{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:44:21Z","timestamp":1792399461100,"version":"4.4.0"},"reference-count":159,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Remarkable progress has been made in the treatment and control of hepatitis B and C viral infections. However, fundamental treatments for diseases in which liver fibrosis is a key factor, such as cirrhosis, alcoholic\/nonalcoholic steatohepatitis, autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis, are still under development and remain an unmet medical need. To solve this problem, it is essential to elucidate the pathogenesis of liver fibrosis in detail from a molecular and cellular perspective and to develop targeted therapeutic agents based on this information. Recently, microRNAs (miRNAs), functional RNAs of 22 nucleotides, have been shown to be involved in the pathogenesis of liver fibrosis. In addition, extracellular vesicles called \u201cexosomes\u201d have been attracting attention, and research is being conducted to establish noninvasive and extremely sensitive biomarkers using miRNAs in exosomes. In this review, we summarize miRNAs directly involved in liver fibrosis, miRNAs associated with diseases leading to liver fibrosis, and miRNAs related to complications of cirrhosis. We will also discuss the efficacy of each miRNA as a biomarker of liver fibrosis and pathology, and its potential application as a therapeutic agent.<\/jats:p>","DOI":"10.3390\/ijms22158139","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:47:46Z","timestamp":1627555666000},"page":"8139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Diagnosis and Therapeutic Management of Liver Fibrosis by MicroRNA"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9975-386X","authenticated-orcid":false,"given":"Tomoko","family":"Tadokoro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahiro","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s13205-020-02498-6","article-title":"Human microRNAs in host-parasite interaction: A review","volume":"10","author":"Paul","year":"2020","journal-title":"3 Biotech"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1053\/j.gastro.2012.02.017","article-title":"Noninvasive methods to assess liver disease in patients with hepatitis B or C","volume":"142","author":"Castera","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3748\/wjg.v26.i11.1113","article-title":"Circulating microRNAs as non-invasive biomarkers for hepatitis B virus liver fibrosis","volume":"26","author":"Iacob","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jgh3.12406","article-title":"Screening and follow-up of chronic liver diseases with understanding their etiology in clinics and hospitals","volume":"4","author":"Ogawa","year":"2020","journal-title":"JGH Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jhbp.245","article-title":"Recent advancement of molecular mechanisms of liver fibrosis","volume":"22","author":"Seki","year":"2015","journal-title":"J. Hepato Biliary Pancreat. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1065062","article-title":"An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans","volume":"294","author":"Lau","year":"2001","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Rauhut","year":"2001","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.bbadis.2018.01.009","article-title":"Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard?","volume":"1864","author":"Lambrecht","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41580-020-0251-y","article-title":"RNA delivery by extracellular vesicles in mammalian cells and its applications","volume":"21","author":"Breyne","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12929-019-0500-6","article-title":"Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: An emerging player in cancer metastasis","volume":"26","author":"Kogure","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"GBD 2013 Risk Factors Collaborators, Forouzanfar, M.H., Alexander, L., Anderson, H.R., Bachman, V.F., Biryukov, S., Brauer, M., Burnett, R., Casey, D., and Coates, M.M. (2015). Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 386, 2287\u20132323.","DOI":"10.1016\/S0140-6736(15)00128-2"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.3748\/wjg.v20.i23.7312","article-title":"Pathogenesis of liver cirrhosis","volume":"20","author":"Zhou","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fasebj.5.3.2001786","article-title":"Perisinusoidal stellate cells of the liver: Important roles in retinol metabolism and fibrosis","volume":"5","author":"Blomhoff","year":"1991","journal-title":"FASEB J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.immuni.2006.11.011","article-title":"Ito cells are liver-resident antigen-presenting cells for activating T cell responses","volume":"26","author":"Winau","year":"2007","journal-title":"Immunity"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kaps, L., and Schuppan, D. (2020). Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers. Cells, 9.","DOI":"10.3390\/cells9092027"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/hep.27043","article-title":"Long noncoding RNA in liver diseases","volume":"60","author":"Takahashi","year":"2014","journal-title":"Hepatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"McGeary, S.E., Lin, K.S., Shi, C.Y., Pham, T.M., Bisaria, N., Kelley, G.M., and Bartel, D.P. (2019). The biochemical basis of microRNA targeting efficacy. Science, 366.","DOI":"10.1126\/science.aav1741"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.clinbiochem.2013.01.025","article-title":"MicroRNAs in liver disease: From diagnostics to therapeutics","volume":"46","author":"Takahashi","year":"2013","journal-title":"Clin. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Oura, K., Morishita, A., and Masaki, T. (2020). Molecular and functional roles of microRNAs in the progression of hepatocellular carcinoma\u2014A review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218362"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Morishita, A., Oura, K., Tadokoro, T., Fujita, K., Tani, J., and Masaki, T. (2021). MicroRNAs in the pathogenesis of hepatocellular carcinoma: A review. Cancers, 13.","DOI":"10.3390\/cancers13030514"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Morishita, A., Oura, K., Tadokoro, T., Fujita, K., Tani, J., and Masaki, T. (2021). MicroRNA interference in hepatic host-pathogen interactions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073554"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"G401","DOI":"10.1152\/ajpgi.00269.2019","article-title":"Role of microRNA-210-3p in hepatitis B virus-related hepatocellular carcinoma","volume":"318","author":"Morishita","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/hepr.13078","article-title":"MicroRNAs as possible biomarkers for hepatocellular carcinoma","volume":"48","author":"Morishita","year":"2018","journal-title":"Hepatol. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3892\/ijo.2015.3036","article-title":"MicroRNA profiles in cisplatin-induced apoptosis of hepatocellular carcinoma cells","volume":"47","author":"Miyata","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3892\/or.2017.5977","article-title":"Telmisartan inhibits hepatocellular carcinoma cell proliferation In Vitro by inducing cell cycle arrest","volume":"38","author":"Oura","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kalluri, R., and LeBleu, V.S. (2020). The biology, function, and biomedical applications of exosomes. Science, 367.","DOI":"10.1126\/science.aau6977"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yamayoshi, A., Oyama, S., Kishimoto, Y., Konishi, R., Yamamoto, T., Kobori, A., Harada, H., Ashihara, E., Sugiyama, H., and Murakami, A. (2020). Development of antibody-oligonucleotide complexes for targeting exosomal microRNA. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12060545"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13075-016-0929-x","article-title":"MicroRNAs in fibrosis: Opportunities and challenges","volume":"18","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.18632\/oncotarget.2621","article-title":"MicroRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K\/AKT pathway","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_38","first-page":"1919","article-title":"Plasma microRNA: A novel non-invasive biomarker for HBV-associated liver fibrosis staging","volume":"17","author":"Wang","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"34935","DOI":"10.1038\/srep34935","article-title":"MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C","volume":"6","author":"Appourchaux","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"Roderburg","year":"2011","journal-title":"Hepatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.19082\/1804","article-title":"Circulating miRNAs as predictor markers for activation of hepatic stellate cells and progression of HCV-induced liver fibrosis","volume":"8","author":"Nagy","year":"2016","journal-title":"Electron. Physician"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Cermelli, S., Ruggieri, A., Marrero, J.A., Ioannou, G.N., and Beretta, L. (2011). Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023937"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Markovic, J., Sharma, A.D., and Balakrishnan, A. (2020). MicroRNA-221: A fine tuner and potential biomarker of chronic liver injury. Cells, 9.","DOI":"10.3390\/cells9081767"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Motawi, T.K., Shaker, O.G., El-Maraghy, S.A., and Senousy, M.A. (2015). Serum microRNAs as potential biomarkers for early diagnosis of hepatitis C virus-related hepatocellular carcinoma in Egyptian patients. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137706"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2217\/bmm-2018-0096","article-title":"Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma","volume":"12","author":"Yoon","year":"2018","journal-title":"Biomark. