{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:19:49Z","timestamp":1782915589135,"version":"3.54.5"},"reference-count":90,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in C. striatum. This review updates global information related to antimicrobial resistance found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination. The resistome of C. striatum comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of C. striatum is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.<\/jats:p>","DOI":"10.3390\/ijms22147499","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T22:25:31Z","timestamp":1626215131000},"page":"7499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-3529","authenticated-orcid":false,"given":"Benjamin","family":"Leyton","sequence":"first","affiliation":[{"name":"Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Carrera de Bioqu\u00edmica, Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-6720","authenticated-orcid":false,"given":"Juliana Nunes","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Pesquisas M\u00e9dicas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz, Rio de Janeiro 21040-361, Brazil"},{"name":"Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro\u2014LDCIC\/FCM\/UERJ, Rio de Janeiro 20550-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Victor Pereira","family":"Baio","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Pesquisas M\u00e9dicas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz, Rio de Janeiro 21040-361, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Fl\u00e1vio Carneiro","family":"Veras","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Pesquisas M\u00e9dicas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz, Rio de Janeiro 21040-361, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-5250","authenticated-orcid":false,"given":"Cassius","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro\u2014LDCIC\/FCM\/UERJ, Rio de Janeiro 20550-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Burkovski","sequence":"additional","affiliation":[{"name":"Department of Biology, Professur f\u00fcr Mikrobiologie, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Staudtstrasse 5, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lu\u00edza","family":"Mattos-Guaraldi","sequence":"additional","affiliation":[{"name":"Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade do Estado do Rio de Janeiro\u2014LDCIC\/FCM\/UERJ, Rio de Janeiro 20550-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica Viana","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Pesquisas M\u00e9dicas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz, Rio de Janeiro 21040-361, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-0041","authenticated-orcid":false,"given":"Michel","family":"Abanto Marin","sequence":"additional","affiliation":[{"name":"Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1590\/S0074-02762013000100004","article-title":"Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil","volume":"108","author":"Baio","year":"2013","journal-title":"Mem. 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