{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:47:11Z","timestamp":1779151631291,"version":"3.51.4"},"reference-count":6,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic myeloid leukemia (CML) is a rare disease in children and adolescents [...]<\/jats:p>","DOI":"10.3390\/ijms22157806","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T11:53:23Z","timestamp":1626868403000},"page":"7806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Myeloid Leukemia in Children and Adolescents: The Achilles Heel of Oncogenesis and Tyrosine Kinase Inhibitors"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-8501","authenticated-orcid":false,"given":"Maria","family":"Moschovi","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, \u201cAghia Sophia\u201d Children\u2019s Hospital, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-624X","authenticated-orcid":false,"given":"Charikleia","family":"Kelaidi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, \u201cAghia Sophia\u201d Children\u2019s Hospital, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"ref_1","unstructured":"(2021, January 31). Chronic Myelogenous Leukemia Treatment (PDQ\u00ae): Patient Version, Available online: https:\/\/www.cancer.gov\/types\/leukemia\/patient\/cml-treatment-pdq."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cris\u00e0, E., Nicolosi, M., Ferri, V., Favini, C., Gaidano, G., and Patriarca, A. (2020). Atypical Chronic Myeloid Leukemia: Where Are We Now?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186862"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bavaro, L., Martelli, M., Cavo, M., and Soverini, S. (2019). Mechanisms of Disease Progression and Resistance to Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia: An Update. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246141"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Carofiglio, F., Lopalco, A., Lopedota, A., Cutrignelli, A., Nicolotti, O., Denora, N., Stefanachi, A., and Leonetti, F. (2020). Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124469"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"22811","DOI":"10.3390\/ijms160922811","article-title":"Pharmacogenetics of BCR\/ABL Inhibitors in Chronic Myeloid Leukemia","volume":"16","author":"Polillo","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Stella, S., Zammit, V., Vitale, S.R., Pennisi, M.S., Massimino, M., Tirr\u00f2, E., Forte, S., Spitaleri, A., Antolino, A., and Siracusa, S. (2019). Clinical Implications of Discordant Early Molecular Responses in CML Patients Treated with Imatinib. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092226"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/15\/7806\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:32:59Z","timestamp":1760164379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/15\/7806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":6,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijms22157806"],"URL":"https:\/\/doi.org\/10.3390\/ijms22157806","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]}}}