{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:09:47Z","timestamp":1791940187520,"version":"4.3.4"},"reference-count":244,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability to degrade fatty acid chains. Although each organelle harbors its own fatty acid \u03b2-oxidation pathway, a distinct mitochondrial system feeds the oxidative phosphorylation pathway for ATP synthesis. At the same time, the peroxisomal \u03b2-oxidation pathway participates in cellular thermogenesis. A scientific milestone in 1965 helped discover the hepatomegaly effect in rat liver by clofibrate, subsequently identified as a peroxisome proliferator in rodents and an activator of the peroxisomal fatty acid \u03b2-oxidation pathway. These peroxisome proliferators were later identified as activating ligands of Peroxisome Proliferator-Activated Receptor \u03b1 (PPAR\u03b1), cloned in 1990. The ligand-activated heterodimer PPAR\u03b1\/RXR\u03b1 recognizes a DNA sequence, called PPRE (Peroxisome Proliferator Response Element), corresponding to two half-consensus hexanucleotide motifs, AGGTCA, separated by one nucleotide. Accordingly, the assembled complex containing PPRE\/PPAR\u03b1\/RXR\u03b1\/ligands\/Coregulators controls the expression of the genes involved in liver peroxisomal fatty acid \u03b2-oxidation. This review mobilizes a considerable number of findings that discuss miscellaneous axes, covering the detailed expression pattern of PPAR\u03b1 in species and tissues, the lessons from several PPAR\u03b1 KO mouse models and the modulation of PPAR\u03b1 function by dietary micronutrients.<\/jats:p>","DOI":"10.3390\/ijms22168969","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T08:44:45Z","timestamp":1629449085000},"page":"8969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":253,"title":["Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPAR\u03b1"],"prefix":"10.3390","volume":"22","author":[{"given":"Mounia","family":"Tahri-Joutey","sequence":"first","affiliation":[{"name":"Bio-PeroxIL Laboratory, University of Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, BP 577, 26000 Settat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-7858","authenticated-orcid":false,"given":"Pierre","family":"Andreoletti","sequence":"additional","affiliation":[{"name":"Bio-PeroxIL Laboratory, University of Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailesh","family":"Surapureddi","sequence":"additional","affiliation":[{"name":"Office of Pollution Prevention and Toxics, United States Environmental Protection Agency, Washington, DC 20460, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubker","family":"Nasser","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, BP 577, 26000 Settat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-739X","authenticated-orcid":false,"given":"Mustapha","family":"Cherkaoui-Malki","sequence":"additional","affiliation":[{"name":"Bio-PeroxIL Laboratory, University of Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6794-2690","authenticated-orcid":false,"given":"Norbert","family":"Latruffe","sequence":"additional","affiliation":[{"name":"Bio-PeroxIL Laboratory, University of Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0248-4900(00)01083-2","article-title":"Evolutionary Aspects of Peroxisomes as Cell Organelles, and of Genes Encoding Peroxisomal Proteins","volume":"92","author":"Latruffe","year":"2000","journal-title":"Biol. 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