{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:15:50Z","timestamp":1793780150970,"version":"4.6.1"},"reference-count":64,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004285","name":"Saint Petersburg State University","doi-asserted-by":"publisher","award":["project ID: 73022475"],"award-info":[{"award-number":["project ID: 73022475"]}],"id":[{"id":"10.13039\/501100004285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Trace amine-associated receptors (TAAR) recognize organic compounds, including primary, secondary, and tertiary amines. The TAAR5 receptor is known to be involved in the olfactory sensing of innate socially relevant odors encoded by volatile amines. However, emerging data point to the involvement of TAAR5 in brain functions, particularly in the emotional behaviors mediated by the limbic system which suggests its potential contribution to the pathogenesis of neuropsychiatric diseases. TAAR5 expression was explored in datasets available in the Gene Expression Omnibus, Allen Brain Atlas, and Human Protein Atlas databases. Transcriptomic data demonstrate ubiquitous low TAAR5 expression in the cortical and limbic brain areas, the amygdala and the hippocampus, the nucleus accumbens, the thalamus, the hypothalamus, the basal ganglia, the cerebellum, the substantia nigra, and the white matter. Altered TAAR5 expression is identified in Down syndrome, major depressive disorder, or HIV-associated encephalitis. Taken together, these data indicate that TAAR5 in humans is expressed not only in the olfactory system but also in certain brain structures, including the limbic regions receiving olfactory input and involved in critical brain functions. Thus, TAAR5 can potentially be involved in the pathogenesis of brain disorders and represents a valuable novel target for neuropsychopharmacology.<\/jats:p>","DOI":"10.3390\/ijms22168802","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T21:27:45Z","timestamp":1629149265000},"page":"8802","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-1065","authenticated-orcid":false,"given":"Anastasia N.","family":"Vaganova","sequence":"first","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-2204","authenticated-orcid":false,"given":"Ramilya Z.","family":"Murtazina","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-7942","authenticated-orcid":false,"given":"Taisiia S.","family":"Shemyakova","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4608","authenticated-orcid":false,"given":"Andrey D.","family":"Prjibelski","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7098-4864","authenticated-orcid":false,"given":"Nataliia V.","family":"Katolikova","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul R.","family":"Gainetdinov","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"},{"name":"St. Petersburg University Hospital, St. Petersburg State University, Universitetskaya nab. 7\/9, 199034 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nature05066","article-title":"A Second Class of Chemosensory Receptors in the Olfactory Epithelium","volume":"442","author":"Liberles","year":"2006","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pharmthera.2017.07.002","article-title":"Pharmacology of Human Trace Amine-Associated Receptors: Therapeutic Opportunities and Challenges","volume":"180","author":"Berry","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.117.015305","article-title":"Trace Amines and Their Receptors","volume":"70","author":"Gainetdinov","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00441-020-03331-5","article-title":"Olfactory Signaling via Trace Amine-Associated Receptors","volume":"383","author":"Dewan","year":"2021","journal-title":"Cell Tissue Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnmol.2020.00018","article-title":"Trace Amine-Associated Receptor 5 Provides Olfactory Input Into Limbic Brain Areas and Modulates Emotional Behaviors and Serotonin Transmission","volume":"13","author":"Espinoza","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"108373","DOI":"10.1016\/j.neuropharm.2020.108373","article-title":"Increased Dopamine Transmission and Adult Neurogenesis in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice","volume":"182","author":"Efimova","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1006\/bbrc.1997.7591","article-title":"Cloning of a Putative Human Neurotransmitter Receptor Expressed in Skeletal Muscle and Brain","volume":"242","author":"Zeng","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12078-010-9075-z","article-title":"Expression of Trace Amine-Associated Receptors in Human Nasal Mucosa","volume":"3","author":"Carnicelli","year":"2010","journal-title":"Chem. Percept."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.1523\/JNEUROSCI.1779-14.2014","article-title":"Olfactory Receptor Patterning in a Higher Primate","volume":"34","author":"Horowitz","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1016\/j.cub.2020.09.012","article-title":"Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming","volume":"30","author":"Gisladottir","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nm1051","article-title":"3-Iodothyronamine Is an Endogenous and Rapid-Acting Derivative of Thyroid Hormone","volume":"10","author":"Scanlan","year":"2004","journal-title":"Nat. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fphys.2014.00402","article-title":"Update on 3-Iodothyronamine and Its Neurological and Metabolic Actions","volume":"5","author":"Zucchi","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.biopha.2016.07.002","article-title":"The Emerging Roles of Human Trace Amines and Human Trace Amine-Associated Receptors (HTAARs) in Central Nervous System","volume":"83","author":"Khan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e12543","DOI":"10.1111\/gbb.12543","article-title":"Accelerated Pseudogenization of Trace Amine-associated Receptor Genes in Primates","volume":"18","author":"Eyun","year":"2019","journal-title":"Genes Brain Behav."