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Waidmann, O., Koberle, V., Brunner, F., Zeuzem, S., Piiper, A., and Kronenberger, B. (2012). Serum microRNA-122 predicts survival in patients with liver cirrhosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045652"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/MEG.0000000000001443","article-title":"Serum CD64 and ascitic fluid calprotectin and microRNA-155 as potential biomarkers of spontaneous bacterial peritonitis","volume":"31","author":"Nabiel","year":"2019","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"40556","DOI":"10.1038\/srep40556","article-title":"MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis","volume":"7","author":"Lutz","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/cncy.21966","article-title":"Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis","volume":"126","author":"Schindler","year":"2018","journal-title":"Cancer Cytopathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"178","DOI":"10.7150\/ijbs.24074","article-title":"MicroRNA-21-5p mediates TGF-beta-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury","volume":"14","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3892\/mmr.2015.3546","article-title":"Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression","volume":"12","author":"Zheng","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.18632\/oncotarget.23262","article-title":"MiR-27a as a predictor for the activation of hepatic stellate cells and hepatitis B virus-induced liver cirrhosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Oncotarget"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1007\/s10620-015-3649-1","article-title":"Serum miR-181b is correlated with hepatitis B virus replication and disease progression in chronic hepatitis B patients","volume":"60","author":"Yu","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.virusres.2018.06.007","article-title":"MiRNA-221 and miRNA-222 are promising biomarkers for progression of liver fibrosis in HCV Egyptian patients","volume":"253","author":"Zoheiry","year":"2018","journal-title":"Virus Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/15384047.2018.1423922","article-title":"Expression analysis of liver-specific circulating microRNAs in HCV-induced hepatocellular carcinoma in Egyptian patients","volume":"19","author":"Mourad","year":"2018","journal-title":"Cancer Biol. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/labinvest.2010.126","article-title":"Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans","volume":"90","author":"Marquez","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lee, E.B., Sung, P.S., Kim, J.H., Park, D.J., Hur, W., and Yoon, S.K. (2020). MicroRNA-99a restricts replication of hepatitis C virus by targeting mTOR and de novo Lipogenesis. Viruses, 12.","DOI":"10.3390\/v12070696"},{"key":"ref_58","first-page":"100814","article-title":"Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients","volume":"24","author":"Cabral","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.3748\/wjg.v21.i25.7814","article-title":"MiR-122 negatively correlates with liver fibrosis as detected by histology and FibroScan","volume":"21","author":"Halasz","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ramachandran, S., Ilias Basha, H., Sarma, N.J., Lin, Y., Crippin, J.S., Chapman, W.C., and Mohanakumar, T. (2013). Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070744"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.26296","article-title":"Up-regulation of circulating miR-20a is correlated with hepatitis C virus-mediated liver disease progression","volume":"58","author":"Shrivastava","year":"2013","journal-title":"Hepatology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"13729","DOI":"10.1038\/srep13729","article-title":"Effect of miR-34a in regulating steatosis by targeting PPARalpha expression in nonalcoholic fatty liver disease","volume":"5","author":"Ding","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Xin, S., Zhan, Q., Chen, X., Xu, J., and Yu, Y. (2020). Efficacy of serum miRNA test as a non-invasive method to diagnose nonalcoholic steatohepatitis: A systematic review and meta-analysis. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01334-8"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Gerhard, G.S., Hanson, A., Wilhelmsen, D., Piras, I.S., Still, C.D., Chu, X., Petrick, A.T., and DiStefano, J.K. (2019). AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219764"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1159\/000362970","article-title":"MicroRNA expression profiles related to early stage murine concanavalin A-induced hepatitis","volume":"33","author":"Jia","year":"2014","journal-title":"Cell Physiol. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3892\/mmr.2017.6606","article-title":"Galectin9 ameliorates fulminant liver injury","volume":"16","author":"Tadokoro","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"110558","DOI":"10.1016\/j.biopha.2020.110558","article-title":"MicroRNAs in autoimmune liver diseases: From diagnosis to potential therapeutic targets","volume":"130","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/s41418-017-0019-x","article-title":"MiRNA-21 ablation protects against liver injury and necroptosis in cholestasis","volume":"25","author":"Afonso","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/hep.30966","article-title":"MicroRNA-210 promotes bile acid-induced cholestatic liver injury by targeting mixed-lineage leukemia-4 methyltransferase in mice","volume":"71","author":"Kim","year":"2020","journal-title":"Hepatology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.3892\/mmr.2016.5606","article-title":"Identification of microRNA profiles associated with refractory primary biliary cirrhosis","volume":"14","author":"Sakamoto","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3892\/ijmm.2016.2610","article-title":"Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis","volume":"38","author":"Liang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Wang, X., Wen, X., Zhou, J., Qi, Y., Wu, R., Wang, Y., Kui, Y., Hua, R., and Jin, Q. (2017). MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184292"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/labinvest.2016.95","article-title":"MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis","volume":"96","author":"Katsumi","year":"2016","journal-title":"Lab. Investig."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1007\/s13277-016-5313-6","article-title":"Profiling of downregulated blood-circulating miR-150-5p as a novel tumor marker for cholangiocarcinoma","volume":"37","author":"Wu","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.15403\/jgld.2014.1121.272.cho","article-title":"Serum miRNA-122 is an independent biomarker of survival in patients with primary sclerosing cholangitis","volume":"27","author":"Friedrich","year":"2018","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/cei.12776","article-title":"Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma","volume":"185","author":"Bernuzzi","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Hayes, C.N., and Chayama, K. (2016). MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030280"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41419-018-0752-1","article-title":"MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression","volume":"9","author":"Ma","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3727\/105221616X693891","article-title":"Knockdown of miR-23, miR-27, and miR-24 alters fetal liver development and blocks fibrosis in mice","volume":"17","author":"Rogler","year":"2017","journal-title":"Gene Expr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1111\/jcmm.13278","article-title":"MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy","volume":"21","author":"Chen","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/mt.2016.127","article-title":"MiR-29a assists in preventing the activation of human stellate cells and promotes recovery from liver fibrosis in mice","volume":"24","author":"Matsumoto","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Lin, H.Y., Wang, F.S., Yang, Y.L., and Huang, Y.H. (2019). MicroRNA-29a suppresses CD36 to ameliorate high fat diet-induced steatohepatitis and liver fibrosis in mice. Cells, 8.","DOI":"10.3390\/cells8101298"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"212","DOI":"10.7150\/ijms.29930","article-title":"MicroRNA-29a is a key regulon that regulates BRD4 and mitigates liver fibrosis in mice by inhibiting hepatic stellate cell activation","volume":"16","author":"Huang","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/cbin.11022","article-title":"MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-beta1\/Smad3 pathway in hepatic stellate cells","volume":"42","author":"Feili","year":"2018","journal-title":"Cell Biol. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"Calvente","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.omtn.2019.05.001","article-title":"MiR-455-3p alleviates hepatic stellate cell activation and liver fibrosis by suppressing HSF1 expression","volume":"16","author":"Wei","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.aohep.2019.06.016","article-title":"MiR-125b acts as anti-fibrotic therapeutic target through regulating Gli3 In Vivo and In Vitro","volume":"18","author":"Hu","year":"2019","journal-title":"Ann. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1038\/ncomms10993","article-title":"MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression","volume":"7","author":"Hyun","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_89","first-page":"425","article-title":"Downregulation of miR-152 contributes to the progression of liver fibrosis via targeting Gli3 In Vivo and In Vitro","volume":"18","author":"Li","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/cvr\/cvr291","article-title":"Role of microRNAs in the reperfused myocardium towards post-infarct remodelling","volume":"94","author":"Zhu","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","article-title":"MiR-126 regulates angiogenic signaling and vascular integrity","volume":"15","author":"Fish","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/j.gastro.2017.09.022","article-title":"MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease","volume":"154","author":"Satishchandran","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gutjnl-2016-311861","article-title":"MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47(phox)-oxidative stress pathway