocomposite loaded collagen membrane as an effective material against methicillin-resistant coagulase-negative Staphylococci. 3 Biotech, 7.","DOI":"10.1007\/s13205-017-0861-z"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1208\/s12249-017-0832-z","article-title":"Association of silver nanoparticles and curcumin solid dispersion: Antimicrobial and antioxidant properties","volume":"19","author":"Alves","year":"2017","journal-title":"Aaps Pharmscitech"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/ayu.AYU_24_18","article-title":"Antifungal activity of curcumin-silver nanoparticles against fluconazole-resistant clinical isolates of Candida species","volume":"39","author":"Paul","year":"2018","journal-title":"AYU"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/14686996.2019.1585131","article-title":"Gelatin-stabilized composites of silver nanoparticles and curcumin: Characterization, antibacterial and antioxidant study","volume":"20","author":"Khanh","year":"2019","journal-title":"Sci. Technol. Adv. Mater."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1007\/s10924-019-01495-y","article-title":"Biomass derived antimicrobial hybrid cellulose hydrogel with green ZnO nanoparticles for curcumin delivery and its kinetic modelling","volume":"27","author":"Anagha","year":"2019","journal-title":"J. Polym. Environ."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"10880","DOI":"10.1021\/acs.jafc.9b01933","article-title":"Biomass-derived dialdehyde cellulose cross-linked chitosan-based nanocomposite hydrogel with phytosynthesized zinc oxide nanoparticles for enhanced curcumin delivery and bioactivity","volume":"67","author":"George","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1007\/s11164-019-03841-0","article-title":"Base-free green synthesis of copper(II) oxide nanoparticles using highly cross-linked poly(curcumin) nanospheres: Synergistically improved antimicrobial activity","volume":"45","author":"Masoule","year":"2019","journal-title":"Res. Chem. Intermed."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Lyu, Y., Yu, M., Liu, Q., Zhang, Q., Liu, Z., Tian, Y., Li, D., and Mu, C. (2020). Synthesis of silver nanoparticles using oxidized amylose and combination with curcumin for enhanced antibacterial activity. Carbohydr. Polym., 230.","DOI":"10.1016\/j.carbpol.2019.115573"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1021\/acs.biomac.9b01724","article-title":"Synthesis of silver nanoparticles using curcumin-cyclodextrins loaded into bacterial cellulose-based hydrogels for wound dressing applications","volume":"21","author":"Gupta","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"El-Nahhal, I.M., Salem, J., Anbar, R., Kodeh, F.S., and Elmanama, A. (2020). Preparation and antimicrobial activity of ZnO-NPs coated cotton\/starch and their functionalized ZnO-Ag\/cotton and Zn(II) curcumin\/cotton materials. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-61306-6"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ijbiomac.2020.02.141","article-title":"A pH-sensitive delivery system based on N-succinyl chitosan-ZnO nanoparticles for improving antibacterial and anticancer activities of curcumin","volume":"151","author":"Ghaffari","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijbiomac.2019.12.077","article-title":"Nonwoven fabric supported, chitosan membrane anchored with curcumin\/TiO2 complex: Scaffolds for MRSA infected wound skin reconstruction","volume":"144","author":"Marulasiddeshwara","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.enceco.2021.01.002","article-title":"Green synthesis of gold nanoparticles using Curcuma pseudomontana isolated curcumin: Its characterization, antimicrobial, antioxidant and anti- inflammatory activities","volume":"3","author":"Muniyappan","year":"2021","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"ref_199","first-page":"813","article-title":"Ordered porous materials for emerging applications","volume":"417","author":"Davis","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1039\/C6CS00829A","article-title":"Hierarchically porous materials: Synthesis strategies and structure design","volume":"46","author":"Yang","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"12218","DOI":"10.1002\/chem.201201127","article-title":"A photoactivated molecular gate","volume":"18","author":"Agostini","year":"2012","journal-title":"Chem. A Eur. J."