{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:47:35Z","timestamp":1787028455607,"version":"build-2736575974"},"reference-count":60,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["872331"],"award-info":[{"award-number":["872331"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Facile method for the preparation of \u03b2\u2013cyclodextrin\u2013functionalized hydrogels based on guanosine quartet assembly was described. A series of seven hydrogels were prepared by linking \u03b2\u2013cyclodextrin molecules with guanosine moieties in different ratios through benzene\u20131,4\u2013diboronic acid linker in the presence of potassium hydroxide. The potassium ions acted as a reticulation agent by forming guanosine quartets, leading to the formation of self\u2013sustained transparent hydrogels. The ratios of the \u03b2\u2013cyclodextrin and guanosine components have a significant effect on the internal structuration of the components and, correspondingly, on the mechanical properties of the final gels, offering a tunablity of the system by varying the components ratio. The insights into the hydrogels\u2019 structuration were achieved by circular dichroism, scanning electron microscopy, atomic force microscopy, and X\u2013ray diffraction. Rheological measurements revealed self\u2013healing and thixotropic properties of all the investigated samples, which, in combination with available cyclodextrin cavities for active components loading, make them remarkable candidates for specific applications in biomedical and pharmaceutical fields. Moreover, all the prepared samples displayed selective antimicrobial properties against S. aureus in planktonic and biofilm phase, the activity also depending on the guanosine and cyclodextrin ratio within the hydrogel structure.<\/jats:p>","DOI":"10.3390\/ijms22179179","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:19:26Z","timestamp":1629937166000},"page":"9179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Injectable Thixotropic \u03b2\u2013Cyclodextrin\u2013Functionalized Hydrogels Based on Guanosine Quartet Assembly"],"prefix":"10.3390","volume":"22","author":[{"given":"Monica-Cornelia","family":"Sardaru","sequence":"first","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-1709","authenticated-orcid":false,"given":"Irina","family":"Rosca","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Morariu","sequence":"additional","affiliation":[{"name":"Natural Polymers, Bioactive and Biocompatible Materials, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena-Laura","family":"Ursu","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Ghiarasim","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-9515","authenticated-orcid":false,"given":"Alexandru","family":"Rotaru","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","article-title":"Designing Cell-Compatible Hydrogels for Biomedical Applications","volume":"336","author":"Seliktar","year":"2012","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Correa, S., Grosskopf, A.K., Lopez Hernandez, H., Chan, D., Yu, A.C., Stapleton, L.M., and Appel, E.A. 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