{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:03:21Z","timestamp":1792789401478,"version":"4.5.0"},"reference-count":104,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation","award":["IOS1355097"],"award-info":[{"award-number":["IOS1355097"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>All organisms confront the challenges of maintaining metabolic homeostasis in light of both variabilities in nutrient supplies and energetic costs of different physiologies and behaviors. While all cells are nutrient sensitive, only relative few cells within Metazoans are nutrient sensing cells. Nutrient sensing cells organize systemic behavioral and physiological responses to changing metabolic states. One group of cells present in the arthropods, is the adipokinetic hormone producing cells (APCs). APCs possess intrinsic nutrient sensors and receive contextual information regarding metabolic state through other endocrine connections. APCs express receptors for different hormones which modulate APC physiology and the secretion of the adipokinetic hormone (AKH). APCs are functionally similar to alpha cells in the mammalian pancreas and display a similar physiological organization. AKH release results in both hypertrehalosemia and hyperlipidemia through high affinity binding to the AKH receptor (AKHR). Another hallmark of AKH signaling is heightened locomotor activity, which accompanies starvation and is thought to enhance foraging. In this review, we discuss mechanisms of nutrient sensing and modulation of AKH release. Additionally, we compare the organization of AKH\/AKHR signaling in different taxa. Lastly, we consider the signals that APCs integrate as well as recent experimental results that have expanded the functional repertoire of AKH signaling, further establishing this as both a metabolic and stress hormone.<\/jats:p>","DOI":"10.3390\/ijms22147515","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T22:25:31Z","timestamp":1626215131000},"page":"7515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Intrinsic Nutrient Sensing Adipokinetic Hormone Producing Cells Function in Modulation of Metabolism, Activity, and Stress"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-5610","authenticated-orcid":false,"given":"Jonathan M.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4863-6994","authenticated-orcid":false,"given":"Cecil J.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA"},{"name":"Center of Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1242\/jeb.041277","article-title":"Effects of nutritional condition on spring migration: Do migrants use resource availability to keep pace with a changing world?","volume":"213","author":"Bridge","year":"2010","journal-title":"J. Exp. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1086\/367950","article-title":"The Role of Energy Availability in Mammalian Hibernation: A Cost-Benefit Approach","volume":"76","author":"Humphries","year":"2003","journal-title":"Physiol. Biochem. Zool."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1890\/0012-9658(2003)084[0398:CORITW]2.0.CO;2","article-title":"Cost of Reproduction in the Wild: Manipulation of Reproductive Effort in the Bank Vole","volume":"84","author":"Koivula","year":"2003","journal-title":"Ecology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/263207a0","article-title":"Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight","volume":"263","author":"Stone","year":"1976","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23038","DOI":"10.1074\/jbc.270.39.23038","article-title":"Molecular Cloning of Three Distinct cDNAs, Each Encoding a Different Adipokinetic Hormone Precursor, of the Migratory Locust, Locusta migratoria: Differential Expression of the Distinct Adipokinetic Hormone Precursor Genes During Flight Activity (\u2217)","volume":"270","author":"Bogerd","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0022-2275(20)37276-X","article-title":"Adipokinetic hormone-induced lipolysis in the fat body of an insect, Manduca sexta: Synthesis of sn-1,2-diacylglycerols","volume":"38","author":"Arrese","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0022-1910(81)90122-0","article-title":"Activation of fat body glycogen phosphorylase in Locusta migratoria by corpus cardiacum extract and synthetic adipokinetic hormone","volume":"27","year":"1981","journal-title":"J. Insect Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"R531","DOI":"10.1152\/ajpregu.00158.2004","article-title":"AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila","volume":"288","author":"Isabel","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1534\/genetics.167.1.311","article-title":"Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster","volume":"167","author":"Lee","year":"2004","journal-title":"Genetics"},{"key":"ref_10","unstructured":"Pfaff, D.W., and Jo\u00ebls, M. (2017). 2.21-Stressed Out Insects II. Physiology, Behavior, and Neuroendocrine Circuits Mediating Stress Responses. Hormones, Brain and Behavior, Academic Press. [3rd ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/bj2690315","article-title":"The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide","volume":"269","author":"Schaffer","year":"1990","journal-title":"Biochem. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Rhea, J.M., Wegener, C., and Bender, M. (2010). The Proprotein Convertase Encoded by amontillado (amon) Is Required in Drosophila Corpora Cardiaca Endocrine Cells Producing the Glucose Regulatory Hormone AKH. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1000967"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ygcen.2012.04.025","article-title":"Structure\u2013activity studies of Drosophila adipokinetic hormone (AKH) by a cellular expression system of dipteran AKH receptors","volume":"177","author":"Caers","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0965-1748(92)90096-W","article-title":"Inactivation of neuropeptide hormones (AKH I and AKH II) studied in vivo and in vitro","volume":"22","author":"Rayne","year":"1992","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12791","DOI":"10.1016\/S0021-9258(18)51555-6","article-title":"Adipokinetic Hormone Gene Sequence from Manduca sexta","volume":"264","author":"Bradfield","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ibmb.2015.11.010","article-title":"Characterization and pharmacological analysis of two adipokinetic hormone receptor variants of the tsetse fly, Glossina morsitans morsitans","volume":"70","author":"Caers","year":"2016","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fphys.2014.00454","article-title":"The contribution of the genomes of a termite and a locust to our understanding of insect neuropeptides and neurohormones","volume":"5","author":"Veenstra","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0143-4160(95)90092-6","article-title":"Signal transduction of adipokinetic hormones involves Ca2+ fluxes and depends on extracellular Ca2+ to potentiate cAMP-induced activation of glycogen phosphorylase","volume":"17","author":"Vroemen","year":"1995","journal-title":"Cell Calcium"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2016.06.046","article-title":"Coupled sensing of hunger and thirst signals balances sugar and water consumption","volume":"166","author":"Jourjine","year":"2016","journal-title":"Cell"},{"key":"ref_20","unstructured":"Saunders, C.J., and GnRH Receptor Tree (2021, June 06). GitHub. Available online: https:\/\/github.com\/JakeSaunders\/GnRHRtree\/."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1432-1033.1991.tb15713.x","article-title":"Isolation and structure elucidation of a novel adipokinetic hormone (Lom-AKH-III) from the glandular lobes of the corpus cardiacum of the migratory locust, Locusta migratoria","volume":"195","author":"Oudejans","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1515\/bchm3.1985.366.2.723","article-title":"Primary Structures of Locust Adipokinetic Hormones II","volume":"366","author":"Siegert","year":"1985","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0196-9781(93)90062-L","article-title":"Adipokinetic peptide hormone content and biosynthesis during locust development","volume":"14","author":"Oudejans","year":"1993","journal-title":"Peptides"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ygcen.2015.09.032","article-title":"Characterization and expression analysis of adipokinetic hormone and its receptor in eusocial aphid Pseudoregma bambucicola","volume":"223","author":"Lee","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.ibmb.2009.09.002","article-title":"The adipokinetic hormone system in Culicinae (Diptera: Culicidae): Molecular identification and characterization of two adipokinetic hormone (AKH) precursors from Aedes aegypti and Culex pipiens and two putative AKH receptor variants from A. aegypti","volume":"39","author":"Kaufmann","year":"2009","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0196-9781(90)90030-9","article-title":"Adipokinetic hormone controls lipid metabolism in adults and carbohydrate metabolism in larvae of Manduca sexta","volume":"11","author":"Ziegler","year":"1990","journal-title":"Peptides"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1534\/genetics.112.143610","article-title":"Energy-Dependent Modulation of Glucagon-Like Signaling in Drosophila via the AMP-Activated Protein Kinase","volume":"192","author":"Braco","year":"2012","journal-title":"Genetics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature02897","article-title":"Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells","volume":"431","author":"Kim","year":"2004","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3389\/fphys.2020.580618","article-title":"Regulation of Metabolism by an Ensemble of Different Ion Channel Types: Excitation-Secretion Coupling Mechanisms of Adipokinetic Hormone Producing Cells in Drosophila","volume":"11","author":"Perry","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature04711","article-title":"KATP channels as molecular sensors of cellular metabolism","volume":"440","author":"Nichols","year":"2006","journal-title":"Nature"},{"key":"ref_31","first-page":"428","article-title":"Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells","volume":"438","author":"Bokvist","year":"1999","journal-title":"Pfl\u00fcg. Arch."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1210\/en.2005-0803","article-title":"Electrophysiological Characterization of Pancreatic Islet Cells in the Mouse Insulin Promoter-Green Fluorescent Protein Mouse","volume":"146","author":"Leung","year":"2005","journal-title":"Endocrinology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/305147a0","article-title":"ATP-regulated K+ channels in cardiac muscle","volume":"305","author":"Noma","year":"1983","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/352244a0","article-title":"ATP-sensitive K+ channel in the mitochondrial inner membrane","volume":"352","author":"Inoue","year":"1991","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1113\/jphysiol.2009.179028","article-title":"Mitochondrial ATP-sensitive K+ channels, protectors of the heart","volume":"588","author":"Yamada","year":"2010","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0896-6273(00)81135-6","article-title":"Ion channels and synaptic organization: Analysis of the Drosophila genome","volume":"26","author":"Littleton","year":"2000","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10402","DOI":"10.1073\/pnas.95.18.10402","article-title":"Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice","volume":"95","author":"Miki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/expphysiol.2006.034835","article-title":"Physiological regulation of the pancreatic {beta}-cell: Functional insights for understanding and therapy of diabetes","volume":"92","author":"McClenaghan","year":"2007","journal-title":"Exp. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2337\/db08-1618","article-title":"The \u03b1-Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing","volume":"58","author":"Jacobson","year":"2009","journal-title":"Diabetes"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ygcen.2014.07.009","article-title":"Evolution of the AKH\/corazonin\/ACP\/GnRH receptor superfamily and their ligands in the Protostomia","volume":"209","author":"Hauser","year":"2014","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ydbio.2004.07.015","article-title":"Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass","volume":"274","author":"Shen","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1432-1033.1991.tb16172.x","article-title":"Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase","volume":"199","author":"Moore","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1006\/bbrc.1994.1627","article-title":"Characterisation of 5\u2019-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5\u2019-AMP analogues on enzyme activity","volume":"200","author":"Sullivan","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11442","DOI":"10.1016\/S0021-9258(19)78143-5","article-title":"Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism","volume":"269","author":"Carling","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10282","DOI":"10.1074\/jbc.271.17.10282","article-title":"Characterization of AMP-activated Protein Kinase \u03b2 and \u03b3 Subunits: ASSEMBLY OF THE HETEROTRIMERIC COMPLEX IN VITRO (\u2217)","volume":"271","author":"Woods","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1113\/jphysiol.2006.120972","article-title":"Predominant \u03b12\/\u03b22\/\u03b33 AMPK activation during exercise in human skeletal muscle","volume":"577","author":"Birk","year":"2006","journal-title":"J. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1074\/jbc.271.2.611","article-title":"Mammalian AMP-activated Protein Kinase Subfamily (\u2217)","volume":"271","author":"Stapleton","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0014-5793(96)01209-4","article-title":"The \u03b11 and \u03b12 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro","volume":"397","author":"Woods","year":"1996","journal-title":"FEBS Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bj20020703","article-title":"A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion","volume":"367","author":"Pan","year":"2002","journal-title":"Biochem. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI29044","article-title":"AMP-activated protein kinase signaling in metabolic regulation","volume":"116","author":"Long","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1474-9726.2009.00459.x","article-title":"Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans","volume":"8","author":"Greer","year":"2009","journal-title":"Aging Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cell.2008.06.051","article-title":"AMPK and PPAR\u03b4 Agonists Are Exercise Mimetics","volume":"134","author":"Narkar","year":"2008","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.2741\/3460","article-title":"Targeting the AMPK pathway for the treatment of Type 2 diabetes","volume":"14","author":"Viollet","year":"2009","journal-title":"Front. Biosci. Landmark Ed."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Johnson, E.C., Kazgan, N., Bretz, C.A., Forsberg, L.J., Hector, C.E., Worthen, R.J., Onyenwoke, R., and Brenman, J.E. (2010). Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012799"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbrc.2010.02.126","article-title":"A critical role of SNF1A\/dAMPK\u03b1 (Drosophila AMP-activated protein kinase \u03b1) in muscle on longevity and stress resistance in Drosophila melanogaster","volume":"394","author":"Tohyama","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/bj20021812","article-title":"Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression","volume":"371","author":"Leclerc","year":"2003","journal-title":"Biochem. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1042\/bj3350533","article-title":"AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic \u03b2 cells, and may regulate insulin release","volume":"335","author":"Salt","year":"1998","journal-title":"Biochem. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00125-010-1929-z","article-title":"AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells","volume":"54","author":"Leclerc","year":"2011","journal-title":"Diabetologia"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neulet.2011.05.060","article-title":"AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats","volume":"499","author":"Kohno","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.1038\/ncomms7846","article-title":"Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3","volume":"6","author":"Kim","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1677\/JOE-08-0290","article-title":"Physiology of the pancreatic \u03b1-cell and glucagon secretion: Role in glucose homeostasis and diabetes","volume":"199","author":"Quesada","year":"2008","journal-title":"J. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1101\/gr.169901","article-title":"Neuropeptides and Neuropeptide Receptors in the Drosophila melanogaster Genome","volume":"11","author":"Hewes","year":"2001","journal-title":"Genome Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11423","DOI":"10.1073\/pnas.162276199","article-title":"Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution","volume":"99","author":"Park","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1073\/pnas.052556499","article-title":"Molecular identification of the insect adipokinetic hormone receptors","volume":"99","author":"Staubli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/jeb.016451","article-title":"A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis","volume":"211","author":"Bharucha","year":"2008","journal-title":"J. Exp. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1534\/genetics.115.178897","article-title":"Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants","volume":"201","author":"Diesner","year":"2015","journal-title":"Genetics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbrc.2006.03.012","article-title":"Cloning and characterization of the adipokinetic hormone receptor from the cockroach Periplaneta americana","volume":"343","author":"Hansen","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.febslet.2009.03.060","article-title":"Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori","volume":"583","author":"Zhu","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.bbrc.2018.07.136","article-title":"Unexpected role of a conserved domain in the first extracellular loop in G protein-coupled receptor trafficking","volume":"503","author":"Rizzo","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jgg.2014.03.005","article-title":"G\u03b1q, G\u03b31 and Plc21C Control Drosophila Body Fat Storage","volume":"41","author":"Baumbach","year":"2014","journal-title":"J. Genet. Genomics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0022-2275(20)32460-3","article-title":"Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in Manduca sexta fat body","volume":"40","author":"Arrese","year":"1999","journal-title":"J. Lipid Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0303-7207(94)03438-Y","article-title":"Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP","volume":"107","author":"Vroemen","year":"1995","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0016-6480(03)00159-X","article-title":"Mode of action of neuropeptides from the adipokinetic hormone family","volume":"132","author":"Auerswald","year":"2003","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.peptides.2007.01.017","article-title":"Is the titer of adipokinetic peptides in Leptinotarsa decemlineata fed on genetically modified potatoes increased by oxidative stress?","volume":"28","author":"Krishnan","year":"2007","journal-title":"Peptides"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Marchal, E., Schellens, S., Monjon, E., Bruyninckx, E., Marco, H.G., G\u00e4de, G., Vanden Broeck, J., and Verlinden, H. (2018). Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020542"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0303-7207(02)00082-5","article-title":"Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: Role of the GnRHR carboxyl-terminus","volume":"191","author":"Conn","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1677\/jme.1.01809","article-title":"Internalization of gonadotropin-releasing hormone receptors (GnRHRs): Does arrestin binding to the C-terminal tail target GnRHRs for dynamin-dependent internalization?","volume":"35","author":"Hislop","year":"2005","journal-title":"J. Mol. Endocrinol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1677\/joe.0.156r009","article-title":"Contrasting internalization kinetics of human and chicken Gonadotropin-Releasing Hormone Receptors mediated by C-terminal tail","volume":"156","author":"Pawson","year":"1998","journal-title":"J. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1210\/edrv.18.2.0295","article-title":"Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor","volume":"18","author":"Sealfon","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Gr\u00f6nke, S., M\u00fcller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., J\u00e4ckle, H., and K\u00fchnlein, R.P. (2007). Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila. PLoS Biol., 5.","DOI":"10.1371\/journal.pbio.0050137"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0965-1748(96)00024-0","article-title":"The use of decapitated insects to study lipid mobilization in adult Manduca sexta: Effects of adipokinetic hormone and trehalose on fat body lipase activity","volume":"26","author":"Arrese","year":"1996","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e15693","DOI":"10.7554\/eLife.15693","article-title":"Regulation of starvation-induced hyperactivity by insulin and glucagon signaling in adult Drosophila","volume":"5","author":"Yu","year":"2016","journal-title":"eLife"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fevo.2015.00151","article-title":"The Adipokinetic Hormone Receptor Modulates Sexual Behavior, Pheromone Perception and Pheromone Production in a Sex-Specific and Starvation-Dependent Manner in Drosophila melanogaster","volume":"3","author":"Lebreton","year":"2016","journal-title":"Front. Ecol. Evol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e08298","DOI":"10.7554\/eLife.08298","article-title":"Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits","volume":"4","author":"Ko","year":"2015","journal-title":"eLife"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbrc.2018.02.088","article-title":"Functional characterization and quantitative expression analysis of two GnRH-related peptide receptors in the mosquito, Aedes aegypti","volume":"497","author":"Oryan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"E5753","DOI":"10.1073\/pnas.1514862112","article-title":"Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2","volume":"112","author":"Guntur","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0167-0115(95)00043-B","article-title":"Evidence that locustatachykinin I is involved in release of adipokinetic hormone from locust corpora cardiaca","volume":"57","author":"Passier","year":"1995","journal-title":"Regul. Pept."