{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:30:22Z","timestamp":1791855022765,"version":"4.3.4"},"reference-count":142,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In recent years, escitalopram (ESC) has been suggested to have different mechanisms of action beyond its well known selective serotonin reuptake inhibition. The aim of this study is to investigate the effects of escitalopram on oxidative stress, apoptosis, brain-derived neurotrophic factor (BDNF), Methyl-CpG-binding protein 2 (MeCP2), and oligodendrocytes number in the brain of chronic unpredictable mild stress-induced depressed rats. The animals were randomised in four groups (8 in each group): control, stress, stress + ESC 5 and stress + ESC 5\/10. ESC was administered for 42 days in a fixed dose (5 mg\/kg b.w.) or in an up-titration regimen (21 days ESC 5 mg\/kg b.w. then 21 days ESC 10 mg\/kg b.w.). Sucrose preference test (SPT) and elevated plus maze (EPM) were also performed. ESC improved the percentage of sucrose preference, locomotion and anxiety. ESC5\/10 reduced the oxidative damage in the hippocampus and improved the antioxidant defence in the hippocampus and frontal lobe. ESC5\/10 lowered caspase 3 activity in the hippocampus. Escitalopram had a modulatory effect on BDNF and the number of oligodendrocytes in the hippocampus and frontal lobe and also improved the MeCP2 expressions. The results confirm the multiple pathways implicated in the pathogenesis of depression and suggest that escitalopram exerts an antidepressant effect via different intricate mechanisms.<\/jats:p>","DOI":"10.3390\/ijms22147483","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T04:26:06Z","timestamp":1626150366000},"page":"7483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-0050","authenticated-orcid":false,"given":"Vlad","family":"Dionisie","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-5486","authenticated-orcid":false,"given":"Adela Magdalena","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"},{"name":"Neuroscience Department, Discipline of Psychiatry, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad Alexandru","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400028 Cluj-Napoca, Romania"},{"name":"Department of Biochemistry and Experimental Biology, Institute of Biological Research, Branch of NIRDBS Bucharest, 400113 Cluj-Napoca, Romania"},{"name":"Department of Molecular and Biomolecular Physics, NIRD for Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-4529","authenticated-orcid":false,"given":"Mihnea Costin","family":"Manea","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Baldea","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, 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Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Manea","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Riga","sequence":"additional","affiliation":[{"name":"Department of Stress Research and Prophylaxis, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"},{"name":"Romanian Academy of Medical Sciences, 927180 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-4925","authenticated-orcid":false,"given":"Gabriela Adriana","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"ref_1","unstructured":"WHO (2017). Depression and Other Common Mental Disorders: Global Health Estimates, World Health Organization. Licence: CC BY-NC-SA 3.0 IGO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1017\/S0033291712001511","article-title":"Global variation in the prevalence and incidence of major depressive disorder: A systematic review of the epidemiological literature","volume":"43","author":"Ferrari","year":"2012","journal-title":"Psychol. Med."},{"key":"ref_3","first-page":"369","article-title":"Treatment-resistant depression: Therapeutic trends, challenges, and future directions","volume":"6","year":"2012","journal-title":"Patient Pref. Adherence"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: How are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pnpbp.2012.10.017","article-title":"Antioxidants as potential therapeutics for neuropsychiatric disorders","volume":"46","author":"Pandya","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajp.2017.01.025","article-title":"The neurobiology of depression: An integrated view","volume":"27","author":"Dean","year":"2017","journal-title":"Asian J. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fnins.2019.00384","article-title":"The interplay between stress, inflammation, and emotional attention: Relevance for depression","volume":"13","author":"Maydych","year":"2019","journal-title":"Front. Neurosci"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-psych-122216-011613","article-title":"Depression\u2019s unholy trinity: Dysregulated stress, immunity, and the microbiome","volume":"71","author":"Rea","year":"2020","journal-title":"Annu. Rev. Psychol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","article-title":"The chronic mild stress (CMS) model of depression: History, evaluation and usage","volume":"6","author":"Willner","year":"2017","journal-title":"Neurobiol Stress"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"112245","DOI":"10.1016\/j.bbr.2019.112245","article-title":"BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: The possible role of prdx-1 in anhedonic behavior","volume":"378","author":"Scotton","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1139\/Y09-027","article-title":"Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures","volume":"87","author":"You","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lee, Y., Kim, H., Lee, C., Hyun, S., Ko, M., Lee, B., Hwang, D., and Ka, M. (2020). 