{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:04:22Z","timestamp":1783544662189,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2020R1C1C1010613"],"award-info":[{"award-number":["2020R1C1C1010613"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2020R1A2C1012166"],"award-info":[{"award-number":["2020R1A2C1012166"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The outbreak of the coronavirus disease 2019 (COVID-19) began at the end of 2019. COVID-19 is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and patients with COVID-19 may exhibit poor clinical outcomes. Some patients with severe COVID-19 experience cytokine release syndrome (CRS) or a cytokine storm\u2014elevated levels of hyperactivated immune cells\u2014and circulating pro-inflammatory cytokines, including interleukin (IL)-1\u03b2 and IL-18. This severe inflammatory response can lead to organ damage\/failure and even death. The inflammasome is an intracellular immune complex that is responsible for the secretion of IL-1\u03b2 and IL-18 in various human diseases. Recently, there has been a growing number of studies revealing a link between the inflammasome and COVID-19. Therefore, this article summarizes the current literature regarding the inflammasome complex and COVID-19.<\/jats:p>","DOI":"10.3390\/ijms22157914","type":"journal-article","created":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T22:06:21Z","timestamp":1627250781000},"page":"7914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Inflammatory Response in COVID-19 Patients Resulting from the Interaction of the Inflammasome and SARS-CoV-2"],"prefix":"10.3390","volume":"22","author":[{"given":"So Yeong","family":"Cheon","sequence":"first","affiliation":[{"name":"Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bon-Nyeo","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"},{"name":"Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4049\/jimmunol.2000513","article-title":"Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19","volume":"205","author":"Yap","year":"2020","journal-title":"J. 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