{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:33:01Z","timestamp":1792153981025,"version":"4.4.0"},"reference-count":100,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"grants from key scientific and technological projects in Henan Province\uff0cChina","award":["202102310153"],"award-info":[{"award-number":["202102310153"]}]},{"name":"the Program for Young Key Teacher of Henan Province","award":["2020GGJS037"],"award-info":[{"award-number":["2020GGJS037"]}]},{"name":"the Youth Talent Promotion Plan of Henan Association for Science and Technology","award":["2020HYTP054"],"award-info":[{"award-number":["2020HYTP054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ischemia\/reperfusion (I\/R) injury is characterized by a limited blood supply to organs, followed by the restoration of blood flow and reoxygenation. In addition to ischemia, blood flow recovery can also lead to very harmful injury, especially inflammatory injury. Autophagy refers to the transport of cellular materials to the lysosomes for degradation, leading to the conversion of cellular components and offering energy and macromolecular precursors. It can maintain the balance of synthesis, decomposition and reuse of the intracellular components, and participate in many physiological processes and diseases. Inflammasomes are a kind of protein complex. Under physiological and pathological conditions, as the cellular innate immune signal receptors, inflammasomes sense pathogens to trigger an inflammatory response. TheNLRP3 inflammasome is the most deeply studied inflammasome and is composed of NLRP3, the adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and pro-caspase-1. Its activation triggers the cleavage of pro-interleukin (IL)-1\u03b2 and pro-IL-18 mediated by caspase-1 and promotes a further inflammatory process. Studies have shown that autophagy and the NLRP3 inflammasome play an important role in the process of I\/R injury, but the relevant mechanisms have not been fully explained, especially how the interaction between autophagy and the NLRP3 inflammasome participates in I\/R injury, which remains to be further studied. Therefore, we reviewed the recent studies about the interplay between autophagy and the NLRP3 inflammasome in I\/R injury and analyzed the mechanisms to provide the theoretical references for further research in the future.<\/jats:p>","DOI":"10.3390\/ijms22168773","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T21:27:45Z","timestamp":1629149265000},"page":"8773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The Interplay between Autophagy and NLRP3 Inflammasome in Ischemia\/Reperfusion Injury"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-3405","authenticated-orcid":false,"given":"Shuangyu","family":"Lv","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-3563","authenticated-orcid":false,"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ichimiya, T., Yamakawa, T., Hirano, T., Yokoyama, Y., Hayashi, Y., Hirayama, D., Wagatsuma, K., Itoi, T., and Nakase, H. (2020). Autophagy and autophagy-related diseases: A review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238974"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1242\/jcs.01620","article-title":"The molecular machinery of autophagy: Unanswered questions","volume":"118","author":"Klionsky","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.semcdb.2010.03.002","article-title":"Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism","volume":"21","author":"Kuma","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/ni.1634","article-title":"Autophagic control of listeria through intracellular innate immune recognition in drosophila","volume":"9","author":"Yano","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.immuni.2009.02.009","article-title":"Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus","volume":"30","author":"Shelly","year":"2009","journal-title":"Immunity"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: Morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1800008","DOI":"10.1002\/bies.201800008","article-title":"Three distinct types of microautophagy based on membrane dynamics and molecular machineries","volume":"40","author":"Oku","year":"2018","journal-title":"Bioessays"},{"key":"ref_10","first-page":"335","article-title":"Hydrogen sulfide plays an important protective role by influencing autophagy in diseases","volume":"68","author":"Wang","year":"2019","journal-title":"Physiol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: Renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural. Regen. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: A disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.drudis.2018.08.005","article-title":"Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys","volume":"24","author":"Yaribeygi","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_18","first-page":"15","article-title":"Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives","volume":"8","author":"Ozaki","year":"2015","journal-title":"J. Inflamm. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"663528","DOI":"10.3389\/fcell.2021.663528","article-title":"The role of the effects of endoplasmic reticulum stress on NLRP3 inflammasome in diabetes","volume":"9","author":"Lv","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.intimp.2018.12.042","article-title":"Inhibition of GSK-3\u03b2 alleviates cerebral ischemia\/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy","volume":"68","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1002\/jcp.29268","article-title":"Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases","volume":"235","author":"Lu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-Associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-\u03b2","volume":"9","author":"Halle","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2337\/db12-0420","article-title":"Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jhep.2013.06.017","article-title":"Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu","volume":"59","author":"Peralta","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Soares, R.O.S., Losada, D.M., Jordani, M.C., Evora, P., and Castro, E.S.O. (2019). Ischemia\/Reperfusion Injury revisited: An Overview of the latest pharmacological strategies. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205034"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.24272\/j.issn.2095-8137.2020.042","article-title":"The pathological role of ferroptosis in ischemia\/reperfusion-related injury","volume":"41","author":"Yan","year":"2020","journal-title":"Zool. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41419-020-02864-5","article-title":"Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion","volume":"11","author":"Hurst","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2217\/fca.12.58","article-title":"Mitochondrial membrane permeabilization and cell death during myocardial infarction: Roles of calcium and reactive oxygen species","volume":"8","author":"Webster","year":"2012","journal-title":"Future Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10863-014-9576-6","article-title":"Impaired mitochondrial homeostasis and neurodegeneration: Towards new therapeutic targets?","volume":"47","author":"Corona","year":"2015","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbadis.2014.05.010","article-title":"The role of the autophagy in myocardial ischemia\/reperfusion injury","volume":"1852","author":"Ma","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108148","DOI":"10.1016\/j.abb.2019.108148","article-title":"Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells","volume":"676","author":"Xin","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"110398","DOI":"10.1016\/j.biopha.2020.110398","article-title":"The effect of Ginsenoside Rg1 in hepatic ischemia reperfusion (I\/R) injury ameliorates ischemia-reperfusion-induced liver injury by inhibiting apoptosis","volume":"129","author":"Lin","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1253\/circj.CJ-19-1039","article-title":"Roxadustat markedly reduces myocardial ischemia reperfusion injury in mice","volume":"84","author":"Deguchi","year":"2020","journal-title":"Circ. J."},{"key":"ref_38","first-page":"314","article-title":"Research on the antioxidant effect of Enshi banqiao radix codonopsis on brain ischemia\/reperfusion (I\/R)injury","volume":"28","author":"Zhong","year":"2012","journal-title":"Chin. J. Appl. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: A neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7018393","DOI":"10.1155\/2017\/7018393","article-title":"Ischemia\/Reperfusion injury following acute myocardial infarction: A critical issue for clinicians and forensic pathologists","volume":"2017","author":"Neri","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1139\/cjpp-2014-0164","article-title":"Analyzing the anti-ischemia-reperfusion injury effects of ginsenoside Rb1 mediated through the inhibition of p38\u03b1 MAPK","volume":"94","author":"Li","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11010-020-03842-3","article-title":"Artemisinin suppresses myocardial ischemia-reperfusion injury via NLRP3 inflammasome mechanism","volume":"474","author":"Wang","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"24270","DOI":"10.18632\/aging.202143","article-title":"Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK\/NLRP3 inflammasome pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.bbrc.2017.10.111","article-title":"shRNA interference of NLRP3 inflammasome alleviate ischemia reperfusion-induced myocardial damage through autophagy activation","volume":"494","author":"Meng","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"815094","DOI":"10.1155\/2013\/815094","article-title":"Antiapoptotic effect of simvastatin ameliorates myocardial ischemia\/reperfusion injury","volume":"2013","author":"Hadi","year":"2013","journal-title":"ISRN Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/FJC.0000000000000710","article-title":"Carthamin yellow protects the heart against ischemia\/reperfusion injury with reduced reactive oxygen species release and inflammatory response","volume":"74","author":"Lu","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/dna.2019.5097","article-title":"Ferroptosis is involved in diabetes myocardial ischemia\/reperfusion injury through endoplasmic reticulum stress","volume":"39","author":"Li","year":"2020","journal-title":"DNA Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1111\/jcmm.15318","article-title":"Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent manner","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8151836","DOI":"10.1155\/2019\/8151836","article-title":"Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia\/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes","volume":"2019","author":"Qiu","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1111\/jcmm.13754","article-title":"Knockdown of lncRNA AK139328 alleviates myocardial ischaemia\/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy","volume":"22","author":"Yu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/jdi.13235","article-title":"Activation of autophagy inhibits nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic rats","volume":"11","author":"Zhang","year":"2020","journal-title":"J. Diabetes Investig."