{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:41:02Z","timestamp":1784644862221,"version":"3.55.0"},"reference-count":126,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education","award":["the Drug Development Center, China Medical University, under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project"],"award-info":[{"award-number":["the Drug Development Center, China Medical University, under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project"]}]},{"name":"Ministry of Education","award":["10971701"],"award-info":[{"award-number":["10971701"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2320-B-039-032-MY3"],"award-info":[{"award-number":["MOST 107-2320-B-039-032-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed\/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.<\/jats:p>","DOI":"10.3390\/ijms22179257","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T09:53:23Z","timestamp":1630058003000},"page":"9257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-0348","authenticated-orcid":false,"given":"Chih-Hung","family":"Tsai","sequence":"first","affiliation":[{"name":"Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Neurology, National Taiwan University Hospital Yunlin Branch, Yunlin 64041, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-5845","authenticated-orcid":false,"given":"Yuan-Ho","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Chinese Medicine of E-Da Cancer Hospital, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-2120","authenticated-orcid":false,"given":"Yung-Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Chinese Medicine of Jiannren Hospital, Kaohsiung 811504, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung-Loc","family":"Ho","sequence":"additional","affiliation":[{"name":"International Master\u2019s Program of Biomedical Sciences, China Medical University, Taichun 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Huynh","family":"Hoai Thuong","sequence":"additional","affiliation":[{"name":"International Master\u2019s Program of Biomedical Sciences, China Medical University, Taichun 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Huei","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung 40402, Taiwan"},{"name":"Drug Development Center, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1200\/JCO.2016.71.3552","article-title":"Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy","volume":"35","author":"Horak","year":"2017","journal-title":"J. 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