{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:16:57Z","timestamp":1770999417840,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1052716"],"award-info":[{"award-number":["2020R1F1A1052716"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brain Korea 21 Four","award":["5199990614277"],"award-info":[{"award-number":["5199990614277"]}]},{"name":"Regional Innovation Strategy","award":["2020RIS0188, 2021RIS0096"],"award-info":[{"award-number":["2020RIS0188, 2021RIS0096"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The nucleus accumbens core (NAcc) is an important component of brain reward circuitry, but studies have revealed its involvement in pain circuitry also. However, its effect on trigeminal neuralgia (TN) and the mechanism underlying it are yet to be fully understood. Therefore, this study aimed to examine the outcomes of optogenetic stimulation of NAcc GABAergic neurons in an animal model of TN. Animals were allocated into TN, sham, and control groups. TN was generated by infraorbital nerve constriction and the optogenetic virus was injected into the NAcc. In vivo extracellular recordings were acquired from the ventral posteromedial nucleus of the thalamus. Alterations of behavioral responses during stimulation \u201cON\u201d and \u201cOFF\u201d conditions were evaluated. In vivo microdialysis was performed in the NAcc of TN and sham animals. During optogenetic stimulation, electrophysiological recordings revealed a reduction of both tonic and burst firing activity in TN animals, and significantly improved behavioral responses were observed as well. Microdialysis coupled with liquid chromatography\/tandem mass spectrometry analysis revealed significant alterations in extracellular concentration levels of GABA, glutamate, acetylcholine, dopamine, and citrulline in NAcc upon optic stimulation. In fine, our results suggested that NAcc stimulation could modulate the transmission of trigeminal pain signals in the TN animal model.<\/jats:p>","DOI":"10.3390\/ijms22168421","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:35:32Z","timestamp":1628156132000},"page":"8421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Stimulating GABAergic Neurons in the Nucleus Accumbens Core Alters the Trigeminal Neuropathic Pain Responses in a Rat Model of Infraorbital Nerve Injury"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-8608","authenticated-orcid":false,"given":"Jaisan","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju 28644, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"KC","sequence":"additional","affiliation":[{"name":"Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju 28644, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soochong","family":"Kim","sequence":"additional","affiliation":[{"name":"ISCRM, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyong Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology, College of Medicine, Chungbuk National University, Cheongju 28644, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju 28644, Korea"},{"name":"ISCRM, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea"},{"name":"Department of Neurosurgery, Chungbuk National University Hospital, Cheongju 28644, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0304-3959(98)00172-9","article-title":"Pharmacological studies on a rat model of trigeminal neuropathic pain: Baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour","volume":"79","author":"Guilbaud","year":"1999","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-020-01174-7","article-title":"Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with\/without CGRP knock-down","volume":"21","author":"Islam","year":"2020","journal-title":"J. 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