{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:14:35Z","timestamp":1788462875829,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent data demonstrate the anabolic effect of oxytocin on bone. Bone cells express oxytocin receptors. Oxytocin promotes osteoblasts differentiation and function, leading to an increased bone formation with no effect on bone resorption and an improvement of bone microarchitecture. Oxytocin is synthetized by osteoblasts, and this synthesis is stimulated by estrogen. Animal studies demonstrate a direct action of oxytocin on bone, as the systemic administration of oxytocin prevents and reverses the bone loss induced by estrogen deficiency. Although oxytocin is involved in bone formation in both sexes during development, oxytocin treatment has no effect on male osteoporosis, underlining the importance of estrogen that amplifies its local autocrine and paracrine secretion. There are few human data showing a decrease in the oxytocin serum level in anorexia nervosa independently of estrogen and in amenorrheic women associated with impaired bone microarchitecture; in post-menopausal women a higher oxytocin serum level is associated with higher bone density, but not in osteoporotic men. Oxytocin displays many effects that may be beneficial in the management of osteoporosis, cardiovascular diseases, cognitive disorders, breast cancer, diabetes and body fat gain, all age-related diseases affecting elderly women, opening exciting therapeutic perspectives, although the issue is to find a single route, dosage and schedule able to reach all these targets.<\/jats:p>","DOI":"10.3390\/ijms22168551","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T09:03:53Z","timestamp":1628499833000},"page":"8551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Oxytocin and Bone: Review and Perspectives"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-2739","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Breuil","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Nice, UMR E-4320 TIRO-MATOs CEA\/DRF\/Institut Joliot, Universit\u00e9 C\u00f4te d\u2019Azur, CEDEX 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Charlotte","family":"Trojani","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Nice, UMR E-4320 TIRO-MATOs CEA\/DRF\/Institut Joliot, Universit\u00e9 C\u00f4te d\u2019Azur, CEDEX 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8426-5396","authenticated-orcid":false,"given":"Amri","family":"Ez-Zoubir","sequence":"additional","affiliation":[{"name":"French National Centre for Scientific Research (CNRS), Inserm, iBV, Universit\u00e9 C\u00f4te d\u2019Azur, CEDEX 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/pr.120.019398","article-title":"Is Oxytocin \u00abNature\u2019s Medicine\u00bb?","volume":"72","author":"Carter","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Elabd, S., and Sabry, I. (2015). Two Birds with One Stone: Possible Dual-Role of Oxytocin in the Treatment of Diabetes and Osteoporosis. Front. Endocrinol., 6.","DOI":"10.3389\/fendo.2015.00121"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet Lond. Engl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tem.2017.02.007","article-title":"Oxytocin\u2014The Sweet Hormone?","volume":"28","author":"Leng","year":"2017","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1073\/pnas.1523762113","article-title":"Functions of vasopressin and oxytocin in bone mass regulation","volume":"113","author":"Sun","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1073\/pnas.1419349111","article-title":"Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor","volume":"111","author":"Sun","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dungan, K., Grossman, A., Hershman, J.M., Hofland, J., and Kalra, S. (2000). The Epidemiology and Pathogenesis of Osteoporosis. Endotext, MDText.com, Inc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40618-019-01041-6","article-title":"State of the art in osteoporosis risk assessment and treatment","volume":"42","author":"Liu","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1210\/endo.140.9.7130","article-title":"Functional oxytocin receptors discovered in human osteoblasts","volume":"140","author":"Copland","year":"1999","journal-title":"Endocrinology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0006-291X(02)02009-0","article-title":"Human osteoclasts express oxytocin receptor","volume":"297","author":"Colucci","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1634\/stemcells.2008-0127","article-title":"Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis","volume":"26","author":"Elabd","year":"2008","journal-title":"Stem Cells"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1073\/pnas.0901890106","article-title":"Oxytocin is an anabolic bone hormone","volume":"106","author":"Tamma","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R970","DOI":"10.1152\/ajpregu.00040.2014","article-title":"Oxytocin and bone","volume":"307","author":"Colaianni","year":"2014","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1016\/S0021-9258(19)39297-X","article-title":"The human oxytocin gene promoter is regulated by estrogens","volume":"265","author":"Richard","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The Oxytocin Receptor System: Structure, Function, and Regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbrc.2011.06.158","article-title":"Regulated production of the pituitary hormone oxytocin from murine and human osteoblasts","volume":"411","author":"Colaianni","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1196\/annals.1346.019","article-title":"Direct and Indirect Estrogen Actions on Osteoblasts and Osteoclasts","volume":"1068","author":"Zallone","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1530\/JOE-17-0680","article-title":"Actions of pituitary hormones beyond traditional targets","volume":"237","author":"Zaidi","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jne.12120","article-title":"The Oxytocin-Bone Axis","volume":"26","author":"Colaianni","year":"2014","journal-title":"J. Neuroendocr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1210\/en.2013-1688","article-title":"Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat Gain","volume":"155","author":"Beranger","year":"2014","journal-title":"Endocrinology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.29252\/rbmb.9.2.147","article-title":"Protective Effect of Oxytocin Against Bone Loss in a Female Rat Model of Osteoporosis","volume":"9","author":"Moghazy","year":"2020","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12891-019-2861-0","article-title":"Bone microarchitectural parameters can detect oxytocin induced changes prior to bone density on mitigating bone deterioration in rabbit osteoporosis model using micro-CT","volume":"20","author":"Qiu","year":"2019","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Beranger, G., Djedaini, M., Battaglia, S., Roux, C.H., Scheideler, M., Heymann, D., Amri, E.