{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:05:46Z","timestamp":1789160746430,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["FK129190"],"award-info":[{"award-number":["FK129190"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["K135457"],"award-info":[{"award-number":["K135457"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Brain Research Program","award":["NAP2017-1.2.1-NKP-2017-00002"],"award-info":[{"award-number":["NAP2017-1.2.1-NKP-2017-00002"]}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["MTA-TKI-14016"],"award-info":[{"award-number":["MTA-TKI-14016"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PTE AOK-TANDEM","award":["2020"],"award-info":[{"award-number":["2020"]}]},{"name":"Economic development and innovation operational programme&quot;","award":["GINOP-2.3.2-15-2016-00050 \u201cPEPSYS\u201d"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00050 \u201cPEPSYS\u201d"]}]},{"name":"EFOP","award":["EFOP-3.6.2-16-2017-00008"],"award-info":[{"award-number":["EFOP-3.6.2-16-2017-00008"]}]},{"name":"EFOP","award":["EFOP-3.6.3-00009"],"award-info":[{"award-number":["EFOP-3.6.3-00009"]}]},{"name":"EFOP","award":["EFOP-3.6.1-16-2016-00004"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00004"]}]},{"name":"EFOP","award":["EFOP-3.6.3--00008"],"award-info":[{"award-number":["EFOP-3.6.3--00008"]}]},{"name":"The role of neuroinflammation in neurodegeneration: from molecules to clinics\u201d; and Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary","award":["20765\/3\/2018\/FEKUTSTRAT"],"award-info":[{"award-number":["20765\/3\/2018\/FEKUTSTRAT"]}]},{"DOI":"10.13039\/501100012550","name":"National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["2020-4.1.1-TKP2020 - FIKP III. Project no. TKP2020-IKA-08"],"award-info":[{"award-number":["2020-4.1.1-TKP2020 - FIKP III. Project no. TKP2020-IKA-08"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Glaucoma is associated with increased intraocular pressure (IOP), causing the apoptosis of retinal ganglion cells (RGCs) and the loss of their axons leading to blindness. Pituitary adenylate cyclase activating polypeptide (PACAP) is neuroprotective in several neural injuries, including retinopathies. The aim of this study was to investigate the effects of PACAP1-38 eye drops in a model of glaucoma. IOP was elevated bilaterally by injections of microbeads to block the aqueous humor outflow. The control groups received the same volume of saline. Animals were treated with PACAP1-38 (1 \u00b5g\/drop, 3 \u00d7 1 drop\/day) or vehicle for 4 weeks starting one day after the injections. Retinal morphology by histology and optical coherence tomography, function by electroretinography, and IOP changes were analyzed. Animals were sacrificed 8 weeks after the injections. Microbeads injections induced a significant increase in the IOP, while PACAP1-38 treatment lowered it to normal levels (~10 mmHg). Significant retinal degeneration and functional impairment were observed in the microbead-injected group without PACAP1-38 treatment. In the microbeads + PACAP1-38 group, the retinal morphology and functionality were close to the normal values. In summary, our results show that PACAP1-38, given in form of eye drops, is neuroprotective in glaucoma, providing the basis for potential future therapeutic administration.<\/jats:p>","DOI":"10.3390\/ijms22168825","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T21:27:40Z","timestamp":1629235660000},"page":"8825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Retinoprotective Effects of PACAP Eye Drops in Microbead-Induced Glaucoma Model in Rats"],"prefix":"10.3390","volume":"22","author":[{"given":"Edina","family":"Szabo","sequence":"first","affiliation":[{"name":"Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin","family":"Patko","sequence":"additional","affiliation":[{"name":"Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Vaczy","sequence":"additional","affiliation":[{"name":"Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Molitor","sequence":"additional","affiliation":[{"name":"Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-2412","authenticated-orcid":false,"given":"Adrienne","family":"Csutak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical Centre, University of Pecs Medical School, 7632 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Reglodi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary"},{"name":"Szentagothai Research Center, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8112-8633","authenticated-orcid":false,"given":"Tamas","family":"Atlasz","sequence":"additional","affiliation":[{"name":"Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary"},{"name":"Szentagothai Research Center, University of Pecs, 7624 Pecs, Hungary"},{"name":"Department of Sportbiology, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.pop.2015.05.008","article-title":"Glaucoma","volume":"42","author":"Mantravadi","year":"2015","journal-title":"Prim. 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