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1210\/endo.138.1.4855","article-title":"Isolation and Characterization of an Adipokinetic Hormone Release-Inducing Factor in Locusts: The Crustacean Cardioactive Peptide","volume":"138","author":"Veelaert","year":"1997","journal-title":"Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1023\/A:1006901123566","article-title":"A possible role of SchistoFLRFamide in inhibition of adipokinetic hormone release from locust corpora cardiaca","volume":"27","author":"Vullings","year":"1998","journal-title":"J. Neurocytol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-3032.1984.tb00709.x","article-title":"Changes in haemolymph octopamine levels associated with food deprivation in the locust, Schistocerca gregaria","volume":"9","author":"Davenport","year":"1984","journal-title":"Physiol. Entomol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1007\/BF01964071","article-title":"Locomotor behavior in relation to octopamine levels in the antLasius niger","volume":"38","author":"David","year":"1982","journal-title":"Experientia"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1073\/pnas.94.8.4131","article-title":"Conserved and sexually dimorphic behavioral responses to biogenic amines in decapitated Drosophila","volume":"94","author":"Yellman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Pauls, D., Selcho, M., R\u00e4derscheidt, J., Amatobi, K.M., Fekete, A., Krischke, M., Hermann-Luibl, C., \u00dcnal, A.G., Ehmann, N., and Itskov, P.M. (2021). Endocrine fine-tuning of daily locomotor activity patterns under non-starving conditions in Drosophila. bioRxiv.","DOI":"10.1101\/2020.02.13.947556"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"11680","DOI":"10.1038\/srep11680","article-title":"The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila","volume":"5","author":"Hentze","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1093\/emboj\/18.21.5892","article-title":"Reverse physiology in Drosophila: Identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin\/galanin\/opioid receptor family","volume":"18","author":"Weise","year":"1999","journal-title":"EMBO J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12264-011-1841-7","article-title":"Central nervous system regulation of food intake and energy expenditure: Role of galanin-mediated feeding behavior","volume":"27","author":"Fang","year":"2011","journal-title":"Neurosci. Bull."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41586-019-1675-4","article-title":"A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila","volume":"574","author":"Oh","year":"2019","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1007\/s00018-012-1097-z","article-title":"Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin","volume":"69","author":"Kapan","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Braco, J.T., Saunders, C.J., Nelson, J.M., and Johnson, E.C. (2020). Modulation of metabolic hormone signaling via a circadian hormone and a biogenic amine in Drosophila melanogaster. bioRxiv.","DOI":"10.1101\/2020.09.25.312967"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Nagy, D., Cusumano, P., Andreatta, G., Anduaga, A.M., Hermann-Luibl, C., Reinhard, N., Gesto, J., Wegener, C., Mazzotta, G., and Rosato, E. (2019). Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster. PLoS Genet., 15.","DOI":"10.1371\/journal.pgen.1008158"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"154460","DOI":"10.1016\/j.metabol.2020.154460","article-title":"AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction","volume":"115","author":"Franssen","year":"2021","journal-title":"Metabolism"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cbpc.2013.07.002","article-title":"Adipokinetic hormone exerts its anti-oxidative effects using a conserved signal-transduction mechanism involving both PKC and cAMP by mobilizing extra- and intracellular Ca2+ stores","volume":"158","author":"Krishnan","year":"2013","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbpc.2015.03.006","article-title":"Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila\u2014A role for dFoxO?","volume":"171","author":"Krishnan","year":"2015","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ygcen.2010.12.009","article-title":"Oxidative stress elicited by insecticides: A role for the adipokinetic hormone","volume":"172","author":"Velki","year":"2011","journal-title":"Gen. Comp. Endocrinol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/14\/7515\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:30:01Z","timestamp":1760164201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/14\/7515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":104,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ijms22147515"],"URL":"https:\/\/doi.org\/10.3390\/ijms22147515","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]}}}