{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:32:59Z","timestamp":1768278779700,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["082610"],"award-info":[{"award-number":["082610"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Proper cardiac function depends on the coordinated expression of multiple gene networks related to fuel utilization and mitochondrial ATP production, heart contraction, and ion transport. Key transcriptional regulators that regulate these gene networks have been identified. Among them, estrogen-related receptors (ERRs) have emerged as crucial modulators of cardiac function by regulating cellular metabolism and contraction machinery. Consistent with this role, lack of ERR\u03b1 or ERR\u03b3 results in cardiac derangements that lead to functional maladaptation in response to increased workload. Interestingly, metabolic inflexibility associated with diabetic cardiomyopathy has been recently associated with increased mitochondrial fatty acid oxidation and expression of ERR\u03b3, suggesting that sustained expression of this nuclear receptor could result in a cardiac pathogenic outcome. Here, we describe the generation of mice with cardiac-specific overexpression of ERR\u03b3, which die at young ages due to heart failure. ERR\u03b3 transgenic mice show signs of dilated cardiomyopathy associated with cardiomyocyte hypertrophy, increased cell death, and fibrosis. Our results suggest that ERR\u03b3 could play a role in mediating cardiac pathogenic responses.<\/jats:p>","DOI":"10.3390\/ijms22158047","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T05:23:48Z","timestamp":1627449828000},"page":"8047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cardiac-Specific Overexpression of ERR\u03b3 in Mice Induces Severe Heart Dysfunction and Early Lethality"],"prefix":"10.3390","volume":"22","author":[{"given":"Jaime","family":"Lasheras","sequence":"first","affiliation":[{"name":"Laboratory of Metabolism and Obesity, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-6037","authenticated-orcid":false,"given":"Rosario","family":"Pardo","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism and Obesity, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-7356","authenticated-orcid":false,"given":"Marc","family":"Velilla","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism and Obesity, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Poncelas","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Salvatella","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism and Obesity, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-3096","authenticated-orcid":false,"given":"Rafael","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"Unit of Diabetes and Metabolism, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"},{"name":"CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"Ruiz-Meana","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Zamora","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biomediques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-2985","authenticated-orcid":false,"given":"Josep A.","family":"Villena","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism and Obesity, Vall d\u2019Hebron\u2014Institut de Recerca, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"},{"name":"CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FJC.0b013e3181e74a14","article-title":"Energy Metabolic Phenotype of the Cardiomyocyte during Development, Differentiation, and Postnatal Maturation","volume":"56","author":"Lopaschuk","year":"2010","journal-title":"J. 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