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.atherosclerosis.2018.08.031","article-title":"Long non-coding RNA nuclear-enriched abundant transcript 1 inhibition blunts myocardial ischemia reperfusion injury via autophagic flux arrest and apoptosis in streptozotocin-induced diabetic rats","volume":"277","author":"Ma","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/13880209.2019.1698619","article-title":"XingNaoJing injection ameliorates cerebral ischaemia\/reperfusion injury via SIRT1-mediated inflammatory response inhibition","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.intimp.2016.09.024","article-title":"The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling","volume":"40","author":"Qiu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s10020-020-00236-5","article-title":"Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis","volume":"26","author":"Sun","year":"2020","journal-title":"Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1021\/jf0112973","article-title":"Plant foods and herbal sources of resveratrol","volume":"50","author":"Burns","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s13197-013-0993-z","article-title":"Resveratrol content and antioxidant properties of underutilized fruits","volume":"52","author":"Shrikanta","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102208","DOI":"10.1016\/j.nano.2020.102208","article-title":"Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats","volume":"28","author":"Lu","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.intimp.2017.06.029","article-title":"Resveratrol alleviates cerebral ischemia\/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction","volume":"50","author":"He","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22236","article-title":"Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway","volume":"69","author":"Wang","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"106547","DOI":"10.1016\/j.intimp.2020.106547","article-title":"Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation\/reoxygenation","volume":"84","author":"Fu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/s41380-017-0007-z","article-title":"GSK3beta negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons","volume":"23","author":"Chien","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20196","DOI":"10.1038\/srep20196","article-title":"GSK-3\u03b2 downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4629495","DOI":"10.1155\/2017\/4629495","article-title":"Multifaceted roles of GSK-3 in cancer and autophagy-related diseases","volume":"2017","author":"Mancinelli","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e00382","DOI":"10.1042\/BSR20160174","article-title":"Knockdown of GSK3\u03b2 increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells","volume":"36","author":"Weikel","year":"2016","journal-title":"Biosci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s11064-013-1033-0","article-title":"Mitophagy in ischaemia\/reperfusion induced cerebral injury","volume":"38","author":"Liu","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s13238-016-0307-0","article-title":"The critical roles of mitophagy in cerebral ischemia","volume":"7","author":"Tang","year":"2016","journal-title":"Protein Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"108326","DOI":"10.1016\/j.neuropharm.2020.108326","article-title":"A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy","volume":"181","author":"Chen","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1096\/fj.201903051R","article-title":"AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner","volume":"34","author":"Seabright","year":"2020","journal-title":"FASEB J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.4161\/auto.32136","article-title":"Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy","volume":"10","author":"Zhang","year":"2014","journal-title":"Autophagy"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"He, Q., Li, Z., Meng, C., Wu, J., Zhao, Y., and Zhao, J. (2019). Parkin-Dependent mitophagy is required for the inhibition of ATF4 on NLRP3 Inflammasome activation in cerebral ischemia-reperfusion injury in rats. Cells, 8.","DOI":"10.2139\/ssrn.3424194"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13071-020-04331-8","article-title":"ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection","volume":"13","author":"Li","year":"2020","journal-title":"Parasit. Vectors"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4149\/gpb_2018020","article-title":"Exercise training and dietary restriction affect PINK1\/Parkin and Bnip3\/Nix-mediated cardiac mitophagy in mice","volume":"37","author":"Zhao","year":"2018","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s10620-019-05535-4","article-title":"miR-219a-5p ameliorates hepatic ischemia\/reperfusion injury via impairing TP53BP2","volume":"64","author":"Xiao","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.intimp.2019.01.002","article-title":"Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis","volume":"68","author":"Hua","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"86339","DOI":"10.18632\/oncotarget.21151","article-title":"Asiatic acid protects against hepatic ischemia\/reperfusion injury by inactivation of Kupffer cells via PPARgamma\/NLRP3 inflammasome signaling pathway","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101254","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Lin, Q., Li, S., Jiang, N., Jin, H., Shao, X., Zhu, X., Wu, J., Zhang, M., Zhang, Z., and Shen, J. (2020). Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy, 1\u201316.","DOI":"10.1080\/15548627.2020.1848971"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Barazzuol, L., Giamogante, F., Brini, M., and Cali, T. (2020). PINK1\/Parkin mediated mitophagy, Ca2+ signaling and ER-mitochondria contacts in Parkinson\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051772"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2020.09.015","article-title":"PINK1-mediated mitophagy protects against hepatic ischemia\/reperfusion injury by restraining NLRP3 inflammasome activation","volume":"160","author":"Xu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15514","DOI":"10.1073\/pnas.1414859111","article-title":"Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy","volume":"111","author":"Yu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/cvr\/cvaa011","article-title":"Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1\/Cdc42\/Arpc1b","volume":"117","author":"Li","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.stemcr.2016.01.011","article-title":"EVA1A\/TMEM166 Regulates embryonic neurogenesis by autophagy","volume":"6","author":"Li","year":"2016","journal-title":"Stem Cell Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.yexcr.2017.02.003","article-title":"EVA1A inhibits GBM cell proliferation by inducing autophagy and apoptosis","volume":"352","author":"Shen","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molimm.2021.01.028","article-title":"Eva1a inhibits NLRP3 activation to reduce liver ischemia-reperfusion injury via inducing autophagy in Kupffer cells","volume":"132","author":"Wang","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"631","DOI":"10.21037\/atm-20-7084","article-title":"Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2\/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells","volume":"9","author":"Xue","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/15548627.2019.1569916","article-title":"The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion","volume":"15","author":"Xia","year":"2019","journal-title":"Autophagy"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6670495","DOI":"10.1155\/2021\/6670495","article-title":"Inhibiting ATP6V0D2 Aggravates liver ischemia-reperfusion injury by promoting NLRP3 Activation via impairing autophagic flux independent of Notch1\/Hes1","volume":"2021","author":"Wang","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10418","DOI":"10.1096\/fj.202000960R","article-title":"Acetate protects against intestinal ischemia-reperfusion injury independent of its cognate free fatty acid 2 receptor","volume":"34","author":"Schofield","year":"2020","journal-title":"FASEB J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"101343","DOI":"10.1016\/j.redox.2019.101343","article-title":"SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia\/reperfusion injury","volume":"28","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"101534","DOI":"10.1016\/j.redox.2020.101534","article-title":"Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway","volume":"32","author":"Jia","year":"2020","journal-title":"Redox Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"107014","DOI":"10.1016\/j.intimp.2020.107014","article-title":"Nervilifordin F alleviates intestinal ischemia\/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway","volume":"89","author":"Tan","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/SHK.0000000000001259","article-title":"Autophagy induction ameliorates inflammatory responses in intestinal ischemia-reperfusion through inhibiting NLRP3 inflammasome activation","volume":"52","author":"Wang","year":"2019","journal-title":"Shock"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"591803","DOI":"10.3389\/fimmu.2020.591803","article-title":"Interplay between NLRP3 Inflammasome and autophagy","volume":"11","author":"Biasizzo","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/abbs\/gmz098","article-title":"Interaction between autophagy and the NLRP3 inflammasome","volume":"51","author":"Cao","year":"2019","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1002\/jcp.28125","article-title":"mTOR and Beclin1: Two key autophagy-related molecules and their roles in myocardial ischemia\/reperfusion injury","volume":"234","author":"Shi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/15548627.2018.1505155","article-title":"Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy","volume":"15","author":"Jia","year":"2019","journal-title":"Autophagy"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41467-017-00213-3","article-title":"Hypoxia ameliorates intestinal inflammation through NLRP3\/mTOR downregulation and autophagy activation","volume":"8","author":"Simmen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3389\/fphar.2020.01170","article-title":"Hydroxysafflor Yellow A Protects Against Myocardial Ischemia\/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy","volume":"11","author":"Ye","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"153169","DOI":"10.1016\/j.phymed.2020.153169","article-title":"Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation","volume":"68","author":"Xu","year":"2020","journal-title":"Phytomedicine"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/16\/8773\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:46:55Z","timestamp":1760165215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/16\/8773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":100,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijms22168773"],"URL":"https:\/\/doi.org\/10.3390\/ijms22168773","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]}}}