{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:17:07Z","timestamp":1787876227726,"version":"build-2784847793"},"reference-count":35,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In our previous work, we built the model of PPAR\u03b3 dependent pathways involved in the development of the psoriatic lesions. Peroxisome proliferator-activated receptor gamma (PPAR\u03b3) is a nuclear receptor and transcription factor which regulates the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPAR\u03b3 expression promote the development of psoriatic lesions triggering the IL17-related signaling cascade. Skin samples of normally looking and lesional skin donated by psoriasis patients and psoriatic CD3+ Tcells samples (n = 23) and samples of healthy CD3+ T cells donated by volunteers (n = 10) were analyzed by real-time PCR, ELISA and immunohistochemistry analysis. We found that the expression of PPAR\u03b3 is downregulated in human psoriatic skin and laser treatment restores the expression. The expression of IL17, STAT3, FOXP3, and RORC in psoriatic skin before and after laser treatment were correlated with PPAR\u03b3 expression according to the reconstructed model of PPAR\u03b3 pathway in psoriasis.In conclusion, we report that PPAR\u03b3 weakens the expression of genes that contribute in the development of psoriatic lesion. Our data show that transcriptional regulation of PPAR\u03b3 expression by FOSL1 and by STAT3\/FOSL1 feedback loop may be central in the psoriatic skin and T-cells.<\/jats:p>","DOI":"10.3390\/ijms22168603","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T08:57:14Z","timestamp":1628585834000},"page":"8603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Analysis of PPAR\u03b3 Signaling Activity in Psoriasis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-156X","authenticated-orcid":false,"given":"Vladimir","family":"Sobolev","sequence":"first","affiliation":[{"name":"I. Mechnikov Research Institute for Vaccines and Sera RAMS, Russian Federation, Malyy Kazennyy Lane, 5, 105064 Moscow, Russia"},{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-8101","authenticated-orcid":false,"given":"Anastasia","family":"Nesterova","sequence":"additional","affiliation":[{"name":"Life Science Research and Development Department, Elsevier Inc., Rockville, MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-1933","authenticated-orcid":false,"given":"Anna","family":"Soboleva","sequence":"additional","affiliation":[{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"},{"name":"Scientific Research Institute of Human Morphology, 3 Tsurupa Street, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mezentsev","sequence":"additional","affiliation":[{"name":"I. Mechnikov Research Institute for Vaccines and Sera RAMS, Russian Federation, Malyy Kazennyy Lane, 5, 105064 Moscow, Russia"},{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Dvoriankova","sequence":"additional","affiliation":[{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastas","family":"Piruzyan","sequence":"additional","affiliation":[{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Denisova","sequence":"additional","affiliation":[{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-3225","authenticated-orcid":false,"given":"Olga","family":"Melnichenko","sequence":"additional","affiliation":[{"name":"Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Russian Federation, 17, Leninskiy Avenue, 119071 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Korsunskaya","sequence":"additional","affiliation":[{"name":"Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Federation, Srednyaya Kalitnikovskaya Street, 30, 109029 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbalip.2013.11.012","article-title":"Role of PPAR, LXR, and PXR in epidermal homeostasis and inflammation","volume":"1841","author":"Schmuth","year":"2014","journal-title":"Biochim. 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