{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:14:01Z","timestamp":1760166841287,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["20182MFDS422"],"award-info":[{"award-number":["20182MFDS422"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A5A2025272"],"award-info":[{"award-number":["2018R1A5A2025272"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Foundation of Korea (NRF) grant","award":["2019R1I1A1A01052581"],"award-info":[{"award-number":["2019R1I1A1A01052581"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency\u2013rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-na\u00efve rats.<\/jats:p>","DOI":"10.3390\/ijms22147519","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T02:28:01Z","timestamp":1626229681000},"page":"7519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-1024","authenticated-orcid":false,"given":"Seong Shoon","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaesuk","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Hyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Ha","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/15563650.2011.590812","article-title":"Clinical experience with and analytical confirmation of \u201cbath salts\u201d and \u201clegal highs\u201d (synthetic cathinones) in the United States","volume":"49","author":"Spiller","year":"2011","journal-title":"Clin. 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