{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:47:33Z","timestamp":1787028453974,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Objective: We aimed to investigate the prognostic performances of oxidative stress (OS), inflammatory and cell activation biomarkers measured at admission in COVID-19 patients. Design: retrospective monocentric study. Setting: patients with suspected SARS-CoV-2 infection (COVID-19) admitted to the hospital. Patients: One hundred and sixty documented and unselected COVID-19-patients. Disease severity (from mild to critical) was scored according to NIH\u2019s classification. Interventions: none. Measurements and main results: We measured OS biomarkers (thiol, advanced oxidation protein products (AOPP), ischemia-modified albumin (IMA)), inflammation biomarkers (interleukin-6 (IL-6), presepsin) and cellular activation biomarkers (calprotectin) in plasma at admission. Thiol concentrations decreased while IMA, IL-6, calprotectin and PSEP increased with disease severity in COVID-19 patients and were associated with increased O2 needs and ICU admission. The best area under the receiver-operating-characteristics curve (AUC) for the prediction of ICU admission was for thiol (AUC = 0.762). A thiol concentration &lt;154 \u00b5mol\/L was predictive for ICU admission (79.7% sensitivity, 64.6% specificity, 58.8% positive predictive value, 78.9% negative predictive value). In a stepwise logistic regression, we found that being overweight, having dyspnoea, and thiol and IL-6 plasmatic concentrations were independently associated with ICU admission. In contrast, calprotectin was the best biomarker to predict mortality (AUC = 0.792), with an optimal threshold at 24.1 mg\/L (94.1% sensitivity, 64.9% specificity, 97.1% positive predictive value and 98.9% negative predictive value), and survival curves indicated that high IL-6 and calprotectin concentrations were associated with a significantly increased risk of mortality. Conclusions: Thiol measurement at admission is a promising tool to predict ICU admission in COVID-19-patients, whereas IL-6 and calprotectin measurements effectively predict mortality.<\/jats:p>","DOI":"10.3390\/ijms22147462","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T21:56:37Z","timestamp":1626126997000},"page":"7462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Oxidative Stress and Inflammatory Biomarkers for the Prediction of Severity and ICU Admission in Unselected Patients Hospitalized with COVID-19"],"prefix":"10.3390","volume":"22","author":[{"given":"Morgane","family":"Ducastel","sequence":"first","affiliation":[{"name":"Department of Automated Biological Diagnostic, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-8182","authenticated-orcid":false,"given":"Camille","family":"Chenevier-Gobeaux","sequence":"additional","affiliation":[{"name":"Department of Automated Biological Diagnostic, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Ballaa","sequence":"additional","affiliation":[{"name":"Department of Automated Biological Diagnostic, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Meritet","sequence":"additional","affiliation":[{"name":"Department of Virology, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Brack","sequence":"additional","affiliation":[{"name":"The Oxidative Stress College Paris, 75007 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0601-3948","authenticated-orcid":false,"given":"Nicolas","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Pene","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"INSERM U1016, CNRS UMR 8104, Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Carlier","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"Institut Cochin, UMR 1016, Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali-Anne","family":"Szwebel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Roche","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"Institut Cochin, UMR 1016, Universit\u00e9 de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Terrier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence Maladies Auto-Immunes et Maladies Syst\u00e9miques Rares d\u2019Ile-de-France, Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"PARCC, INSERM U970, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Borderie","sequence":"additional","affiliation":[{"name":"Department of Automated Biological Diagnostic, Cochin Hospital, APHP-Centre Universit\u00e9 de Paris, 75014 Paris, France"},{"name":"INSERM UMRs 1124, Environmental Toxicity, Therapeutic Targets, Cellular Signaling and Biomarkers, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"ref_1","unstructured":"(2021, March 26). 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