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF\/Trkb\/CREB Signaling Pathway. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239103"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pnpbp.2010.08.026","article-title":"In Animal Models, Psychosocial Stress-Induced (Neuro)Inflammation, Apoptosis and Reduced Neurogenesis Are Associated to the Onset of Depression","volume":"35","author":"Kubera","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10787-020-00777-5","article-title":"The anti-inflammatory role of SSRI and SNRI in the treatment of depression: A review of human and rodent research studies","volume":"29","author":"Dionisie","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/imm.12443","article-title":"Immune Mechanisms Linked to Depression via Oxidative Stress and Neuroprogression","volume":"144","author":"Bakunina","year":"2015","journal-title":"Immunology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/nu4101399","article-title":"Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases","volume":"4","author":"Johnson","year":"2012","journal-title":"Nutrients"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3109\/13880200903296154","article-title":"SCLM, Total Saponins Extracted Fromchaihu-Jia-Longgu-Muli-Tang, Reduces Chronic Mild Stress-Induced Apoptosis in the Hippocampus in Mice","volume":"48","author":"Liu","year":"2010","journal-title":"Pharm. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wigner, P., Synowiec, E., J\u00f3\u017awiak, P., Czarny, P., Bijak, M., Bia\u0142ek, K., Szemraj, J., Gruca, P., Papp, M., and \u015aliwi\u0144ski, T. (2020). The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses As Well As Tryptophan Catabolites Pathway in the Blood and Brain Structures. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010010"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/npp.2015.171","article-title":"Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex","volume":"41","author":"McEwen","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00213-019-05257-5","article-title":"Paeoniflorin Attenuates Impairment of Spatial Learning and Hippocampal Long-Term Potentiation in Mice Subjected to Chronic Unpredictable Mild Stress","volume":"236","author":"Liu","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2147\/NDT.S5700","article-title":"Brain-Derived Neurotrophic Factor: Role in Depression and Suicide","volume":"5","author":"Dwivedi","year":"2009","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_23","first-page":"3295","article-title":"Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation","volume":"56","author":"Doorduin","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Miao, Z., Wang, Y., and Sun, Z. (2020). The Relationships between Stress, Mental Disorders, and Epigenetic Regulation of BDNF. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041375"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mp.2009.67","article-title":"Knockdown of Brain-Derived Neurotrophic Factor in Specific Brain Sites Precipitates Behaviors Associated with Depression and Reduces Neurogenesis","volume":"15","author":"Taliaz","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/pr.111.005108","article-title":"Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders","volume":"64","author":"Autry","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/aps.2010.184","article-title":"The Role of BDNF in Depression on the Basis of Its Location in the Neural Circuitry","volume":"32","author":"Yu","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/mp.2016.144","article-title":"Nrf2-Dependent Persistent Oxidative Stress Results in Stress-Induced Vulnerability to Depression","volume":"22","author":"Bouvier","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lee, K., Cha, M., and Lee, B. (2020). Neuroprotective Effect of Antioxidants in the Brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197152"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3389\/fphar.2018.01182","article-title":"Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective","volume":"9","author":"Hashimoto","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuropharm.2015.11.029","article-title":"Modulation of the Antioxidant Nuclear Factor (Erythroid 2-Derived)-Like 2 Pathway by Antidepressants in Rats","volume":"103","author":"Bris","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12974-018-1294-2","article-title":"Intracellular Inflammatory and Antioxidant Pathways in Postmortem Frontal Cortex of Subjects with Major Depression: Effect of Antidepressants","volume":"15","author":"Caso","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"30659","DOI":"10.1038\/srep30659","article-title":"Role of Keap1-Nrf2 Signaling