{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:47:42Z","timestamp":1790660862508,"version":"4.1.0"},"reference-count":102,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-04-00131"],"award-info":[{"award-number":["20-04-00131"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-015-00072"],"award-info":[{"award-number":["20-015-00072"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mitochondria are considered to be important organelles in the cell and play a key role in the physiological function of the heart, as well as in the pathogenesis and development of various heart diseases. Under certain pathological conditions, such as cardiovascular diseases, stroke, traumatic brain injury, neurodegenerative diseases, muscular dystrophy, etc., mitochondrial permeability transition pore (mPTP) is formed and opened, which can lead to dysfunction of mitochondria and subsequently to cell death. This review summarizes the results of studies carried out by our group of the effect of astaxanthin (AST) on the functional state of rat heart mitochondria upon direct addition of AST to isolated mitochondria and upon chronic administration of AST under conditions of mPTP opening. It was shown that AST exerted a protective effect under all conditions. In addition, AST treatment was found to prevent isoproterenol-induced oxidative damage to mitochondria and increase mitochondrial efficiency. AST, a ketocarotenoid, may be a potential mitochondrial target in therapy for pathological conditions associated with oxidative damage and mitochondrial dysfunction, and may be a potential mitochondrial target in therapy for pathological conditions.<\/jats:p>","DOI":"10.3390\/ijms22157964","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T22:22:46Z","timestamp":1627338166000},"page":"7964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mitochondrion as a Target of Astaxanthin Therapy in Heart Failure"],"prefix":"10.3390","volume":"22","author":[{"given":"Olga","family":"Krestinina","sequence":"first","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Baburina","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Krestinin","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-94-007-2869-1_11","article-title":"Mitochondria and Heart Disease","volume":"942","author":"Griffiths","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kim, S.H., and Kim, H. (2018). Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction\u2014A Mini-Review. Nutrients, 10.","DOI":"10.3390\/nu10091137"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0757.2012.00455.x","article-title":"Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: A shared pathology via oxidative stress and mitochondrial dysfunction?","volume":"64","author":"Bullon","year":"2014","journal-title":"Periodontol. 2000"},{"key":"ref_5","first-page":"135698","article-title":"Mitochondrial dysfunction: A basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities","volume":"2013","author":"Rull","year":"2013","journal-title":"Mediators Inflamm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"A31","DOI":"10.1253\/circj.CJ-08-0014","article-title":"Oxidative Stress and Mitochondrial DNA Damage in Heart Failure","volume":"72","author":"Tsutsui","year":"2008","journal-title":"Circ. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21295","DOI":"10.1074\/jbc.M501527200","article-title":"Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools","volume":"280","author":"James","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury","volume":"19","author":"Adlam","year":"2005","journal-title":"FASEB J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/HYPERTENSIONAHA.109.130351","article-title":"Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy","volume":"54","author":"Graham","year":"2009","journal-title":"Hypertension"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"R1095","DOI":"10.1152\/ajpregu.90902.2008","article-title":"MitoQ administration prevents endotoxin-induced cardiac dysfunction","volume":"297","author":"Supinski","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/01.CIR.0000109701.77059.E9","article-title":"Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice","volume":"109","author":"Shiomi","year":"2004","journal-title":"Circulation"},{"key":"ref_13","first-page":"146","article-title":"Reduction in oxidative stress and modulation of heart failure subsequent to myocardial infarction in rats","volume":"10","author":"Hill","year":"2005","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","article-title":"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase","volume":"11","author":"Li","year":"1995","journal-title":"Nat. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1080\/10715760310001604143","article-title":"Oral alpha-tocopherol supplementation inhibits lipid oxidation in established human atherosclerotic lesions","volume":"37","author":"Carpenter","year":"2003","journal-title":"Free Radic. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.numecd.2008.01.006","article-title":"Vitamin C consumption is associated with less progression in carotid intima media thickness in elderly men: A 3-year intervention study","volume":"19","author":"Ellingsen","year":"2009","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"956792","DOI":"10.1155\/2013\/956792","article-title":"Achieving the balance between ros and antioxidants: When to use the synthetic antioxi-dants","volume":"2013","author":"Poljsak","year":"2013","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.amjcard.2008.02.008","article-title":"The Chemistry of Novel Xanthophyll Carotenoids","volume":"101","author":"Jackson","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbamem.2006.09.010","article-title":"Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis","volume":"1768","author":"McNulty","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3354\/meps08849","article-title":"Estimating spatial distribution of American lobster Homarus americanus using habitat variables","volume":"420","author":"Chang","year":"2010","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1021\/jo050101l","article-title":"Efficient