-Z., and Pisani, D.F. (2015). Oxytocin Reverses Osteoporosis in a Sex-Dependent Manner. Front. Endocrinol., 6.","DOI":"10.3389\/fendo.2015.00081"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/03008207.2016.1141902","article-title":"The effect of oxytocin on osseointegration of titanium implant in ovariectomized rats","volume":"57","author":"Wang","year":"2016","journal-title":"Connect. Tissue Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/jor.24607","article-title":"Oxytocin-loaded sustained-release hydrogel graft provides accelerated bone formation: An experimental rat study","volume":"38","author":"Akay","year":"2020","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biochi.2020.08.004","article-title":"Osteoporosis: A role for lipids","volume":"178","author":"During","year":"2020","journal-title":"Biochimie"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1515\/hmbci-2016-0045","article-title":"Control of bone and fat mass by oxytocin","volume":"28","author":"Amri","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-physiol-021119-034513","article-title":"Marrow Adipocytes: Origin, Structure, and Function","volume":"82","author":"Rosen","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00198-014-2933-9","article-title":"Longitudinal assessment of oxytocin efficacy on bone and bone marrow fat masses in a rabbit osteoporosis model through 3.0-T magnetic resonance spectroscopy and micro-CT","volume":"26","author":"Qiu","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.4088\/JCP.10m06617","article-title":"Decreased Nocturnal Oxytocin Levels in Anorexia Nervosa Are Associated With Low Bone Mineral Density and Fat Mass","volume":"72","author":"Lawson","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jbspin.2011.02.002","article-title":"Oxytocin and bone remodelling: Relationships with neuropituitary hormones, bone status and body composition","volume":"78","author":"Breuil","year":"2011","journal-title":"Jt. Bone Spine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1530\/EJE-12-0869","article-title":"Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters","volume":"168","author":"Lawson","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"E634","DOI":"10.1210\/jc.2013-4126","article-title":"Oxytocin, a New Determinant of Bone Mineral Density in Post-Menopausal Women: Analysis of the OPUS Cohort","volume":"99","author":"Breuil","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s00198-015-3201-3","article-title":"Oxytocin and bone status in men: Analysis of the MINOS cohort","volume":"26","author":"Breuil","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000492001","article-title":"Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables","volume":"11","author":"Maestrini","year":"2018","journal-title":"Obes. Facts"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000506638","article-title":"Lower Oxytocin Levels Are Associated with Lower Bone Mineral Density and Less Favorable Hip Geometry in Hypopituitary Men","volume":"111","author":"Aulinas","year":"2021","journal-title":"Neuroendocrinology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1210\/er.2014-1024","article-title":"Sex Steroid Actions in Male Bone","volume":"35","author":"Vanderschueren","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3390\/ijms22041568","article-title":"Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications","volume":"22","author":"Emmanuelle","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref_39","first-page":"1","article-title":"Anorexia Nervosa and Osteoporosis","volume":"5","author":"Hung","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Jankowski, M., Broderick, T.L., and Gutkowska, J. (2020). The Role of Oxytocin in Cardiovascular Protection. Front. Psychol., 11.","DOI":"10.3389\/fpsyg.2020.02139"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/2045125316672574","article-title":"Oxytocin for frontotemporal dementia: A systematic review","volume":"7","author":"Tampi","year":"2016","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jnen\/nlz023","article-title":"Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia","volume":"78","author":"McKay","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"McKay, E.C., and Counts, S.E. (2020). Oxytocin Receptor Signaling in Vascular Function and Stroke. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.574499"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Abramova, O., Zorkina, Y., Ushakova, V., Zubkov, E., Morozova, A., and Chekhonin, V. (2020). The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders. Neuropeptides, 83.","DOI":"10.1016\/j.npep.2020.102079"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1038\/s41388-020-01415-8","article-title":"The oxytocin receptor signalling system and breast cancer: A critical review","volume":"39","author":"Liu","year":"2020","journal-title":"Oncogene"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yang, F., Li, N., Gaman, M.