in Depression and Dietary Intake of Glucoraphanin Confers Stress Resilience in Mice","volume":"6","author":"Yao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pejhan, S., and Rastegar, M. (2021). Role of DNA Methyl-Cpg-Binding Protein Mecp2 in Rett Syndrome Pathobiology and Mechanism of Disease. Biomolecules, 11.","DOI":"10.3390\/biom11010075"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.3892\/mmr.2015.4104","article-title":"Mecp2 Controls Hippocampal Brain-Derived Neurotrophic Factor Expression via Homeostatic Interactions with Microrna-132 in Rats with Depression","volume":"12","author":"Su","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14355","DOI":"10.1523\/JNEUROSCI.2156-12.2012","article-title":"Phosphorylation of Mecp2 at Ser421 Contributes to Chronic Antidepressant Action","volume":"32","author":"Hutchinson","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2015.04.019","article-title":"Exploring the Possible Link between Mecp2 and Oxidative Stress in Rett Syndrome","volume":"88","author":"Filosa","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/scnp.2001.0060277","article-title":"The Neuroimmunology of Stress and Depression","volume":"6","author":"Raison","year":"2001","journal-title":"Semin. Clin. Neuropsychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.clinpsy.1.102803.143938","article-title":"Stress and Depression","volume":"1","author":"Hammen","year":"2005","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic Plasticity and Depression: New Insights from Stress and Rapid-Acting Antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.npp.1301410","article-title":"Chronic Unpredictable Stress Induces A Cognitive Deficit and Anxiety-Like Behavior in Rats That Is Prevented by Chronic Antidepressant Drug Treatment","volume":"33","author":"Bondi","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1566-2772(03)00086-0","article-title":"Stress Models of Depression","volume":"3","author":"Vollmayr","year":"2003","journal-title":"Clin. Neurosci. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/0706743716659417","article-title":"Canadian Network For Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines For the Management of Adults with Major Depressive Disorder","volume":"61","author":"Kennedy","year":"2016","journal-title":"Can. J. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bcp.2018.09.005","article-title":"The Activity of Brain and Liver Cytochrome P450 2D (CYP2D) Is Differently Affected by Antidepressants in the Chronic Mild Stress (CMS) Model of Depression in the Rat","volume":"156","author":"Haduch","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuropharm.2007.11.009","article-title":"The Number of Granule Cells in Rat Hippocampus Is Reduced After Chronic Mild Stress and Re-Established After Chronic Escitalopram Treatment","volume":"54","author":"Jayatissa","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.encep.2007.11.001","article-title":"Escitalopram: A selective inhibitor and allosteric modulator of the serotonin transporter","volume":"33","author":"Scarna","year":"2007","journal-title":"Encephale"},{"key":"ref_48","first-page":"471","article-title":"The Antidepressant- and Anxiolytic-Like Effects Following Co-Treatment with Escitalopram and Risperidone in Rats","volume":"67","author":"Kaminska","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1515\/jbcpp-2013-0160","article-title":"Effect of (4A) A Novel 5-HT3 Receptor Antagonist on Chronic Unpredictable Mild Stress Induced Depressive-Like Behavior in Mice: An Approach Using Behavioral Tests Battery","volume":"26","author":"Kurhe","year":"2015","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_50","first-page":"pyv018","article-title":"Differences in Anxiety-Like Behavior within A Batch of Wistar Rats Are Associated with Differences in Serotonergic Transmission, Enhanced by Acute SRI Administration, and Abolished by Serotonin Depletion","volume":"18","author":"Studer","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Doron, R., Lotan, D., Versano, Z., Benatav, L., Franko, M., Armoza, S., Kately, N., and Rehavi, M. (2014). Escitalopram Or Novel Herbal Mixture Treatments During Or Following Exposure to Stress Reduce Anxiety-Like Behavior Through Corticosterone and BDNF Modifications. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091455"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/ijnp\/pyy083","article-title":"Making Sense of Rodent Models of Anhedonia","volume":"21","author":"Scheggi","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_53","first-page":"e52587","article-title":"The Forced Swim Test as a Model of Depressive-Like Behavior","volume":"97","author":"Franko","year":"2015","journal-title":"J. Vis. Exp."},{"key":"ref_54","first-page":"78","article-title":"Catechin Ameliorates Depressive Symptoms in Sprague Dawley Rats Subjected to Chronic Unpredictable Mild Stress by Decreasing Oxidative Stress","volume":"11","author":"Rai","year":"2019","journal-title":"Biomed. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/WNR.0000000000000944","article-title":"Evaluation of Antidepressant Activity of Methanolic Extract of Saraca Asoca Bark in a Chronic Unpredictable Mild Stress Model","volume":"29","author":"Gill","year":"2018","journal-title":"Neuroreport"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2010.06.028","article-title":"Time-Dependent Effects of Escitalopram on Brain Derived Neurotrophic Factor (BDNF) and Neuroplasticity Related Targets in the Central Nervous System of Rats","volume":"643","author":"Alboni","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2018.12.033","article-title":"Effects of Escitalopram and Ibuprofen on a Depression-Like Phenotype Induced by Chronic Stress in Rats","volume":"696","author":"Seo","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yfrne.2012.11.002","article-title":"Role of the Hypothalamic\u2013Pituitary\u2013Adrenal Axis in Developmental Programming of Health and Disease","volume":"34","author":"Xiong","year":"2013","journal-title":"Front. Neuroendocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.nbd.2012.03.012","article-title":"How Does the Brain Deal with Cumulative Stress? A Review with Focus on Developmental Stress, HPA Axis Function and Hippocampal Structure in Humans","volume":"52","author":"Frodl","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fnins.2014.00456","article-title":"Activation of the Hypothalamic-Pituitary-Adrenal Stress Axis Induces Cellular Oxidative Stress","volume":"8","author":"Spiers","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_61","first-page":"963520","article-title":"ROS and Brain Diseases: The Good, the Bad, and the Ugly","volume":"2013","author":"Mitran","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 Reasons Why the Brain Is Susceptible to Oxidative Stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2014.10.031","article-title":"Chronic Unpredictable Stress Impairs Endogenous Antioxidant Defense in Rat Brain","volume":"584","author":"Che","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s11064-007-9289-x","article-title":"Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-Induced Oxidative Stress in Rat Brain","volume":"32","author":"Eren","year":"2007","journal-title":"Neurochem. Res."},{"key":"ref_65","first-page":"154","article-title":"Effect of Escitalopram on GABA Level and Anti-Oxidant Markers in Prefrontal Cortex and Nucleus Accumbens of Chronic Mild Stress-Exposed Albino Rats","volume":"1","author":"Shalaby","year":"2009","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"R814","DOI":"10.1152\/ajpregu.00337.2014","article-title":"Chronic Selective Serotonin Reuptake Inhibition Modulates Endothelial Dysfunction and Oxidative State in Rat Chronic Mild Stress Model of Depression","volume":"309","author":"Matchkov","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuint.2009.01.001","article-title":"Effects of Chronic Mild Stress on the Oxidative Parameters in the Rat Brain","volume":"54","author":"Lucca","year":"2009","journal-title":"Neurochem. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00232-012-9436-4","article-title":"Oxidative Parameters in the Rat Brain of Chronic Mild Stress Model For Depression: Relation to Anhedonia-Like Responses","volume":"245","author":"Wang","year":"2012","journal-title":"J. Membr. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11064-004-9691-6","article-title":"Repeated Restraint Stress Induces Oxidative Damage in Rat Hippocampus","volume":"30","author":"Fontella","year":"2005","journal-title":"Neurochem. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1096\/fasebj.10.13.8940299","article-title":"Immobilization Stress Causes Oxidative Damage to Lipid, Protein, and DNA in the Brain of Rats","volume":"10","author":"Liu","year":"1996","journal-title":"FASEB J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.neuint.2012.07.024","article-title":"Synergist Effects of N-Acetylcysteine and Deferoxamine Treatment on Behavioral and Oxidative Parameters Induced by Chronic Mild Stress in Rats","volume":"61","author":"Arent","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-011-2463-5","article-title":"Escitalopram, an Antidepressant with an Allosteric Effect at the Serotonin Transporter\u2014A Review of Current Understanding of Its Mechanism of Action","volume":"219","author":"Zhong","year":"2011","journal-title":"Psychopharmacology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2011.03.017","article-title":"A Study of the Relative Importance of the Peroxiredoxin-, Catalase-, and Glutathione-Dependent Systems in Neural Peroxide Metabolism","volume":"51","author":"Mitozo","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00534-002-0824-5","article-title":"Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Various Rat Tissues After Carbon Tetrachloride Intoxication","volume":"10","author":"Czechowska","year":"2003","journal-title":"J. Hepatobiliary Pancreat. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.55782\/ane-2006-1581","article-title":"Role of serotonin in cerebral oxidative stress in rats","volume":"66","author":"Montilla","year":"2006","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/abbi.1993.1189","article-title":"Monoamine Metabolism Provides an Antioxidant Defense in the Brain against Oxidant- and Free Radical-Induced Damage","volume":"302","author":"Liu","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0887-2333(02)00083-8","article-title":"Serotonin\u2013Cu(II)-Mediated DNA Cleavage: Mechanism of Copper Binding by Serotonin","volume":"16","author":"Hadi","year":"2002","journal-title":"Toxicol. In Vitro"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.bpj.2017.03.037","article-title":"Antioxidant and Membrane Binding Properties of Serotonin Protect Lipids from Oxidation","volume":"112","author":"Azouzi","year":"2017","journal-title":"Biophys. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/22115528112019990006","article-title":"Radical Scavenging and Antioxidant Capacity of Serotonin","volume":"9","author":"Sarikaya","year":"2013","journal-title":"Curr. Bioact. Compd."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev-med-052209-100430","article-title":"Stress- and Allostasis-Induced Brain Plasticity","volume":"62","author":"McEwen","year":"2011","journal-title":"Annu. Rev. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nrn2648","article-title":"Stress Signalling Pathways That Impair Prefrontal Cortex Structure and Function","volume":"10","author":"Arnsten","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fnins.2014.00420","article-title":"Influence of Sex and Stress Exposure Across the Lifespan on Endophenotypes of Depression: Focus on Behavior, Glucocorticoids, and Hippocampus","volume":"8","author":"Gobinath","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/depr.3050020202","article-title":"Prefrontal Cortex Dysfunction in Clinical Depression","volume":"2","author":"George","year":"1994","journal-title":"Depression"},{"key":"ref_84","first-page":"41","article-title":"A Meta-Analysis Examining Clinical Predictors of Hippocampal Volume in Patients with Major Depressive Disorder","volume":"34","author":"McKinnon","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/mp.2008.119","article-title":"The Mood-Improving Actions of Antidepressants Do Not Depend on Neurogenesis But Are Associated with Neuronal Remodeling","volume":"14","author":"Bessa","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1523\/JNEUROSCI.4372-06.2007","article-title":"The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress","volume":"27","author":"Cerqueira","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"458","DOI":"10.2174\/1570159X1304150831121909","article-title":"Brain Structural Effects of Antidepressant Treatment in Major Depression","volume":"13","author":"Dusi","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2014.09.059","article-title":"Hippocampus Remodeling by Chronic Stress Accompanied by GR, Proteasome and Caspase-3 Overexpression","volume":"1593","author":"Orlovsky","year":"2014","journal-title":"Brain Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neulet.2008.06.081","article-title":"Chronic Unpredictable Stress Promotes Neuronal Apoptosis in the Cerebral Cortex","volume":"442","author":"Bachis","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/jnr.22687","article-title":"Chronic Isolation Stress Predisposes the Frontal Cortex But Not the Hippocampus to the Potentially Detrimental Release of Cytochrome C from Mitochondria and the Activation of Caspase-3","volume":"89","author":"Inta","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"104106","DOI":"10.1016\/j.jff.2020.104106","article-title":"Antidepressant Effect of EGCG Through the Inhibition of Hippocampal Neuroinflammation in Chronic Unpredictable Mild Stress-Induced Depression Rat Model","volume":"73","author":"Wang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fnins.2017.00428","article-title":"Mir-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats","volume":"11","author":"Yang","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3389\/fpsyt.2018.00696","article-title":"Metoprolol, N-Acetylcysteine, and Escitalopram Prevents Chronic Unpredictable Mild Stress-Induced Depression by Inhibition of Endoplasmic Reticulum Stress","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fnmol.2018.00255","article-title":"cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia","volume":"11","author":"Wang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1734-1140(13)71031-4","article-title":"BDNF and VEGF in the Pathogenesis of Stress-Induced Affective Diseases: An Insight from Experimental Studies","volume":"65","author":"Nowacka","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jpsychires.2010.01.005","article-title":"Regulation of Brain-Derived Neurotrophic Factor (BDNF) in the Chronic Unpredictable Stress Rat Model and the Effects of Chronic Antidepressant Treatment","volume":"44","author":"Larsen","year":"2010","journal-title":"J. Psychiatry Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.psychres.2015.05.098","article-title":"Effects of Antipsychotic Drugs on the Expression of Synapse-Associated Proteins in the Frontal Cortex of Rats Subjected to Immobilization Stress","volume":"229","author":"Seo","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2006.03.028","article-title":"Effects of Quetiapine on the Brain-Derived Neurotrophic Factor Expression in the Hippocampus and Neocortex of Rats","volume":"402","author":"Park","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1734-1140(11)70520-5","article-title":"Chronic