{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:58:45Z","timestamp":1790719125057,"version":"4.1.0"},"reference-count":202,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2018-06218"],"award-info":[{"award-number":["2018-06218"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["284011"],"award-info":[{"award-number":["284011"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Locomotion results in an alternance of flexor and extensor muscles between left and right limbs generated by motoneurons that are controlled by the spinal interneuronal circuit. This spinal locomotor circuit is modulated by sensory afferents, which relay proprioceptive and cutaneous inputs that inform the spatial position of limbs in space and potential contacts with our environment respectively, but also by supraspinal descending commands of the brain that allow us to navigate in complex environments, avoid obstacles, chase prey, or flee predators. Although signaling pathways are important in the establishment and maintenance of motor circuits, the role of DSCAM, a cell adherence molecule associated with Down syndrome, has only recently been investigated in the context of motor control and locomotion in the rodent. DSCAM is known to be involved in lamination and delamination, synaptic targeting, axonal guidance, dendritic and cell tiling, axonal fasciculation and branching, programmed cell death, and synaptogenesis, all of which can impact the establishment of motor circuits during development, but also their maintenance through adulthood. We discuss herein how DSCAM is important for proper motor coordination, especially for breathing and locomotion.<\/jats:p>","DOI":"10.3390\/ijms22168511","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T21:49:41Z","timestamp":1628459381000},"page":"8511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of DSCAM in the Development of Neural Control of Movement and Locomotion"],"prefix":"10.3390","volume":"22","author":[{"given":"Maxime","family":"Lemieux","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Thiry","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3413-2226","authenticated-orcid":false,"given":"Olivier D.","family":"Laflamme","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bretzner","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, CHUL-Neurosciences P09800, 2705 boul. Laurier, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Department of Psychiatry and Neurosciences, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0092-8674(00)80878-8","article-title":"Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity","volume":"101","author":"Schmucker","year":"2000","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(02)01183-2","article-title":"Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam","volume":"37","author":"Hummel","year":"2003","journal-title":"Neuron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neuron.2004.07.020","article-title":"Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies","volume":"43","author":"Zhan","year":"2004","journal-title":"Neuron"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1242\/dev.023739","article-title":"Dscam guides embryonic axons by Netrin-dependent and -independent functions","volume":"135","author":"Andrews","year":"2008","journal-title":"Development"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fnmol.2012.00086","article-title":"DSCAMs: Restoring balance to developmental forces","volume":"5","author":"Garrett","year":"2012","journal-title":"Front. 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