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Adult Ascaris nematodes are long-lived in the host intestine where they interact with host cells as well as members of the microbiota resulting in chronic infections. Nematode interactions with host cells and the microbial environment are prominently mediated by parasite-secreted proteins and peptides possessing immunomodulatory and antimicrobial activities. Previously, we discovered the C-type lectin protein AsCTL-42 in the secreted products of adult Ascaris worms. Here we tested recombinant AsCTL-42 for its ability to interact with bacterial and host cells. We found that AsCTL-42 lacks bactericidal activity but neutralized bacterial cells without killing them. Treatment of bacterial cells with AsCTL-42 reduced invasion of intestinal epithelial cells by Salmonella. Furthermore, AsCTL-42 interacted with host myeloid C-type lectin receptors. Thus, AsCTL-42 is a parasite protein involved in the triad relationship between Ascaris, host cells, and the microbiota.<\/jats:p>","DOI":"10.3390\/ijms22168739","type":"journal-article","created":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T21:43:55Z","timestamp":1629063835000},"page":"8739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-9680","authenticated-orcid":false,"given":"Ankur","family":"Midha","sequence":"first","affiliation":[{"name":"Institute of Immunology, Freie Universit\u00e4t Berlin, 14163 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7158-9594","authenticated-orcid":false,"given":"Guillaume","family":"Goyette-Desjardins","sequence":"additional","affiliation":[{"name":"Institute for Immunology & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Goerdeler","sequence":"additional","affiliation":[{"name":"Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany"},{"name":"Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Moscovitz","sequence":"additional","affiliation":[{"name":"Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany"},{"name":"Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-8466","authenticated-orcid":false,"given":"Peter H.","family":"Seeberger","sequence":"additional","affiliation":[{"name":"Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany"},{"name":"Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Tedin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Epizootics, Freie Universit\u00e4t Berlin, 14163 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-5395","authenticated-orcid":false,"given":"Luca D.","family":"Bertzbach","sequence":"additional","affiliation":[{"name":"Institute of Virology, Freie Universit\u00e4t Berlin, 14163 Berlin, Germany"},{"name":"Department of Viral Transformation, Leibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Lepenies","sequence":"additional","affiliation":[{"name":"Institute for Immunology & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Freie Universit\u00e4t Berlin, 14163 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2017, March 27). Fact Sheet: Soil-Transmitted Helminth Infections. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs366\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-016-1349-0","article-title":"Environmental Contamination and Transmission of Ascaris Suum in Danish Organic Pig Farms","volume":"9","author":"Katakam","year":"2016","journal-title":"Parasites Vectors"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1365-3156.2008.02103.x","article-title":"Hookworm, Ascaris Lumbricoides Infection and Polyparasitism Associated with Poor Cognitive Performance in Brazilian Schoolchildren","volume":"13","author":"Raff","year":"2008","journal-title":"Trop. Med. Int. Health"},{"key":"ref_4","first-page":"1","article-title":"Patterns of Geohelminth Infection, Impact of Albendazole Treatment and Re-Infection after Treatment in Schoolchildren from Rural KwaZulu-Natal\/South-Africa","volume":"4","author":"Saathoff","year":"2004","journal-title":"BMC Infect. Dis."},{"key":"ref_5","first-page":"270","article-title":"Risk Factors and Relationship Between Intestinal Parasites and the Growth Retardation and Psychomotor Development Delays of Children in \u015eanl\u0131urfa, Turkey","volume":"39","author":"Simsek","year":"2015","journal-title":"T\u00fcrkiye Parazitolojii Derg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.micinf.2010.09.012","article-title":"Ascaris and Ascariasis","volume":"13","author":"Dold","year":"2011","journal-title":"Microbes Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S003118200005873X","article-title":"The Epidemiology of Ascaris Lumbricoides and Other Soil-Transmitted Helminths in Primary School Children from Ile-Ife, Nigeria","volume":"99","author":"Holland","year":"1989","journal-title":"Parasitology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2307\/3284450","article-title":"Ascaris Suum: A Revision of Its Early Migratory Path and Implications for Human Ascariasis","volume":"83","author":"Murrell","year":"1997","journal-title":"J. Parasitol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1017\/S0031182097001480","article-title":"Experimental Ascaris Suum Infection in the Pig: Worm Population Kinetics Following Single Inoculations with Three Doses of Infective Eggs","volume":"115","author":"Roepstorff","year":"1997","journal-title":"Parasitology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tim.2011.11.002","article-title":"The Pig: A Model for Human Infectious Diseases","volume":"20","author":"Meurens","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S0954422413000152","article-title":"Use of Pigs as a Potential Model for Research into Dietary Modulation of the Human Gut Microbiota","volume":"26","author":"Heinritz","year":"2013","journal-title":"Nutr. Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0065-308X(01)48008-0","article-title":"Ascaris and Ascariasis","volume":"48","author":"Crompton","year":"2001","journal-title":"Adv. Parasitol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1017\/S095026881700036X","article-title":"Salmonella in the Pork Production Chain and Its Impact on Human Health in the European Union","volume":"145","author":"Bonardi","year":"2017","journal-title":"Epidemiol. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Williams, A.R., Krych, L., Ahmad, H.F., Nejsum, P., Skovgaard, K., Nielsen, D.S., and Thamsborg, S.M. (2017). A Polyphenol-Enriched Diet and Ascaris Suum Infection Modulate Mucosal Immune Responses and Gut Microbiota Composition in Pigs. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186546"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijpara.2018.10.007","article-title":"Ascaris Suum Infection Was Associated with a Worm-Independent Reduction in Microbial Diversity and Altered Metabolic Potential in the Porcine Gut Microbiome","volume":"49","author":"Wang","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pt.2020.09.002","article-title":"Trilateral Relationship: Ascaris, Microbiota, and Host Cells","volume":"37","author":"Midha","year":"2021","journal-title":"Trends Parasitol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, T., Van Steendam, K., Dhaenens, M., Vlaminck, J., Deforce, D., Jex, A.R., Gasser, R.B., and Geldhof, P. (2013). Proteomic Analysis of the Excretory-Secretory Products from Larval Stages of Ascaris Suum Reveals High Abundance of Glycosyl Hydrolases. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002467"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fcimb.2018.00271","article-title":"The Intestinal Roundworm Ascaris Suum Releases Antimicrobial Factors Which Interfere With Bacterial Growth and Biofilm Formation","volume":"8","author":"Midha","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bauters, L., Naalden, D., and Gheysen, G. (2017). The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010091"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.3389\/fimmu.2018.02282","article-title":"Parasitic Nematodes Exert Antimicrobial Activity and Benefit From Microbiota-Driven Support for Host Immune Regulation","volume":"9","author":"Rausch","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1209791","article-title":"The Antibacterial Lectin RegIIIgamma Promotes the Spatial Segregation of Microbiota and Host in the Intestine","volume":"334","author":"Vaishnava","year":"2011","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0960-9822(02)00928-4","article-title":"Inducible Antibacterial Defense System in C. Elegans","volume":"12","author":"Mallo","year":"2002","journal-title":"Curr. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1101\/gr.50823006","article-title":"Genomic Clusters, Putative Pathogen Recognition Molecules, and Antimicrobial Genes Are Induced by Infection of C. Elegans with M. Nematophilum","volume":"16","author":"Baban","year":"2006","journal-title":"Genome Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.dci.2014.02.002","article-title":"The C-Type Lectin-like Domain Containing Proteins Clec-39 and Clec-49 Are Crucial for Caenorhabditis Elegans Immunity against Serratia Marcescens Infection","volume":"45","author":"Miltsch","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nmicrobiol.2016.23","article-title":"Mosquito C-Type Lectins Maintain Gut Microbiome Homeostasis","volume":"1","author":"Pang","year":"2016","journal-title":"Nat. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","article-title":"Helminth Immunoregulation: The Role of Parasite Secreted Proteins in Modulating Host Immunity","volume":"167","author":"Hewitson","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri.2016.29","article-title":"The Immunology of Host Defence Peptides: Beyond Antimicrobial Activity","volume":"16","author":"Hancock","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1046-5928(02)00001-3","article-title":"Non-Pathogenic Trypanosomatid Protozoa as a Platform for Protein Research and Production","volume":"25","author":"Breitling","year":"2002","journal-title":"Protein Expr. Purif."