Unpredictable Stress-Induced Reduction in the Hippocampal Brain-Derived Neurotrophic Factor (BDNF) Gene Expression Is Antagonized by Zinc Treatment","volume":"63","author":"Ossowska","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"ref_100","first-page":"1001","article-title":"Expression of Brain-Derived Neurotrophic Factor Is Not Modulated by Chronic Mild Stress in the Rat Hippocampus and Amygdala","volume":"60","author":"Allaman","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2007.12.025","article-title":"Stress Sensitivity and Resilience in the Chronic Mild Stress Rat Model of Depression; an in Situ Hybridization Study","volume":"1196","author":"Jayatissa","year":"2008","journal-title":"Brain Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/jnr.22080","article-title":"Effects of Escitalopram on the Regulation of Brain-Derived Neurotrophic Factor and Nerve Growth Factor Protein Levels in a Rat Model of Chronic Stress","volume":"87","author":"Fuchs","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.mp.4001637","article-title":"BDNF in Schizophrenia, Depression and Corresponding Animal Models","volume":"10","author":"Angelucci","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"106729","DOI":"10.1016\/j.intimp.2020.106729","article-title":"DL0410 Attenuates Oxidative Stress and Neuroinflammation via BDNF\/Trkb\/ERK\/CREB and Nrf2\/HO-1 Activation","volume":"86","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF02704114","article-title":"Cyclic AMP Response Element Binding Protein and Brain-Derived Neurotrophic Factor: Molecules That Modulate Our Mood?","volume":"31","author":"Nair","year":"2006","journal-title":"J. Biosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s40520-014-0194-2","article-title":"Effects of Escitalopram on Serum BDNF Levels in Elderly Patients with Depression: A Preliminary Report","volume":"26","author":"Martocchia","year":"2014","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.pnpbp.2011.06.013","article-title":"Serum BDNF Levels Before Treatment Predict SSRI Response in Depression","volume":"35","author":"Wolkowitz","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.pnpbp.2006.03.025","article-title":"Brain-Derived Neurotrophic Factor (BDNF) Changes in the Serum of Depressed Women","volume":"30","author":"Aydemir","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2147\/NDT.S64913","article-title":"Lower Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Failure to Achieve Remission in Patients with Major Depression After Escitalopram Treatment","volume":"10","author":"Park","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1874467211003010012","article-title":"Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity","volume":"3","author":"Cowansage","year":"2010","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ijdevneu.2013.10.001","article-title":"Exposure to Caregiver Maltreatment Alters Expression Levels of Epigenetic Regulators in the Medial Prefrontal Cortex","volume":"31","author":"Blaze","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"18267","DOI":"10.1073\/pnas.0608702103","article-title":"Enhanced Anxiety and Stress-Induced Corticosterone Release Are Associated with Increased Crh Expression in a Mouse Model of Rett Syndrome","volume":"103","author":"McGill","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.psyneuen.2015.08.013","article-title":"BDNF Methylation and Depressive Disorder in Acute Coronary Syndrome: The K-DEPACS and Esdepacs Studies","volume":"62","author":"Kim","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"14926","DOI":"10.1038\/s41598-017-13929-5","article-title":"Alleviative Effects of Fluoxetine on Depressive-Like Behaviors by Epigenetic Regulation of BDNF Gene Transcription in Mouse Model of Post-Stroke Depression","volume":"7","author":"Jin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Webb, L., Phillips, K., Ho, M., Veldic, M., and Blacker, C. (2020). The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030826"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1038\/tp.2012.34","article-title":"A Putative Functional Role for Oligodendrocytes in Mood Regulation","volume":"2","author":"Edgar","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Kuhn, S., Gritti, L., Crooks, D., and Dombrowski, Y. (2019). Oligodendrocytes in Development, Myelin Generation and Beyond. Cells, 8.","DOI":"10.3390\/cells8111424"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.04.001","article-title":"The Effects of Running Exercise on Oligodendrocytes in the Hippocampus of Rats with Depression Induced by Chronic Unpredictable Stress","volume":"149","author":"Tang","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/cne.24914","article-title":"The Effects of Fluoxetine on Oligodendrocytes in the Hippocampus of Chronic Unpredictable Stress-Induced Depressed Model Rats","volume":"528","author":"Wang","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41398-019-0662-8","article-title":"Running Exercise Protects Oligodendrocytes in the Medial Prefrontal Cortex in Chronic Unpredictable Stress Rat