{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:25:21Z","timestamp":1787509521093,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T00:00:00Z","timestamp":1630195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007707","name":"Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro","doi-asserted-by":"publisher","award":["12010"],"award-info":[{"award-number":["12010"]}],"id":[{"id":"10.13039\/501100007707","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sensor Regione Campania","award":["23"],"award-info":[{"award-number":["23"]}]},{"name":"Goodwater Regione Campania","award":["POR Campania FESR 2014\/2020 O.S. 1.1 Az. 1.1.3 E 1.1.4\u2013CUP 572 B63D18000150007"],"award-info":[{"award-number":["POR Campania FESR 2014\/2020 O.S. 1.1 Az. 1.1.3 E 1.1.4\u2013CUP 572 B63D18000150007"]}]},{"name":"POR FESR 2014-2020 Regione Campania","award":["RARE PLATNET, SATIN and COEPICA"],"award-info":[{"award-number":["RARE PLATNET, SATIN and COEPICA"]}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Thyroid hormone levels are usually genetically determined. Thyrocytes produce a unique set of enzymes that are dedicated to thyroid hormone synthesis. While thyroid transcriptional regulation is well-characterized, post-transcriptional mechanisms have been less investigated. Here, we describe the involvement of ZFP36L2, a protein that stimulates degradation of target mRNAs, in thyroid development and function, by in vivo and in vitro gene targeting in thyrocytes. Thyroid-specific Zfp36l2-\/- females were hypothyroid, with reduced levels of circulating free Thyroxine (cfT4) and Triiodothyronine (cfT3). Their hypothyroidism was due to dyshormonogenesis, already evident one week after weaning, while thyroid development appeared normal. We observed decreases in several thyroid-specific transcripts and proteins, such as Nis and its transcriptional regulators (Pax8 and Nkx2.1), and increased apoptosis in Zfp36l2-\/- thyroids. Nis, Pax8, and Nkx2.1 mRNAs were also reduced in Zfp36l2 knock-out thyrocytes in vitro (L2KO), in which we confirmed the increased apoptosis. Finally, in L2KO cells, we showed an altered response to TSH stimulation regarding both thyroid-specific gene expression and cell proliferation and survival. This result was supported by increases in P21\/WAF1 and p-P38MAPK levels. Mechanistically, we confirmed Notch1 as a target of ZFP36L2 in the thyroid since its levels were increased in both in vitro and in vivo models. In both models, the levels of Id4 mRNA, a potential inhibitor of Pax8 activity, were increased. Overall, the data indicate that the regulation of mRNA stability by ZFP36L2 is a mechanism that controls the function and survival of thyrocytes.<\/jats:p>","DOI":"10.3390\/ijms22179379","type":"journal-article","created":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T21:45:16Z","timestamp":1630273516000},"page":"9379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["ZFP36L2 Role in Thyroid Functionality"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-7688","authenticated-orcid":false,"given":"Francesco","family":"Albano","sequence":"first","affiliation":[{"name":"IEOS-CNR, 80131 Naples, Italy"},{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Tucci","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"},{"name":"Department of Precision Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry J.","family":"Blackshear","sequence":"additional","affiliation":[{"name":"Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA"},{"name":"Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-4784","authenticated-orcid":false,"given":"Carla","family":"Reale","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Roberto","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Russo","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-8325","authenticated-orcid":false,"given":"Pina","family":"Marotta","sequence":"additional","affiliation":[{"name":"Stazione Zoologica Anton Dohrn, 80121 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immacolata","family":"Porreca","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colella","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"},{"name":"Department of Science and Technology, University of Sannio, 82100 Benevento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mallardo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-8725","authenticated-orcid":false,"given":"Mario","family":"de Felice","sequence":"additional","affiliation":[{"name":"IEOS-CNR, 80131 Naples, Italy"},{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3954-8842","authenticated-orcid":false,"given":"Concetta","family":"Ambrosino","sequence":"additional","affiliation":[{"name":"Biogem, Istituto di Biologia e Genetica Molecolare, 83031 Ariano Irpino, Italy"},{"name":"Department of Science and Technology, University of Sannio, 82100 Benevento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000363156","article-title":"Clinical genetics of congenital hypothyroidism","volume":"26","author":"Szinnai","year":"2014","journal-title":"Endocr. Dev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1056\/NEJM199705083361914","article-title":"Congenital hypothyroidism caused by mutations in the thyrotropin-receptor gene","volume":"336","author":"Biebermann","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/1294","article-title":"Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia","volume":"19","author":"Wentworth","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng0598-83","article-title":"PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis","volume":"19","author":"Macchia","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"U39","DOI":"10.1530\/eje.0.151u039","article-title":"Molecular genetic defects in congenital hypothyroidism","volume":"151","author":"Gruters","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/jmg.2004.024158","article-title":"Genetics of congenital hypothyroidism","volume":"42","author":"Park","year":"2005","journal-title":"J. Med. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/1289","article-title":"A mouse model for hereditary thyroid dysgenesis and cleft palate","volume":"19","author":"Ovitt","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1043-2760(96)00115-4","article-title":"Thyroid-specific enhancer-binding protein role in thyroid function and organogenesis","volume":"7","author":"Kimura","year":"1996","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ng0598-87","article-title":"Follicular cells of the thyroid gland require Pax8 gene function","volume":"19","author":"Mansouri","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1242\/dev.127.11.2433","article-title":"The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation","volume":"127","author":"Clements","year":"2000","journal-title":"Development"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1530\/EJE-06-0709","article-title":"Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: Identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism","volume":"156","author":"Biebermann","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/er.2003-0028","article-title":"Thyroid development and its disorders: Genetics and molecular mechanisms","volume":"25","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1297\/cpe.19.91","article-title":"One novel and two recurrent THRB mutations associated with resistance to thyroid hormone: Structure-based computational mutation prediction","volume":"19","author":"Narumi","year":"2010","journal-title":"Clin. Pediatr. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.beem.2018.05.002","article-title":"Genetics and management of congenital hypothyroidism","volume":"32","author":"Persani","year":"2018","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1210\/en.2011-1888","article-title":"Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish","volume":"153","author":"Porazzi","year":"2012","journal-title":"Endocrinology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000506423","article-title":"Physiologic significance of epigenetic regulation of thyroid hormone target gene expression","volume":"9","author":"Anselmo","year":"2020","journal-title":"Eur. Thyroid J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/msb.2010.59","article-title":"Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line","volume":"6","author":"Vogel","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1581","DOI":"10.1002\/wrna.1581","article-title":"Understanding and targeting the disease-related RNA binding protein human antigen R (HuR)","volume":"11","author":"Schultz","year":"2020","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1756-6614-4-S1-S5","article-title":"AUF1 and HuR: Possible implications of mRNA stability in thyroid function and disorders","volume":"4","author":"Trojanowicz","year":"2011","journal-title":"Thyroid Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mce.2011.09.036","article-title":"New insights about the posttranscriptional mechanisms triggered by iodide excess on sodium\/iodide symporter (NIS) expression in PCCl3 cells","volume":"349","author":"Nunes","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"C893","DOI":"10.1152\/ajpcell.00224.2009","article-title":"Posttranscriptional regulation of sodium-iodide symporter mRNA expression in the rat thyroid gland by acute iodide administration","volume":"298","author":"Nunes","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/jir.2013.0150","article-title":"Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins","volume":"34","author":"Blackshear","year":"2014","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1095\/biolreprod.105.040527","article-title":"Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins","volume":"73","author":"Blackshear","year":"2005","journal-title":"Biol. Reprod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.semcancer.2015.02.006","article-title":"Sustained proliferation in cancer: Mechanisms and novel therapeutic targets","volume":"35","author":"Feitelson","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E1740","DOI":"10.1073\/pnas.1320873111","article-title":"Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase","volume":"111","author":"Tan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1038\/sj.onc.1205526","article-title":"Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways","volume":"21","author":"Johnson","year":"2002","journal-title":"Oncogene"},{"key":"ref_27","first-page":"7418","article-title":"The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation","volume":"44","author":"Tiedje","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1128\/MCB.24.14.6445-6455.2004","article-title":"Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family","volume":"24","author":"Stumpo","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1182\/blood-2009-04-214619","article-title":"Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis","volume":"114","author":"Stumpo","year":"2009","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1242\/dev.01336","article-title":"The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development","volume":"131","author":"Ramos","year":"2004","journal-title":"Development"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1093\/nar\/gku652","article-title":"ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway","volume":"42","author":"Adachi","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ydbio.2011.08.015","article-title":"Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning","volume":"359","author":"Fagman","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Reale, C., Russo, F., Credendino, S.C., Cuomo, D., De Vita, G., Mallardo, M., Pennino, F., Porreca, I., Triassi, M., and De Felice, M. (2019). A toxicogenomic approach reveals a novel gene regulatory network active in in vitro and in vivo models of thyroid carcinogenesis. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16010122"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"38131","DOI":"10.1038\/srep38131","article-title":"Pesticide toxicogenomics across scales: In vitro transcriptome predicts mechanisms and outcomes of exposure in vivo","volume":"6","author":"Porreca","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.devcel.2018.01.006","article-title":"Chromatin modification and global transcriptional silencing in the oocyte mediated by the mRNA decay activator ZFP36L2","volume":"44","author":"Dumdie","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/gene.20008","article-title":"Tissue-specific expression of cre recombinase from the Pax8 locus","volume":"38","author":"Bouchard","year":"2004","journal-title":"Genesis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","article-title":"The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clin. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1073\/pnas.91.19.9004","article-title":"Long-term culture and functional characterization of follicular cells from adult normal human thyroids","volume":"91","author":"Curcio","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1038\/s41598-018-21160-z","article-title":"ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner","volume":"8","author":"Suk","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1055\/s-0029-1211171","article-title":"Thyroid growth in vitro","volume":"100","author":"Gartner","year":"1992","journal-title":"Exp. Clin. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Porreca, I., Ulloa Severino, L., D\u2019Angelo, F., Cuomo, D., Ceccarelli, M., Altucci, L., Amendola, E., Nebbioso, A., Mallardo, M., and De Felice, M. (2016). \u201cStockpile\u201d of slight transcriptomic changes determines the indirect genotoxicity of low-dose BPA in thyroid cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151618"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ni.1901","article-title":"Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia","volume":"11","author":"Hodson","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Carre, A., Rachdi, L., Tron, E., Richard, B., Castanet, M., Schlumberger, M., Bidart, J.M., Szinnai, G., and Polak, M. (2011). Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016752"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1210\/jc.2008-0528","article-title":"Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors","volume":"93","author":"Ferretti","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/wrna.28","article-title":"The roles of TTP and BRF proteins in regulated mRNA decay","volume":"2","author":"Sanduja","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/dgd.12626","article-title":"Regulation of active and quiescent somatic stem cells by Notch signaling","volume":"62","author":"Sueda","year":"2020","journal-title":"Dev. Growth Differ."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Meier-Stiegen, F., Schwanbeck, R., Bernoth, K., Martini, S., Hieronymus, T., Ruau, D., Zenke, M., and Just, U. (2010). Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011481"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/MCB.21.2.524-533.2001","article-title":"Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding","volume":"21","author":"Roberts","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1210\/en.2009-1240","article-title":"A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid","volume":"151","author":"Amendola","year":"2010","journal-title":"Endocrinology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1042\/bst0300945","article-title":"Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover","volume":"30","author":"Blackshear","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1242\/dev.01648","article-title":"Thyroid hormone T3 acting through the thyroid hormone alpha receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse","volume":"132","author":"Domenget","year":"2005","journal-title":"Development"},{"key":"ref_52","first-page":"245","article-title":"Thyroid hormones in ovarian follicular fluid: Association with oocyte retrieval in women undergoing assisted fertilization procedures","volume":"24","author":"Rosales","year":"2020","journal-title":"JBRA Assist. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ball, C.B., Rodriguez, K.F., Stumpo, D.J., Ribeiro-Neto, F., Korach, K.S., Blackshear, P.J., Birnbaumer, L., and Ramos, S.B. (2014). The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097324"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/bbrc.1999.1764","article-title":"TSH control of PKA catalytic subunit activity in thyroid cell cultures","volume":"266","author":"Mamoune","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3892\/or.2016.5281","article-title":"Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53","volume":"37","author":"Li","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fmolb.2020.00126","article-title":"ZFP36 Binds With PRC1 to Inhibit Tumor Growth and Increase 5-Fu Chemosensitivity of Hepatocellular Carcinoma","volume":"7","author":"Chen","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E944","DOI":"10.1210\/jc.2013-1450","article-title":"Hypermethylation of a New Distal Sodium\/Iodide Symporter (NIS) enhancer (NDE) is associated with reduced NIS expression in thyroid tumors","volume":"99","author":"Galrao","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1210\/jc.2010-1784","article-title":"Enhancer of zeste homolog 2 overexpression has a role in the development of anaplastic thyroid carcinomas","volume":"96","author":"Borbone","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0248-4900(01)01124-8","article-title":"Cell cycle regulation by p38 MAP kinases","volume":"93","author":"Ambrosino","year":"2001","journal-title":"Biol. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1210\/me.2002-0400","article-title":"CCAAT\/enhancer-binding protein-homologous protein expression and transcriptional activity are regulated by 3\u2019,5\u2019-cyclic adenosine monophosphate in thyroid cells","volume":"17","author":"Pomerance","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/sj.onc.1206399","article-title":"Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells","volume":"22","author":"Tourneur","year":"2003","journal-title":"Oncogene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1073\/pnas.94.11.5568","article-title":"Characterization of the thyroid Na+\/I- symporter with an anti-COOH terminus antibody","volume":"94","author":"Levy","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","first-page":"97","article-title":"Expression of the RET\/PTC1 oncogene impairs the activity of TTF-1 and Pax-8 thyroid transcription factors","volume":"9","author":"Zannini","year":"1998","journal-title":"Cell Growth Differ."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/dvdy.10118","article-title":"Distribution of the titf2\/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair","volume":"224","author":"Dathan","year":"2002","journal-title":"Dev. Dyn."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mce.2014.08.004","article-title":"The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells","volume":"396","author":"Marotta","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41419-017-0026-3","article-title":"The expression of inhibitor of bruton\u2019s tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis","volume":"9","author":"Albano","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/JOE-20-0134","article-title":"Peripheral T3 signaling is the target of pesticides in zebrafish larvae and adult liver","volume":"247","author":"Colella","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.abb.2018.06.016","article-title":"Dibutyryl cAMP- or Interleukin-6-induced astrocytic differentiation enhances mannose binding lectin (MBL)-associated serine protease (MASP)-1\/3 expression in C6 glioma cells","volume":"653","author":"Pagliara","year":"2018","journal-title":"Arch. Biochem. Biophys."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/17\/9379\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:55:08Z","timestamp":1760165708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/22\/17\/9379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,29]]},"references-count":69,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ijms22179379"],"URL":"https:\/\/doi.org\/10.3390\/ijms22179379","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,29]]}}}