{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:24:37Z","timestamp":1791822277518,"version":"4.3.4"},"reference-count":48,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["20\u2010ASTC\u20100032\u201001\u2010hErOiSmE"],"award-info":[{"award-number":["20\u2010ASTC\u20100032\u201001\u2010hErOiSmE"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds National de la Recherche Scientifique et M\u00e9dicale","award":["FNRS, PDR T.0211.18"],"award-info":[{"award-number":["FNRS, PDR T.0211.18"]}]},{"name":"Action de Recherche Concert\u00e9e de la Communaut\u00e9 Wallonie-Bruxelles","award":["ARC16\/21-074"],"award-info":[{"award-number":["ARC16\/21-074"]}]},{"name":"Fundamental Research of excellence in Strategic areas \u2013 Walloon Excellence in Life Sciences and Biotechnology","award":["FRFS-WELBIO, WELBIO-CR-2019A-01"],"award-info":[{"award-number":["FRFS-WELBIO, WELBIO-CR-2019A-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis in the young population, which is particularly at risk, is rarely studied. O-GlcNAcylation is a post-translational modification involved in cell survival, stress response and metabolic regulation. O-GlcNAc stimulation is beneficial in adult septic rats. This modification is physiologically higher in the young rat, potentially limiting the therapeutic potential of O-GlcNAc stimulation in young septic rats. The aim is to evaluate whether O-GlcNAc stimulation can improve sepsis outcome in young rats. Endotoxemic challenge was induced in 28-day-old rats by lipopolysaccharide injection (E. Coli O111:B4, 20 mg\u00b7kg\u22121) and compared to control rats (NaCl 0.9%). One hour after lipopolysaccharide injection, rats were randomly assigned to no therapy, fluidotherapy (NaCl 0.9%, 10 mL\u00b7kg\u22121) \u00b1 NButGT (10 mg\u00b7kg\u22121) to increase O-GlcNAcylation levels. Physiological parameters and plasmatic markers were evaluated 2h later. Finally, untargeted mass spectrometry was performed to map cardiac O-GlcNAcylated proteins. Lipopolysaccharide injection induced shock with a decrease in mean arterial pressure and alteration of biological parameters (p &lt; 0.05). NButGT, contrary to fluidotherapy, was associated with an improvement of arterial pressure (p &lt; 0.05). ATP citrate lyase was identified among the O-GlcNAcylated proteins. In conclusion, O-GlcNAc stimulation improves outcomes in young septic rats. Interestingly, identified O-GlcNAcylated proteins are mainly involved in cellular metabolism.<\/jats:p>","DOI":"10.3390\/ijms22179236","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T09:53:23Z","timestamp":1630058003000},"page":"9236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat"],"prefix":"10.3390","volume":"22","author":[{"given":"Manon","family":"Denis","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l\u2019Institut du Thorax, F-44000 Nantes, France"},{"name":"Pediatric Intensive Care Unit, CHU de Nantes, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-3526","authenticated-orcid":false,"given":"Thomas","family":"Dupas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l\u2019Institut du Thorax, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Persello","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l\u2019Institut du Thorax, F-44000 Nantes, France"},{"name":"InFlectis BioScience, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Dontaine","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain, Institut de Recherche Exp\u00e9rimentale et Clinique, P\u00f4le of Cardiovascular Research, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-0101","authenticated-orcid":false,"given":"Laurent","family":"Bultot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain, Institut de Recherche Exp\u00e9rimentale et Clinique, P\u00f4le of Cardiovascular Research, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Betus","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l\u2019Institut du Thorax, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pel\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CHU Nantes, CNRS, INSERM, l\u2019Institut du Thorax, F-44000 Nantes, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(04)16815-3","article-title":"Multiorgan Failure Is an Adaptive, Endocrine-Mediated, Metabolic Response to Overwhelming Systemic Inflammation","volume":"364","author":"Singer","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1208623","article-title":"Severe Sepsis and Septic Shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. 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