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Staubert, C., B\u00f6selt, I., Bohnekamp, J., R\u00f6mpler, H., Enard, W., and Sch\u00f6neberg, T. (2010). Structural and Functional Evolution of the Trace Amine-Associated Receptors TAAR3, TAAR4 and TAAR5 in Primates. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011133"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Dinter, J., M\u00fchlhaus, J., Wienchol, C.L., Yi, C.-X., N\u00fcrnberg, D., Morin, S., Gr\u00fcters, A., K\u00f6hrle, J., Sch\u00f6neberg, T., and Tsch\u00f6p, M. (2015). Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117774"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wallrabenstein, I., Kuklan, J., Weber, L., Zborala, S., Werner, M., Altm\u00fcller, J., Becker, C., Schmidt, A., Hatt, H., and Hummel, T. (2013). Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054950"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1523\/JNEUROSCI.4299-12.2013","article-title":"Ultrasensitive Detection of Amines by a Trace Amine-Associated Receptor","volume":"33","author":"Zhang","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s12640-018-9902-6","article-title":"Identification of TAAR5 Agonist Activity of Alpha-NETA and Its Effect on Mismatch Negativity Amplitude in Awake Rats","volume":"34","author":"Aleksandrov","year":"2018","journal-title":"Neurotox Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2019.04.028","article-title":"The TAAR5 Agonist \u03b1-NETA Causes Dyskinesia in Mice","volume":"704","author":"Aleksandrov","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainresbull.2020.03.005","article-title":"Putative TAAR5 Agonist Alpha-NETA Affects Event-Related Potentials in Oddball Paradigm in Awake Mice","volume":"158","author":"Aleksandrov","year":"2020","journal-title":"Brain Res. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10571-019-00716-1","article-title":"Putative Trace-Amine Associated Receptor 5 (TAAR5) Agonist \u03b1-NETA Increases Electrocorticogram Gamma-Rhythm in Freely Moving Rats","volume":"40","author":"Belov","year":"2020","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10571-019-00743-y","article-title":"Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders","volume":"40","author":"Rutigliano","year":"2020","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-Based Map of the Human Proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An Anatomically Comprehensive Atlas of the Adult Human Brain Transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature13185","article-title":"Transcriptional Landscape of the Prenatal Human Brain","volume":"508","author":"Miller","year":"2014","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.devcel.2004.05.005","article-title":"Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function","volume":"6","author":"Rinn","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_28","unstructured":"(2021, March 10). Allen Cell Types Database (2015), RNAseq Data Navigator. Available online: http:\/\/www.celltypes.brain-map.org\/rnaseq\/human."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1038\/s41598-021-83541-1","article-title":"Characterization of the Nuclear and Cytosolic Transcriptomes in Human Brain Tissue Reveals New Insights into the Subcellular Distribution of RNA Transcripts","volume":"11","author":"Zaghlool","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gaudel, F., Guiraudie-Capraz, G., and F\u00e9ron, F. (2021). Limbic Expression of MRNA Coding for Chemoreceptors in Human Brain\u2014Lessons from Brain Atlases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136858"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.celrep.2012.06.006","article-title":"An Olfactory Subsystem That Mediates High-Sensitivity Detection of Volatile Amines","volume":"2","author":"Pacifico","year":"2012","journal-title":"Cell Rep."},{"key":"ref_32","first-page":"S41","article-title":"Trace Amine-Associated Receptor 2: Brain Expression and It\u2019s Role in Neurochemistry and Behaviour","volume":"40","author":"Kuvarzin","year":"2020","journal-title":"Neurochemistry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0893-133X(98)00066-9","article-title":"Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain: Comparison with D2 Receptor Expressing Neurons","volume":"20","author":"Gurevich","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuroimage.2009.01.049","article-title":"Cerebral Morphology and Dopamine D2\/D3 Receptor Distribution in Humans: A Combined [18F]Fallypride and Voxel-Based Morphometry Study","volume":"46","author":"Woodward","year":"2009","journal-title":"Neuroimage"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2004.12.001","article-title":"Distribution of D1-like and D2-like Dopamine Receptors in the Brain of Genetic Epileptic WAG\/Rij Rats","volume":"63","author":"Birioukova","year":"2005","journal-title":"Epilepsy Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/adb.12512","article-title":"Dopamine D1 or D2 Receptor-Expressing Neurons in the Central Nervous System","volume":"23","author":"Wei","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0169-328X(95)00038-T","article-title":"Distribution of Dopamine D1, D2, and D5 Receptor MRNAs in the Monkey Brain: Ribonuclease Protection Assay Analysis","volume":"31","author":"Machida","year":"1995","journal-title":"Mol. Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2174\/1381612043384754","article-title":"PET Imaging of Beta-Adrenoceptors in Human Brain: A Realistic Goal or a Mirage?","volume":"10","author":"Vaalburg","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(95)00104-X","article-title":"The Distribution of 5-HT1A and 5-HT2A Receptor MRNA in Human Brain","volume":"676","author":"Burnet","year":"1995","journal-title":"Brain Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(96)01131-6","article-title":"Autoradiographic Localization of 5-HT1A Receptors in the Post-Mortem Human Brain Using [3H]WAY-100635 and [11C]Way-100635","volume":"745","author":"Hall","year":"1997","journal-title":"Brain Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1523\/JNEUROSCI.16-24-07812.1996","article-title":"Translocation of RNA Granules in Living Neurons","volume":"16","author":"Knowles","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0166-2236(02)02188-4","article-title":"Axonal and Presynaptic Protein Synthesis: New Insights into the Biology of the Neuron","volume":"25","author":"Giuditta","year":"2002","journal-title":"Trends Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134470","DOI":"10.1016\/j.neulet.2019.134470","article-title":"Effect of Alpha-NETA on Auditory Event Related Potentials in Sensory Gating Study Paradigm in Mice","volume":"712","author":"Aleksandrov","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S2215-0366(17)30015-9","article-title":"How Do Antidepressants Work? New Perspectives for Refining Future Treatment Approaches","volume":"4","author":"Harmer","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/jnnp.50.3.341","article-title":"Dopaminergic Neurotransmitter Systems in Alzheimer\u2019s Disease and in Down\u2019s Syndrome at Middle Age","volume":"50","author":"Mann","year":"1987","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00004703-200102000-00007","article-title":"Down Syndrome: Advances in Molecular Biology and the Neurosciences","volume":"22","author":"Capone","year":"2001","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2017.09.035","article-title":"Assessing Disease-Modifying Effects of Norepinephrine in Down Syndrome and Alzheimer\u2019s Disease","volume":"1702","author":"Ponnusamy","year":"2019","journal-title":"Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Gelman, B.B., Chen, T., Lisinicchia, J.G., Soukup, V.M., Carmical, J.R., Starkey, J.M., Masliah, E., Commins, D.L., Brandt, D., and Grant, I. (2012). The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046178"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/QAI.0000000000000800","article-title":"Gene Expression in HIV-Associated Neurocognitive Disorders: A Meta-Analysis","volume":"70","author":"Siangphoe","year":"2015","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneuroim.2007.08.006","article-title":"Expression of Neuronal Trace Amine-Associated Receptor (Taar) MRNAs in Leukocytes","volume":"192","author":"Nelson","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for Functional Genomics Data Sets\u2014Update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_52","unstructured":"(2021, March 17). GEO Browser, Available online: http:\/\/www.ncbi.nlm.nih.gov\/geo\/browse\/."},{"key":"ref_53","unstructured":"(2021, March 20). Phantasus. Available online: http:\/\/genome.ifmo.ru\/phantasus-dev\/."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma Powers Differential Expression Analyses for RNA-Sequencing and Microarray Studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_55","unstructured":"(2021, March 20). GEO2R, Available online: http:\/\/www.ncbi.nlm.nih.gov\/geo\/geo2r\/."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1086\/519850","article-title":"Identification of Genetic Variants Contributing to Cisplatin-Induced Cytotoxicity by Use of a Genomewide Approach","volume":"81","author":"Huang","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jmoldx.2012.01.007","article-title":"Genes with Bimodal Expression Are Robust Diagnostic Targets That Define Distinct Subtypes of Epithelial Ovarian Cancer with Different Overall Survival","volume":"14","author":"Kernagis","year":"2012","journal-title":"J. Mol. Diagn."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3389\/fphys.2019.01218","article-title":"Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats","volume":"10","author":"Mulla","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_59","unstructured":"JASP Team (2020). JASP [Computer Software], JASP."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1038\/s41598-019-43935-8","article-title":"GREIN: An Interactive Web Platform for Re-Analyzing GEO RNA-Seq Data","volume":"9","author":"Mahi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_61","unstructured":"(2021, March 23). GREIN. Available online: http:\/\/www.ilincs.org\/apps\/grein\/?gse=."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"EdgeR: A Bioconductor Package for Differential Expression Analysis of Digital Gene Expression Data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_63","first-page":"D77","article-title":"Expression Atlas Update: From Tissues to Single Cells","volume":"48","author":"Papatheodorou","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1093\/bioinformatics\/btw392","article-title":"ABAEnrichment: An R Package to Test for Gene Set Expression Enrichment in the Adult and Developing Human Brain","volume":"32","author":"Grote","year":"2016","journal-title":"Bioinformatics"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/16\/8802\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:47:05Z","timestamp":1760165225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/16\/8802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":64,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ijms22168802"],"URL":"https:\/\/doi.org\/10.3390\/ijms22168802","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]}}}