{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:44:28Z","timestamp":1788965068556,"version":"build-2803163510"},"reference-count":113,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Honeybee venom is a source of proteins with allergenic properties which can result in in various symptoms, ranging from local reactions through to systematic life-threatening anaphylaxis, or even death. According to the World Allergy Organization (WAO), honeybee venom allergy is one of the most common causes of anaphylaxis. Among the proteins present in honeybee venom, 12 protein fractions were registered by the World Health Organization\u2019s Allergen Nomenclature Sub-Committee (WHO\/IUIS) as allergenic. Most of them are highly immunogenic glycoproteins that cross-react with IgE and, as a consequence, may give false positive results in allergy diagnosis. Allergenic fractions are different in terms of molecular weight and biological activity. Eight of these allergenic fractions have also been identified in honey. This explains frequent adverse reactions after consuming honey in people allergic to venom and sheds new light on the causes of allergic symptoms in some individuals after honey consumption. At the same time, it also indicates the possibility of using honey as a natural source of allergen in specific immunotherapy.<\/jats:p>","DOI":"10.3390\/ijms22168371","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T08:47:52Z","timestamp":1628066872000},"page":"8371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["A Review of Honeybee Venom Allergens and Allergenicity"],"prefix":"10.3390","volume":"22","author":[{"given":"Marta","family":"Burzy\u0144ska","sequence":"first","affiliation":[{"name":"Department of Food Biochemistry and Analysis, Poznan University of Life Sciences, Mazowiecka 48 str., 60-623 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4848-6957","authenticated-orcid":false,"given":"Dorota","family":"Piasecka-Kwiatkowska","sequence":"additional","affiliation":[{"name":"Department of Food Biochemistry and Analysis, Poznan University of Life Sciences, Mazowiecka 48 str., 60-623 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.all.0000173783.42906.95","article-title":"Bee Venom Allergy in Beekeepers and Their Family Members","volume":"5","author":"Muller","year":"2005","journal-title":"Curr. 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