{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:01:07Z","timestamp":1760821267929,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","award":["2018-Projekt0104"],"award-info":[{"award-number":["2018-Projekt0104"]}],"id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sk\u00e5ne university hospital","award":["2019-659"],"award-info":[{"award-number":["2019-659"]}]},{"name":"The Swedish Diabetes Foundation","award":["DIA2020-492"],"award-info":[{"award-number":["DIA2020-492"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We investigated injury-induced heat shock protein 27 (HSP27) expression and its association to axonal outgrowth after injury and different nerve repair models in healthy Wistar and diabetic Goto-Kakizaki rats. By immunohistochemistry, expression of HSP27 in sciatic nerves and DRG and axonal outgrowth (neurofilaments) in sciatic nerves were analyzed after no, immediate, and delayed (7-day delay) nerve repairs (7- or 14-day follow-up). An increased HSP27 expression in nerves and in DRG at the uninjured side was associated with diabetes. HSP27 expression in nerves and in DRG increased substantially after the nerve injuries, being higher at the site where axons and Schwann cells interacted. Regression analysis indicated a positive influence of immediate nerve repair compared to an unrepaired injury, but a shortly delayed nerve repair had no impact on axonal outgrowth. Diabetes was associated with a decreased axonal outgrowth. The increased expression of HSP27 in sciatic nerve and DRG did not influence axonal outgrowth. Injured sciatic nerves should appropriately be repaired in healthy and diabetic rats, but a short delay does not influence axonal outgrowth. HSP27 expression in sciatic nerve or DRG, despite an increase after nerve injury with or without a repair, is not associated with any alteration in axonal outgrowth.<\/jats:p>","DOI":"10.3390\/ijms22168624","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T04:56:22Z","timestamp":1628657782000},"page":"8624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2440-7369","authenticated-orcid":false,"given":"Lena","family":"Stenberg","sequence":"first","affiliation":[{"name":"Department of Translational Medicine\u2014Hand Surgery, Lund University, 205 02 Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-1146","authenticated-orcid":false,"given":"Derya Burcu","family":"Hazer Rosberg","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine\u2014Hand Surgery, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Neurosurgery, Faculty of Medicine, Mugla S\u0131tk\u0131 Kocman University, Mugla 48100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Kohyama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-8597","authenticated-orcid":false,"given":"Seigo","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-3099","authenticated-orcid":false,"given":"Lars B.","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine\u2014Hand Surgery, Lund University, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Hand Surgery, Sk\u00e5ne University Hospital, 205 02 Malm\u00f6, Sweden"},{"name":"Department of Biomedical and Clinical Sciences, Link\u00f6ping University, 581 83 Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1302\/2058-5241.2.160071","article-title":"Nerve injuries of the upper extremity and hand","volume":"2","author":"Dahlin","year":"2017","journal-title":"EFORT Open Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/WCO.0b013e328357a797","article-title":"Diabetic neuropathy: One disease or two?","volume":"25","author":"Callaghan","year":"2012","journal-title":"Curr. 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