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Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1093\/rheumatology\/keaa061","article-title":"Diagnosis of fibromyalgia: Comparison of the 2011\/2016 ACR and AAPT criteria and validation of the modified Fibromyalgia Assessment Status","volume":"59","author":"Salaffi","year":"2020","journal-title":"Rheumatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2019.12.020","article-title":"Peripheral immune aberrations in fibromyalgia: A systematic review, meta-analysis and meta-regression","volume":"87","author":"Carvalho","year":"2020","journal-title":"Brain. Behav. Immun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1093\/rheumatology\/keab146","article-title":"Is fibromyalgia associated with a unique cytokine profile? 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