Syntheses of the Keto-carotenoids Canthaxanthin, Astaxanthin, and Astacene","volume":"70","author":"Choi","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s002530051413","article-title":"Production of ketocarotenoids by microalgae","volume":"51","author":"Margalith","year":"1999","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/md12010128","article-title":"Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications\u2014A Review","volume":"12","author":"Ambati","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/109662003765184741","article-title":"Safety of an Astaxanthin-Rich Haematococcus pluvialisAlgal Extract: A Randomized Clinical Trial","volume":"6","author":"Spiller","year":"2003","journal-title":"J. Med. Food"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Vitale, G.A., Coppola, D., Palma Esposito, F., Buonocore, C., Ausuri, J., Tortorella, E., and De Pascale, D. (2020). Antioxidant Molecules from Marine Fungi: Methodologies and Perspectives. Antioxidants (Basel), 9.","DOI":"10.3390\/antiox9121183"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1021\/np050354+","article-title":"Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition","volume":"69","author":"Hussein","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbrc.2007.03.120","article-title":"Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer","volume":"357","author":"Liu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fcell.2015.00062","article-title":"Mitochondrial dysfunction in inflammatory bowel disease","volume":"3","author":"Novak","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1021\/acs.jafc.8b00988","article-title":"Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer\u2019s Disease in APP\/PS1 Double-Transgenic Mice","volume":"66","author":"Che","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0005-2736(97)00182-X","article-title":"Effects of polar carotenoids on the shape of the hydrophobic barrier of phospholipid bilayers","volume":"1368","author":"Wisniewska","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.abb.2010.07.026","article-title":"Reduction of oxidized guanosine by dietary carotenoids: A pulse radiolysis study","volume":"504","author":"Edge","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/mnfr.201000414","article-title":"Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae","volume":"55","author":"Yuan","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_33","first-page":"807","article-title":"Antibacterial properties of spirulina platensis, haematococcus pluvialis, botryococcus braunii micro algal extracts","volume":"4","author":"Rao","year":"2010","journal-title":"Curr. Trends Biotechnol. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-7075-7-18","article-title":"Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans","volume":"7","author":"Park","year":"2010","journal-title":"Nutr. Metab. (Lond.)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1179\/135100002125000811","article-title":"Astaxanthin protects beta-cells against glucose toxicity in diabetic db\/db mice","volume":"7","author":"Uchiyama","year":"2002","journal-title":"Redox Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cbi.2010.05.011","article-title":"Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats","volume":"186","author":"Otton","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2009.03.031","article-title":"Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells","volume":"283","author":"Palozza","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_38","first-page":"2171","article-title":"Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB\/c mice","volume":"30","author":"Nakao","year":"2010","journal-title":"Anticancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1472-8206.2009.00669.x","article-title":"Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis","volume":"23","author":"Prabhu","year":"2009","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3164\/jcbn.08-238","article-title":"Preliminary Clinical Evaluation of Toxicity and Efficacy of A New Astaxanthin-rich Haematococcus pluvialis Extract","volume":"44","author":"Satoh","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10653-007-9117-x","article-title":"Impact of astaxanthin-enriched algal powder of Haematococcus pluvialis on memory improvement in BALB\/c mice","volume":"29","author":"Zhang","year":"2007","journal-title":"Environ. Geochem. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.18388\/abp.2012_2168","article-title":"Cosmetic benefits of astaxanthin on humans subjects","volume":"59","author":"Tominaga","year":"2012","journal-title":"Acta Biochim. Pol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3390\/md10030604","article-title":"Fucoxantin: A Treasure from the Sea","volume":"10","author":"Gemello","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What is the mitochondrial permeability transition pore?","volume":"46","author":"Halestrap","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10495-006-0525-7","article-title":"Role of the mitochondrial membrane permeability transition in cell death","volume":"12","author":"Tsujimoto","year":"2007","journal-title":"Apoptosis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10863-016-9672-x","article-title":"Mitochondrial Ca(2+) and regulation of the permeability transition pore","volume":"49","author":"Hurst","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yjmcc.2014.08.015","article-title":"Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury","volume":"78","author":"Morciano","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10863-014-9541-4","article-title":"Identification of phosphorylated form of 2\u2019, 3\u2019-cyclic nucleotide 3\u2019-phosphodiesterase (cnpase) as 46 kda phosphoprotein in brain non-synaptic mitochondria overloaded by calcium","volume":"46","author":"Azarashvili","year":"2014","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"C1428","DOI":"10.1152\/ajpcell.00006.2009","article-title":"Ca2+-dependent permeability transition regulation in rat brain mitochondria