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"BSR20171641","DOI":"10.1042\/BSR20171641","article-title":"Inhibition of N-Glycosylation by Tunicamycin Attenuates Cell\u2013Cell Adhesion via Impaired Desmosome Formation in Normal Human Epidermal Keratinocytes","volume":"38","author":"Jin","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1469-0691.2012.03829.x","article-title":"Enterococci of Animal Origin and Their Significance for Public Health","volume":"18","author":"Hammerum","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.vetmic.2007.10.006","article-title":"Methicillin Resistant Staphylococcus Aureus Colonization in Pigs and Pig Farmers","volume":"128","author":"Khanna","year":"2008","journal-title":"Vet. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40813-017-0063-4","article-title":"Swine Enteric Colibacillosis: Diagnosis, Therapy and Antimicrobial Resistance","volume":"3","author":"Luppi","year":"2017","journal-title":"Porc. Health Manag."},{"key":"ref_33","first-page":"1","article-title":"Weaned Piglets: Another Factor to Be Considered for the Control of Salmonella Infection in Breeding Pig Farms","volume":"50","author":"Alvarez","year":"2019","journal-title":"Vet. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1073\/pnas.1800853116","article-title":"Microbe-Focused Glycan Array Screening Platform","volume":"116","author":"Geissner","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","unstructured":"Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A.G., Kinoshita, T., Packer, N.H., and Prestegard, J.H. (2015). Glycan-Recognizing Probes as Tools. Essentials of Glycobiology, Cold Spring Harbor Laboratory Press."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1074\/jbc.M116.759456","article-title":"Salmonella Co-Opts Host Cell Chaperone-Mediated Autophagy for Intracellular Growth *","volume":"292","author":"Singh","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.acthis.2018.02.005","article-title":"Tetrazolium Salts and Formazan Products in Cell Biology: Viability Assessment, Fluorescence Imaging, and Labeling Perspectives","volume":"120","author":"Stockert","year":"2018","journal-title":"Acta Histochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0014-4894(72)90060-4","article-title":"Infectivity, Fecundity, and Survival of Nematospiroides Dubius in Gnotobiotic Mice","volume":"32","author":"Chang","year":"1972","journal-title":"Exp. Parasitol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2307\/3276048","article-title":"A Comparison of the Development of Nippostrongylus Brasiliensis in Germ-Free and Conventional Mice","volume":"50","author":"Wescott","year":"1964","journal-title":"J. Parasitol."},{"key":"ref_40","first-page":"1","article-title":"Type 2 Immunity-Dependent Reduction of Segmented Filamentous Bacteria in Mice Infected with the Helminthic Parasite Nippostrongylus Brasiliensis","volume":"3","author":"Fricke","year":"2015","journal-title":"Microbiome"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4161\/gmic.32155","article-title":"Commensal-Pathogen Interactions in the Intestinal Tract: Lactobacilli Promote Infection with, and Are Promoted by, Helminth Parasites","volume":"5","author":"Reynolds","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/all.12496","article-title":"Therapeutic Potential of Larval Excretory\/Secretory Proteins of the Pig Whipworm Trichuris Suis in Allergic Disease","volume":"69","author":"Ebner","year":"2014","journal-title":"Allergy"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/jb\/mvi005","article-title":"Cytotoxicity of a GalNAc-Specific C-Type Lectin CEL-I toward Various Cell Lines","volume":"137","author":"Kuramoto","year":"2005","journal-title":"J. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/jam.14055","article-title":"Lectins as Antimicrobial Agents","volume":"125","author":"Coelho","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1021\/acs.biomac.5b01118","article-title":"Latent Ice Recrystallization Inhibition Activity in Nonantifreeze Proteins: Ca2+-Activated Plant Lectins and Cation-Activated Antimicrobial Peptides","volume":"16","author":"Mitchell","year":"2015","journal-title":"Biomacromolecules"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.4049\/jimmunol.177.6.4002","article-title":"Role of N-Acetylglucosamine within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209)","volume":"177","author":"Zhang","year":"2006","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lindenwald, D.L., and Lepenies, B. (2020). C-Type Lectins in Veterinary Species: Recent Advancements and Applications. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145122"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/glycob\/cwg052","article-title":"The Dendritic Cell\u2013Specific C-Type Lectin DC-SIGN Is a Receptor for Schistosoma Mansoni Egg Antigens and Recognizes the Glycan Antigen Lewis x","volume":"13","author":"Nyame","year":"2003","journal-title":"Glycobiology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2567.2011.03449.x","article-title":"C-Type Lectins on Macrophages Participate in the Immunomodulatory Response to Fasciola Hepatica Products","volume":"133","author":"Guasconi","year":"2011","journal-title":"Immunology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-5-42","article-title":"Are Ascaris Lumbricoides and Ascaris Suum a Single Species?","volume":"5","author":"Leles","year":"2012","journal-title":"Parasites Vectors"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fcimb.2017.00341","article-title":"Toxoplasma Co-Infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response","volume":"7","author":"Ahmed","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-1135(00)00294-7","article-title":"Herd Level Husbandry Factors Associated with the Serological Salmonella Prevalence in Finishing Pig Herds in The Netherlands","volume":"78","author":"Wolbers","year":"2001","journal-title":"Vet. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/infdis\/jix141","article-title":"Enteric Helminths Promote Salmonella Co-Infection by Altering the Intestinal Metabolome","volume":"215","author":"Reynolds","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijpara.2009.12.006","article-title":"Acetate Formation in the Energy Metabolism of Parasitic Helminths and Protists","volume":"40","author":"Tielens","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1046\/j.1365-2958.2002.03268.x","article-title":"Intestinal Short-Chain Fatty Acids Alter Salmonella Typhimurium Invasion Gene Expression and Virulence through BarA\/SirA","volume":"46","author":"Lawhon","year":"2002","journal-title":"Mol. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.chom.2018.07.002","article-title":"A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection","volume":"24","author":"Jacobson","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lamas, A., Regal, P., V\u00e1zquez, B., Cepeda, A., and Franco, C.M. (2019). Short Chain Fatty Acids Commonly Produced by Gut Microbiota Influence Salmonella Enterica Motility, Biofilm Formation, and Gene Expression. Antibiotics, 8.","DOI":"10.3390\/antibiotics8040265"},{"key":"ref_58","first-page":"121","article-title":"Prevalence of Infection, Mean Worm Burden and Degree of Worm Aggregation as Determinants of Prevalence of Disease Due to Intestinal Helminths","volume":"28","author":"Ruiz","year":"1997","journal-title":"Arch. Med. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ijpara.2004.12.003","article-title":"Prevalence, Intensity and Aggregation of Intestinal Parasites in Mountain Hares and Their Potential Impact on Population Dynamics","volume":"35","author":"Newey","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"ref_60","unstructured":"Holland, C. (2013). Chapter 7\u2014Ascaris lumbricoides: New Epidemiological Insights and Mathematical Approaches. Ascaris: The Neglected Parasite, Elsevier."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0169-4758(00)01704-X","article-title":"Helminth C-Type Lectins and Host-Parasite Interactions","volume":"16","author":"Loukas","year":"2000","journal-title":"Parasitol. Today"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.parint.2009.08.011","article-title":"C-Type Lectins from the Nematode Parasites Heligmosomoides Polygyrus and Nippostrongylus Brasiliensis","volume":"58","author":"Harcus","year":"2009","journal-title":"Parasitol. Int."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Caraballo, L., Zakzuk, J., and Acevedo, N. (2021). Helminth-Derived Cystatins: The Immunomodulatory Properties of an Ascaris Lumbricoides Cystatin. Parasitology, 1\u201313.","DOI":"10.1017\/S0031182021000214"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Robinson, M.W., Donnelly, S., Hutchinson, A.T., To, J., Taylor, N.L., Norton, R.S., Perugini, M.A., and Dalton, J.P. (2011). A Family of Helminth Molecules That Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002042"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijpara.2017.12.004","article-title":"TGF-\u03b2 Mimic Proteins Form an Extended Gene Family in the Murine Parasite Heligmosomoides Polygyrus","volume":"48","author":"Smyth","year":"2018","journal-title":"Int. J. Parasitol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Venugopal, G., Mueller, M., Hartmann, S., and Steinfelder, S. (2017). Differential Immunomodulation in Human Monocytes versus Macrophages by Filarial Cystatin. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188138"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-459","article-title":"The Effect and Underlying Mechanism of Timosaponin B-II on RGC-5 Necroptosis Induced by Hydrogen Peroxide","volume":"14","author":"Jiang","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jconrel.2013.12.011","article-title":"A Platform to Screen for C-Type Lectin Receptor-Binding Carbohydrates and Their Potential for Cell-Specific Targeting and Immune Modulation","volume":"175","author":"Maglinao","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fimmu.2018.00213","article-title":"C-Type Lectin Receptor (CLR)\u2013Fc Fusion Proteins As Tools to Screen for Novel CLR\/Bacteria Interactions: An Exemplary Study on Preselected Campylobacter Jejuni Isolates","volume":"9","author":"Mayer","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_70","first-page":"511","article-title":"S-Layer From Lactobacillus Brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis","volume":"12","author":"Scheffel","year":"2021","journal-title":"Front. 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