{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:40:37Z","timestamp":1784688037930,"version":"3.55.0"},"reference-count":61,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education, Wroclaw Medical University","award":["SUB.D060.21.054"],"award-info":[{"award-number":["SUB.D060.21.054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The ongoing search for effective treatment of Acne vulgaris is concentrated, i.a., on natural peptides with antimicrobial properties. The aim of this work was the development of new amino acid derivatives with potential activity on dermal infections against selected microorganisms, including the facultative anaerobe C. acne. The peptides P1\u2013P6 were synthesized via Fmoc solid phase peptide synthesis using Rink amide AM resin, analyzed by RP-HPLC-MS, FTIR, DPPH radical scavenging activity, and evaluated against C. acne and S. aureus, both deposited and non-deposited in BC. Peptides P1\u2013P6 presented a lack of cytotoxicity, antimicrobial activity, or antioxidative properties correlated with selected structural properties. P2 and P4\u2013P6 sorption in BC resulted in variable data, i.a., confirming the prospective topical application of these peptides in a BC carrier.<\/jats:p>","DOI":"10.3390\/ijms22147466","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T21:56:37Z","timestamp":1626126997000},"page":"7466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Antimicrobial and Antioxidative Activity of Newly Synthesized Peptides Absorbed into Bacterial Cellulose Carrier against Acne vulgaris"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-6374","authenticated-orcid":false,"given":"Iwona","family":"Golonka","sequence":"first","affiliation":[{"name":"Department of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna E.","family":"Greber","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gda\u0144sk, Al. Gen. J. Hallera 107, 80-416 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Oleksy-Wawrzyniak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-7123","authenticated-orcid":false,"given":"Justyna","family":"Paleczny","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-1616","authenticated-orcid":false,"given":"Andrzej","family":"Dry\u015b","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7559-8903","authenticated-orcid":false,"given":"Adam","family":"Junka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw","family":"Sawicki","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gda\u0144sk, Al. Gen. J. Hallera 107, 80-416 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-5998","authenticated-orcid":false,"given":"Witold","family":"Musia\u0142","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4103\/0378-6323.199579","article-title":"Effects of air pollution on the skin: A review","volume":"83","author":"Puri","year":"2017","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"McLaughlin, J., Watterson, S., Layton, A.M., Bjourson, A.J., Barnard, E., and McDowell, A. (2019). Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies. Microorganisms, 7.","DOI":"10.3390\/microorganisms7050128"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.dsi.2015.12.004","article-title":"New insights into acne pathogenesis: Exploring the role of acne-associated microbial populations","volume":"34","author":"Kumar","year":"2016","journal-title":"Dermatol. Sin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1472-765X.2006.01866.x","article-title":"Propionibacterium acnes","volume":"42","author":"Perry","year":"2006","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/CMR.00092-13","article-title":"Propionibacterium acnes: From Commensal to Opportunistic Biofilm-Associated Implant Pathogen","volume":"27","author":"Achermann","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","article-title":"Acne and sebaceous gland function","volume":"22","author":"Zouboulis","year":"2004","journal-title":"Clin. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0939-6411(02)00195-9","article-title":"Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum","volume":"55","author":"Kubis","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e00016-12","DOI":"10.1128\/genomeA.00016-12","article-title":"Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient","volume":"1","author":"Minegishi","year":"2013","journal-title":"Genome Announc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1099\/mic.0.29219-0","article-title":"Variable expression of immunoreactive surface proteins of Propionibacterium acnes","volume":"152","author":"Lodes","year":"2006","journal-title":"Microbiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1099\/mic.0.27788-0","article-title":"CAMP factor homologues in Propionibacterium acnes: A new protein family differentially expressed by types I and II","volume":"151","author":"Valanne","year":"2005","journal-title":"Microbiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1001\/archdermatol.2011.67","article-title":"Antibiotics, Acne, and Staphylococcus aureus Colonization","volume":"147","author":"Fanelli","year":"2011","journal-title":"Arch. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5070\/D34HP8N68P","article-title":"Acne in adolescents: Quality of life, self-esteem, mood, and psychological disorders","volume":"17","author":"Dunn","year":"2011","journal-title":"Dermatol. Online J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/02713680590968637","article-title":"A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs","volume":"30","author":"Gordon","year":"2005","journal-title":"Curr. Eye Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dean, S.N., Bishop, B.M., and Van Hoek, M.L. (2011). Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus. BMC Microbiol., 11.","DOI":"10.1186\/1471-2180-11-114"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3389\/fmicb.2017.01138","article-title":"Production of Lipopeptide Biosurfactant by a Marine Nesterenkonia sp. and Its Application in Food Industry","volume":"8","author":"Kiran","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00726-014-1744-9","article-title":"Biological and surface-active properties of double-chain cationic amino acid-based surfactants","volume":"46","author":"Greber","year":"2014","journal-title":"Amino Acids"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2006.00156.x","article-title":"Anti-inflammatory activity of cationic peptides: Application to the treatment of Acne vulgaris","volume":"257","author":"Guarna","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s40259-013-0039-0","article-title":"Cationic host defence peptides: Potential as antiviral therapeutics","volume":"27","author":"Findlay","year":"2013","journal-title":"BioDrugs"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/exd.13854","article-title":"Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome","volume":"28","author":"Burns","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1473550407003837","article-title":"Laboratory simulation of UV irradiation from the Sun on amino acids. II. Irradiation of phenylalanine and tryptophan","volume":"6","author":"Scappini","year":"2007","journal-title":"Int. J. Astrobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1007\/s10570-020-03273-9","article-title":"The optimization of bacterial cellulose production and its applications: A review","volume":"27","author":"Andriani","year":"2020","journal-title":"Cellulose"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Krzy\u017cek, P., Go\u015bciniak, G., Fija\u0142kowski, K., Migda\u0142, P., Dziadas, M., Owczarek, A., Czajkowska, J., Anio\u0142ek, O., and Junka, A. (2020). Potential of Bacterial Cellulose Chemisorbed with Anti-Metabolites, 3-Bromopyruvate or Sertraline, to Fight against Helicobacter pylori Lawn Biofilm. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249507"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7417","DOI":"10.1007\/s00253-018-9198-8","article-title":"Production and properties of bacterial cellulose by the strain Komagataeibacter xylinus B-12068","volume":"102","author":"Volova","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/1751-7915.13392","article-title":"Bacterial cellulose: A versatile biopolymer for wound dressing applications","volume":"12","author":"Portela","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Aslanli, A., Lyagin, I., Stepanov, N., Presnov, D., and Efremenko, E. (2020). Bacterial Cellulose Containing Combinations of Antimicrobial Peptides with Various QQ Enzymes as a Prototype of an \u201cEnhanced Antibacterial\u201d Dressing: In Silico and In Vitro Data. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12121155"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e00502","DOI":"10.1016\/j.btre.2020.e00502","article-title":"Applicability of bacterial cellulose in cosmetics\u2014Bibliometric review","volume":"27","author":"Bianchet","year":"2020","journal-title":"Biotechnol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.burns.2019.10.006","article-title":"Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy ofoctenidine and povidone-iodine","volume":"46","author":"Nischwitz","year":"2020","journal-title":"Burns"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Popa, G.-M.L., Tru\u015fc\u0103, R.D., Ilie, C.-I., \u021aiplea, R.E., Ficai, D., Oprea, O., Stoica-Guzun, A., Ficai, A., and Di\u021bu, L.-M. (2020). Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies. Molecules, 25.","DOI":"10.3390\/molecules25184069"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tracton, A. (2006). Sunlight, ultraviolet and accelerated weathering. Chp. 12. Coatings Technology Handbook, Taylor & Francis. [3rd ed.].","DOI":"10.1201\/9781420044089.ch12"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1084\/jem.36.4.427","article-title":"Experimental rickets in rats: VII. The prevention of rickets by sunlight, by the rays of the mercury vapor lamp, and by the carbon arc lamp","volume":"36","author":"Hess","year":"1922","journal-title":"J. Exp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1745-7270.2007.00320.x","article-title":"Fourier transform infrared spectroscopic analysis of protein secondary structures","volume":"39","author":"Kong","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.saa.2005.08.022","article-title":"IR-LD spectroscopic characterization of l-Tryptophan containing dipeptides","volume":"64","author":"Ivanova","year":"2006","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s11743-017-2002-4","article-title":"Synthesis and Surface Activity of Cationic Amino Acid-Based Surfactants in Aqueous Solution","volume":"20","author":"Greber","year":"2017","journal-title":"J. Surfactants Deterg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jphotobiol.2005.08.003","article-title":"Effects of solar radiation on collagen and chitosan films","volume":"82","author":"Sionkowska","year":"2006","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/molecules21010072","article-title":"The structure-activity relationship of the antioxidant peptides from natural proteins","volume":"21","year":"2016","journal-title":"Molecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.peptides.2010.06.020","article-title":"Antioxidative peptides from food proteins: A review","volume":"31","author":"Sarmadi","year":"2010","journal-title":"Peptides"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/00021369.1965.10858470","article-title":"Antioxidative and prooxidative abilities of some biological substances and physiologically active substances on the oxidation of unsaturated fatty acids","volume":"29","author":"Matsushita","year":"1965","journal-title":"Agric. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1021\/jf021156g","article-title":"Antioxidant activity of peptides obtained from porcine myofibrillar proteins by protease treatment","volume":"51","author":"Saiga","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.foodchem.2008.06.081","article-title":"Structures and properties of antioxidative peptides derived from royal jelly protein","volume":"113","author":"Guo","year":"2009","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.foodres.2004.10.002","article-title":"Purification of a radical scavenging peptide from fermented mussel sauce and its antioxidant properties","volume":"38","author":"Rajapakse","year":"2005","journal-title":"Food Res. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1038\/s41598-020-68262-1","article-title":"Antimicrobial activity of Epsilon-Poly-l-lysine against phytopathogenic bacteria","volume":"10","author":"Rodrigues","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"14658","DOI":"10.1038\/s41598-019-50746-4","article-title":"In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria","volume":"9","author":"Blaskovich","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/archophthalmol.2010.138","article-title":"Selected Sun-Sensitizing Medications and Incident Cataract","volume":"128","author":"Klein","year":"2010","journal-title":"Arch. Ophthalmol."},{"key":"ref_44","first-page":"25","article-title":"Adressing free radical oxidation in Acne vulgaris","volume":"9","author":"Mills","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Malanovic, N., and Lohner, K. (2016). Antimicrobial Peptides Targeting Gram-Positive Bacteria. Pharmaceutics, 9.","DOI":"10.3390\/ph9030059"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"246","DOI":"10.12968\/jowc.2019.28.4.246","article-title":"Re-evaluation of polihexanide use in wound antisepsis in order to clarify ambiguities of two animal studies","volume":"28","author":"Kramer","year":"2019","journal-title":"J. Wound Care"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000314699","article-title":"Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds","volume":"23","author":"Siebert","year":"2010","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2147\/JAA.S207980","article-title":"Chlorhexidine Allergy: Current Challenges and Future Prospects","volume":"13","author":"Chiewchalermsri","year":"2020","journal-title":"J. Asthma Allergy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1515\/intox-2015-0029","article-title":"Toxicological assessment of polyhexamethylene biguanide for water treatment","volume":"8","author":"Mahmood","year":"2015","journal-title":"Interdiscip. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/1753193411414353","article-title":"Aseptic tissue necrosis and chronic inflammation after irrigation of penetrating hand wounds using Octenisept\u00ae","volume":"37","author":"Franz","year":"2012","journal-title":"J. Hand Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"00959-19","DOI":"10.1128\/mSphere.00959-19","article-title":"Systematic Analysis of Efflux Pump-Mediated Antiseptic Resistance in Staphylococcus aureus Suggests a Need for Greater Antiseptic Stewardship","volume":"5","author":"LaBreck","year":"2020","journal-title":"mSphere"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.jhin.2018.03.037","article-title":"Pseudomonas aeruginosa adapts to octenidine in the laboratory and a simulated clinical setting, leading to increased tolerance to chlorhexidine and other biocides","volume":"100","author":"Shepherd","year":"2018","journal-title":"J. Hosp. Infect."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e00272-17","DOI":"10.1128\/AAC.00272-17","article-title":"Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo","volume":"61","author":"Renzoni","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Drayton, M., Kizhakkedathu, J.N., and Straus, S.K. (2020). Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance. Molecules, 25.","DOI":"10.3390\/molecules25133048"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents","volume":"19","author":"Jenssen","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Cole, J.N., and Nizet, V. (2016). Bacterial Evasion of Host Antimicrobial Peptide Defenses. Microbiol. Spectr., 4.","DOI":"10.1128\/microbiolspec.VMBF-0006-2015"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Golonka, I., Wilk, S., and Musia\u0142, W. (2020). The Influence of UV Radiation on the Degradation of Pharmaceutical Formulations Containing Quercetin. Molecules, 25.","DOI":"10.3390\/molecules25225454"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Cuvelier","year":"1995","journal-title":"LWT"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcis.2010.11.044","article-title":"Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of Rutin","volume":"355","author":"Chat","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/jf0502698","article-title":"Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements","volume":"53","author":"Prior","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.carbpol.2018.06.126","article-title":"Bacterial cellulose yield increased over 500% by supplementation of medium with vegetable oil","volume":"199","author":"Junka","year":"2018","journal-title":"Carbohydr. Polym."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/14\/7466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:29:22Z","timestamp":1760164162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/14\/7466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,12]]},"references-count":61,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijms22147466"],"URL":"https:\/\/doi.org\/10.3390\/ijms22147466","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,12]]}}}