{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:45:42Z","timestamp":1792122342535,"version":"4.4.0"},"reference-count":193,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RTI2018-097189-C2-2"],"award-info":[{"award-number":["RTI2018-097189-C2-2"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["201880E109  and 201980E030"],"award-info":[{"award-number":["201880E109  and 201980E030"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (&gt;10, &lt;28 \u00b0C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity. An increased number of experimental results indicate the implication of TRPM8 channels in cold thermal transduction and pain detection, transmission, and maintenance in different tissues and organs. These channels also have a repercussion on different kinds of life-threatening tumors and other pathologies, which include urinary and respiratory tract dysfunctions, dry eye disease, and obesity. This compendium firstly covers newly described papers on the expression of TRPM8 channels and their correlation with pathological states. An overview on the structural knowledge, after cryo-electron microscopy success in solving different TRPM8 structures, as well as some insights obtained from mutagenesis studies, will follow. Most recently described families of TRPM8 modulators are also covered, along with a section of molecules that have reached clinical trials. To finalize, authors provide an outline of the potential prospects in the TRPM8 field.<\/jats:p>","DOI":"10.3390\/ijms22168502","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T21:49:41Z","timestamp":1628459381000},"page":"8502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation"],"prefix":"10.3390","volume":"22","author":[{"given":"Carolina","family":"Izquierdo","sequence":"first","affiliation":[{"name":"Departamento de Biomim\u00e9ticos, Instituto de Qu\u00edmica M\u00e9dica, Juan de la Cierva 3, 28006 Madrid, Spain"},{"name":"Programa de Doctorado en Qu\u00edmica Org\u00e1nica, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Mart\u00edn-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Biomim\u00e9ticos, Instituto de Qu\u00edmica M\u00e9dica, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-2606","authenticated-orcid":false,"given":"Isabel","family":"G\u00f3mez-Monterrey","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, Via D. Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-4328","authenticated-orcid":false,"given":"Rosario","family":"Gonz\u00e1lez-Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Departamento de Biomim\u00e9ticos, Instituto de Qu\u00edmica M\u00e9dica, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.tips.2004.10.004","article-title":"The TRPM ion channel subfamily: Molecular, biophysical and functional features","volume":"25","author":"Fleig","year":"2004","journal-title":"Trends Pharmacol. 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