-A., and Wang, N. (2021). Raloxifene has favorable effects on the lipid profile in women explaining its beneficial effect on cardiovascular risk: A meta-analysis of randomized controlled trials. Pharmacol. Res., 166.","DOI":"10.1016\/j.phrs.2021.105512"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1007\/s00198-020-05497-8","article-title":"Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?","volume":"31","author":"Rozenberg","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1056\/NEJMcp1714787","article-title":"Hormone Therapy for Postmenopausal Women","volume":"382","author":"Pinkerton","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Davis, S.R., Lambrinoudaki, I., Lumsden, M., Mishra, G.D., Pal, L., Rees, M., Santoro, N., and Simoncini, T. (2015). Menopause. Nat. Rev. Dis. Prim., 1.","DOI":"10.1038\/nrdp.2015.4"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Mancuso, P., and Bouchard, B. (2019). The Impact of Aging on Adipose Function and Adipokine Synthesis. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00137"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Pugliese, G., Barrea, L., Laudisio, D., Aprano, S., Castellucci, B., Framondi, L., di Matteo, R., Savastano, S., Colao, A., and Muscogiur, G. (2020). Mediterranean diet as tool to manage obesity in menopause: A narrative review. Nutrition, 79\u201380.","DOI":"10.1016\/j.nut.2020.110991"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ajog.2019.04.023","article-title":"Fat mass changes during menopause: A metaanalysis","volume":"221","author":"Ambikairajah","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.mayocp.2017.08.004","article-title":"Weight Gain in Women at Midlife: A Concise Review of the Pathophysiology and Strategies for Management","volume":"92","author":"Kapoor","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1038\/s41598-020-64683-0","article-title":"Oxytocin and bone quality in the femoral neck of rats in periestropause","volume":"10","author":"Fernandes","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hidalgo-Mora, J.J., Cort\u00e9s-Sierra, L., Garc\u00eda-P\u00e9rez, M.-\u00c1., Tar\u00edn, J.J., and Cano, A. (2020). Diet to Reduce the Metabolic Syndrome Associated with Menopause. The Logic for Olive Oil. Nutrients, 12.","DOI":"10.3390\/nu12103184"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e12805","DOI":"10.1111\/jne.12805","article-title":"The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis","volume":"32","author":"Lawson","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"26808","DOI":"10.1073\/pnas.1913611116","article-title":"Oxytocin regulates body composition","volume":"116","author":"Sun","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2019.10.012","article-title":"Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review","volume":"108","author":"Horta","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Panaro, M.A., Benameur, T., and Porro, C. (2020). Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051534"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/17446651.2020.1772051","article-title":"Updates in epidemiology, pathophysiology and management strategies of glucocorticoid-induced osteoporosis","volume":"15","author":"Chiodini","year":"2020","journal-title":"Expert. Rev. Endocrinol. Metab."},{"key":"ref_61","first-page":"71","article-title":"Diabetes and Bone Fragility","volume":"12","author":"Mendivil","year":"2021","journal-title":"Diabetes Ther. Res. Treat. Educ. Diabetes Relat. Disord."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1042\/CS20200220","article-title":"Bone marrow fat: Friend or foe in people with diabetes mellitus?","volume":"134","author":"Santopaolo","year":"2020","journal-title":"Clin. Sci. Lond. Engl."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1111\/1756-185X.13680","article-title":"Management of glucocorticoid-induced osteoporosis: What is new?","volume":"22","author":"Compston","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Piotrowska, K., and Tarnowski, M. (2021). Bone Marrow Adipocytes-Role in Physiology and Various Nutritional Conditions in Human and Animal Models. Nutrients, 13.","DOI":"10.3390\/nu13051412"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"Napoli","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bone.2014.06.014","article-title":"Marrow fat composition in anorexia nervosa","volume":"66","author":"Bredella","year":"2014","journal-title":"Bone"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1530\/EJE-18-0824","article-title":"Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa","volume":"180","author":"Fazeli","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s00213-020-05626-5","article-title":"Potential shortcomings in current studies on the effect of intranasal oxytocin in Anorexia Nervosa and healthy controls\u2014A systematic review and meta-analysis","volume":"237","author":"Hasselbalch","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1212\/WNL.0000000000001133","article-title":"Oxytocin for frontotemporal dementia: A randomized dose-finding study of safety and tolerability","volume":"84","author":"Finger","year":"2015","journal-title":"Neurology"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Mohan, S., McCloskey, A.G., McKillop, A.M., Flatt, P.R., Irwin, N., and Moffett, R.C. (2021). Development and characterisation of novel, enzymatically stable oxytocin analogues with beneficial antidiabetic effects in high fat fed mice. Biochim. Biophys. Acta Gen. Subj., 1865.","DOI":"10.1016\/j.bbagen.2020.129811"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.2147\/IJN.S198116","article-title":"In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: A potential novel treatment for obstetric complications","volume":"14","author":"Hua","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"34710","DOI":"10.1038\/srep34710","article-title":"Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice","volume":"6","author":"Refuerzo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Sharma, S., Masud, M.K., Kaneti, Y.V., Rewatkar, P., Koradia, A., Hossain, M.S.A., Yamauchi, Y., Popat, A., and Salomon, C. (2021). Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications. 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