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.nano.2014.09.014","article-title":"Mesoporous silica nanoparticles in drug delivery and biomedical applications","volume":"11","author":"Wang","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1002\/anie.200604488","article-title":"Mesoporous materials for drug delivery","volume":"46","author":"Balas","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jphotobiol.2017.03.003","article-title":"Phototherapeutic spectrum expansion through synergistic effect of mesoporous silica trio-nanohybrids against antibiotic-resistant gram-negative bacterium","volume":"169","author":"Kuthati","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodchem.2019.03.010","article-title":"Enhanced functional properties of biopolymer film incorporated with curcurmin-loaded mesoporous silica nanoparticles for food packaging","volume":"288","author":"Wu","year":"2019","journal-title":"Food Chem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.colsurfb.2019.04.057","article-title":"Multifunctional mesoporous curcumin encapsulated iron-phenanthroline nanocluster: A new anti-HIV agent","volume":"180","author":"Sharma","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Cheng, Y., Zhang, Y., Deng, W., and Hu, J. (2020). Antibacterial and anticancer activities of asymmetric lollipop-like mesoporous silica nanoparticles loaded with curcumin and gentamicin sulfate. Colloids Surf. B Biointerfaces, 186.","DOI":"10.1016\/j.colsurfb.2019.110744"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"15083","DOI":"10.1021\/acsomega.0c00912","article-title":"Phytochemical curcumin-coformulated, silver-decorated melanin-like polydopamine\/mesoporous silica composites with improved antibacterial and chemotherapeutic effects against drug-resistant cancer cells","volume":"5","author":"Song","year":"2020","journal-title":"ACS Omega"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Lawal, A.T. (2019). Graphene-based nano composites and their applications. A review. Biosens. Bioelectron., 141.","DOI":"10.1016\/j.bios.2019.111384"},{"key":"ref_210","first-page":"1581","article-title":"Extending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells","volume":"13","author":"Farani","year":"2019","journal-title":"Drug Des. Dev."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Ghorbanzadeh, R., Assadian, H., Chiniforush, N., Parker, S., Pourakbari, B., Ehsani, B., Alikhani, M.Y., and Bahador, A. (2020). Modulation of virulence in Enterococcus faecalis cells surviving antimicrobial photodynamic inactivation with reduced graphene oxide-curcumin: An ex vivo biofilm model. Photodiagn. Photodyn., 29.","DOI":"10.1016\/j.pdpdt.2019.101643"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Oves, M., Rauf, M.A., Ansari, M.O., Khan, A.A.P., Qari, H., Alajmi, M.F., Sau, S., and Iyer, A.K. (2020). Graphene decorated zinc oxide and curcumin to disinfect the methicillin-resistant Staphylococcus aureus. Nanomaterials, 10.","DOI":"10.3390\/nano10051004"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Singh, A., Prakash, P., Singh, R., Nandy, N., Firdaus, Z., Bansal, M., Singh, R.K., Srivastava, A., Roy, J.K., and Mishra, B. (2017). Curcumin quantum dots mediated degradation of bacterial biofilms. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01517"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Lin, C., Chang, L., Chu, H., Lin, H., Chang, P., Wang, R.Y.L., Unnikrishnan, B., Mao, J., Chen, S., and Huang, C. (2019). High Amplification of the antiviral activity of curcumin through transformation into carbon quantum dots. Small, 15.","DOI":"10.1002\/smll.201902641"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/acs.chemrestox.9b00135","article-title":"MoS2-modified curcumin nanostructures: The novel theranostic hybrid having potent antibacterial and antibiofilm activities against multidrug-resistant hypervirulent Klebsiella pneumoniae","volume":"32","author":"Singh","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pdpdt.2019.08.025","article-title":"Photoexcitation triggering via semiconductor graphene quantum dots by photochemical doping with curcumin versus perio-pathogens mixed biofilms","volume":"28","author":"Pourhajibagher","year":"2019","journal-title":"Photodiagn. Photodyn."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s10311-020-00984-0","article-title":"Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review","volume":"18","author":"Iravani","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Mirzahosseinipour, M., Khorsandi, K., Hosseinzadeh, R., Ghazaeian, M., and Shahidi, F.K. (2020). Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles. Photodiagn. Photodyn., 29.","DOI":"10.1016\/j.pdpdt.2019.101639"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"23050","DOI":"10.1021\/acsami.9b07499","article-title":"Selective antimicrobial effects of curcumin@halloysite nanoformulation: A Caenorhabditis elegans Study","volume":"11","author":"Fakhrullina","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.7150\/thno.33925","article-title":"Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues","volume":"9","author":"Zou","year":"2019","journal-title":"Theranostics"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.joen.2019.08.004","article-title":"Curcumin-a natural medicament for root canal disinfection: Effects of irrigation, drug release, and photoactivation","volume":"45","author":"Sotomil","year":"2019","journal-title":"J. Endod."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ijbiomac.2019.11.144","article-title":"Fabrication of new generation of co-delivery systems based on graphene-g-cyclodextrin\/chitosan nanofiber","volume":"156","author":"Sattaria","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Yang, Y.-N., Lu, K.-Y., Wang, P., Ho, Y.-C., Tsai, M.-L., and Mi, F.-L. (2020). Development of bacterial cellulose\/chitin multi-nanofibers based smart films containing natural active microspheres and nanoparticles formed in situ. Carbohydr. Polym., 228.","DOI":"10.1016\/j.carbpol.2019.115370"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ijbiomac.2020.02.295","article-title":"The biomedical potential of cellulose acetate\/polyurethane nanofibrous mats containing reduced graphene oxide\/silver nanocomposites and curcumin: Antimicrobial performance and cutaneous wound healing","volume":"152","author":"Esmaeili","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1021\/acsnano.9b07173","article-title":"Bioactive anti-inflammatory, antibacterial, antioxidative silicon-based nanofibrous dressing enables cutaneous tumor photothermo-chemo therapy and infection-induced wound healing","volume":"14","author":"Xi","year":"2020","journal-title":"ACS Nano"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Shababdoust, A., Zandi, M., Ehsani, M., Shokrollahi, P., and Foudazi, R. (2020). Controlled curcumin release from nanofibers based on amphiphilic-block segmented polyurethanes. Int. J. Pharm., 575.","DOI":"10.1016\/j.ijpharm.2019.118947"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/jphp.13088","article-title":"Curcumin solid dispersion-loaded in situ hydrogels for local treatment of injured vaginal bacterial infection and improvement of vaginal wound healing","volume":"71","author":"Zhang","year":"2019","journal-title":"J. Pharm. Pharm."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Roy, S., and Rhim, J.-W. (2020). Preparation of antimicrobial and antioxidant gelatin\/curcumin composite films for active food packaging application. Colloids Surf. B Biointerfaces, 188.","DOI":"10.1016\/j.colsurfb.2019.110761"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ijbiomac.2020.01.204","article-title":"Carboxymethyl cellulose-based antioxidant and antimicrobial active packaging film incorporated with curcumin and zinc oxide","volume":"148","author":"Roy","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Ezati, P., and Rhim, J.-W. (2020). pH-responsive pectin-based multifunctional films incorporated with curcumin and sulfur nanoparticles. Carbohydr. Polym., 230.","DOI":"10.1016\/j.carbpol.2019.115638"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijbiomac.2019.12.255","article-title":"Characterization of curcumin incorporated guar gum\/orange oil antimicrobial emulsion films","volume":"148","author":"Aydogdu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Dai, C., Wang, Y., Sharma, G., Shen, J., Velkov, T., and Xiao, X. (2020). Polymyxins\u2013curcumin combination antimicrobial therapy: Safety implications and efficacy for infection treatment. Antioxidants, 9.","DOI":"10.3390\/antiox9060506"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Hakeem, M.J., Asseri, K.A., Ma, L., Chou, K.C., Konkel, M.E., and Lu, X. (2019). A novel mathematical model for studying antimicrobial interactions against Campylobacter jejuni. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01038"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s10103-014-1700-7","article-title":"Longitudinal effect of curcumin-photodynamic antimicrobial chemotherapy in adolescents during fixed orthodontic treatment: A single-blind randomized clinical trial study","volume":"30","author":"Paschoal","year":"2014","journal-title":"Lasers Med. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/13\/7130\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:42Z","timestamp":1760163882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/13\/7130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":234,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijms22137130"],"URL":"https:\/\/doi.org\/10.3390\/ijms22137130","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}