Model","volume":"9","author":"Luo","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/jnc.12792","article-title":"Desvenlafaxine Prevents White Matter Injury and Improves the Decreased Phosphorylation of the Rate-Limiting Enzyme of Cholesterol Synthesis in a Chronic Mouse Model of Depression","volume":"131","author":"Wang","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/mp.2013.190","article-title":"Stress and Glucocorticoids Promote Oligodendrogenesis in the Adult Hippocampus","volume":"19","author":"Chetty","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neubiorev.2021.01.025","article-title":"How Stress Physically Re-Shapes the Brain: Impact on Brain Cell Shapes, Numbers and Connections in Psychiatric Disorders","volume":"124","author":"Kaul","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative Stress and the Central Nervous System","volume":"360","author":"Salim","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2013.09.033","article-title":"Depression, Anxiety-Like Behavior and Memory Impairment Are Associated with Increased Oxidative Stress and Inflammation in a Rat Model of Social Stress","volume":"1539","author":"Patki","year":"2013","journal-title":"Brain Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","article-title":"Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications","volume":"246","author":"Felger","year":"2013","journal-title":"Neuroscience"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/j.1471-4159.2008.05864.x","article-title":"The CREB\/CRE Transcriptional Pathway: Protection against Oxidative Stress-Mediated Neuronal Cell Death","volume":"108","author":"Lee","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.npp.1301571","article-title":"Interaction between BDNF and Serotonin: Role in Mood Disorders","volume":"33","author":"Martinowich","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2012.08.020","article-title":"Escitalopram Improves Memory Deficits Induced by Maternal Separation in the Rat","volume":"695","author":"Couto","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.bbr.2009.07.027","article-title":"Depression-Like and Anxiety-Like Behavioural Aftermaths of Impact Accelerated Traumatic Brain Injury in Rats: A Model of Comorbid Depression and Anxiety?","volume":"205","author":"Pandey","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0149-7634(05)80194-0","article-title":"Chronic Mild Stress-Induced Anhedonia: A Realistic Animal Model of Depression","volume":"16","author":"Willner","year":"1992","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_132","unstructured":"Hoffman, K.L. (2015). Modeling Neuropsychiatric Disorders in Laboratory Animals, Woodhead Publishing. [1st ed.]."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbr.2016.08.005","article-title":"Fluvoxamine Maleate Normalizes Striatal Neuronal Inflammatory Cytokine Activity in a Parkinsonian Rat Model Associated with Depression","volume":"316","author":"Daniels","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2014.03.052","article-title":"Antidepressant Effects of Resveratrol in an Animal Model of Depression","volume":"268","author":"Hurley","year":"2014","journal-title":"Behav. Brain Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fnbeh.2017.00013","article-title":"Behavior of Male and Female C57BL\/6J Mice Is More Consistent with Repeated Trials in the Elevated Zero Maze than in the Elevated Plus Maze","volume":"11","author":"Tucker","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The Use of the Elevated Plus Maze as an Assay of Anxiety-Related Behavior in Rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2015.03.053","article-title":"Effects of the Aqueous Extract of Pimpinella Anisum L. Seeds on Exploratory Activity and Emotional Behavior in Rats Using the Open Field and Elevated Plus Maze Tests","volume":"168","author":"Gamberini","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3037876","DOI":"10.1155\/2017\/3037876","article-title":"Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1\/2\/NF-\u039ab Pathway in Brain","volume":"2017","author":"Toma","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/clinchem\/37.7.1273","article-title":"Improved Fluorometric Determination of Malonaldehyde","volume":"37","author":"Conti","year":"1991","journal-title":"Clin. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/1534735407301632","article-title":"Advances in the Use of Milk Thistle (Silybum marianum)","volume":"6","author":"Ladas","year":"2007","journal-title":"Integr. Cancer Ther."},{"key":"ref_141","first-page":"299","article-title":"Regulatory Antioxidant Enzymes","volume":"108","author":"Pippenger","year":"1998","journal-title":"Methods Mol. Biol."},{"key":"ref_142","unstructured":"GraphPad Software GraphPad Prism, Version 8.0, GraphPad Software. Software for Windows."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/14\/7483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:29:38Z","timestamp":1760164178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/14\/7483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":142,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijms22147483"],"URL":"https:\/\/doi.org\/10.3390\/ijms22147483","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]}}}