{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:37:17Z","timestamp":1784345837689,"version":"3.55.0"},"reference-count":242,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["21593"],"award-info":[{"award-number":["21593"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","award":["III\/CC\/191350"],"award-info":[{"award-number":["III\/CC\/191350"]}],"id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC 773\/III\/CC\/101350"],"award-info":[{"award-number":["BRC 773\/III\/CC\/101350"]}],"id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.<\/jats:p>","DOI":"10.3390\/ijms22147619","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T10:52:58Z","timestamp":1626432778000},"page":"7619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus"],"prefix":"10.3390","volume":"22","author":[{"given":"James","family":"Greenan-Barrett","sequence":"first","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Doolan","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devina","family":"Shah","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrun","family":"Virdee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Royal Free Hospital, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara","family":"Choida","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Gak","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University College London Hospital NHS Foundation Trust, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"de Gruijter","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rosser","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthana","family":"Al-Obaidi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Rheumatology, Great Ormond Street Hospital, London WC1N 3JH, UK"},{"name":"NIHR Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Leandro","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University College London Hospital NHS Foundation Trust, London NW1 2BU, UK"},{"name":"Centre for Rheumatology, Division of Medicine, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Zandi","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth J.","family":"Pepper","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Royal Free Hospital, University College London, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Royal Free Hospital, University College London, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Jury","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology, Division of Medicine, University College London, London WC1E 6DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coziana","family":"Ciurtin","sequence":"additional","affiliation":[{"name":"Centre for Adolescent Rheumatology Versus Arthritis, University College London, London WC1E 6DH, UK"},{"name":"Department of Rheumatology, University College London Hospital NHS Foundation Trust, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11926-014-0471-2","article-title":"Biomarkers for Childhood-Onset Systemic Lupus Erythematosus","volume":"17","author":"Abulaban","year":"2015","journal-title":"Curr. 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