{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:57:02Z","timestamp":1791899822146,"version":"4.3.4"},"reference-count":144,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Phospholipids (PLs) are amphiphilic molecules that were essential for life to become cellular. PLs have not only a key role in compartmentation as they are the main components of membrane, but they are also involved in cell signaling, cell metabolism, and even cell pathophysiology. Considered for a long time to simply be structural elements of membranes, phospholipids are increasingly being viewed as sensors of their environment and regulators of many metabolic processes. After presenting their main characteristics, we expose the increasing methods of PL detection and identification that help to understand their key role in life processes. Interest and importance of PL homeostasis is growing as pathogenic variants in genes involved in PL biosynthesis and\/or remodeling are linked to human diseases. We here review diseases that involve deregulation of PL homeostasis and present a predominantly muscular phenotype.<\/jats:p>","DOI":"10.3390\/ijms22158176","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T03:46:42Z","timestamp":1627616802000},"page":"8176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Phospholipids: Identification and Implication in Muscle Pathophysiology"],"prefix":"10.3390","volume":"22","author":[{"given":"Rezl\u00e8ne","family":"Bargui","sequence":"first","affiliation":[{"name":"Basic and Translational Myology Laboratory, CNRS UMR8251, Universit\u00e9 de Paris, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Solgadi","sequence":"additional","affiliation":[{"name":"UMS-IPSIT-SAMM, Universit\u00e9 Paris-Saclay, INSERM, CNRS, Ing\u00e9nierie et Plateformes au Service de l\u2019Innovation Th\u00e9rapeutique, F-92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-2844","authenticated-orcid":false,"given":"Bastien","family":"Prost","sequence":"additional","affiliation":[{"name":"UMS-IPSIT-SAMM, Universit\u00e9 Paris-Saclay, INSERM, CNRS, Ing\u00e9nierie et Plateformes au Service de l\u2019Innovation Th\u00e9rapeutique, F-92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Chester","sequence":"additional","affiliation":[{"name":"Basic and Translational Myology Laboratory, CNRS UMR8251, Universit\u00e9 de Paris, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-5386","authenticated-orcid":false,"given":"Ana","family":"Ferreiro","sequence":"additional","affiliation":[{"name":"Basic and Translational Myology Laboratory, CNRS UMR8251, Universit\u00e9 de Paris, F-75013 Paris, France"},{"name":"AP-HP, Reference Centre for Neuromuscular Disorders, Institute of Myology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-8683","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Piquereau","sequence":"additional","affiliation":[{"name":"Signalling and Cardiovascular Pathophysiology, INSERM UMR1180, Universit\u00e9 Paris-Saclay, F-92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1851-8727","authenticated-orcid":false,"given":"Maryline","family":"Moulin","sequence":"additional","affiliation":[{"name":"Basic and Translational Myology Laboratory, CNRS UMR8251, Universit\u00e9 de Paris, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3181\/00379727-17-75","article-title":"Outline of a classification of the lipids","volume":"17","author":"Bloor","year":"1920","journal-title":"Proc. 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