{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:41:10Z","timestamp":1788489670555,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009624","name":"Yonsei University College of Dentistry","doi-asserted-by":"publisher","award":["6-2019-0006"],"award-info":[{"award-number":["6-2019-0006"]}],"id":[{"id":"10.13039\/501100009624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Replacement and inflammatory resorption are serious complications associated with the delayed replantation of avulsed teeth. In this study, we aimed to assess whether deferoxamine (DFO) can suppress inflammation and osteoclastogenesis in vitro and attenuate inflammation and bone resorption in a replanted rat tooth model. Cell viability and inflammation were evaluated in RAW264.7 cells. Osteoclastogenesis was confirmed by tartrate-resistant acid phosphatase staining, reactive oxygen species (ROS) measurement, and quantitative reverse transcriptase\u2013polymerase chain reaction in teeth exposed to different concentrations of DFO. In vivo, molars of 31 six-week-old male Sprague\u2013Dawley rats were extracted and stored in saline (n = 10) or DFO solution (n = 21) before replantation. Micro-computed tomography (micro-CT) imaging and histological analysis were performed to evaluate inflammation and root and alveolar bone resorption. DFO downregulated the genes related to inflammation and osteoclastogenesis. DFO also reduced ROS production and regulated specific pathways. Furthermore, the results of the micro-CT and histological analyses provided evidence of the decrease in inflammation and hard tissue resorption in the DFO group. Overall, these results suggest that DFO reduces inflammation and osteoclastogenesis in a tooth replantation model, and thus, it has to be further investigated as a root surface treatment option for an avulsed tooth.<\/jats:p>","DOI":"10.3390\/ijms22158225","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T12:59:24Z","timestamp":1627649964000},"page":"8225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Deferoxamine Reduces Inflammation and Osteoclastogenesis in Avulsed Teeth"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5641-4443","authenticated-orcid":false,"given":"Ko Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea"},{"name":"Department of Pediatric Dentistry, Kyung Hee University Dental Hospital, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghan","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-5082","authenticated-orcid":false,"given":"Hyo-Seol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Kyung Hee University Dental Hospital, Seoul 02447, Korea"},{"name":"Department of Pediatric Dentistry, Kyung Hee University School of Dentistry, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijeong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea"},{"name":"Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-5629","authenticated-orcid":false,"given":"Je Seon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea"},{"name":"Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Jun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea"},{"name":"Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-6403","authenticated-orcid":false,"given":"Hyunsoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-3741","authenticated-orcid":false,"given":"Chung-Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul 03722, Korea"},{"name":"Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-9657.2011.01053.x","article-title":"Periodontal healing following avulsion and replantation of teeth: A multi-centre randomized controlled trial to compare two root canal medicaments","volume":"28","author":"Day","year":"2012","journal-title":"Dent. 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