in neutrophils","volume":"66","author":"Li","year":"2017","journal-title":"Gut"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2016.01.035","article-title":"The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis","volume":"64","author":"Bala","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/hep.29144","article-title":"MicroRNA 181b-3p and its target importin alpha5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol","volume":"66","author":"Saikia","year":"2017","journal-title":"Hepatology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1074\/jbc.M111.333534","article-title":"MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1","volume":"287","author":"Yin","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., and Her, G.M. (2021). MicroRNA-21 plays multiple oncometabolic roles in the process of NAFLD-related hepatocellular carcinoma via PI3K\/AKT, TGF-beta, and STAT3 signaling. Cancers, 13.","DOI":"10.3390\/cancers13050940"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Yang, Y.L., Kuo, H.C., Wang, F.S., and Huang, Y.H. (2019). MicroRNA-29a disrupts DNMT3b to ameliorate diet-induced non-alcoholic steatohepatitis in mice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061499"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/j.gastro.2020.05.056","article-title":"Agonist of RORA attenuates nonalcoholic fatty liver progression in mice via up-regulation of MicroRNA 122","volume":"159","author":"Chai","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"563265","DOI":"10.3389\/fgene.2020.563265","article-title":"Downregulated microRNA-129-5p by long non-coding RNA NEAT1 upregulates PEG3 expression to aggravate non-alcoholic steatohepatitis","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Genet."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1111\/jcmm.16376","article-title":"Inhibition of miR-188-5p alleviates hepatic fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN\/PI3K\/AKT pathway","volume":"25","author":"Riaz","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"He, Y., Rodrigues, R.M., Wang, X., Seo, W., Ma, J., Hwang, S., Fu, Y., Trojnar, E., Matyas, C., and Zhao, S. (2021). Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis. J. Clin. Investig., 131.","DOI":"10.1172\/JCI141513"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Benito-Vicente, A., Uribe, K.B., Rotllan, N., Ramirez, C.M., Jebari-Benslaiman, S., Goedeke, L., Canfran-Duque, A., Galicia-Garcia, U., Saenz De Urturi, D., and Aspichueta, P. (2020). MiR-27b modulates insulin signaling in hepatocytes by regulating insulin receptor expression. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228675"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jcb.27338","article-title":"Silencing of microRNA-375 affects immune function in mice with liver failure by upregulating astrocyte elevated gene-1 through reducing apoptosis of Kupffer cells","volume":"120","author":"Ke","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wang, Y.Q., Lan, Y.Y., Guo, Y.C., Yuan, Q.W., and Liu, P. (2019). Down-regulation of microRNA-138 improves immunologic function via negatively targeting p53 by regulating liver macrophage in mice with acute liver failure. Biosci. Rep., 39.","DOI":"10.1042\/BSR20190763"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.29573","article-title":"MicroRNA 15a\/16-1 suppresses aryl hydrocarbon receptor-dependent interleukin-22 secretion in CD4(+) T cells and contributes to immune-mediated organ injury","volume":"67","author":"Lu","year":"2018","journal-title":"Hepatology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.toxlet.2016.06.010","article-title":"MicroRNA-674-5p\/5-LO axis involved in autoimmune reaction of Concanavalin A-induced acute mouse liver injury","volume":"258","author":"Su","year":"2016","journal-title":"Toxicol. Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/jcmm.14750","article-title":"MicroRNA-143-3p attenuated development of hepatic fibrosis in autoimmune hepatitis through regulation of TAK1 phosphorylation","volume":"24","author":"Tu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1159\/000369658","article-title":"MicroRNA-223 acts as an important regulator to Kupffer cells activation at the early stage of Con A-induced acute liver failure via AIM2 signaling pathway","volume":"34","author":"Yang","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/hep.27262","article-title":"Activation of the developmental pathway neurogenin-3\/microRNA-7a regulates cholangiocyte proliferation in response to injury","volume":"60","author":"Marzioni","year":"2014","journal-title":"Hepatology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41419-018-1014-y","article-title":"MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis","volume":"9","author":"Navasa","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jss.2017.05.020","article-title":"Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2(-\/-) mice","volume":"217","author":"Hall","year":"2017","journal-title":"J. Surg. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"G491","DOI":"10.1152\/ajpgi.00140.2015","article-title":"Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1","volume":"309","author":"Chen","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.ajpath.2016.07.011","article-title":"Fibrogenic signaling is suppressed in hepatic stellate cells through targeting of connective tissue growth factor (CCN2) by cellular or exosomal microRNA-199a-5p","volume":"186","author":"Chen","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jcmgh.2015.07.007","article-title":"Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-gamma","volume":"1","author":"Povero","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/acer.13116","article-title":"Processing of miR17-92 cluster in hepatic stellate cells promotes hepatic fibrogenesis during alcohol-induced injury","volume":"40","author":"Feilen","year":"2016","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2015.09.166","article-title":"Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice","volume":"467","author":"Geiger","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1111\/jcmm.13208","article-title":"MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis","volume":"21","author":"Lou","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1461505","DOI":"10.1080\/20013078.2018.1461505","article-title":"Therapeutic effects of serum extracellular vesicles in liver fibrosis","volume":"7","author":"Chen","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"797898","DOI":"10.1155\/2014\/797898","article-title":"Therapeutic potential of microRNA: A new target to treat intrahepatic portal hypertension?","volume":"2014","author":"Guo","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2005-858989","article-title":"TGF-beta\/Smad signaling in the injured liver","volume":"44","author":"Breitkopf","year":"2006","journal-title":"Z. Gastroenterol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.3748\/wjg.15.4529","article-title":"Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis","volume":"15","author":"Liang","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jhep.2010.07.004","article-title":"Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?","volume":"53","author":"Thabut","year":"2010","journal-title":"J. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jceh.2014.12.008","article-title":"Portal vein thrombosis","volume":"5","author":"Chawla","year":"2015","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s11011-014-9545-0","article-title":"Acute liver failure-induced hepatic encephalopathy s associated with changes in microRNA expression rofiles in cerebral cortex of the mouse [corrected]","volume":"29","author":"Vemuganti","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s11011-016-9906-y","article-title":"New technologies\u2014New insights into the pathogenesis of hepatic encephalopathy","volume":"31","author":"Baker","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"18493","DOI":"10.1038\/srep18493","article-title":"Ammonia-induced miRNA expression changes in cultured rat astrocytes","volume":"6","author":"Oenarto","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/gut.32.3.294","article-title":"Natural history and prognostic factors for chronic hepatitis type B","volume":"32","author":"Fattovich","year":"1991","journal-title":"Gut"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Kanda, T., Goto, T., Hirotsu, Y., Moriyama, M., and Omata, M. (2019). Molecular mechanisms driving progression of liver cirrhosis towards hepatocellular carcinoma in chronic hepatitis B and C infections: A review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061358"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/gast.2003.50013","article-title":"Histological outcome during long-term lamivudine therapy","volume":"124","author":"Dienstag","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1053\/j.gastro.2006.09.020","article-title":"Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years","volume":"131","author":"Hadziyannis","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.3748\/wjg.v20.i23.7197","article-title":"Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity","volume":"20","author":"Jiang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Hayes, C.N., Akamatsu, S., Tsuge, M., Miki, D., Akiyama, R., Abe, H., Ochi, H., Hiraga, N., Imamura, M., and Takahashi, S. (2012). Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047490"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/jmv.23540","article-title":"Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B","volume":"85","author":"Arataki","year":"2013","journal-title":"J. Med. Virol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.bbagrm.2011.04.008","article-title":"Role of microRNAs in hepatitis B virus replication and pathogenesis","volume":"1809","author":"Liu","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/1566523214666141224095610","article-title":"MiR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir","volume":"15","author":"Thakral","year":"2015","journal-title":"Curr. Gene Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1111\/j.1365-2893.2011.01443.x","article-title":"Circulating microRNAs in hepatitis B virus-infected patients","volume":"18","author":"Ji","year":"2011","journal-title":"J. Viral Hepat."