{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T17:23:55Z","timestamp":1773509035910,"version":"3.50.1"},"reference-count":113,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid\u2019s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.<\/jats:p>","DOI":"10.3390\/ijms22169000","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"9000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Angioedema and Fatty Acids"],"prefix":"10.3390","volume":"22","author":[{"given":"Akane","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/jid.2011.198","article-title":"Skin as a peripheral lymphoid organ: Revisiting the concept of skin-associated lymphoid tissues","volume":"131","author":"Egawa","year":"2011","journal-title":"J. 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