{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:54:39Z","timestamp":1771235679199,"version":"3.50.1"},"reference-count":97,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX003304"],"award-info":[{"award-number":["BX003304"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dopamine D1 receptor (D1R) function is regulated by membrane\/lipid raft-resident protein caveolin-1 (Cav1). We examined whether altered expression of Cav1 in the dorsal striatum would affect self-administration of methamphetamine, an indirect agonist at the D1Rs. A lentiviral construct expressing Cav1 (LV-Cav1) or containing a short hairpin RNA against Cav1 (LV-shCav1) was used to overexpress or knock down Cav1 expression respectively, in the dorsal striatum. Under a fixed-ratio schedule, LV-Cav1 enhanced and LV-shCav1 reduced responding for methamphetamine in an extended access paradigm compared to LV-GFP controls. LV-Cav1 and LV-shCav1 also produced an upward and downward shift in a dose\u2013response paradigm, generating a drug vulnerable\/resistant phenotype. LV-Cav1 and LV-shCav1 did not alter responding for sucrose. Under a progressive-ratio schedule, LV-shCav1 generally reduced positive-reinforcing effects of methamphetamine and sucrose as seen by reduced breakpoints. Western blotting confirmed enhanced Cav1 expression in LV-Cav1 rats and reduced Cav1 expression in LV-shCav1 rats. Electrophysiological findings in LV-GFP rats demonstrated an absence of high-frequency stimulation (HFS)-induced long-term potentiation (LTP) in the dorsal striatum after extended access methamphetamine self-administration, indicating methamphetamine-induced occlusion of plasticity. LV-Cav1 prevented methamphetamine-induced plasticity via increasing phosphorylation of calcium calmodulin kinase II, suggesting a mechanism for addiction vulnerability. LV-shCav1 produced a marked deficit in the ability of HFS to produce LTP and, therefore, extended access methamphetamine was unable to alter striatal plasticity, indicating a mechanism for resistance to addiction-like behavior. Our results demonstrate that Cav1 expression and knockdown driven striatal plasticity assist with modulating addiction to drug and nondrug rewards, and inspire new strategies to reduce psychostimulant addiction.<\/jats:p>","DOI":"10.3390\/ijms22158219","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T12:59:24Z","timestamp":1627649964000},"page":"8219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Caveolin-1 Expression in the Dorsal Striatum Drives Methamphetamine Addiction-Like Behavior"],"prefix":"10.3390","volume":"22","author":[{"given":"Yosef","family":"Avchalumov","sequence":"first","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison D.","family":"Kreisler","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulfran","family":"Trenet","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahasweta","family":"Nayak","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P.","family":"Head","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA"},{"name":"Department of Anesthesiology, University of California San Diego, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-7377","authenticated-orcid":false,"given":"Juan C.","family":"Pi\u00f1a-Crespo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-205X","authenticated-orcid":false,"given":"Chitra D.","family":"Mandyam","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA"},{"name":"Department of Anesthesiology, University of California San Diego, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1126\/science.1102384","article-title":"Addiction as a computational process gone awry","volume":"306","author":"Redish","year":"2004","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1749-6632.1999.tb07876.x","article-title":"Stress, corticotropin-releasing factor, and drug addiction","volume":"897","author":"Koob","year":"1999","journal-title":"Ann. 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