by 2\u2019,3\u2019-cyclic nucleotides and 2\u2019,3\u2019-cyclic nucleotide 3\u2019-phosphodiesterase","volume":"296","author":"Azarashvili","year":"2009","journal-title":"Am. J. Physiol Cell Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1111\/j.1471-4159.2009.06089.x","article-title":"The brain-specific protein, p42(iP4)(ADAP 1) is localized in mitochondria and involved in regulation of mitochondrial Ca2+","volume":"109","author":"Galvita","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuint.2015.07.012","article-title":"Mitochondrial 2\u2032, 3\u2032-cyclic nucleotide 3\u2032-phosphodiesterase (CNP) interacts with mPTP modulators and functional complexes (I\u2013V) coupled with release of apoptotic factors","volume":"90","author":"Baburina","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0006-291X(80)91514-4","article-title":"1-Butanol extracted proteolipid. Proton conducting properties","volume":"92","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbabio.2008.04.027","article-title":"Structural organization of mitochondrial ATP synthase","volume":"1777","author":"Wittig","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ceca.2013.12.002","article-title":"Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening","volume":"55","author":"Azarashvili","year":"2014","journal-title":"Cell Calcium"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.febslet.2004.03.071","article-title":"Calcium and mitochondria","volume":"567","author":"Gunter","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0300-9084(02)01368-8","article-title":"Mitochondrial intermembrane junctional complexes and their involvement in cell death","volume":"84","author":"Crompton","year":"2002","journal-title":"Biochimie"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1432-1033.1988.tb14475.x","article-title":"Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress. A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload","volume":"178","author":"Crompton","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1042\/bj2450915","article-title":"Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria","volume":"245","author":"Crompton","year":"1987","journal-title":"Biochem. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0022-2828(91)90181-K","article-title":"Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A","volume":"23","author":"Nazareth","year":"1991","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1113\/jphysiol.1996.sp021669","article-title":"The relationship between mitochondrial state, ATP hydrolysis, [Mg2+]i and [Ca2+]i studied in isolated rat cardiomyocytes","volume":"496","author":"Leyssens","year":"1996","journal-title":"J. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/bj3070093","article-title":"Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion","volume":"307","author":"Griffiths","year":"1995","journal-title":"Biochem. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1006\/jmcc.1993.1162","article-title":"Protection by Cyclosporin A of Ischemia\/Reperfusion-Induced Damage in Isolated Rat Hearts","volume":"25","author":"Griffiths","year":"1993","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cardiores.2006.01.016","article-title":"Mitochondria and ischemia\u2013reperfusion injury of the heart: Fixing a hole","volume":"70","author":"Bernardi","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0008-6363(03)00533-9","article-title":"Mitochondrial permeability transition pore opening during myocardial reperfusion\u2014A target for cardioprotection","volume":"61","author":"Halestrap","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.bbabio.2008.12.017","article-title":"The role of the mitochondrial permeability transition pore in heart disease","volume":"1787","author":"Halestrap","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial Reperfusion Injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: Another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1196\/annals.1420.023","article-title":"The identity and regulation of the mitochondrial permeability transition pore: Where the known meets the unknown","volume":"1123","author":"Juhaszova","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"H2024","DOI":"10.1152\/ajpheart.00683.2005","article-title":"Reactive oxygen species, but not ca2+ overloading, trigger ph- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion","volume":"290","author":"Kim","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jnutbio.2009.01.011","article-title":"Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress","volume":"21","author":"Wolf","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10815-013-9987-z","article-title":"Astaxanthin ameliorates heat stress-induced impairment of blastocyst development in vitro:--astaxanthin colocalization with and action on mitochondria","volume":"30","author":"Kuroki","year":"2013","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6859523","DOI":"10.1155\/2016\/6859523","article-title":"Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2527\/jas.2012-5341","article-title":"Astaxanthin modulates age-associated mi-tochondrial dysfunction in healthy dogs","volume":"91","author":"Park","year":"2013","journal-title":"J. Anim. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Baburina, Y., Krestinin, R., Odinokova, I., Sotnikova, L., Kruglov, A., and Krestinina, O. (2019). Astaxanthin Inhibits Mitochondrial Permeability Transition Pore Opening in Rat Heart Mitochondria. Antioxidants (Basel), 8.","DOI":"10.3390\/antiox8120576"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00702-016-1624-4","article-title":"Phytochemicals prevent mitochondrial membrane permeabilization and protect SH-SY5Y cells against apoptosis induced by PK11195, a ligand for outer membrane translocator protein","volume":"124","author":"Wu","year":"2016","journal-title":"J. Neural Transm. (Vienna)"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.12.003","article-title":"Mitochondrial translocator protein (TSPO): From physiology to cardioprotection","volume":"105","author":"Morin","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1073\/pnas.89.8.3170","article-title":"Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier","volume":"89","author":"McEnery","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1253\/circj.CJ-13-0321","article-title":"Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore","volume":"77","author":"Elrod","year":"2013","journal-title":"Circ. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"18558","DOI":"10.1074\/jbc.C500089200","article-title":"Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D","volume":"280","author":"Basso","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"33982","DOI":"10.1074\/jbc.M109.020115","article-title":"Cy-clophilin d modulates mitochondrial f0f1-atp synthase by interacting with the lateral stalk of the complex","volume":"284","author":"Giorgio","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Porter, G.A., and Beutner, G. (2018). Cyclophilin d, somehow a master regulator of mitochondrial function. Biomolecules, 8.","DOI":"10.3390\/biom8040176"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mito.2011.04.007","article-title":"Modulation of the mitochondrial permeability transition by cyclophilin D: Moving closer to f(0)\u2013f(1) ATP synthase?","volume":"12","author":"Chinopoulos","year":"2012","journal-title":"Mitochondrion"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4161\/cc.23599","article-title":"Role of the c subunit of the fo atp synthase in mitochondrial permeability transition","volume":"12","author":"Bonora","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.celrep.2018.12.033","article-title":"Atp synthase c-subunit-deficient mitochondria have a small cyclosporine a-sensitive channel, but lack the permeability transition pore","volume":"26","author":"Neginskaya","year":"2019","journal-title":"Cell Rep."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Krestinin, R., Baburina, Y., Odinokova, I., Kruglov, A., Fadeeva, I., Zvyagina, A., Sotnikova, L., and Krestinina, O. (2020). Isoproterenol-induced permeability transition pore-related dysfunction of heart mitochondria is attenuated by astaxanthin. Biomedicines, 8.","DOI":"10.3390\/biomedicines8100437"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.yexmp.2009.10.011","article-title":"The study of ISO induced heart failure rat model","volume":"88","author":"Feng","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.cell.2017.07.050","article-title":"Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2","volume":"170","author":"Guo","year":"2017","journal-title":"Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.281.5373.64","article-title":"Complete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc1 Complex","volume":"281","author":"Iwata","year":"1998","journal-title":"Science"},{"key":"ref_89","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0163-7827(00)00005-9","article-title":"The biosynthesis and functional role of cardiolipin","volume":"39","author":"Schlame","year":"2000","journal-title":"Prog. Lipid Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"C33","DOI":"10.1152\/ajpcell.00243.2006","article-title":"Role of cardiolipin alterations in mitochondrial dysfunction and disease","volume":"292","author":"Chicco","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bbalip.2016.03.008","article-title":"Cardiac mitochondrial energy metabolism in heart failure: Role of cardiolipin and sirtuins","volume":"1861","author":"Dolinsky","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature19794","article-title":"Atomic structure of the entire mammalian mitochondrial complex i","volume":"538","author":"Fiedorczuk","year":"2016","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"31303","DOI":"10.1074\/jbc.M302195200","article-title":"Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion qo site inhibitor bound","volume":"278","author":"Palsdottir","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/sj.emboj.7601618","article-title":"Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase","volume":"26","author":"Aoyama","year":"2007","journal-title":"EMBO J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15252\/emmm.201505644","article-title":"Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome","volume":"8","author":"Dudek","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fcell.2017.00090","article-title":"Role of Cardiolipin in Mitochondrial Signaling Pathways","volume":"5","author":"Dudek","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1155\/2013\/974358","article-title":"Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage","volume":"35","author":"Rodrigo","year":"2013","journal-title":"Dis. Mark."},{"key":"ref_99","first-page":"19","article-title":"Regulation of mitochondrial ATP synthase in cardiac pathophysiology","volume":"5","author":"Long","year":"2015","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"ref_100","first-page":"44","article-title":"Metabolic cardiology: An integrative strategy in the treatment of congestive heart failure","volume":"15","author":"Sinatra","year":"2009","journal-title":"Altern. Ther. Health Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"31761","DOI":"10.1074\/jbc.M401353200","article-title":"Mitochondrial atp synthasome: Three-dimensional structure by electron microscopy of the atp synthase in complex formation with carriers for pi and adp\/atp","volume":"279","author":"Chen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"13777","DOI":"10.1074\/jbc.M513369200","article-title":"Mitochondrial atp synthase. Crystal structure of the catalytic f1 unit in a vanadate-induced transition-like state and implications for mechanism","volume":"281","author":"Chen","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/15\/7964\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:35:11Z","timestamp":1760164511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/15\/7964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":102,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijms22157964"],"URL":"https:\/\/doi.org\/10.3390\/ijms22157964","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]}}}