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/jmv.23551","article-title":"Association of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection","volume":"85","author":"Cheong","year":"2013","journal-title":"J. Med. Virol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.bbrc.2010.07.021","article-title":"MiR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV","volume":"398","author":"Qiu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_140","first-page":"742","article-title":"Expression of microRNA-122 and microRNA-22 in HBV-related liver cancer and the correlation with clinical features","volume":"21","author":"Qiao","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3389\/fimmu.2018.01334","article-title":"Correlation between the hepatic expression of human microRNA hsa-miR-125a-5p and the progression of fibrosis in patients with overt and occult HBV infection","volume":"9","author":"Coppola","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/hep.29690","article-title":"Global microRNA expression profiling in the liver biopsies of hepatitis B virus-infected patients suggests specific microRNA signatures for viral persistence and hepatocellular injury","volume":"67","author":"Singh","year":"2018","journal-title":"Hepatology"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/jvh.12696","article-title":"Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients","volume":"24","author":"Shaker","year":"2017","journal-title":"J. Viral Hepat."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Kunden, R.D., Khan, J.Q., Ghezelbash, S., and Wilson, J.A. (2020). The role of the liver-specific microRNA, miRNA-122 in the HCV replication cycle. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165677"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: Pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/hep.25873","article-title":"Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases","volume":"56","author":"Bala","year":"2012","journal-title":"Hepatology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1074\/jbc.M110.145870","article-title":"Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor \u03b1 (TNF\u03b1) production via increased mRNA half-life in alcoholic liver disease","volume":"286","author":"Bala","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.287.3.356","article-title":"Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey","volume":"287","author":"Ford","year":"2002","journal-title":"JAMA"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/hep4.1080","article-title":"Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis","volume":"1","author":"Kamada","year":"2017","journal-title":"Hepatol. Commun."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/qjmed\/hcp158","article-title":"Pathogenesis of non-alcoholic fatty liver disease","volume":"103","author":"Dowman","year":"2010","journal-title":"QJM"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1756284818815184","DOI":"10.1177\/1756284818815184","article-title":"Function and therapeutic advances of chemokine and its receptor in nonalcoholic fatty liver disease","volume":"11","author":"Chen","year":"2018","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.3390\/ijms15058591","article-title":"Evolving concepts in the pathogenesis of NASH: Beyond steatosis and inflammation","volume":"15","author":"Peverill","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.3748\/wjg.v24.i36.4104","article-title":"Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease","volume":"24","author":"Torres","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3892\/ijmm.2015.2092","article-title":"MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis","volume":"35","author":"Katsura","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"Zwiers","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/hep4.1497","article-title":"Integrated GWAS and mRNA microarray analysis identified IFNG and CD40L as the central upstream regulators in primary biliary cholangitis","volume":"4","author":"Ueno","year":"2020","journal-title":"Hepatol. Commun."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra050408","article-title":"Autoimmune hepatitis","volume":"354","author":"Krawitt","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2015). EASL Clinical Practice Guidelines: Autoimmune hepatitis. J. Hepatol., 63, 971\u20131004.","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/cmi.2015.86","article-title":"The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis","volume":"14","author":"Tomiyama","year":"2017","journal-title":"Cell. Mol. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/15\/8139\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:36:46Z","timestamp":1760164606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/15\/8139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":159,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijms22158139"],"URL":"https:\/\/doi.org\/10.3390\/ijms22158139","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}